Propionibacterium freudenreichii subsp. freudenreichii DSM 20271: RM25_0849
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Entry
RM25_0849 CDS
T03860
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
pfre
Propionibacterium freudenreichii subsp. freudenreichii DSM 20271
Pathway
pfre00290
Valine, leucine and isoleucine biosynthesis
pfre00620
Pyruvate metabolism
pfre01100
Metabolic pathways
pfre01110
Biosynthesis of secondary metabolites
pfre01210
2-Oxocarboxylic acid metabolism
pfre01230
Biosynthesis of amino acids
Module
pfre_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
pfre00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
RM25_0849
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
RM25_0849
Enzymes [BR:
pfre01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
RM25_0849
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Motif
Pfam:
HMGL-like
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
AJQ90573
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Position
985040..986806
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AA seq
588 aa
AA seq
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MSTTFQPSKSFAAPHVCGLSQPIATPSGMNYERYQPFHPMSLPDRTWPDQRITKAPRWLS
TDLRDGNQALIDPMTPARKRKMFDLLVKMGYKEIEIGFPSASQTEWDFVRSLIEDPEAIP
DDVVISVLTQAREDLIDRTVQSLVGAKRATVHMYNATAELFRRVVFHTTQQGTIDLAQQG
TRWVIDAIEKYLPDTPIGYEYSPEIFTQTPTDYAIEVCDRVMDVWQPDDEREIILNLPAT
VEMSTPNTYADQIEYFSRNISHRDNVCISMHCHNDRGCAVAASELGQMAGAQRVEGCLFG
HGERTGNVDLVTLGMNLFSQGIDPMIDFSDMDTIRRTVEYCTGMPVPARSPYAGDLVYTA
FSGSHQDAIKKGLEDLETRARAEGTSIHKIRWEAPYLPVDPQDVGRTYEAVIRVNSQSGK
GGMAYLMKADHHLELPRRLQMEFSGVVQAQADDSGHEVTSPVLWDIFDSEYLRRDTPFKL
GEFTVGAAHGQTQITADLDVRGKQTTVTGEGNGPLSAFIDALGQVGAHVRVLDYTEHALT
SGGDAYAAAYVECEVGEGDNTQVLWGVGIDPDITTATLKAALSALDRA
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccacctttcaaccttccaagagcttcgccgccccgcacgtctgtgggctctcc
cagcccatcgcgacgcccagcggcatgaactacgagcgctaccagcccttccatccgatg
agcctgcccgaccgcacatggccggaccagcggatcaccaaggcgccccggtggctgtcc
accgacttgcgcgacggcaaccaggccctgatcgatccgatgaccccggcccgcaagcgc
aagatgttcgacctgctggtcaagatggggtacaaggagatcgagatcggcttcccgtcc
gcgtcacagaccgaatgggacttcgtccgctccctcatcgaggaccccgaggcgattccc
gatgacgtggtgatctcggttctgacgcaggcccgtgaggacctgatcgatcgcacggtg
cagtcgctggtcggcgccaagcgcgccaccgtccacatgtacaacgcgacggccgagctg
ttccgccgcgtcgtcttccacaccacccaacagggcaccatcgacctggcccaacagggc
acccgatgggtgatcgacgccatcgagaagtacctgcccgacacacccatcggctacgag
tacagccccgagatcttcacccagacgcccaccgactacgccattgaggtgtgcgatcgc
gtcatggacgtatggcagcccgacgatgaacgcgaaatcatcctgaacctgccggcgacc
gtcgagatgtcgacgccgaacacctacgccgaccagatcgagtacttctcgcgtaatatc
tcgcaccgtgacaatgtgtgcatctcaatgcactgccacaacgaccggggctgcgccgtg
gcagcctccgagctgggccagatggccggcgcccaacgcgtcgagggttgcctgttcggc
cacggcgagcgtaccggcaatgtcgacctggtgaccctgggcatgaacctgttcagccag
ggcatcgatccgatgatcgacttctccgacatggacaccatccggcgcaccgtcgagtac
tgcaccgggatgccggtgccggcccgttccccctatgccggcgacctggtctacacggcg
ttctcgggatcgcatcaggatgcgatcaagaagggcctggaagacctggagacccgggcc
agggcagagggcacctcgatccacaagatccgttgggaggccccctacctgccggttgat
ccccaggacgtggggcgcacctatgaggccgtgatccgcgtcaacagccagtcgggcaag
ggcggcatggcctacctgatgaaggcggatcaccacctggagctgccccgtcgcctgcag
atggagttcagtggcgtggtgcaggcccaggcggatgattccggccacgaggtcaccagc
ccggtgctgtgggacatctttgattccgagtacctccgccgcgatacccccttcaagctg
ggtgaattcaccgtcggtgcagcccacggccagacgcagatcactgccgacctcgatgtg
cggggcaagcagaccacggtgaccggggagggcaacggcccgctgtcggcattcatcgac
gcgctgggccaggtgggcgcccacgtgcgcgtgctcgactacaccgagcacgccctgacc
tccggcggcgacgcctatgcggccgcctatgtggaatgtgaggtgggcgagggcgacaac
acccaggtgctgtggggcgtgggcatcgatcccgacatcaccaccgccaccctgaaggcg
gcattgagcgcgctcgaccgggcctga
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