KEGG   Physeter catodon (sperm whale): 102976764
Entry
102976764         CDS       T06011                                 

Gene name
STAT3
Definition
(RefSeq) signal transducer and activator of transcription 3 isoform X1
  KO
K04692  signal transducer and activator of transcription 3
Organism
pcad  Physeter catodon (sperm whale)
Pathway
pcad01521  EGFR tyrosine kinase inhibitor resistance
pcad04062  Chemokine signaling pathway
pcad04066  HIF-1 signaling pathway
pcad04068  FoxO signaling pathway
pcad04217  Necroptosis
pcad04550  Signaling pathways regulating pluripotency of stem cells
pcad04630  JAK-STAT signaling pathway
pcad04659  Th17 cell differentiation
pcad04917  Prolactin signaling pathway
pcad04920  Adipocytokine signaling pathway
pcad04931  Insulin resistance
pcad04933  AGE-RAGE signaling pathway in diabetic complications
pcad04935  Growth hormone synthesis, secretion and action
pcad05145  Toxoplasmosis
pcad05160  Hepatitis C
pcad05161  Hepatitis B
pcad05162  Measles
pcad05163  Human cytomegalovirus infection
pcad05167  Kaposi sarcoma-associated herpesvirus infection
pcad05169  Epstein-Barr virus infection
pcad05200  Pathways in cancer
pcad05203  Viral carcinogenesis
pcad05205  Proteoglycans in cancer
pcad05206  MicroRNAs in cancer
pcad05212  Pancreatic cancer
pcad05221  Acute myeloid leukemia
pcad05223  Non-small cell lung cancer
pcad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcad05321  Inflammatory bowel disease
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    102976764 (STAT3)
   04066 HIF-1 signaling pathway
    102976764 (STAT3)
   04068 FoxO signaling pathway
    102976764 (STAT3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    102976764 (STAT3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102976764 (STAT3)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    102976764 (STAT3)
   04062 Chemokine signaling pathway
    102976764 (STAT3)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    102976764 (STAT3)
   04917 Prolactin signaling pathway
    102976764 (STAT3)
   04935 Growth hormone synthesis, secretion and action
    102976764 (STAT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102976764 (STAT3)
   05206 MicroRNAs in cancer
    102976764 (STAT3)
   05205 Proteoglycans in cancer
    102976764 (STAT3)
   05203 Viral carcinogenesis
    102976764 (STAT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102976764 (STAT3)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    102976764 (STAT3)
   05221 Acute myeloid leukemia
    102976764 (STAT3)
   05223 Non-small cell lung cancer
    102976764 (STAT3)
  09163 Immune disease
   05321 Inflammatory bowel disease
    102976764 (STAT3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    102976764 (STAT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102976764 (STAT3)
  09172 Infectious disease: viral
   05162 Measles
    102976764 (STAT3)
   05161 Hepatitis B
    102976764 (STAT3)
   05160 Hepatitis C
    102976764 (STAT3)
   05163 Human cytomegalovirus infection
    102976764 (STAT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102976764 (STAT3)
   05169 Epstein-Barr virus infection
    102976764 (STAT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102976764 (STAT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102976764 (STAT3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:pcad03000]
    102976764 (STAT3)
Transcription factors [BR:pcad03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    102976764 (STAT3)
SSDB
Motif
Pfam: STAT_alpha STAT_bind STAT_int SH2 E2R135 DUF4795 Syntaxin-6_N AP1AR Fib_alpha
Other DBs
NCBI-GeneID: 102976764
NCBI-ProteinID: XP_028354098
UniProt: A0A455C2E0
LinkDB
Position
14
AA seq 770 aa
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
NT seq 2313 nt   +upstreamnt  +downstreamnt
atggcccaatggaatcagttacagcagctggacacacggtacttggagcagcttcatcag
ctgtacagtgacagcttcccgatggagctacggcagtttctggccccttggatcgagagt
caagattgggcatatgcggctagcaaagaatcacatgcaactttggtgtttcataatctc
ttgggtgaaattgaccagcagtatagccgcttcctgcaagagtccaatgttctctatcag
cacaacctgcgaagaatcaagcagttccttcagagcagataccttgagaagccaatggag
attgcccgaattgtggcccggtgcctgtgggaagagtcccgcctcctccaaactgcagcc
actgcagcccagcaagggggccaggccaaccatcccacagccgccgtggtgacggagaag
cagcaaatgctggagcaacacctacaggatgtccggaagcgtgtccaggatctagaacag
aaaatgaaagtggtagagaatctccaggatgactttgatttcaactacaaaaccctcaag
agtcaaggagatatgcaggatctgaatggaaacaaccagtcagtgaccaggcagaagatg
cagcagctcgaacagatgcttactgcgctggaccagatgcggcgaagcatcgtgagtgag
ttggcagggcttttgtcagctatggagtacgtgcagaaaacgctcacggatgaagagctg
gcggactggaagaggcggcagcagattgcttgcattggaggccctcccaacatctgccta
gatcggctagaaaactggataacctcattggcagaatctcaacttcagacccgccaacaa
attaagaaactggaggagttgcagcagaaagttagctacaaaggggatcccattgtacag
caccggccaatgctggaggagagaatcgtagagctgtttagaaacttaatgaaaagcgcc
ttcgtggtagagcggcagccctgcatgcctatgcatcctgaccggccattagtcatcaag
accggtgtccagtttacaactaaagtcagattgctggtcaaattccctgagctaaattat
cagcttaaaattaaagtgtgcattgacaaagactccggggatgttgcagctctcagagga
tcccggaaatttaacatcctgggcacaaacacgaaagtgatgaacatggaagagtccaac
aacggcagcctctccgcagagttcaaacacttgaccctgagagagcagagatgtggtaac
gggggccgagccaactgcgacgcctccctgatcgtgactgaggagctgcacctgatcacc
tttgagactgaggtgtatcaccaaggcctcaagattgacctggagacccactccttgcca
gttgtggtgatctccaacatctgtcagatgcccaacgcctgggcgtccatcctgtggtat
aacatgctgaccaacaaccccaagaacgtgaactttttcaccaagcccccaattggaacg
tgggatcaagtggccgaggtgctgagctggcagttctcctccaccaccaagcgtgggctg
agcatcgagcagttgacaacgctggcggagaaactcttaggacctggtgtgaactattca
gggtgtcagatcacgtgggctaaattttgcaaagaaaacatggccggcaagggcttctcc
ttctgggtctggctggacaatatcattgaccttgtgaaaaagtacatcctggccctttgg
aatgaagggtacataatgggctttatcagtaaggagagggagcgggccatcttgagcacc
aagcccccaggcaccttcctgctgagattcagtgaaagtagcaaagaaggaggagtcacc
ttcacttgggtggagaaggacatcagcggtaagacccagatccagtcggtggaaccatac
accaagcagcagctgaacaacatgtcgtttgctgaaatcatcatgggctataagatcatg
gatgccaccaatatcctcgtgtctccgctggtctatctctaccctgacattccaaaggag
gaggcgttcggaaagtactgtcggccagagagccaggagcatcccgaagctgacccaggt
agtgccgccccatacctgaagactaagttcatctgtgtgacaccaacgacctgcagcaat
accattgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataat
ggtgaaggtgctgaaccctcagcaggagggcagttcgaatccctcacgttcgacatggag
ctgacctcggagtgcgctacctcccccatgtga

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