KEGG T05867: 110197417

KEGG Orthology (KO) [BR:pcw00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110197417 (MAP2K2)
   04012 ErbB signaling pathway
    110197417 (MAP2K2)
   04014 Ras signaling pathway
    110197417 (MAP2K2)
   04015 Rap1 signaling pathway
    110197417 (MAP2K2)
   04370 VEGF signaling pathway
    110197417 (MAP2K2)
   04371 Apelin signaling pathway
    110197417 (MAP2K2)
   04066 HIF-1 signaling pathway
    110197417 (MAP2K2)
   04068 FoxO signaling pathway
    110197417 (MAP2K2)
   04072 Phospholipase D signaling pathway
    110197417 (MAP2K2)
   04071 Sphingolipid signaling pathway
    110197417 (MAP2K2)
   04024 cAMP signaling pathway
    110197417 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    110197417 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    110197417 (MAP2K2)
   04150 mTOR signaling pathway
    110197417 (MAP2K2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110197417 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    110197417 (MAP2K2)
   04218 Cellular senescence
    110197417 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    110197417 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    110197417 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110197417 (MAP2K2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110197417 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    110197417 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    110197417 (MAP2K2)
   04660 T cell receptor signaling pathway
    110197417 (MAP2K2)
   04662 B cell receptor signaling pathway
    110197417 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    110197417 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110197417 (MAP2K2)
   04929 GnRH secretion
    110197417 (MAP2K2)
   04912 GnRH signaling pathway
    110197417 (MAP2K2)
   04915 Estrogen signaling pathway
    110197417 (MAP2K2)
   04917 Prolactin signaling pathway
    110197417 (MAP2K2)
   04921 Oxytocin signaling pathway
    110197417 (MAP2K2)
   04926 Relaxin signaling pathway
    110197417 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    110197417 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    110197417 (MAP2K2)
   04916 Melanogenesis
    110197417 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110197417 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    110197417 (MAP2K2)
   04730 Long-term depression
    110197417 (MAP2K2)
   04722 Neurotrophin signaling pathway
    110197417 (MAP2K2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110197417 (MAP2K2)
   05206 MicroRNAs in cancer
    110197417 (MAP2K2)
   05205 Proteoglycans in cancer
    110197417 (MAP2K2)
   05230 Central carbon metabolism in cancer
    110197417 (MAP2K2)
   05231 Choline metabolism in cancer
    110197417 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110197417 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110197417 (MAP2K2)
   05225 Hepatocellular carcinoma
    110197417 (MAP2K2)
   05226 Gastric cancer
    110197417 (MAP2K2)
   05214 Glioma
    110197417 (MAP2K2)
   05216 Thyroid cancer
    110197417 (MAP2K2)
   05221 Acute myeloid leukemia
    110197417 (MAP2K2)
   05220 Chronic myeloid leukemia
    110197417 (MAP2K2)
   05218 Melanoma
    110197417 (MAP2K2)
   05211 Renal cell carcinoma
    110197417 (MAP2K2)
   05219 Bladder cancer
    110197417 (MAP2K2)
   05215 Prostate cancer
    110197417 (MAP2K2)
   05213 Endometrial cancer
    110197417 (MAP2K2)
   05224 Breast cancer
    110197417 (MAP2K2)
   05223 Non-small cell lung cancer
    110197417 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110197417 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    110197417 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110197417 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110197417 (MAP2K2)
   05135 Yersinia infection
    110197417 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110197417 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    110197417 (MAP2K2)
   05161 Hepatitis B
    110197417 (MAP2K2)
   05160 Hepatitis C
    110197417 (MAP2K2)
   05164 Influenza A
    110197417 (MAP2K2)
   05163 Human cytomegalovirus infection
    110197417 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110197417 (MAP2K2)
   05165 Human papillomavirus infection
    110197417 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110197417 (MAP2K2)
   01522 Endocrine resistance
    110197417 (MAP2K2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110197417 (MAP2K2)
Enzymes [BR:pcw01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     110197417 (MAP2K2)
Protein kinases [BR:pcw01001]
Serine/threonine kinases: STE group
  STE7 family
   110197417 (MAP2K2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like Kdo APH Seadorna_VP7

Other DBs

NCBI-GeneID:

110197417

NCBI-ProteinID:

XP_020826984

UniProt:

A0A6P5J7I0

LinkDB

Position

Unknown

AA seq 400 aa
MLAKRKPVLPALNITPTIAEGPSPTSEGASEANLADLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNTRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPMVEGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAM

NT seq 1203 nt +upstreamnt +downstreamnt
atgctggccaagaggaagccggtgctgccggcgctcaacatcaccccgaccatcgccgag
ggcccgtccccgaccagcgagggcgcgtccgaggcgaacctggcagatctgcagaaaaaa
ttagaagagctagaacttgatgagcagcagaagaagcggctggaagctttcctcacccag
aaggcaaaggtgggggagctgaaggatgatgactttgagaggatctccgagctgggagct
ggcaatggcggggtggtcaccaaagtacagcatagaccttcagggctcatcatggcccga
aagttgattcacctagagatcaaaccagcaatccggaaccagattatccgtgaactccaa
gtcctacatgaatgcaactctccatacatcgtgggtttctatggtgccttttatagcgac
ggagagatcagcatctgcatggagcacatggatggaggctctctggatcaagtattgaaa
gaggccaagagaattcctgaagaaatcttggggaaagttagcattgcggttcttcggggt
ttggcttatctaagagagaaacaccagattatgcacagagatgtgaaaccttctaatatt
ttggtcaacactcggggagagatcaagctctgtgacttcggagtgagtgggcaactcatc
gactctatggcaaattcctttgtaggaacccgatcctacatgtctccggagcggttacaa
ggcacccactactcagtccagtcagatatctggagcatgggcctgtccctagtagagctg
tccattggacggtatccgattcccccaccagactccaaggaactagaagcgatatttggt
cggcccatggtcgaaggggcagagggagaacctcacagcatctcgccacggccacgaccc
ccaggacgccccatcagtggtcatgggatggacagtcggcctgccatggccatctttgag
ctattggactatattgttaacgagcctccacctaagttgccgaatggtgttttcacacaa
gatttccaggagtttgtaaataaatgcttaattaaaaacccagccgagagggcagatctg
aagatgctgatgaatcacacttttatcaagcggtcagaagtggaagaagtggattttgca
ggctggttatgtaaaactctgaggttaaaccagcccagtactcccacacgcactgccatg
tga

Phascolarctos cinereus (koala): 110205943

Entry

110205943 CDS T05867

Gene name

MAP2K1

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 1

K04368

mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

Organism

pcw Phascolarctos cinereus (koala)

Pathway

pcw01521

EGFR tyrosine kinase inhibitor resistance

pcw01522

Endocrine resistance

pcw04010

MAPK signaling pathway

pcw04012

ErbB signaling pathway

pcw04014

Ras signaling pathway

pcw04015

Rap1 signaling pathway

pcw04022

cGMP-PKG signaling pathway

pcw04024

cAMP signaling pathway

pcw04062

Chemokine signaling pathway

pcw04066

HIF-1 signaling pathway

pcw04068

FoxO signaling pathway

pcw04071

Sphingolipid signaling pathway

pcw04072

Phospholipase D signaling pathway

pcw04114

Oocyte meiosis

pcw04140

Autophagy - animal

pcw04150

mTOR signaling pathway

pcw04151

PI3K-Akt signaling pathway

pcw04210

Apoptosis

pcw04218

Cellular senescence

pcw04270

Vascular smooth muscle contraction

pcw04370

VEGF signaling pathway

pcw04371

Apelin signaling pathway

pcw04380

Osteoclast differentiation

pcw04510

Focal adhesion

pcw04540

Gap junction

pcw04550

Signaling pathways regulating pluripotency of stem cells

pcw04613

Neutrophil extracellular trap formation

pcw04620

Toll-like receptor signaling pathway

pcw04650

Natural killer cell mediated cytotoxicity

pcw04660

T cell receptor signaling pathway

pcw04662

B cell receptor signaling pathway

pcw04664

Fc epsilon RI signaling pathway

pcw04666

Fc gamma R-mediated phagocytosis

pcw04668

TNF signaling pathway

pcw04720

Long-term potentiation

pcw04722

Neurotrophin signaling pathway

pcw04725

Cholinergic synapse

pcw04726

Serotonergic synapse

pcw04730

Long-term depression

pcw04810

Regulation of actin cytoskeleton

pcw04910

Insulin signaling pathway

pcw04912

GnRH signaling pathway

pcw04914

Progesterone-mediated oocyte maturation

pcw04915

Estrogen signaling pathway

pcw04916

Melanogenesis

pcw04917

Prolactin signaling pathway

pcw04919

Thyroid hormone signaling pathway

pcw04921

Oxytocin signaling pathway

pcw04926

Relaxin signaling pathway

pcw04928

Parathyroid hormone synthesis, secretion and action

pcw04929

GnRH secretion

pcw04934

Cushing syndrome

pcw04935

Growth hormone synthesis, secretion and action

pcw05010

Alzheimer disease

pcw05022

Pathways of neurodegeneration - multiple diseases

pcw05034

Alcoholism

pcw05132

Salmonella infection

pcw05135

Yersinia infection

pcw05160

Hepatitis C

pcw05161

Hepatitis B

pcw05163

Human cytomegalovirus infection

pcw05164

Influenza A

pcw05165

Human papillomavirus infection

pcw05166

Human T-cell leukemia virus 1 infection

pcw05167

Kaposi sarcoma-associated herpesvirus infection

pcw05170

Human immunodeficiency virus 1 infection

pcw05200

Pathways in cancer

pcw05205

Proteoglycans in cancer

pcw05206

MicroRNAs in cancer

pcw05210

Colorectal cancer

pcw05211

Renal cell carcinoma

pcw05212

Pancreatic cancer

pcw05213

Endometrial cancer

pcw05214

Glioma

pcw05215

Prostate cancer

pcw05216

Thyroid cancer

pcw05218

Melanoma

pcw05219

Bladder cancer

pcw05220

Chronic myeloid leukemia

pcw05221

Acute myeloid leukemia

pcw05223

Non-small cell lung cancer

pcw05224

Breast cancer

pcw05225

Hepatocellular carcinoma

pcw05226

Gastric cancer

pcw05230

Central carbon metabolism in cancer

pcw05231

Choline metabolism in cancer

pcw05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:pcw00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110205943 (MAP2K1)
   04012 ErbB signaling pathway
    110205943 (MAP2K1)
   04014 Ras signaling pathway
    110205943 (MAP2K1)
   04015 Rap1 signaling pathway
    110205943 (MAP2K1)
   04370 VEGF signaling pathway
    110205943 (MAP2K1)
   04371 Apelin signaling pathway
    110205943 (MAP2K1)
   04668 TNF signaling pathway
    110205943 (MAP2K1)
   04066 HIF-1 signaling pathway
    110205943 (MAP2K1)
   04068 FoxO signaling pathway
    110205943 (MAP2K1)
   04072 Phospholipase D signaling pathway
    110205943 (MAP2K1)
   04071 Sphingolipid signaling pathway
    110205943 (MAP2K1)
   04024 cAMP signaling pathway
    110205943 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    110205943 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    110205943 (MAP2K1)
   04150 mTOR signaling pathway
    110205943 (MAP2K1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110205943 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110205943 (MAP2K1)
   04210 Apoptosis
    110205943 (MAP2K1)
   04218 Cellular senescence
    110205943 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110205943 (MAP2K1)
   04540 Gap junction
    110205943 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110205943 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110205943 (MAP2K1)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110205943 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    110205943 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    110205943 (MAP2K1)
   04660 T cell receptor signaling pathway
    110205943 (MAP2K1)
   04662 B cell receptor signaling pathway
    110205943 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    110205943 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    110205943 (MAP2K1)
   04062 Chemokine signaling pathway
    110205943 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110205943 (MAP2K1)
   04929 GnRH secretion
    110205943 (MAP2K1)
   04912 GnRH signaling pathway
    110205943 (MAP2K1)
   04915 Estrogen signaling pathway
    110205943 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    110205943 (MAP2K1)
   04917 Prolactin signaling pathway
    110205943 (MAP2K1)
   04921 Oxytocin signaling pathway
    110205943 (MAP2K1)
   04926 Relaxin signaling pathway
    110205943 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    110205943 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    110205943 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    110205943 (MAP2K1)
   04916 Melanogenesis
    110205943 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110205943 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    110205943 (MAP2K1)
   04726 Serotonergic synapse
    110205943 (MAP2K1)
   04720 Long-term potentiation
    110205943 (MAP2K1)
   04730 Long-term depression
    110205943 (MAP2K1)
   04722 Neurotrophin signaling pathway
    110205943 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110205943 (MAP2K1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110205943 (MAP2K1)
   05206 MicroRNAs in cancer
    110205943 (MAP2K1)
   05205 Proteoglycans in cancer
    110205943 (MAP2K1)
   05230 Central carbon metabolism in cancer
    110205943 (MAP2K1)
   05231 Choline metabolism in cancer
    110205943 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110205943 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110205943 (MAP2K1)
   05212 Pancreatic cancer
    110205943 (MAP2K1)
   05225 Hepatocellular carcinoma
    110205943 (MAP2K1)
   05226 Gastric cancer
    110205943 (MAP2K1)
   05214 Glioma
    110205943 (MAP2K1)
   05216 Thyroid cancer
    110205943 (MAP2K1)
   05221 Acute myeloid leukemia
    110205943 (MAP2K1)
   05220 Chronic myeloid leukemia
    110205943 (MAP2K1)
   05218 Melanoma
    110205943 (MAP2K1)
   05211 Renal cell carcinoma
    110205943 (MAP2K1)
   05219 Bladder cancer
    110205943 (MAP2K1)
   05215 Prostate cancer
    110205943 (MAP2K1)
   05213 Endometrial cancer
    110205943 (MAP2K1)
   05224 Breast cancer
    110205943 (MAP2K1)
   05223 Non-small cell lung cancer
    110205943 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110205943 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    110205943 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    110205943 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110205943 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110205943 (MAP2K1)
   05135 Yersinia infection
    110205943 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110205943 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    110205943 (MAP2K1)
   05161 Hepatitis B
    110205943 (MAP2K1)
   05160 Hepatitis C
    110205943 (MAP2K1)
   05164 Influenza A
    110205943 (MAP2K1)
   05163 Human cytomegalovirus infection
    110205943 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110205943 (MAP2K1)
   05165 Human papillomavirus infection
    110205943 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110205943 (MAP2K1)
   01522 Endocrine resistance
    110205943 (MAP2K1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110205943 (MAP2K1)
Enzymes [BR:pcw01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     110205943 (MAP2K1)
Protein kinases [BR:pcw01001]
Serine/threonine kinases: STE group
  STE7 family
   110205943 (MAP2K1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Seadorna_VP7 Kinase-like

Other DBs

NCBI-GeneID:

110205943

NCBI-ProteinID:

XP_020838600

UniProt:

A0A6P5K0H0

LinkDB

Position

Unknown

AA seq 393 aa
MPKKKPGPIQLNPTPDGSTINGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPMEGDAPETSPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

NT seq 1182 nt +upstreamnt +downstreamnt
atgcctaagaagaagccagggcccattcagctgaacccgaccccggatggctccacgatt
aacgggaccagctcggccgagactaacctcgaggcgctgcagaagaagctggaggaatta
gaacttgatgaacagcaacgcaagcgactggaggcttttctcacccagaaacagaaagtg
ggcgagctgaaagatgatgacttcgagaagatcagtgaactaggagctgggaatggtggt
gtcgtgtttaaagtttcccacaagccctctggcctaatcatggcaaggaagctaattcac
ctggagatcaagccagcaattcggaaccagattatacgggagctgcaagtcctgcacgag
tgcaactctccatatattgtagggttttatggtgccttttacagcgatggggagatcagt
atctgcatggagcacatggatggaggatctttggaccaggttcttaagaaggctggaaga
attcctgagcagatattggggaaagttagcattgctgtaataaagggtcttacatatctg
agggagaagcataagataatgcacagagacgtcaagccatccaacatcttggtgaactca
cgaggggaaatcaaactttgtgactttggcgtcagtgggcagctgattgattccatggct
aactctttcgtgggcacaaggtcctatatgtcgccagaaagactccagggaactcactac
tcagtacagtcagacatctggagcatgggactttctttggtggagatggcaattggacga
tatcccattccaccgccagattccaaggagctagaactgatgtttggctgtccaatggag
ggagatgctcctgagacgtcaccaaggccaagaactcctgggaggcctttaagctcttat
ggaatggatagccgaccacctatggcaatttttgagctgctggattacatagtcaatgag
cctcctccaaagttgcccagtggagtctttagtctggaatttcaagattttgtgaataaa
tgcctaataaaaaacccagcagagagagctgatttgaagcaacttatggttcatgctttt
atcaagaggtctgatgccgaggaagttgattttgcaggctggctgtgctccaccataggc
cttaaccagcctagcacaccaactcatgctgctggcgtctaa

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