KEGG   Pantholops hodgsonii (chiru): 102319778Help
Entry
102319778         CDS       T02909                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
phd  Pantholops hodgsonii (chiru)
Pathway
phd00310  Lysine degradation
phd05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:phd00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    102319778 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    102319778 (DOT1L)
Enzymes [BR:phd01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     102319778 (DOT1L)
Chromosome and associated proteins [BR:phd03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     102319778 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1 HALZ
Motif
Other DBs
NCBI-GeneID: 102319778
NCBI-ProteinID: XP_005979397
LinkDB All DBs
Position
Un
AA seq 1812 aa AA seqDB search
MQPLVAQGSWGPLQALQEEGPWTCPGCLGAQKGSAVHSWAHCCHMVGLLHMGIHGAFHVH
GASSPQSKRLSIGEEAQTVRFIPWLPHGPVHCSCELVSEWTLQDSVASSLLCCGGPGMPA
RAPALFTALLTKVGVKDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESM
QRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPF
SPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIP
AKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFVNNFAFGPEVDH
QLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVS
YYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVPESKAAVPADTP
VDSGAEEEKAGTAAVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSATNPERKPKKTQS
ALDLLHAQTVSRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPTPPALHRLLESF
RIQYLQFLAYTKTPQYKATLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEESKRLFQQKL
DELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLLKARCEELKLDW
STLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDEALAL
QLRGKPEAEPGRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSTLGRPSPKQNTPQ
YLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQDHAASGKAAA
SELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPEKGVKERAYASS
GEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPARESSSTLEKQV
AANTHGAGGNAAGSKSLVLAPTGFAYSGSVAISGALAGSPAPLGPGAEPPALDESSSSGS
LFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCTSPRLGALGPLPDSGKGDLPCDASFS
DPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSGARGDSGQGHGPDSRKRGRRKRASAG
TPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPV
PYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKIATISLESKSPP
KTLENGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQAASALSHNSLFAF
RPGLEEPSAADGKLATHSRKSFPGTLPGAGGLSPNSLPASGFALGGGLAADLSLHSFSDG
ASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFANKRQLDGLGPKGEGGLPTCGPPDK
ASTAHSKAGKGREREPDVKNGHNLFMAAAAAPPAGLLSGPGLXPQVHPHRPFLGTFAPGP
QFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAATRLTNSHAMGSFSSGVAGGAVGG
VFNHAVPPASAHPFGASFGSGAACRSTTLSLTPLQAVASTPASSFQAPSSAEPRPPQPPP
HLGRPPPGQPALHAPPHPNATLPPPPALLPANSEPVLLQNLASLPANQAFLPAASAASLP
PANASLSIKLASLPHKVSRPALTVHHQPLPGLALAQAAPVNPQASSTGPPAVWVSLGMPP
PYAARLAGVKPR
NT seq 5439 nt NT seq  +upstreamnt  +downstreamnt
atgcagccactggttgctcagggatcctgggggcccctgcaggccctgcaggaggagggg
ccctggacttgtcctggctgcctgggggcccagaaagggagcgcggtccacagctgggca
cactgctgccacatggtggggcttttgcacatgggcattcatggggcctttcacgtccac
ggggcgagttcccctcagagtaagcgtctcagcattggtgaagaggcccagaccgtccgc
ttcattccgtggctgccccacggccctgtgcactgttcgtgtgagcttgtctctgagtgg
acccttcaggacagcgtggcgtcgtctctgctgtgctgtgggggcccggggatgcctgcc
agggctcccgcgctcttcacggccctcctcaccaaggttggagtgaaagacaaacaccac
gatgctgctcatgaaatcatcgagaccatcagatgggtctgtgaggaaatcccggatctc
aagcttgctatggagaattacgttttaattgactacgataccaaaagctttgagagtatg
cagaggctctgtgacaagtacaaccgggccatcgacagcatccaccagctgtggaagggc
accacacagcccatgaagctgaacacacggccgtccactgggctcctgcggcacatcctg
cagcaggtctacaaccactcggtgaccgaccctgagaagctcaacaactatgagcccttc
tccccagaggtgtatggggagacctccttcgacctggtcgcccagatgatcgatgagatc
aagatgaccgaagatgacctgttcgtggacctgggcagtggggtgggccaggtcgtgctg
caggttgccgcggccaccaactgcaaacatcattatggtgtagagaaagctgacatccca
gccaagtacgcggagacgatggaccgagagttcaggaagtggatgaaatggtatggaaaa
aagcatgcagaatacacactggagaggggggacttcctctcggaggagtggagagaacgg
attgctaacacaagtgttgtatttgtgaataactttgcctttggtcctgaggtggatcac
cagctgaaggagcggtttgcaaacatgaaggaaggtggcagaatcgtgtcctcgaagccc
tttgcgcctctgaacttcagaataaacagtagaaacttgagtgacatcggcaccatcatg
cgcgtcgtggagctgtcgccgctaaaaggctcggtgtcatggacggggaagccagtctcc
tactacctgcacaccatcgaccgcaccatacttgaaaactatttttctagtctaaaaaat
ccaaaactcagggaggaacaagaggcagctcggcgccggcagcagcgggagaacaagagc
aacacaaccacacccaccaaggtgcccgaaagcaaggcagctgtgccggcagacaccccc
gtggactccggtgctgaggaggagaaagccgggacggccgctgtcaagaagccatctccc
tccaaggcccgtaagaagaagctgaacaagaagggccggaagatggtgggtcggaagcgt
gggcgccccaagaagatgagtgccaccaaccccgagcgcaagcccaagaagacccagagc
gcactggacctgctgcacgcccagactgtgtcacgagcggcctcccccttgccgcaggac
gcgcacaggccacctcacagcccattctaccagctacctcccagcgtgcagcggcctacc
cctgagcagctgctgctggcacccaccccgcccgcgctgcacaggctgctagagtccttc
aggattcagtatctacagttcctggcatacacgaagacccctcagtacaaggccaccctg
cagcagctgttggaccaggagaaggagaagaatgcccggttgctaggcgcagcgcagcag
ctgtttggccactgccaagctcagaaggaggagagcaagaggctcttccagcagaaactg
gacgagctgggagtgaaggcgctgacctacaacgacctgatccaagcgcagaaggagatc
tcggctcacaaccagcagttgagggaacagacggagcagctagagaagggcaaccgggag
ctgaggagccagagcctgcggctgctcaaggcacggtgtgaggagctgaagctggactgg
tccacgctgtccctggagaatctgctgaaggagaagcaggccctgaagagccagatctca
gagaagcagaggcactgcctagaactgcagatcagcatcgtggagctggagaagagccag
cggcagcaggagttgctccagctcaagtcctgcgtgccgcctgatgaggcgctggccctg
cagcttcgtgggaagccggaggctgagcctggccggcttcacttggagctggactgcgcc
cgcttctccctgccgcccttcagcagcttgagccccgagctctccatgaatggccacgcg
gccggctatgagctctgcagcacgctgggtcggccctcacccaagcagaacaccccccag
tacctggcctccccgctagaccaggaggtcgtgccctgcacccctagccacagcggccgg
ccacggctggagaagctatccggcctggccctgcctgactacaccaggctatcccctgcc
aagctggtgctgcggcgccacctgagccaggaccacgcggccagtggcaaggcagctgcc
agtgagctgcacccacgagccgagcatgccaaggagaacgggctcccttaccagagccct
ggcatcaccaacggcatcaagctgagcccacaagacccccgaccttcatcccccacggct
ttacagatgggagagaagggccctgagaagggtgtgaaggagcgtgcctacgccagcagt
ggggaggccatcaccagcctgcccgtcagcatcccgctgagcaccgtgcagcccagcaag
ctgcccgtcagcatccccctggccagcgtggtgctgcccagccgcgccgagaaggcgaga
agcacacccagccctgggccaccggcccgagagtcctcgtctacgctggagaagcaggtg
gctgctaacacccatggtgccgggggcaacgctgctgggagcaagagcctcgtcctggct
cccacaggctttgcatacagcggctcggtggccatcagtggggccctggcaggcagccca
gcaccccttggccctggagctgagcccccggccctggacgagtcctccagctctggaagc
ctctttgccactgtggggtcccgcagctctaccccgcagcacccacccctgctgacgcag
ccacgcacctgcggctcagcctcgccggccccccagctgtgcaccagcccccggctaggc
gccctgggcccgctccctgactccggcaaaggggacctgccctgcgacgccagcttctca
gaccctgagagcgaagccaaaaggaggatcgtcttcaccatctcggcgggtgccagcagc
gccaagcagtcaccttccagcaaacacagccctctgccctcgggtgcccgtggggacagt
ggccagggccatgggccagacagccgcaagcggggccggaggaagcgggcatcagcgggg
acccccagcctgagctcgagtgtgtcccccaagcgccgggccttgccatctgtcgctggg
cttttcacgcagtcttcagggtcccccctgaatctcaactccatggtcagcaacatcaac
cagcccctggagatcacggccatctcgtcccctgagagctccctaaagagctcacccgtc
ccctaccaggacaatgaccaaccacctgtgctaaagaaggagaagcccctgagccagacc
aatggtgcccactactccccactgacctcggacgaggagccaggctctgaggatgagccc
ggcagtgccagaattgagagaaaaattgcaacaatctccttagaaagcaagtctccacca
aaaaccttggaaaatggtggcagcctagcaggaaggaaggcaccattggccagcgagccg
gtcaacagcagcaagtggaagtccaccttctcacccatctccgacctgggcctggccaag
gcagctgacagcccactgcaggctgcctccgctctgagccacaactccctgttcgctttc
cggcccggcctggaggagcccagcgcagccgatggcaagctggccacccactccaggaag
agcttcccaggcaccctgccgggggcgggcgggctgagccccaatagccttcctgccagc
ggctttgccctgggcgggggcctagcagctgacctcagtttacacagcttcagtgatggt
gcttctctctcccacaaggcccccgaggcagctggcctgggtgcccccctgagcttccct
ggcccacggggcaaagagggtggcgctgcagagtctggccccttcgcgaacaagcggcag
ctggacggactgggcccaaaaggcgaggggggccttcccacatgcggacccccggacaag
gcctccacagcgcatagcaaggcaggcaagggccgtgagcgtgagcctgacgtcaagaac
ggccacaacctgttcatggccgctgccgccgcgccccctgcaggcctcctcagcggccca
ggtcttnngccccaggtgcacccccaccgccccttcctgggcaccttcgcccctgggcca
cagttcgcgctgggccccatgtcgctacaggccaacctgggcccgtctgtgctgcagtcc
ctgttcagttctgtgcccgccgccggcctggttcacgtctcgaccgccgccaccagattg
accaactcgcacgccatgggcagcttctcctccggggtggccggcggcgcagttggaggt
gtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttcggcagt
ggggctgcatgtcgcagcaccacgctgagcttaaccccgctgcaggcggtggccagcacc
ccggcctcttcctttcaggccccgtcctctgcggagccgaggccaccccaaccccctccg
cacctgggccggccccctccggggcagcctgccctccacgcacccccccatcctaacgcc
accttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctgcagaac
ctcgcatccctccctgctaaccaggctttcttgcccgccgcctctgccgcctctctgccg
cctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcccggccc
gccttgacggtgcaccaccagcccctgcctgggttggccctggcccaggccgcgcccgtg
aacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatgccgcct
ccgtatgccgcgcgccttgcgggggttaagccacgataa

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