KEGG   PATHWAY: xma05132
Entry
xma05132                    Pathway                                
Name
Salmonella infection - Xiphophorus maculatus (southern platyfish)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
xma05132  Salmonella infection
xma05132

Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102235917  podxl; podocalyxin [KO:K06817]
102221561  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
102221989  ras-related protein Rab-5A [KO:K07887]
102233132  ras-related protein Rab-5A-like [KO:K07887]
102224939  ras-related protein Rab-5B-like isoform X2 [KO:K07888]
102225780  rab5c; ras-related protein Rab-5C [KO:K07889]
102231109  ras-related protein Rab-5C [KO:K07889]
102231703  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
102221039  ras-related protein rab7-like isoform X1 [KO:K07897]
102230535  ras-related protein rab7 [KO:K07897]
102219790  ras-related protein rab7-like [KO:K07897]
102219869  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
102220843  vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
102217466  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
102233942  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
102236162  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
102221152  vps39; vam6/Vps39-like protein [KO:K20183]
102225435  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
102231506  RILP-like protein 1 [KO:K13883]
102224928  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
102220918  dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
102216642  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102234260  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102220424  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
102236636  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
102231867  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X3 [KO:K10416]
102232620  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
102224538  dynein light chain 2, cytoplasmic-like [KO:K10418]
102236607  dynein light chain 2, cytoplasmic [KO:K10418]
102227793  dynein light chain 2, cytoplasmic-like [KO:K10418]
102228081  dynein light chain roadblock-type 1-like [KO:K10419]
102228332  dynein light chain roadblock-type 1 [KO:K10419]
102225912  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
102232341  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
102237012  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
102233096  dynein light chain Tctex-type 1-like [KO:K10420]
102238322  dctn1; dynactin subunit 1 isoform X3 [KO:K04648]
102224407  dynactin subunit 1-like isoform X1 [KO:K04648]
102237333  dctn2; dynactin subunit 2 isoform X3 [KO:K10424]
102230272  dctn3; dynactin subunit 3 [KO:K10425]
102237498  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
102228124  dctn5; dynactin subunit 5 [KO:K10427]
102236166  dctn6; dynactin subunit 6 [KO:K10428]
102225238  dynactin subunit 6-like [KO:K10428]
102228756  beta-centractin [KO:K16575]
102221583  actr10; actin-related protein 10 [KO:K16576]
102234423  tubulin alpha-1B chain [KO:K07374]
102223550  tubulin alpha chain [KO:K07374]
102224061  tubulin alpha chain-like [KO:K07374]
102217094  tubulin alpha-1A chain [KO:K07374]
102217348  tubulin alpha-1B chain-like isoform X2 [KO:K07374]
102226394  tubulin alpha chain-like [KO:K07374]
102218092  tubulin alpha-8 chain-like [KO:K07374]
102223804  tubulin alpha-1C chain-like [KO:K07374]
102223433  tuba4a; tubulin alpha-4A chain [KO:K07374]
102224440  tubulin alpha-1B chain-like [KO:K07374]
102221968  tubulin alpha-1C chain-like [KO:K07374]
102217235  tubulin alpha chain-like [KO:K07374]
102223894  tubulin alpha-1B chain-like [KO:K07374]
106700148  tubulin alpha-1B chain-like [KO:K07374]
102226042  tubulin beta chain-like isoform X1 [KO:K07375]
102217151  tubulin beta-4B chain-like isoform X2 [KO:K07375]
102231664  tubulin beta chain-like [KO:K07375]
102232796  tubulin beta chain [KO:K07375]
102228617  tubulin beta-4B chain-like [KO:K07375]
102229930  tubulin beta-4B chain-like [KO:K07375]
102226155  tubulin beta-4B chain-like [KO:K07375]
102230583  tubulin beta-4B chain isoform X1 [KO:K07375]
102237703  tubulin beta chain-like [KO:K07375]
102236594  tubulin beta-1 chain [KO:K07375]
102228734  tubb4b; tubulin beta-4B chain [KO:K07375]
111610383  tubulin beta chain-like [KO:K07375]
102218511  fyco1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
102230637  FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
102222952  arl8b; ADP-ribosylation factor-like protein 8B [KO:K07955]
102219721  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
102237483  ADP-ribosylation factor-like protein 8A [KO:K07955]
102235579  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
102231314  kinesin heavy chain-like [KO:K10396]
102224761  kinesin heavy chain [KO:K10396]
102222665  kinesin heavy chain-like [KO:K10396]
102235968  kinesin-1 heavy chain [KO:K10396]
102237623  kif5b; kinesin-1 heavy chain isoform X2 [KO:K10396]
102230096  kif5a; kinesin heavy chain isoform X2 [KO:K10396]
102233978  kinesin light chain 1 isoform X5 [KO:K10407]
102225315  kinesin light chain 1-like isoform X1 [KO:K10407]
102235667  klc1; kinesin light chain 1 isoform X5 [KO:K10407]
102234750  klc2; kinesin light chain 2 isoform X1 [KO:K10407]
102235508  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
102225527  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
102234531  rho-related GTP-binding protein RhoA-C [KO:K04513]
102222710  transforming protein RhoA [KO:K04513]
102229174  rho-related GTP-binding protein RhoA-D [KO:K04513]
102233685  transforming protein RhoA-like [KO:K04513]
102218174  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
102228803  rab9a; ras-related protein Rab-9A [KO:K07899]
102216793  ras-related protein Rab-9A-like [KO:K07899]
102228683  ras-related protein Rab-9B-like [KO:K07900]
102218301  gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
102236574  stx10; syntaxin-10 [KO:K23937]
102228356  profilin-2-like isoform X1 [KO:K05759]
102232684  profilin-2-like isoform X2 [KO:K05759]
102226806  profilin-1-like [KO:K05759]
102236849  filamin-A-like isoform X1 [KO:K04437]
102222416  exoc7; exocyst complex component 7 isoform X2 [KO:K07195]
102228527  exoc5; exocyst complex component 5 [KO:K19984]
102236265  exoc4; exocyst complex component 4 [KO:K06111]
102225535  exoc2; exocyst complex component 2 [KO:K17637]
102226410  ras-related protein Ral-A [KO:K07834]
102218394  actin, cytoplasmic 2 [KO:K05692]
102222885  actb; actin, cytoplasmic 1 [KO:K05692]
102225599  protein S100-A1-like [KO:K17274]
102230575  protein S100-A1-like [KO:K17274]
102232185  annexin A2 [KO:K17092]
102232071  annexin A2-like [KO:K17092]
102217557  annexin A2-like [KO:K17092]
102218570  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
102221496  neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
102230325  neuroblast differentiation-associated protein AHNAK-like isoform X1 [KO:K23934]
111608641  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
102238387  arhgef26; rho guanine nucleotide exchange factor 26 [KO:K13744]
102227222  rho-related GTP-binding protein RhoG-like [KO:K07863]
102227484  rho-related GTP-binding protein RhoG-like [KO:K07863]
102223754  rho-related GTP-binding protein RhoG-like [KO:K07863]
102236635  elmo1; engulfment and cell motility protein 1 isoform X3 [KO:K12366]
102218110  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
102226221  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102230495  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
102221311  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102235799  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
102229585  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102224997  myosin regulatory light polypeptide 9 [KO:K12755]
102237517  myosin regulatory light polypeptide 9 [KO:K12757]
102228027  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
102234161  myosin regulatory light chain 2, skeletal muscle isoform-like isoform X1 [KO:K12758]
102228744  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102237305  FH1/FH2 domain-containing protein 1-like isoform X1 [KO:K23938]
111610887  FH1/FH2 domain-containing protein 1-like [KO:K23938]
102236058  cell division control protein 42 homolog [KO:K04393]
102225189  cell division control protein 42 homolog isoform X1 [KO:K04393]
102223132  cell division control protein 42 homolog [KO:K04393]
102226130  cell division control protein 42 homolog [KO:K04393]
102216748  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102217008  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102218748  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102226330  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102217124  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102233899  nckap1l; nck-associated protein 1-like [KO:K05750]
102226848  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
102234440  cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102222230  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
102223211  abi1; abl interactor 1 isoform X6 [KO:K23649]
102225665  abl interactor 1-like isoform X1 [KO:K23649]
102217910  brk1; protein BRICK1 [KO:K05752]
102220511  wasf3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
102230109  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
102220310  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
102231009  actr2; actin-related protein 2 [KO:K17260]
102216726  actin-related protein 2-like [KO:K17260]
102238087  actin-related protein 3B isoform X1 [KO:K18584]
102224211  actin-related protein 3 [KO:K18584]
102223384  actin-related protein 3 [KO:K18584]
102228495  actin-related protein 2/3 complex subunit 1A [KO:K05757]
102228761  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
102219367  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
102218741  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102227047  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102227255  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102230269  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
102228457  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102221449  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
102217297  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102230909  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102223118  unconventional myosin-VI-like [KO:K10358]
102231856  myo6; unconventional myosin-VI isoform X1 [KO:K10358]
102225882  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102226157  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102231707  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102218230  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102230257  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102225994  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
102229099  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102225822  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
102218236  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2 [KO:K00923] [EC:2.7.1.154]
102221445  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
102232591  cytohesin-3-like [KO:K18441]
102222215  cytohesin-2-like [KO:K18441]
102223380  cytohesin-1 isoform X1 [KO:K18441]
102224859  cytohesin-3-like [KO:K18441]
102226583  cytohesin-3 isoform X2 [KO:K18441]
102228191  cyth2; cytohesin-2 [KO:K18441]
102231734  cytohesin-1-like isoform X1 [KO:K18441]
102229843  ADP-ribosylation factor 6 [KO:K07941]
102220348  ADP-ribosylation factor 6 [KO:K07941]
102224888  ADP-ribosylation factor 1 [KO:K07937]
102228520  ADP-ribosylation factor 1-like [KO:K07937]
102225746  arf1; ADP-ribosylation factor 1 [KO:K07937]
102237684  snx9; sorting nexin-9 isoform X1 [KO:K17923]
102230893  snx18; sorting nexin-18 [KO:K17923]
102224457  snx33; sorting nexin-33 [KO:K17923]
102221247  sorting nexin-9-like [KO:K17923]
102223559  sorting nexin-18-like [KO:K17923]
102228862  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102228105  wiskott-Aldrich syndrome protein-like [KO:K23612]
102221167  neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102231683  dynamin-2 isoform X3 [KO:K23484] [EC:3.6.5.5]
102226787  toll-like receptor 2 type-2 [KO:K10159]
102227045  toll-like receptor 2 type-1 [KO:K10159]
102230797  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
102237713  tirap; LOW QUALITY PROTEIN: toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
102234764  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102232760  tlr5; toll-like receptor 5 isoform X1 [KO:K10168]
102234695  toll-like receptor 5 [KO:K10168]
102231075  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102235789  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102220826  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102226534  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102232287  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
102220462  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102236763  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102235135  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
102233509  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102226088  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
102221657  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
102223773  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102228531  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
102217801  NF-kappa-B inhibitor alpha-like [KO:K04734]
102218233  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
102219636  transcription factor p65-like isoform X1 [KO:K04735]
102231540  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
102219317  heat shock protein HSP 90-beta [KO:K04079]
102218115  heat shock protein HSP 90-alpha [KO:K04079]
102218377  heat shock protein HSP 90-alpha 1 [KO:K04079]
102226044  hsp90b1; endoplasmin [KO:K09487]
102234179  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
102226998  cse1l; exportin-2 [KO:K18423]
102237596  kpna1; importin subunit alpha-5 [KO:K23940]
102219118  kpna3; importin subunit alpha-4 [KO:K23583]
102236520  kpna4; importin subunit alpha-3 [KO:K23583]
102236438  rps3; 40S ribosomal protein S3 [KO:K02985]
102217290  hras; GTPase HRas [KO:K02833]
102234445  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102217036  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102225775  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102235941  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102237032  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
102219049  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
102221885  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102231047  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
102218102  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
102233918  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
102223674  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
102223422  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
102233752  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
102223477  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
102225231  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
102232155  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
102238025  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102237237  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
102226476  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102234094  mitogen-activated protein kinase 8-like isoform X3 [KO:K04440] [EC:2.7.11.24]
102221148  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102224057  proto-oncogene c-Fos-like [KO:K04379]
102222672  proto-oncogene c-Fos-like [KO:K04379]
102223022  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
102234665  transcription factor AP-1-like [KO:K04448]
102230050  jun; transcription factor AP-1 [KO:K04448]
102231253  tumor necrosis factor-like isoform X1 [KO:K03156]
111609466  tumor necrosis factor-like [KO:K03156]
106700093  interleukin-1 beta isoform X1 [KO:K04519]
102231459  interleukin-1 beta [KO:K04519]
111610322  interleukin-1 beta-like [KO:K04519]
102217177  interleukin-8-like [KO:K10030]
102217432  interleukin-8-like [KO:K10030]
102233259  permeability factor 2-like [KO:K10030]
102234936  catenin beta-1-like [KO:K02105]
102233058  ctnnb1; catenin beta-1 [KO:K02105]
111610761  transcription factor 7-like [KO:K02620]
102221228  tcf7; transcription factor 7 isoform X1 [KO:K02620]
102218641  transcription factor 7-like 1-A isoform X1 [KO:K04490]
102234111  transcription factor 7-like 1-A isoform X1 [KO:K04490]
102216716  tcf7l2; transcription factor 7-like 2 isoform X10 [KO:K04491]
102226301  lef1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
111609564  lymphoid enhancer-binding factor 1-like [KO:K04492]
102224917  myc; myc proto-oncogene protein [KO:K04377]
102229551  transcriptional regulator Myc-B-like [KO:K04377]
102220374  transcriptional regulator Myc-2-like [KO:K04377]
102230198  serine/threonine-protein kinase N1-like isoform X3 [KO:K06071] [EC:2.7.11.13]
102238285  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
102228429  fbxo22; F-box only protein 22 [KO:K10302]
102221489  skp1; S-phase kinase-associated protein 1 [KO:K03094]
102237252  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102233408  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102217350  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102227944  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
102228470  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102228638  birc2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
102226461  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102237772  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102222621  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111607857  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
102221075  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
102230681  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
102220811  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
102221406  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
102230597  fadd; FAS-associated death domain protein [KO:K02373]
111608841  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102236921  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102237850  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
102237443  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
102226269  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
111612340  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
102229835  apoptosis regulator BAX-like isoform X1 [KO:K02159]
102238210  apoptosis regulator BAX-like [KO:K02159]
106700271  apoptosis regulator BAX-like [KO:K02159]
102228435  cytochrome c-b [KO:K08738]
102224281  cytochrome c [KO:K08738]
102223266  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
102224433  caspase-3 [KO:K02187] [EC:3.4.22.56]
102227213  caspase-3-like [KO:K02187] [EC:3.4.22.56]
102230553  casp7; caspase-7 isoform X2 [KO:K04397] [EC:3.4.22.60]
102218392  caspase-3-like [KO:K04397] [EC:3.4.22.60]
102232719  rho-related GTP-binding protein RhoB-like [KO:K07856]
102219588  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
102225808  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102237954  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102224082  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102232504  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102222390  mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
102220812  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
102229646  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
102223468  txn2; thioredoxin, mitochondrial [KO:K03671]
102229876  thioredoxin-like [KO:K03671]
102230139  thioredoxin-like [KO:K03671]
102235142  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111608209  uncharacterized protein LOC111608209 [KO:K12799]
102220624  caspase-1-like [KO:K01370] [EC:3.4.22.36]
102220363  caspase-1-like [KO:K01370] [EC:3.4.22.36]
102229031  caspase-1-like [KO:K01370] [EC:3.4.22.36]
111605766  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
102222709  il18; interleukin-18 isoform X2 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
xma04010  MAPK signaling pathway
xma04210  Apoptosis
xma04217  Necroptosis
xma04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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