KEGG   PATHWAY: phi04340
Entry
phi04340                    Pathway                                

Name
Hedgehog signaling pathway - Pseudopodoces humilis (Tibetan ground-tit)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
phi04340  Hedgehog signaling pathway
phi04340

Organism
Pseudopodoces humilis (Tibetan ground-tit) [GN:phi]
Gene
102104157  PTCH1; patched 1 [KO:K06225]
102108629  PTCH2; patched 2 [KO:K11101]
102107642  SMO; smoothened, frizzled class receptor [KO:K06226]
102099451  GPR161; G protein-coupled receptor 161 [KO:K08439]
102112800  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102099948  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102104998  CSNK1G1; casein kinase 1 gamma 1 [KO:K08958] [EC:2.7.11.1]
102109201  CSNK1G2; casein kinase 1 gamma 2 [KO:K08958] [EC:2.7.11.1]
102107375  CSNK1G3; casein kinase 1 gamma 3 [KO:K08958] [EC:2.7.11.1]
102101922  CSNK1D; casein kinase I isoform delta [KO:K08959] [EC:2.7.11.1]
102112017  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
102105491  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102102160  GLI1; GLI family zinc finger 1 [KO:K16797]
102109885  GLI2; GLI family zinc finger 2 [KO:K16798]
102102459  GLI3; GLI family zinc finger 3 [KO:K06230]
102103421  SUFU; SUFU negative regulator of hedgehog signaling [KO:K06229]
102102495  KIF7; kinesin family member 7 [KO:K18806]
102114672  HHIP; hedgehog interacting protein [KO:K06231]
102099659  CCND1; cyclin D1 [KO:K04503]
102114518  CCND2; cyclin D2 [KO:K10151]
102113262  BCL2; BCL2, apoptosis regulator [KO:K02161]
102100590  CUL1; cullin 1 [KO:K03347]
102101586  BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
102103643  FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
102103261  SHH; sonic hedgehog [KO:K11988]
102102115  IHH; indian hedgehog [KO:K11989]
102100094  DHH; desert hedgehog [KO:K11990]
102112245  BOC; BOC cell adhesion associated, oncogene regulated [KO:K20020]
102103693  CDON; cell adhesion associated, oncogene regulated [KO:K20033]
102104518  GAS1; growth arrest specific 1 [KO:K06232]
102112858  LRP2; LDL receptor related protein 2 [KO:K06233]
102109115  chromosome unknown open reading frame, human C16orf52 [KO:K23663]
102105366  MGRN1; mahogunin ring finger 1 [KO:K10604] [EC:2.3.2.27]
102107051  SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
102102573  SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
102108753  GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
102114443  GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
102110311  EVC; EvC ciliary complex subunit 1 [KO:K19605]
102104990  EVC2; EvC ciliary complex subunit 2 [KO:K19608]
102106559  ARRB1; arrestin beta 1 [KO:K04439]
102112425  KIF3A; kinesin family member 3A [KO:K10394]
102104772  CUL3; cullin 3 [KO:K03869]
102114473  SPOPL; speckle type BTB/POZ protein like [KO:K10523]
102100694  SPOP; speckle type BTB/POZ protein [KO:K10523]
Compound
C00575  3',5'-Cyclic AMP
Reference
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Related
pathway
phi04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   
LinkDB

DBGET integrated database retrieval system