KEGG   PATHWAY: vvp05216
Entry
vvp05216                    Pathway                                

Name
Thyroid cancer - Vulpes vulpes (red fox)
Description
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class
Human Diseases; Cancer: specific types
Pathway map
vvp05216  Thyroid cancer
vvp05216

Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112913604  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
112931065  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
112913316  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
112918800  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112913093  tropomyosin alpha-3 chain-like [KO:K09290]
112918879  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
112921828  TPR; nucleoprotein TPR [KO:K09291]
112913387  TFG; protein TFG isoform X1 [KO:K09292]
112914428  HRAS; GTPase HRas isoform X1 [KO:K02833]
112916766  NRAS; GTPase NRas [KO:K07828]
112917213  KRAS; GTPase KRas isoform X1 [KO:K07827]
112907060  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112935545  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112929340  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112907501  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112916651  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
112933683  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
112906873  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
112913873  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
112914313  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112913942  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112908633  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112910526  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112935608  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112913897  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112924073  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112919752  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
112929524  CDH1; cadherin-1 [KO:K05689]
112924654  cadherin-1-like [KO:K05689]
112921625  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112917059  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
112916685  TCF7L1; transcription factor 7-like 1 [KO:K04490]
112916157  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112934208  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
112915979  MYC; myc proto-oncogene protein [KO:K04377]
112924157  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Related
pathway
vvp03320  PPAR signaling pathway
vvp04010  MAPK signaling pathway
vvp04115  p53 signaling pathway
vvp04310  Wnt signaling pathway
vvp04520  Adherens junction
KO pathway
ko05216   
LinkDB

DBGET integrated database retrieval system