Paramormyrops kingsleyae: 111841417 Help Entry 111841417         CDS       T05788                                  Symbol ryr1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism pki  Paramormyrops kingsleyae Pathway pki04020   Calcium signaling pathway pki04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pki00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     111841417 (ryr1)    04020 Calcium signaling pathway     111841417 (ryr1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pki01009]     111841417 (ryr1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pki04147]     111841417 (ryr1)    04040 Ion channels [BR:pki04040]     111841417 (ryr1) Protein phosphatases and associated proteins [BR:pki01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      111841417 (ryr1) Exosome [BR:pki04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    111841417 (ryr1) Ion channels [BR:pki04040]  Voltage-gated cation channels   Ryanodine receptor    111841417 (ryr1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 YebO EF-hand_8 Motif Other DBs NCBI-GeneID:  111841417 NCBI-ProteinID:  XP_023662897 LinkDB All DBs Position Unknown AA seq 5057 aa AA seqDB search MAEAPEGEEEIQFLRTEDQVVLQCTATVVKEQIKLCLSSEGFGNRLCFLEPTSNAQNVPP DLAICCFTLEQSLSVRALQEMLANTVEMNEGVDLDKWSSQGGGHRTLLYGHAILLRHCHS GMYLSCLTTSRSLTDKLACDVGLQENSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWNMNPVCSGCELAEGYLTGGHVIRLFHGHMDECLA IPPPDQGDDQRRIAEYEGGAVCSQARALWRLEPLRIGWSGSHMKWGHPFRVRHVTTGRYL CLHEEKGLMVLDPKRANTKMSAFCFRASKEKTEVAPKRDIEGMGLPEIKYGESMCFMQHV STGLWLTYASVDAKARLGPLKRRGILHQEGHMDDALCPSRSQMEESQAARMIFNTTGLFT QFIKELDALNPKNKNPTPLSLSLDRVVLSLQDLIFYFSYPEDDLEHEEKQTKLRSLRSRQ NLFQEEGMITLVLNCIDRLNVYNTSAHFADFAGEEAGEYWKEIVNLLYELLASLIRGNRS NCALFCDNLDWLVSKLDRLEASGGILEVLYCILIESPEVLNIIQENHIKSIISLLDKHGR NYKVLDVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNLVNYATSMRPNIFLGTCEG STQYKKWYCEVVVDYVEPFVTAQAAHLRVGWAMNVGYSPYPGGGEGWGSNGIGDDLYSYG FDGLHLWSGHVPRAVASHSQHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDG LFFPVISFSAGVKARFLLGGRHGDFKFLPPPGYAPCYEALLPKERMRIEPVKEYTHDFDG VRSMLGPMQSLTHTSFTPYPVDTIQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYAA FRDDNKKLHPCLVDFQNLPEPERNYNLQMSGETIKTLLALGCHVGMGDEKAEENLKKIKL PKTYMMSNGYKPAPLDLSHVKLTPNQNTLVEKLAENGHNVWARDRVRQGWTYSIVQDIMN KRNPRLVPYNLLDERTKKTNRDSVCAAVRTLIGYGYNIEPPDQESSGHGMENGHTDKVRL FRAEKSYAVTQGKWYFEFEAVTAGEMRVGWARPSVRSDIELGTDELAFVFNGNKAQRWHI GNEPFGRQWQAGDVVGCMIDLAERTIMFTLNGEMLISDSGSEMAFKEIEIGEGFIPVCSL GQSQVGRINLGQNVSTLRFFSICGLQEGFEPFAINMKRDITMWFSKSLPQFISVPTNHPH IEVSRVDGTADTAPCLKLTHKTFGSQNANTDMLFMRLSMPVQFHETFKVQAGATPLTRAL TIPEDEALEVEPDSEYEVLKKSASRKEQEEKEASVAREVPGVKAENEKDVTTEKVKKKGF LFKAKKAAMITPPPVVPTMPRLVQDVVPDDRDDPEIILHTTTYYYSVRIFAGQEPSGVWV GWVTPDFHQYDLHFDLNKVRCVTVTVGDDKGNIHGSMKQSNCYMVWGAEFTSTQQACFSQ EDLVIGCLVDLATGLMTFTANGKEMNTFFQVEPNTKLFPAVFAVPSSQNMLQVDLGKLKN IMPISAAMFQSEQKNPVPQCPPRLDFQMLTPVIWSRVPNGFLYPEVSRVSERHGWMVECT EPLTMMALHIPEENRCIDVLELSERLDLLKFHYHTLKLYCAVCALGNNRVAHALCSHVDE SQLLYAIESTFLPGPLRSGCYDLLISIHLESAKRARLLTNREFIVPMTEETLSIQLYSEG HALPGVGLTTCLRPKPHFSPVGFVNTDPDIYTLSPIIPLQVLKIKAISMLTEAVFDGSQA VRDPVGGSVEFHFVPILKLISTLLIMGIFEDEDVKHVLKMIDPSVFNGKEAQAAEEEEGE KGEEEEAAAEEEGGEAKSLEGELEDEGVGEEEEEDELKALKSETEDVEEEEGEKEGGEIT EEEKERESGPKEDEVKEEEEAPEEGLLQMKLPESVKLQMCTLLQYFCDCELRHRVEAIIA FSDSFVNNIQTNQRQRYNDLMVAFTMTAAETARRTREFRSPPQEQVMLLTNFRHLPDDEE CPVPDEVREILQEFHKELLSHCGVHLEEEEEEEEVDTSLRGRLLSLVEKVKNLRKKKEEE EPESEEEPKPSTLHELISHTMIHWAQESFIQNPELVRVMFSLLHRQYDPLGELIRALPKA YSINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPNLMRAL GMHETVMEVMVNVLGAGGEAIRFPQMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSG IGLGMSGSTPLDVAAASCIDNNELALALQEQDLEKVVTYLAGCGLQSCPILLSKGYPDIG WNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIED AIKISEDPARDGPTPKKDRRFMFGGEHLEENRVHLGHAIMSFYSALIDLLGRCAPEMHLI QAGKGEALRIRAILRSLVPIDDLVGVISLSVQIPSFGKDESIIEPKMSASFVPDHKASMV LFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFSTTEMALALNRYLCSSVLPLLT KCAPLFAGSDHRAIMVDSMLHTIYRLSRGRALTKAQKDVIRECLMSLCKHLRPSMLQHLL RRLVFDVPILSPHAIMPLKLLTNHYERCWKYYCLPNGWANFGVSSEEELHLSRKLFWGIF ESLSHKKYDSELFKIAMLCICAIAGAIPPDYVDASYSHTEKKASVDAEGNFDPRPVETTN TIIPEKLDAFINKFAEHTHDRWAFEKIQNNWTYGEVHDENAKTHPMLRPYKTFSEKDKEI YRWPIKESIKAMIAWEWTIEKARDGEEEKIQKTTRKISHTAQVTYDPSQGYNPQPIDITG MAISRELQSMAEQLAENYHNTWGRKKKLELQAKGGGTHPLLVPYDTLTAKEKARDREKAQ DLLKFLQFNGYAVTRGLKDLEQDISSIEKRFAYGFLQKLLKWLDIAQEFIAHLEAVVSSG RVEKSPHEQEIKFFAKILLPLINQYFKNHCMYFLSTPAKLLGSGGHASNKEKEMIASIFC KMAALVRHRVSLFGTDANAVVNCLLILSRSLDARTVMKSGPEIVKAGLRSFFESAADDIE KMVENLKLGKVSSRNQVKGVSQNINYTTVALLPILSTLFDHIAQHQFGDDVILDDLQISC YRIMCSIYSVGTVKTTHVEKLRPALGECLGHLAAAMPVAFLEPSLNEYNAYSVYTTKTPR ERTILGLPNQVEELCPDIPELNILMKEIGDLAESGARYTEMPHVIEITLPMLCNYLPRWW ERGEENFPEQEGSLCTDVTSEQLNQLLGSIMKIVVNNLGIDEASWMKRLAVFTQPIVSRA KPEMLRSHFIPTMEKLKKRSGKVVAEEDQLRMEGKTESENEECTIRDEFAVLCRDLYALY PLLIRYIDNNRPRWLTCPDPDAEDLFRIVGEVFIFWSKSHNFKREEQNFVVMNEINNMSF LMADSKSKMSKTGDAEGGGSDVERSKKKRRGDRYSVQTSLIVAAVKKLLPIGLNMCSPAD QELINLAKIRYSLKDTNEEVRDFLQNNLHLQGKVEDPSMRWQMALYKEGAGKAEDAEAPE KVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKLLSKQRRRAVVACFRMTPLYNIPRHRGS NMFLDAYKRNWIGNEGYSFEDKMIDDLSKVMEEVEEEEEEPEAKPDPLHQLILHFSRTAL TEKMKLDVDYLYMAYADIMAKSCHIDEEGGGEEEEGSEEMTFEEKEMEKQRLLYQQSRLH NRGAAEMVLQMISACKGEPGSMVSSTLKLGISILNGGNSDVQQRMLDYLKDKKDVGFFLS AQALMQTCSVLDLNAFERQNKAEGLGMVSEEGSNVKLERDEKVMADNEFTCDLFRFLQLL CEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIDEPGKRNF SKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQMHPDPG LRNADLFWSRKHSEDSRQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVES SSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEIQFL LSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVL NYFRPFLGRIEIMGASKRIERIYFEISEVNRNQWEMPQVRESKRQFIFDVVNEGGESEKM ELFVNFCEDTIFEMNIAAQISEPEEGEKEDEDEDEGSAEGGSEEGENGEAASESTSAFAD FINGVFNFFGKFTFRNLRRQYRRVRKMTVKDIVVGLATFFWTILMGILHFIYSICRGFFL LIWHTLFGGSLVEGAKKITVTEILASMPDPTQDEVHGDLPADPAAGVVQEAGGAADLMEG GGGEEEEPDSKEQEGGRIPGIDIPGGLGDIGDTTPAEPPTPEGSPITKRKVLGSEEDEAE PEVIEEPSAEPEKADAENGEKAEKEAEAEPEAMGESPEEIKEETVKVKAKKDKRSAGEQG FELWNELDIQRNKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSDSPPGMEEYEGSGM FEGSGAEPEGSGMEDDGGDEDEEDGLVYYILEESTGYMEPAMTLLAVIHSIISFLCIIGY NCLKVPLVIFKREKELARKLEFDGVYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFVK RKVLEKYGDIYGRERIAELLGMDLASLDVSTQQREKKPAPDTSLFTWITSIDVKYQIWKL GVVFTDNTFLYLVWYLVMSLLGHYNNFFFACHLLDIAMGVKTLRTILSSVTHNGKQLVMT VGLLAVVVYLYTVVAFNFFRKFYNMSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDE IEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFI CGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWD FFPAGDCFRKQYEDQLG NT seq 15174 nt NT seq  +upstreamnt  +downstreamnt atggcagaggcaccggaaggggaagaggagattcagttcttgcggacggaagaccaggtg gttctgcagtgcactgcaacagtagtgaaggagcagatcaaactgtgcctgtccagtgag ggctttgggaaccgcctctgctttctggaacccacctccaatgcccagaatgtgccgcca gacctggctatctgctgcttcaccctggagcagtctctctcggtgcgagctctgcaggag atgctggccaacaccgtggagatgaatgagggagtcgatttggacaaatggtcgtcccag ggtgggggtcaccgcaccctgctgtacggtcatgccattcttctccggcactgccactct ggaatgtacctcagttgcttgaccacgtctcggtcacttacggacaagctagcctgcgat gtgggcttgcaggagaattccactggggaagcatgttggtggaccatccacccggcatcc aagcagaggtctgaaggtgagaaggtccgggtgggagacgacctcatcctggtcagcgta tcctcagagcgatacttgcatctgtcctacgccagcggggatctgatggtggacgcctcc ttcatgcagaccttgtggaacatgaacccggtgtgctcggggtgcgagctggcagagggc tacctgactggcggacacgttatcagactcttccacggtcacatggacgagtgcctggcc atccccccccccgaccaaggggacgaccaacgtcgaatcgccgagtatgaggggggggcc gtctgtagccaggcccgggctctgtggagattggagcccctgcggatcgggtggagcggt agccacatgaagtgggggcatccgtttcgggtgcgtcacgtgaccacaggccgatacctg tgcctgcatgaagagaagggcctgatggtcctggatcccaagcgggctaacaccaagatg tcagctttctgcttccgagcctcaaaggagaagacggaggtagccccaaagcgtgacatt gagggaatgggcttgccagagatcaagtacggagagtccatgtgcttcatgcagcatgtt tccacgggcctgtggctcacctacgcttcagtggatgccaaagcccgcctgggacctctc aagaggaggggcatcctgcaccaggagggacacatggacgacgcgctgtgcccctcccgt tcacagatggaggagtcacaggcggcccgcatgatcttcaacaccacgggtctcttcacg cagttcatcaaggaactggatgctctgaatccaaaaaacaagaaccccacaccgctatct ctgtctctggaccgagtggtcctgtccctgcaggatctcatcttctacttcagctaccct gaagatgacctggagcatgaggagaagcagaccaagctgcgctctctccgtagccggcag aacctctttcaggaggagggcatgatcacccttgttttgaattgcatcgaccggcttaac gtctacaacacgtctgcccactttgcggacttcgctggcgaggaggccggcgagtattgg aaggagatcgtcaacctgctgtacgagctgcttgcttctctgatccgagggaatcgctcc aactgtgctctcttttgtgataatctcgattggctggttagcaaactggatcgcctggaa gcctctggagggattctggaggtgttgtactgcattttgatcgagagcccagaagtgctg aacatcatccaggaaaaccacatcaaatcaatcatctcccttctggacaaacacgggcgc aattacaaggtgctggacgtgcttcgctctctgtgtgtgtgtaatggtgtggctgtcagg tccaatcagaacctcatcactgaaaacctgctgccaggtcgtgacctcctattgcagacc aacttagtgaactatgccaccagtatgagaccaaacatcttccttgggacgtgtgaaggc tccacacagtacaagaagtggtactgcgaggtggttgttgactacgtggagccgttcgtg acggcccaggctgctcacctgcgtgtagggtgggctatgaacgtaggctacagcccatac cctggtgggggtgaaggttggggcagcaacggaattggggatgacctctattcctatggt tttgatggcctgcatttgtggtcagggcacgtcccccgcgccgtggcctcgcatagccag cacattctggcggcggatgacgttgtcagctgctgccttgacctcagtgtgcccagcata tccttccgcatcaacggtcatcccgtccagggcatgtttgagaacttcaacgtggacggc ctcttcttccccgtcatcagcttctccgcgggtgttaaagcccgctttcttcttggtggt cgccatggggatttcaagttcctcccaccccctggctatgcaccctgttacgaggcctta ctgcctaaggagaggatgcgtatcgagcccgtgaaggagtacacgcatgacttcgatggt gtccgcagtatgctgggtcccatgcaatcactcacgcacacctccttcacgccctatcct gtggacaccattcagatcgtgctgcccccccatctggaacgcatccgggagaagctggca gagaacattcatgaactgtgggcggtgacccgcatcgagcagggctggacttatgcagcg ttccgggatgacaataaaaagctgcacccttgcctggtggatttccagaaccttccagaa cctgagcgaaactataaccttcaaatgtctggagaaaccataaagactttgctggctctg gggtgccatgtggggatgggggatgaaaaggcagaggagaacctgaaaaagatcaaactt cccaagacctatatgatgagcaatggatacaagcctgcccccctggaccttagtcatgtc aagctgacacccaatcagaacaccctggtggagaaactggctgagaatgggcacaatgtg tgggcacgggatcgggtgcgacagggctggacctacagcattgtgcaggacattatgaac aagcgcaaccctcgcctggtgccgtacaacctgttggatgaacgaaccaagaaaactaac agggacagtgtgtgtgcagctgtgaggacactcatcggctatgggtacaacatagaacct ccagatcaggagagcagtggccatggtatggagaatgggcacactgacaaggtgcgcctg ttccgagctgaaaagtcatatgctgtgacccaggggaaatggtactttgagtttgaggct gtgacagctggggagatgagggtgggctgggcccgacccagcgttcgatccgacatcgag ctgggaacagatgaactggcttttgttttcaatgggaacaaggctcagcgatggcacatt ggcaatgaacctttcggccgtcagtggcaggcgggtgacgtagtagggtgcatgatcgac ctggcagagaggaccatcatgttcaccctcaacggggagatgctcataagtgactctggt tccgagatggccttcaaggaaattgagattggggaggggtttatccccgtgtgcagcttg ggtcaatcccaggtgggcaggatcaacctgggccagaatgtcagcacccttcgtttcttt tccatatgtggcctccaggagggttttgagcccttcgccatcaacatgaagagagacatt accatgtggttcagcaagagtctgccccagtttatttctgtgccaaccaaccacccgcac atagaggtttctcgtgtggatggaacagcggatactgccccctgtctgaagctgacccac aagacctttggctctcagaatgccaacacagatatgctgttcatgcggttaagcatgccg gtgcagttccatgagaccttcaaggttcaggctggggccacaccccttactcgtgccctc accatccctgaggatgaggcactggaggtggaacctgactctgaatatgaggtgctgaag aagtcagcaagccgcaaagagcaggaggagaaggaggcttccgtggccagggaggtcccc ggtgtcaaagcggagaacgagaaggacgtcacgacagagaaggtcaagaagaaagggttc ctatttaaagccaagaaagctgctatgatcactccccctcctgtggtacccacaatgccc cgcttggtgcaagatgttgtcccagatgatcgagacgacccagaaattattctccacacc accacgtactactattctgtgaggatctttgccggacaggagccgagtggcgtgtgggtg ggctgggtgacccctgactttcaccagtacgacctgcactttgacctcaataaagtgcgt tgtgtcactgttactgttggtgatgacaagggcaacatccatggcagcatgaagcagagt aactgttacatggtgtggggggcagagtttaccagcacccagcaggcctgcttcagtcaa gaggacctggtgattggctgcctggtcgacctggcaactgggctgatgaccttcacggcc aatgggaaggagatgaataccttcttccaggtggagcccaacaccaagctgtttcccgcc gtgttcgccgtgccttccagccagaacatgctgcaggtggacctgggcaagctgaagaac atcatgcccatctcagccgccatgttccagagcgagcagaagaacccggtcccgcagtgt cccccccgcctagacttccagatgttgacaccagtgatctggagccgagtgcccaacggc ttcctgtaccccgaggtgtcacgggtcagtgagcggcacggctggatggtggaatgcact gagccgctcaccatgatggccctgcacatcccggaggagaacagatgcatcgacgtcctg gagctctccgagcgcctggacttgttgaagttccactaccacaccttaaagctgtactgc gccgtgtgcgcactgggcaacaaccgcgtggcacacgccctctgcagccatgtggatgaa tcgcagctgctgtacgccatcgagagcaccttcctgccagggccgctgcgcagtggctgc tatgacctgctgatcagcatccacctggaatcggccaagcgcgcgcgcttgctgaccaat cgagagttcatcgtgcccatgacggaggagacgctcagcatccaactgtacagcgagggc cacgccctgcccggggtgggcctcacaacctgcctgcggcccaaaccgcacttctcgcca gtgggtttcgtgaacactgacccggacatctacaccctcagccccataattcccctgcag gttctgaagatcaaagccatcagcatgctgacggaggctgtgtttgatgggagtcaagct gtgcgcgacccagtagggggcagtgtagagttccactttgtgccgatcctcaaactcatc agcactctcctgatcatgggtatttttgaagatgaggacgtcaagcatgtcctaaagatg atcgacccctccgtcttcaacggcaaggaagcgcaggcggccgaggaagaagagggtgaa aagggagaagaagaggaagcagctgccgaagaagagggaggggaggccaagagtcttgag ggagagctggaggatgagggagtgggagaggaggaagaggaagatgaattgaaggctttg aagtcagagacggaagatgtggaggaggaagagggagaaaaggagggtggagagatcacc gaagaggaaaaggaaagggaatctggacctaaagaggatgaagtaaaagaggaagaggaa gcaccagaggaaggcctactccagatgaaactcccagagtctgtaaagttacagatgtgc acccttctgcagtacttctgtgactgtgagctccggcaccgtgtggaggccataatcgcc ttctcggactcgttcgtcaacaacatacagactaaccagcgacagcggtacaatgacctg atggtggccttcaccatgactgcagcagagactgctcgaaggacccgcgagttccgttca cctccgcaggagcaggttatgctgctcacaaactttagacatttaccggatgatgaggag tgtcctgtccctgatgaggttcgggagattctgcaggaattccacaaggagcttctgtct cactgtggtgttcaccttgaagaggaggaggaagaggaggaggtagacacctcactccgc ggaaggctcctgagcttggtggagaaggtcaagaacctccggaagaaaaaggaggaagaa gagcctgagtcagaggaagaacccaaaccctccaccctccatgaactcatctcacatacc atgatccactgggcccaagagtctttcatccagaacccagagttagtgcgggtcatgttc agcctgctgcaccggcagtacgatccactcggggaactgatccgtgcgctgcctaaggcg tactccatcaatgccgtgtccgtgcaggacaccatggacctcttggagtgtcttggtcag atccgttctctgctcattgtccagatggggcccgaggaagaaaggcttatgattcagagc attggaaacatcatgaacaacaaggtgttctaccagcaccccaacctgatgcgtgcacta ggcatgcatgagactgtaatggaggtcatggtcaatgttctgggagctggaggggaggcg atccgatttccacagatggtgactagctgctgtcgtttcctgtgttacttctgccgcatc agtagacagaatcagcggtccatgtttgaccacctcagctacctgctggagaacagtggc attggcttgggaatgagtggctctacccctcttgatgtggcagcagcgtcctgtattgac aacaatgaactggcgctggctttgcaggagcaggacctggagaaggttgtgacatacctg gcaggttgtggcctacaaagttgccccatccttctgtctaaaggctaccctgacataggg tggaacccttgtggaggagaacgataccttgatttccttcgatttgcggtctttgtcaat ggggagagcgtggaggagaacgccaatgttgtggtccgtctccttatccggaggcctgag tgcttcggcccggccctgaggggtgagggtggtgctggactgttagctgccatagaggac gccatcaaaatctctgaggatcctgccagggatggacctactcccaaaaaggacaggcgc ttcatgtttggtggagaacatctggaggagaaccgtgtgcatcttggtcatgccatcatg tccttctactcagctctcatcgacctgctgggccgctgtgctcctgagatgcatctgatc caggctggcaagggtgaggcactaagaatccgtgctatcctgaggtccctggtgcccatt gatgatctagtgggtgtaatcagcttgtccgttcagatcccaagcttcgggaaagacgag agcattattgagccaaaaatgtctgccagttttgtcccggaccacaaagcctccatggta ctattcttggacagagtctacggcattgacaaccaggactttctgctgcacgtgctggag gtgggattcttaccagacatgagggcagcagcttcccttgatacggctgccttcagcacc actgagatggcactggccctcaaccgctacttgtgttcctccgtattgcctctgctcacc aagtgcgccccgctttttgctggttctgaccaccgcgccatcatggttgactccatgctc cacactatctaccggctctcccggggccgtgccctcacaaaggcccagaaggacgtcatt agggagtgcttgatgtcactttgcaaacacctgcgcccatccatgttgcaacacttgctg aggaggttggtctttgatgttccaatacttagtccacatgccataatgcctctcaagctc ctaaccaatcactatgagcgttgttggaagtactactgcctacccaacggctgggccaac tttggtgtttcatcagaagaggagttacacctttcccgcaagctcttctggggtatattt gagtctctgtcacacaagaaatatgattctgagctgttcaagattgccatgctgtgcatc tgcgccattgctggtgccattccccctgattatgtagacgccagttactcccacacagaa aagaaagcctctgttgacgctgagggcaactttgaccccaggcctgtggagaccaccaac accattatccctgaaaaacttgatgccttcatcaacaagtttgctgagcacacacatgac agatgggcctttgaaaagattcagaataactggacttatggagaggtgcatgacgagaat gcgaaaacacacccaatgcttaggccatataagactttctctgagaaggacaaagagata taccgttggcccatcaaagagtccatcaaggccatgattgcctgggagtggactattgag aaggccagggatggtgaggaagagaagattcagaagacgacccgcaagatatcacacaca gcacaggtgacctatgaccccagccaaggctacaatccacagcccattgatatcaccggc atggcaatatcaagagagcttcagtccatggcagagcagttagctgagaactaccacaac acatggggcaggaaaaagaagctggagcttcaggccaaagggggcggcactcatcccctg cttgtgccctacgacaccctgactgccaaggagaaggcccgtgatcgagagaaagctcag gacctcctcaaattcttgcagtttaatggatatgccgtcaccaggggcttgaaggacttg gaacaggacatctcctctattgagaagcgctttgcctacggcttcttgcagaaattgctg aagtggttggacattgcccaagagttcattgcacacttggaggccgtggtgagcagtggc agggtggagaagtctccgcatgagcaggagatcaagttctttgcaaagatcctgctgccg ctgataaaccagtactttaagaaccactgtatgtacttcctgtccacgcctgccaagttg ctggggagtggcggtcatgcctctaacaaggaaaaggagatgattgccagtatcttctgt aaaatggccgctttggtgaggcacagagtttctctgtttggtacggatgctaatgctgtg gtcaactgtctgctaatcctgtcacggtcgctggatgccaggacggtgatgaagtctgga cctgaaattgtgaaagcaggcctacggtcattttttgagagtgctgcggatgacattgag aagatggtggagaatctgaagctggggaaggtgtccagccgcaaccaggtgaagggcgtg tcccagaacatcaattataccaccgtcgccctgcttcccatcctcagtacactgtttgat cacattgctcagcaccagtttggcgatgatgtcatcttggacgacttgcagatctcttgt tatcgaattatgtgcagcatctactctgtgggcacggtcaaaaccacacacgtggaaaag ttgcggccagccctgggagaatgtctcggtcatcttgctgctgccatgcccgtggccttc ctggagccttccctcaatgagtataatgcttactctgtctacaccactaagacaccacgt gaacgaaccatccttggcctcccaaaccaagtcgaggagctgtgcccagatatccctgag ctaaacattttgatgaaggagattggggacttggcagagtcgggtgcccgctacacggag atgccccatgtaatcgagatcaccctacccatgctatgcaactacttgccacgctggtgg gaaagaggggaggagaacttccctgagcaggagggcagcctgtgcacagatgtcacctcc gagcaactcaaccaacttcttggaagcatcatgaaaatcgtggttaacaacctaggaatc gacgaggcctcgtggatgaagaggctggctgtgttcacccagcccatagtgagcagagcc aaaccagagatgctgaggtcccatttcattcccaccatggagaagctgaagaaacgctct gggaaggtggtggctgaggaggatcagctgcgcatggaagggaaaactgagtcggaaaac gaagagtgcaccatccgtgatgagtttgctgtgctctgcagggatctgtatgccctctac cctctgctcatcagatacatagacaacaacaggccaaggtggcttacctgcccagatcct gatgcagaggacctcttcagaatagtgggagaagtctttatcttctggtccaaatctcat aacttcaagcgagaggagcaaaactttgttgtgatgaatgagatcaacaacatgtctttt ctcatggccgacagcaagagcaagatgagcaagaccggggatgctgaggggggcggctca gatgtggagcgttcaaagaagaagcgccggggcgaccgttactcggtgcagacatcgctc attgttgctgctgtgaagaagctccttcccatcggcctcaacatgtgctcgcctgcggac caggagctcattaacctggccaaaattagatactctctgaaagacacaaatgaggaggtg agagacttccttcagaacaacctccatcttcaggggaaggtggaggacccgtccatgcgc tggcagatggccctgtacaaggagggtgccggcaaggctgaggacgcagaggctcctgag aaggtggtgaagagggtgcaggaggtgtctgcagtgctgtatcacatcgaggtgacagaa catcccttcaagtctaagaagatggtatggcacaagctgctctcgaaacagcgtcgccgt gccgtggtggcctgcttcaggatgacgcctctgtacaatatccccaggcacagaggatcc aacatgttccttgatgcatacaagcgcaactggatcgggaatgagggctactcgtttgag gataaaatgatagacgacctgtctaaagtcatggaggaagtagaagaggaggaggaggag cctgaagcaaagccggaccccctccaccagctcatccttcacttcagtcgcacggctctc accgaaaagatgaaacttgacgtggattatctctacatggcttatgctgacattatggca aagagttgccacattgatgaggaaggtggaggggaagaggaagagggcagtgaggagatg acttttgaggagaaagagatggagaagcagaggctcttataccagcagtccaggctgcac aaccgtggagcggcagagatggtccttcagatgatcagcgcctgcaaaggtgagccagga tccatggtgtcctccaccctgaagttaggcatctccatcttgaatgggggcaacagtgat gtccagcagagaatgctggactacttgaaggacaagaaggatgtgggatttttcctgagt gcccaggcactgatgcagacctgcagtgtcctggacctgaacgcctttgaaagacagaac aaggcagaggggctgggcatggtgtctgaggagggctcaaacgtaaagctagaacgcgat gagaaggtcatggctgacaatgaatttacctgcgatctcttccgcttcctgcaactgctc tgtgaaggtcataataatgattttcagaactacctgcggacccagacaggcagcacaacc accatcaacatcatcatctgcactgtggactatcttctcaggcttcaggagtccatcagc gacttctactggtattactctgggaaggatgtcatcgatgagccaggcaagaggaacttc tccaaagcgatgacggtggcaaaacaggtgttcaacagcttgacagagtacatccagggc ccctgcactggaaaccagcagtccctggcacacagcaggctgtgggatgctgtagtggga ttcctgcacgtctttgcccatatgatgatgaaactggcccagatgcaccctgaccctgga ctccgaaatgcagatcttttctggagtcgaaaacattcagaggactcgcgtcagattggt ctgcttaaagaactgctggacctccagaaagacatggtcgttatgcttctgtctcttttg gagggtaacgttgtgaacggaaccatcgcccgccagatggtagacatgctggtggagtcc tccagtaatgtggagatgattctcaagttctttgacatgttcctcaagctcaaggacatt gtggcctcagatgcattccgtgactatgtgacggacccccgtggcctgatctccaagaag gacttccagaaggctatggatagccagaagcagtactcgccctcagagatccagtttctg ctgtcctgctcggaagccgatgaaaatgagatgatcaactttgaagagtttgcagaccgc ttccaggagcccgctaaagatattgggttcaacattgcagtgctgctcacaaacttgtca gaacatgttccacatgatacgcggctgcagaacttccttgagcaggcagagagtgttctc aattacttccgccccttcctaggccgtattgagataatgggtgccagcaagagaatagag cgtatctactttgagatcagcgaagtcaaccgcaatcagtgggagatgccccaggtcaga gagtctaagcgacagttcatcttcgatgtagtgaatgagggcggcgaatctgaaaaaatg gaactttttgtcaacttctgtgaggacactatttttgaaatgaatattgctgcacagatt tctgagccagaggaaggggagaaggaggatgaagatgaggatgagggtagtgcggagggt ggcagtgaagagggagaaaatggagaagcagcttcagagtcaacctcagccttcgcggat ttcatcaatggcgtgttcaatttctttggaaagttcaccttccgcaacctgcggcgacag tatcgcagagtgaggaaaatgaccgtgaaggacatagtggttgggcttgctaccttcttc tggaccatccttatgggaatcctgcacttcatctacagcatctgcagaggcttcttcttg ctcatttggcacacactgtttggtggtagtctagtggaaggggctaagaaaattactgtg actgagatcctggctagcatgccagatcccacacaggatgaggttcatggagacctacca gcagatccagcagcaggggtggtgcaggaagcgggcggagcagctgacctgatggaaggt ggtggtggagaagaggaagagccagactccaaggaacaggaaggtggccggatacctggt atagacatacctggagggctgggcgacataggtgataccactccagctgagccacctacc ccagaaggctcacccataaccaagaggaaagtgttgggttctgaggaagatgaagctgag cctgaggtcatagaggaaccatctgcagaacccgagaaggctgatgccgaaaatggagaa aaggcagaaaaggaggcagaagctgagcctgaagcaatgggtgaatcaccagaagagata aaggaagagacagtgaaggtcaaagccaagaaggacaagagatcagcgggagagcaaggc tttgagctctggaatgaactggacatccagaggaataaattcatgaactacctgtcccgt aacttttataacctacgtttcctggctcttttcattgcttttgctctgaacttcatcctg ctcttctacaaggtgtcggacagccccccaggtatggaagagtatgagggctcagggatg tttgaaggttctggggctgagcctgagggttctggaatggaggatgatggaggggatgag gatgaggaagatggactggtgtactacatcctagaagagagtactggctacatggaacca gccatgactttacttgccgtcatccatagcatcatctccttcctttgcatcattggctac aactgccttaaggtccccttggtcatcttcaagagagagaaggagctggcacgaaagctg gagtttgacggtgtttatgtcaccgagcaacctgaggatgatgacatcaagggacaatgg gatcgactggtcctcaacacaccgagcttcccaaataactactgggacaagtttgtcaag agaaaggtcctggagaagtatggtgacatctatggccgggagaggatagcagagctgctt ggcatggacctggcctctttggatgtgagcacccagcagagggagaagaagcccgcacct gacacctctttgtttacatggatcacatccattgacgtgaagtaccagatctggaagttg ggagtagtgttcacagacaacaccttcttgtacctggtgtggtaccttgtgatgtctttg ctaggacattacaacaacttcttctttgcttgtcacctgctggacattgccatgggggtc aagaccctgcgtaccatcctgtcctctgtcacccacaatggcaaacagttggtgatgaca gtgggcctgctagcggtcgtagtctacctctacactgtggtggccttcaacttcttccgc aaattctacaatatgagtgaggacgaggacgagccagacatgaagtgtgatgacatgatg acatgctacctgttccacatgtatgttggggtgcgcgctggtggaggcataggagatgag atcgaggaccccgcgggagatgagtatgagctctaccgtgtggtctttgacatcaccttc ttcttcttcgtcatcgtcatccttctggccatcatccagggtctcatcattgatgccttt ggcgagctgagagatcagcaggaacaggtcagagaggatatggagactaagtgcttcatc tgtggaattgggagtgactactttgacacgacaccacatggctttgagacgcacaccctt gaagagcacaacttggccaattacatgttcttcctcatgtatttaatcaacaaagacgaa acagagcacactggacaggagtcttacgtatggaagatgtaccaagagcgctgttgggat ttcttcccggctggtgactgtttccggaagcaatatgaggatcagctgggataa

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