KEGG   PATHWAY: vvp04115
Entry
vvp04115                    Pathway                                

Name
p53 signaling pathway - Vulpes vulpes (red fox)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
vvp04115  p53 signaling pathway
vvp04115

Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112925961  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112906959  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
112934959  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112920276  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
112923476  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
112911644  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
112922285  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112914392  MDM4; protein Mdm4 [KO:K10127]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112913942  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112924157  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112917379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112913983  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112922331  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112923889  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112931227  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112928464  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112922404  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112931790  SFN; 14-3-3 protein sigma [KO:K06644]
112921925  G2/mitotic-specific cyclin-B1-like [KO:K05868]
112935841  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112917134  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
112931083  CDK1; LOW QUALITY PROTEIN: cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112908633  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112910526  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112935608  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112935856  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
112931965  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112924121  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
112922873  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112917438  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112919301  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
112931366  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
112930309  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
112909902  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112919203  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
112908482  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
112920278  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
112912079  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
112919473  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
112926216  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
112931753  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
112916549  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
112915706  cytochrome c [KO:K08738]
112930669  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112929772  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112934766  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112923938  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
112930717  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112935788  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
112909226  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
112924116  CD82; CD82 antigen [KO:K06509]
112919933  THBS1; thrombospondin-1 [KO:K16857]
112919310  SERPINB5; serpin B5 isoform X1 [KO:K10139]
112924073  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112927720  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
112916984  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
112915770  SESN3; sestrin-3 isoform X1 [KO:K10141]
112925157  SESN1; sestrin-1 isoform X1 [KO:K10141]
112931735  SESN2; sestrin-2 [KO:K20394]
112931976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112909041  TSC2; tuberin isoform X1 [KO:K07207]
112934329  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
112921727  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
112915542  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
112926540  CCNG1; cyclin-G1 [KO:K10145]
112910878  cyclin-G1 [KO:K10145]
112919717  CCNG2; cyclin-G2 [KO:K10146]
112917953  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
112924708  TP73; tumor protein p73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
vvp04110  Cell cycle
vvp04210  Apoptosis
vvp04218  Cellular senescence
KO pathway
ko04115   
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