KEGG   PATHWAY: pon04540
Entry
pon04540                    Pathway                                

Name
Gap junction - Pongo abelii (Sumatran orangutan)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pon04540  Gap junction
pon04540

Other DBs
GO: 0005921
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100436252  GJA1; gap junction alpha-1 protein [KO:K07372]
100441866  GJD2; gap junction delta-2 protein [KO:K07373]
100458931  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100456074  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100440212  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100460243  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100437861  PDGFC; platelet-derived growth factor C [KO:K05450]
100172718  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
100455021  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100431735  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100460001  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100450054  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100449213  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
100451029  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100436042  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100445003  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100445613  TUBA1A; tubulin alpha-1A chain isoform X2 [KO:K07374]
100446260  tubulin alpha-1C chain [KO:K07374]
100444582  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100449357  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
100439869  tubulin alpha-3 chain [KO:K07374]
100434822  tubulin alpha-3 chain [KO:K07374]
112129091  tubulin alpha-3 chain [KO:K07374]
100439587  TUBA3E; tubulin alpha-3E chain [KO:K07374]
100172938  TUBB; tubulin beta chain [KO:K07375]
100448146  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
100443487  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100434432  LOW QUALITY PROTEIN: tubulin beta-8 chain [KO:K07375]
100443594  TUBB4A; tubulin beta-4A chain [KO:K07375]
100450699  TUBB2A; tubulin beta-2A chain [KO:K07375]
100452448  LOW QUALITY PROTEIN: tubulin beta-2B chain [KO:K07375]
100441382  uncharacterized protein LOC100441382 [KO:K07375]
100438882  TUBB4B; tubulin beta-4B chain [KO:K07375]
100452886  tubulin beta-8 chain-like isoform X7 [KO:K07375]
100452363  TUBB8; LOW QUALITY PROTEIN: tubulin beta-8 chain [KO:K07375]
100172245  CSNK1D; casein kinase I isoform delta [KO:K08959] [EC:2.7.11.1]
100172184  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100446271  TJP1; tight junction protein ZO-1 isoform X4 [KO:K05701]
100441708  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100447185  DRD1; D(1A) dopamine receptor [KO:K04144]
100442753  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X3 [KO:K04632]
103888841  neuroendocrine secretory protein 55 [KO:K04632]
100442948  DRD2; D(2) dopamine receptor [KO:K04145]
100449504  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100445431  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100460806  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100438178  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100173935  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100461323  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
100440561  HTR2C; 5-hydroxytryptamine receptor 2C isoform X2 [KO:K04157]
100451342  GRM1; metabotropic glutamate receptor 1 isoform X3 [KO:K04603]
100452002  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100460338  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100458686  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100445922  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100434318  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100434127  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100172608  GUCY1A1; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
100445361  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100434873  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
100445008  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
100437791  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
100438589  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
pon04010  MAPK signaling pathway
pon04020  Calcium signaling pathway
pon04060  Cytokine-cytokine receptor interaction
pon04070  Phosphatidylinositol signaling system
pon04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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