Physeter catodon (sperm whale): 102976725 Help Entry 102976725         CDS       T06011                                  Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism pcad  Physeter catodon (sperm whale) Pathway pcad04020   Calcium signaling pathway pcad04371   Apelin signaling pathway pcad04713   Circadian entrainment pcad04730   Long-term depression pcad04921   Oxytocin signaling pathway pcad05017   Spinocerebellar ataxia pcad05020   Prion disease pcad05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102976725    04020 Calcium signaling pathway     102976725  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102976725   09156 Nervous system    04730 Long-term depression     102976725   09159 Environmental adaptation    04713 Circadian entrainment     102976725  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     102976725    05020 Prion disease     102976725    05022 Pathways of neurodegeneration - multiple diseases     102976725  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pcad01009]     102976725   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pcad04147]     102976725    04040 Ion channels [BR:pcad04040]     102976725 Protein phosphatases and associated proteins [BR:pcad01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      102976725 Exosome [BR:pcad04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    102976725 Ion channels [BR:pcad04040]  Voltage-gated cation channels   Ryanodine receptor    102976725 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY MIR Ins145_P3_rec RIH_assoc CDC45 Motif Other DBs NCBI-GeneID:  102976725 NCBI-ProteinID:  XP_028339683 Ensembl:  ENSPCTG00005019885 UniProt:  A0A455AUX3 LinkDB All DBs Position Unknown AA seq 4137 aa AA seqDB search MGDGGEGEDEVQFLRTDDEMVLQCSAMVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHSHSGMYLSC LTTSRSMTDKLAFDVGLQEDAIGEACWWTTHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHMDECLTISPADSDD QRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALSEDQGLV VVDASKAHTKATSFCFRISKEKLDTSPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAILHQEGHMDDALSLTRCQQEESQAARMIYSTGGLYNHFIKGLDS FSGKPRGSGSPAGTALPLEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALF SNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINFVTSIRPNIFVGRAESSTQYL KWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVPRLVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTMLVDRLAENGHNVWARDRVAQGWTYSSVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKS YVVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFG RPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEATPPEHPHYEVTRV DGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAE DEARAAEPDPDYENLRRSAGHWGEAEGGKEGTAKEGSSGGTAQAGVEAQPPRAENEKDAT TEKNKKRGFLFKAKKAAMMTQPPATPTLPRLPREVVPTDDRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFDLSKVRVVTVTMGDEQGNIHSSLKCSNCYMVWGGDF VSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPTPQCPPRLEVQMLMPVSWSRMPNHFLQVDTRRA GERLGWAVQCQEPLTMMALHVPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTP ETRAITLFPPGKRADDGPRRYGLPGVGVTTSLRPPHHFLAPCFVAALPAAGAAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDV KQILKMIEPEVFTEEEEEEEEEEEEEDEEEKEEDEEEEAREKEDEEKEEEETAEGEKEED LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYSILV KSFTMPAAETARRTREFRSPPQEQINMLLHFKDAEDEEDCPVPEEIRQDLLEFHQDLLTH CGIQLAGEEEELEEEATLGSRLMSLLEKVRLLKKKEEKPEEEPPAEEHKPQSLQELVSHT VVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQ IRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESK EIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVI DNNELALALQEQDLEKVVSYLAGCGLQSCPILLAKGYPDIGWNPCGGERYLDFLRFAVFV NGESVEENANVVVRLLIRKPECFGPALRGEGSSGLLATIEEAIRISEDPARDGPGVRRDR RRELFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLV PLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQEFLLHV LDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFARTEHRAIMVDS MLHTVYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPL KLLTNHYERCWKYYCLPTGWANYGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAMP CLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEY THEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEW TIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLTGVTLSRELQAMAEQLAEN YHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGL KDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKI LLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDA PAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQTRTQ VKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNT YVEKLRPALGECLACLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCP DIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPLALPAGAP PPCTAITSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLHSHFIPT IGRLRKRAGKVVSEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRA HWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMTKS GGSDQERTKKKRRGDRYSVQTSLIVAMLKKMLPIGLNMCAPTDQELITLAKTRYALKDTD EEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHL EQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTQRACNMFVESYKAAWILTED HSFEDRMIDDLSKAGKQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYIAYA DIMAKSCHLEEGGENGEAEEQEVELSFEEKEMEKQRLLYQQARLHNRGTAEMVLQMISAC KGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNA FERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQ TGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLT EYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVM LLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRG LISKKDFQKVSTGRRMGGVPSASHALPGCLLQARDFSGCLSFLICKTGIKLSSLDLF NT seq 12414 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggatgaggtccagtttctgcggacggacgacgagatg gtcctgcagtgcagcgccatggtgctcaaggagcagctcaagctctgcctggccgccgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaatgcccagaacgtgcccccc gatctggccatctgttgcttcgtcctggagcagtccctgtccgtccgagccctgcaggag atgctggccaacaccgtggaggccggcgtggagtcgtcccagggtgggggacacaggaca ctcctgtacggccatgccatcctgctccggcactcgcacagcggcatgtacctgagctgc ctcaccacctcccgctccatgactgacaagctggccttcgacgtgggactgcaggaggat gcaataggagaggcctgttggtggacgacacacccggcctccaagcagaggtccgaagga gagaaggtccgagttggggatgacctcatcctcgtcagcgtctcctctgagcgctacctg cacctgtcgacggccagtggggagctccaggttgacgcctccttcatgcagacactgtgg aacatgaaccccatctgctccggctgcgaagagggctatgtgaccgggggccatgtcctc cgcctctttcatggacacatggatgaatgtctgaccatctcccctgctgacagtgatgac cagcgcagacttgtctactatgaggggggatctgtgtgcacccacgcccgctccctctgg agactggagccactgagaatcagctggagtgggagccacctgcgctggggccagccactc cgcatccggcatgtcaccaccgggcggtacttggcactctctgaggaccagggcctagtg gtggttgacgccagcaaggcccacaccaaggccacttccttctgcttccgaatctccaag gagaagctggatacgtcccccaagcgggatgtggagggcatgggcccccctgaaatcaaa tatggggagtcactgtgctttgtgcagcacgtggcctcaggcctgtggctcacctatgct gccccggaccccaaggccctgcggctcggcgtgctcaagaagaaggccattctgcaccag gaaggccacatggacgacgcgctgtcactgacccgctgtcagcaggaggagtcccaggcc gcccgcatgatctacagcactggcggcctctacaaccacttcatcaagggcctggacagc ttcagcggaaagccgaggggctcggggtctccggctggcacagcactgcctctcgagggc gtcatcctgagcctgcaggacctcatcggctacttcgagccaccctccgaggagctgcag catgaggagaagcagagcaagctgcgcagcctgcgcaaccgccagagcctcttccaggag gaggggatgctctccctggtcctgaactgcatcgaccgcctaaatgtttacaccactgct gcccactttgctgaatttgccggggaggaggcagccgagtcctggaaagagattgtgaac ctgctgtatgaaatcctggcctctctgatccgtggcaatcgtgccaactgtgccctcttc tccaacaacctggattggctggtcagcaaactggatcggctggaggcctcctcggggatc ctggaggtgctgtactgtgtcctgattgagagtcctgaggtcctgaacatcatccaggag aaccacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtgctg gatgtgctgtgttccctgtgtgtgtgcaatggtgtggccgtgcgctccaaccaagatctc attactgagaacttgctccctggccgtgagcttctgctgcagacaaacctcatcaacttt gtcaccagcatccgccccaacatttttgtgggccgagcagagagctccacgcagtacctc aaatggtactttgaggtgatggtggacgaggtggccccattcctgacagctcaggccacc cacctgcgggtgggctgggccctcactgagggctacagcccgtaccctgggggcggcgag ggctggggcggcaacggggtcggcgatgacctctattcctacggctttgatgggctgcat ctctggacaggacacgtgccacgcctggtgacttccccagggcagcacctcctggccccc gaggacgtggtcagctgctgcctggacctcagcgtgccatccatctccttccgcatcaat ggctgtcctgtgcagggtgtctttgaggccttcaaccttgatgggctcttcttccccgtt gtcagcttctcagctggtgtcaaggtgcggttccttcttggtggccgccatggtgaattc aagttcctccctccgcctggctatgccccttgtcatgaggctgtgctcccgcgagagcga ctccatctggagcccatcaaggagtatcggcgggaagggccccgggggccccacctggtg ggccccagccgctgcctctcacacaccgactttgtgccctgccctgtggacactgtccag attgtcctgcctccccatctggagcgtattcgggagaagctggcggagaacatccatgaa ctctgggcactgactcgcattgagcagggctggacctacggcccggttcgggatgacaat aagaggctgcacccgtgtctcgtggacttccacagcctaccggagcccgagaggaattac aacctgcagatgtcgggggagacgctcaagaccctgctggcgctgggctgccacgtgggc atggcggacgagaaggcggaagacaacctgaagaagacaaaactccccaagacgtacatg atgagcaatgggtacaagccggcgcctctggacctgagccacgtgagactgacgcccgcg cagacgatgctggtggaccggctggcggagaacggacacaatgtgtgggcacgagaccga gtggcccagggctggacctacagctctgtgcaggacatccctgcgcgccggaaccctcgc cttgtgccctaccgcctgctggacgaggccaccaagcgcagcaaccgggacagcctctgc caggccgtgcgcaccctgctgggctacggctacaacattgagccgcccgaccaggagccc agtcaggtggagagccagtctcgctgggaccgggtgcgcatcttcagggcagagaaatcc tatgtggtgcagagcggccgctggtacttcgagtttgaggcagtcaccaccggcgagatg cgagtgggctgggcgaggcctgagctgcggcctgacgtggagctgggagctgatgagctg gcctacgtcttcaacgggcaccgcggtcagcgctggcacttgggcagtgaaccgtttggg cgtccctggcagtcaggtgatgtcgtgggctgcatgatcgacctcacagagaacaccatt atcttcaccctcaacggcgaggtgctcatgtccgattcaggctctgaaacagccttccgg gatattgagattggggatggcttcctgcccgtctgcagcttgggacctggccaggtgggt cacctgaacctgggccaggatgtgagctccctgcggttctttgccatctgtggcctccag gaaggttttgagccgtttgccatcaacatgcagcgcccggtcaccacctggttcagcaaa agccttccccagtttgaggccacgccccctgagcatccccactatgaggtgactcgtgtg gacggcaccgtggacacccccccctgcctgcgcctgacccaccgcacttggggttcccag aacagtctggtggagatgctctttctccggctgagccttccggtccagttccaccagcac ttccgctgcaccgcaggggccacccctctggcaccccctggcctgcagcctcctgctgag gatgaggcccgggcagcggagcctgatcccgactatgaaaacctgcgccgctcggctggg cactggggcgaggctgagggcggcaaagaaggaactgccaaggaagggtcatccgggggc accgcccaggccggggtagaggcccagcctcccagggcagagaatgagaaggatgctacc acagagaagaacaagaagagagggttcttgttcaaggccaagaaggccgccatgatgacc cagccaccagccacccccactctgccccgactgcctcgcgaggtggtgcccactgacgac cgtgatgaccctgagatcatcctcaataccaccacgtactattactccgtgagggtcttt gccggccaggagcccagctgcgtgtgggtgggctgggtcacccccgactaccatcagcac gacatgaacttcgacctcagcaaggtccgggtggtgacggtgaccatgggggacgagcaa ggcaacatacacagcagcctcaagtgcagcaactgctacatggtgtggggtggagacttc gtgagccccgggcagcagggccggatcagccacacggaccttgtcattggctgcctggtg gacttggccactggcctaatgacgtttaccgccaacggcaaagagagcaacacctttttc caggtggaacccaatacgaagctgtttcctgctgtctttgtcctgccgacacaccagaac gtcatccagtttgagctggggaagcagaagaacatcatgccgctgtcggccgccatgttt ctgagcgagcgcaagaaccccaccccgcagtgcccgccgcggctcgaggtgcagatgctg atgcccgtgtcgtggagccgcatgcccaaccacttcctgcaggtggacacgcggcgtgcg ggcgagcggctgggctgggctgtgcagtgccaggagccgctgaccatgatggcgctgcac gtccccgaggagaaccgatgcatggacatcctggagctgtcggagcgcttggacctgcag cggttccactcgcacaccctccgcctctaccgcgctgtgtgcgccctgggcaacaaccgc gtggcacatgctctgtgcagccacgtggaccaggcacagctgctgcacgccctggaggac gcgcacctgcccgggcccctgcgtgcaggctactacgacctcctcatcagcatccatctc gaaagcgcctgccgcagccgccgctccatgctctctgagtacatcgtgcccctcactcct gagacccgtgccatcaccctcttcccgcctggaaaaagagcagatgatggtccccgccgc tacggccttcctggtgtcggcgtcaccacctcgctgcggcctccacaccatttcttagct ccctgttttgtggctgccctgccagctgctggggcggcagaagctccagcccgtctcagc cccagcatccctctggaggctcttcgggacaaagcactaaggatgctgggggaggcagtg cgagacggtgggcagcacgcgcgagaccctgtcgggggctccgtggagttccagtttgtg cctgtgctcaagcttgtgtccaccctgctggtgatgggcatctttggcgatgaggatgta aaacagatcttgaagatgattgagcctgaagtattcactgaggaagaagaggaagaagag gaagaggaggaagaggaggatgaggaggagaaggaggaggatgaggaggaagaggcacgg gagaaggaagatgaagaaaaagaggaagaggagacagcagaaggggaaaaagaagaagac ttggaggaggggctgctccagatgaagttgccggagtccgttaagttacagatgtgtcac ctgctggagtatttctgtgaccaagagctgcagcaccgtgtggagtctcttgcagccttt gcagagcgctacgtggacaagctccaggccaaccagagggaccgctacagcatccttgtg aaatccttcaccatgcccgcagctgagactgcccgacgtactcgcgagttccgctcccca ccccaggagcagatcaacatgctattgcacttcaaagatgctgaggatgaggaagattgt cctgtccctgaagagatccgacaggatttgctcgaatttcatcaagacctgctgacacac tgtggaattcagctggcaggggaggaggaagaactagaggaagaagccaccctgggcagc cgcctgatgagcctgttggagaaggtgcggctgctgaagaagaaggaggagaaaccggag gaggagccacctgctgaggagcacaaaccccagtcgctgcaggagctggtgtcccacaca gtggtgcgttgggcccaagaggacttcgtgcagagccccgagctggtacgggccatgttc agcctcctgcaccggcagtacgatgggctcggggagctgctgcgtgccctgccccgggcc tacactatctcaccctcctccgtggaggacaccatgagcctgcttgagtgccttggccag atccggtccctgctcatcgtgcagatgggcccccaggaggaaaacctcatgatccagagc attgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatgcgggcgctg ggcatgcatgagacagtcatggaggtcatggtgaatgtccttgggggaggcgaatccaag gagatccgcttccccaagatggtgaccagctgctgccgcttcctctgctacttctgccgc atcagccggcagaaccagcgctccatgtttgaccacctgagctacctgctggagaacagc ggcattggcctgggcatgcagggctccacgcccctggacgtggcagctgcctccgtcatc gacaacaacgagctggccttggcgttgcaggagcaggatctggagaaggtggtgtcctac ctggcaggctgtggcctccaaagctgccccatactcctggccaaagggtacccagacatc ggctggaacccctgcggcggcgagcgctacctggacttcctgcgcttcgctgtctttgtc aacggtgagagcgtggaggagaatgccaacgtggtggtgcgcctgctgatccgcaagcct gagtgcttcgggcccgccctgcggggcgagggcagctcggggctgctggccaccattgaa gaggccatccgcatctccgaggaccccgcaagggatggcccaggagtccgcagggaccgg cggcgtgagctcttcggggaggagccccccgaggaaaaccgggtgcaccttggacacgcc atcatgtccttctacgctgccttgatcgacctcctgggccgctgtgcaccagagatgcat ctaatccaagccggcaaaggcgaggccctgcggatccgcgccatcctgcgctccctcgtg cccctggacgacctcgtgggcatcatcagcctcccattgcagatccccaccctgggcaaa gatggggcactggtacagccaaagatgtcggcatcctttgtgccggaccacaaggcgtcg atggtgctcttcctggaccgcgtgtacggcatcgagaaccaggagttcttgctgcatgtg ctagatgtgggtttcctgcccgacatgcgggcggccgcctcgctggacacggccactttc agcaccacggagatggcgctggcgctgaaccgttacctgtgcctggcggtgctgccgctc atcaccaagtgtgcgccactcttcgcgagaaccgagcatcgcgccatcatggtggactcc atgcttcacacggtgtaccgcctgtcccgcggccgctcgctcaccaaggcgcagcgcgac gtcatcgaggaatgcctgatggcgctctgcaggtacatccgcccgtccatgctgcagcac ctgctgcggcgcctggtgttcgacgtgcccatccttaacgagttcgccaagatgccgctc aagctcctcaccaaccactatgagcgttgttggaagtactactgtctccccacaggctgg gccaactacggggtgacctcggaggaagagctgcacctcacccgtaaactcttctggggc atctttgactctctggcccataagaaatatgacccagagctgtaccgcatggctatgccc tgcctgtgtgccatcgcaggggccctgccccccgactacgtggacgcctcatactcatcc aaggctgagaaaaaggccacggtggacgctgaaggcaactttgatcctcggcctgtggag accctcaatgtgatcatcccagagaagctggactccttcattaacaagtttgcggagtac acacacgagaagtgggccttcgacaagatccagaacaactggtcctatggggagaacata gatgaggaactgaagacccatcctatgctgaggccctacaagacgttttcggagaaggac aaagagatttaccgctggcccatcaaggagtccttgaaggccatgattgcctgggaatgg acgatagagaaagccagggagggtgaggaggagaagacggagaagaaaaaaacccggaag atatcccagagtgcccagacctatgatccacgggaaggctacaacccccagccccctgac ctcaccggagttaccctgtcccgggagctgcaggccatggcagaacaactggcagaaaat taccacaacacatggggacggaagaagaaacaggagctggaagccaagggtggtgggacc caccccctgctggttccctacgacacacttacggccaaggagaaggcacgagatagagag aaggcccaggagctgctgaagttcctgcagatgaacggctacgcggtcaccaggggcctt aaggacatggaactggacacgtcttccattgagaaacggttcgccttcggcttcctgcag cagttgctccgctggatggacatttctcaggagtttatcgcccacctggaggctgtggtc agcagtggacgagtggaaaagtcccctcacgaacaggagattaaattctttgctaagatc ctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcctgtccacaccg gccaaagtgctgggcagtggtggccacgcctccaacaaggagaaggaaatgatcaccagc ctcttctgcaagcttgccgctcttgtccgtcaccgagtctctctctttgggacggatgcc ccagctgtggtcaactgtcttcatatcctggcacgctccctggatgccaggaccgtgatg aagtctggccccgagatcgtgaaggctggtctccgttccttctttgagagtgcctcggag gacatcgagaagatggtggagaacctgcggctaggcaaggtgtcgcagacacgcacgcag gtgaagggtgtgggccagaacctcacctacaccaccgtggccctgctgcctgtgctcacc accctcttccagcacatcgcccagcaccagtttggagacgatgttatcctggatgatgtc caggtctcttgctaccgaacgctgtgcagtatctactctctgggaaccaccaagaacact tacgtggaaaagcttcggccagccctgggcgagtgcctcgcctgcctggcagcggccatg ccggtggcgttcctggagcctcagctgaacgagtataatgcctgctcagtgtacaccacc aaatctccccgggagcgggccatcctggggctccccaacagcgtggaggagatgtgtcct gacatcccggtgctggagcggctcatggcagacatcggggggctggctgagtcgggggcc cgctacacagagatgccgcacgtcatcgagatcacgctgcccatgctgtgcagctatctg ccccgctggtgggagcgcggacccgaggcacccccgcttgccctgcctgcaggggcccct ccaccctgcacagccatcacttccgaccatctcaactccctgctggggaatatcctgcgg atcatcgtcaacaacctgggcattgacgaggcctcgtggatgaagcggctggctgtgttt gcccagcccatcgtgagccgggcccggcctgagctcctgcactcacacttcatccccacc atcgggcggctgcgcaagcgggcagggaaggtggtgtccgaggaggagcagctgcgccta gaggccaaggcggaagccgaggagggcgagctcctggtgcgggacgagttctctgtgctc tgccgggacctgtacgccctctatccactgctcatccgctacgtggacaacaacagggca cactggctgaccgagcccaatcccagtgcggaggagctgttcaggatggtgggcgagatc ttcatctactggtccaagtcccacaactttaagcgcgaagagcagaactttgtggtccag aatgagatcaacaacatgtcatttctgactgcagacagcaagagcaaaatgaccaagtca ggtggctcagaccaggaacgcaccaagaagaagcgccggggggaccggtactccgtgcag acatcgctgattgtggccatgctcaagaagatgctgcccattggcctgaacatgtgtgca cccactgaccaggaactcattacactggccaagacccgctatgccctgaaagacacagat gaggaggtccgggaatttctgcaaaacaaccttcaccttcagggaaaggtcgaaggctcc ccttctttacgctggcagatggccctgtaccggggcctcccgggccgcgaggaggacgct gacgacccggagaaaatcgtgcgcagagtccaggaagtgtctgcagtgctctatcatctg gagcagatcgagcacccttataaatccaagaaggccgtgtggcacaagctcttgtccaag cagcgccggagggcggtcgtcgcctgtttccgcatgacccccctgtacaacctgcccacg caacgggcctgtaacatgtttgtggagagctacaaggcggcgtggatcctgactgaagac cacagtttcgaggaccgcatgatagatgacctttcaaaagctggtaagcaggaggaggag gaggaagaggtggaggagaagaagccagaccccctgcaccagctcgtcctgcacttcagc cgtaccgccctgactgaaaagagcaaactggatgaagattacttgtatatagcgtatgcc gatatcatggcaaagagctgccacctggaggagggaggggagaatggcgaagctgaagaa caggaggttgagctttcctttgaggagaaagagatggagaagcagaggctcctgtaccag caggcgcggctgcacaaccggggcaccgcggagatggtgctccagatgatcagtgcctgc aaaggagagacgggcgccatggtgtcctccaccctgaagctgggaatctccatcctaaat ggaggcaatgccgatgtgcagcagaaaatgctggattacctgaaggacaagaaggaagtt ggcttcttccagagcatccaggcgctgatgcaaacctgcagtgtcctggatctcaatgcc ttcgagagacagaacaaggcagaggggctgggcatggtgaacgaggatggaaccgtcatc aaccgccagaacggagagaaggtcatggcagatgatgaattcacccaagatctgttccga ttcctgcaattgctctgcgaggggcacaataatgatttccaaaactacctacggacacag acagggaatacaaccaccattaacatcatcatctgtactgtggactacctcctgcggctt caggaatccatcagcgacttctactggtactactcgggcaaggatgtcattgaggagcag ggcaagaggaacttttccaaggccatgtctgtggctaaacaggtgttcaacagcctcacc gaatacattcaggggccctgcaccgggaaccagcagagtctagcgcacagccgcctctgg gacgccgtggtgggattcctgcacgtgtttgcccacatgatgatgaagctcgctcaggac tcgagccagatcgagctgttgaaggagctcctggatctacagaaggacatggtggtgatg ttgctgtcactactagaagggaacgtggtgaacggcatgattgcccggcagatggtggac atgcttgtggaatcctcatccaacgtggagatgatcctcaagttcttcgacatgttcctg aaactcaaggacattgtgggctctgaggccttccaggactacgtcactgatccccgtggc ctcatctccaagaaggacttccagaaagtgagtactggaaggcggatgggtggggtgcca agtgccagtcatgcccttcctggctgcctgctgcaggcaagagacttctctggatgcctc agtttccttatctgtaaaacggggataaaattatcatccttggacttgttttga

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