Entry
Name
NF-kappa B signaling pathway - Ursus maritimus (polar bear)
Description
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Organism
Ursus maritimus (polar bear) [GN:
umr ]
Gene
103657908 LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362 ]
103669754 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
103662093 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
103676546 CARD10; caspase recruitment domain-containing protein 10 [KO:K20912 ]
103670075 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
103665979 CARD14; caspase recruitment domain-containing protein 14 [KO:K20913 ]
103676304 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
103680724 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
103656234 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
103673673 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
103682573 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
103661962 EDARADD; ectodysplasin-A receptor-associated adapter protein isoform X1 [KO:K23324 ]
103681147 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
103663749 CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391 ]
103660655 toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
103669702 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
103677566 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
103676207 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
103681870 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
103656207 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
103676518 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
103666926 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
103668292 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
103657543 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
103674152 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
103671099 PIDD1; LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130 ]
103675710 ERC1; ELKS/Rab6-interacting/CAST family member 1 isoform X1 [KO:K16072 ]
103677947 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
103681651 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
103663135 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402 ]
103663314 growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
121100135 growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402 ]
103659023 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Oeckinghaus A, Hayden MS, Ghosh S
Title
Crosstalk in NF-kappaB signaling pathways.
Journal
Reference
Authors
Gloire G, Piette J
Title
Redox regulation of nuclear post-translational modifications during NF-kappaB activation.
Journal
Reference
Authors
Perkins ND
Title
Integrating cell-signalling pathways with NF-kappaB and IKK function.
Journal
Reference
Authors
Lindstrom TM, Bennett PR
Title
The role of nuclear factor kappa B in human labour.
Journal
Reference
Authors
Razani B, Reichardt AD, Cheng G
Title
Non-canonical NF-kappaB signaling activation and regulation: principles and perspectives.
Journal
Reference
Authors
Sun SC
Title
Non-canonical NF-kappaB signaling pathway.
Journal
Reference
Authors
Neumann M, Naumann M
Title
Beyond IkappaBs: alternative regulation of NF-kappaB activity.
Journal
Reference
Authors
Verhelst K, Carpentier I, Beyaert R
Title
Regulation of TNF-induced NF-kappaB activation by different cytoplasmic ubiquitination events.
Journal
Reference
Authors
Rickert RC, Jellusova J, Miletic AV
Title
Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.
Journal
Reference
Authors
Naude PJ, den Boer JA, Luiten PG, Eisel UL
Title
Tumor necrosis factor receptor cross-talk.
Journal
Reference
Authors
Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA
Title
Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms.
Journal
Reference
Authors
Wada T, Nakashima T, Hiroshi N, Penninger JM
Title
RANKL-RANK signaling in osteoclastogenesis and bone disease.
Journal
Reference
Authors
Schulze-Luehrmann J, Ghosh S
Title
Antigen-receptor signaling to nuclear factor kappa B.
Journal
Reference
Authors
Weil R, Israel A
Title
T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes.
Journal
Reference
Authors
Siebenlist U, Brown K, Claudio E
Title
Control of lymphocyte development by nuclear factor-kappaB.
Journal
Reference
Authors
Lucas PC, McAllister-Lucas LM, Nunez G
Title
NF-kappaB signaling in lymphocytes: a new cast of characters.
Journal
Reference
Authors
Khan WN
Title
B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
Journal
Reference
Authors
Vallabhapurapu S, Karin M
Title
Regulation and function of NF-kappaB transcription factors in the immune system.
Journal
Reference
Authors
Hacker H, Karin M
Title
Regulation and function of IKK and IKK-related kinases.
Journal
Reference
Authors
Sabatel H, Pirlot C, Piette J, Habraken Y
Title
Importance of PIKKs in NF-kappaB activation by genotoxic stress.
Journal
Reference
Authors
Miyamoto S
Title
Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage.
Journal
Reference
Authors
Brzoska K, Szumiel I
Title
Signalling loops and linear pathways: NF-kappaB activation in response to genotoxic stress.
Journal
Reference
Authors
Wu ZH, Miyamoto S
Title
Many faces of NF-kappaB signaling induced by genotoxic stress.
Journal
Reference
Authors
Maelfait J, Beyaert R
Title
Emerging role of ubiquitination in antiviral RIG-I signaling.
Journal
Reference
Authors
Ware CF
Title
Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways.
Journal
Reference
Authors
Schneider K, Potter KG, Ware CF
Title
Lymphotoxin and LIGHT signaling pathways and target genes.
Journal
Reference
Authors
Remouchamps C, Boutaffala L, Ganeff C, Dejardin E
Title
Biology and signal transduction pathways of the Lymphotoxin-alphabeta/LTbetaR system.
Journal
Reference
Authors
Liu S, Chen ZJ
Title
Expanding role of ubiquitination in NF-kappaB signaling.
Journal
Reference
Authors
Skaug B, Jiang X, Chen ZJ
Title
The role of ubiquitin in NF-kappaB regulatory pathways.
Journal
Reference
Authors
Wertz IE, Dixit VM
Title
Signaling to NF-kappaB: regulation by ubiquitination.
Journal
Reference
Authors
Karin M, Lin A
Title
NF-kappaB at the crossroads of life and death.
Journal
Reference
Authors
Lin A, Karin M
Title
NF-kappaB in cancer: a marked target.
Journal
Reference
Authors
Morlon A, Munnich A, Smahi A
Title
TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
Journal
Reference
Authors
Sadier A, Viriot L, Pantalacci S, Laudet V
Title
The ectodysplasin pathway: from diseases to adaptations.
Journal
Reference
Authors
Verhelst K, Gardam S, Borghi A, Kreike M, Carpentier I, Beyaert R
Title
XEDAR activates the non-canonical NF-kappaB pathway.
Journal
Reference
Authors
McDaniel DK, Eden K, Ringel VM, Allen IC
Title
Emerging Roles for Noncanonical NF-kappaB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.
Journal
Reference
Authors
Mikkola ML, Thesleff I
Title
Ectodysplasin signaling in development.
Journal
Reference
Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
Journal
Related pathway
umr04060 Cytokine-cytokine receptor interaction
umr04620 Toll-like receptor signaling pathway
umr04622 RIG-I-like receptor signaling pathway
umr04660 T cell receptor signaling pathway
umr04662 B cell receptor signaling pathway
KO pathway
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