Pongo abelii (Sumatran orangutan): 100137030 Help Entry 100137030         CDS       T01416                                  Gene name MET Definition (RefSeq) hepatocyte growth factor receptor precursor   KO K05099   proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04360   Axon guidance pon04510   Focal adhesion pon04520   Adherens junction pon05100   Bacterial invasion of epithelial cells pon05144   Malaria pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05205   Proteoglycans in cancer pon05206   MicroRNAs in cancer pon05211   Renal cell carcinoma pon05218   Melanoma pon05223   Non-small cell lung cancer pon05225   Hepatocellular carcinoma pon05226   Gastric cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100137030 (MET)    04014 Ras signaling pathway     100137030 (MET)    04015 Rap1 signaling pathway     100137030 (MET)    04020 Calcium signaling pathway     100137030 (MET)    04151 PI3K-Akt signaling pathway     100137030 (MET)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100137030 (MET)    04520 Adherens junction     100137030 (MET)  09150 Organismal Systems   09158 Development and regeneration    04360 Axon guidance     100137030 (MET)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100137030 (MET)    05202 Transcriptional misregulation in cancer     100137030 (MET)    05206 MicroRNAs in cancer     100137030 (MET)    05205 Proteoglycans in cancer     100137030 (MET)    05230 Central carbon metabolism in cancer     100137030 (MET)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     100137030 (MET)    05226 Gastric cancer     100137030 (MET)    05218 Melanoma     100137030 (MET)    05211 Renal cell carcinoma     100137030 (MET)    05223 Non-small cell lung cancer     100137030 (MET)   09171 Infectious disease: bacterial    05100 Bacterial invasion of epithelial cells     100137030 (MET)   09174 Infectious disease: parasitic    05144 Malaria     100137030 (MET)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100137030 (MET)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100137030 (MET) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100137030 (MET) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   MET family    100137030 (MET) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Sema Pkinase TIG PSI Pkinase_fungal Kinase-like Motif Other DBs NCBI-GeneID:  100137030 NCBI-ProteinID:  NP_001162038 Ensembl:  ENSPPYG00000017932 UniProt:  Q2IBD8 A0A2J8UPG2 LinkDB All DBs Position 7 AA seq 1390 aa AA seqDB search MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETLIQNVILHEH HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL LDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECSSGTWTQQICLPAIYKVFPSSAPLEGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNILKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT GISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISIALLLLLGFFLWLKKRKQ IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD TRPASFWETS NT seq 4173 nt NT seq  +upstreamnt  +downstreamnt atgaaggcccccgctgtgcttgcacctggcatcctcgtgctcctgtttaccttggtgcag aggagcaatggggagtgtaaagaggcactagcaaagtccgagatgaatgtgaatatgaag tatcagcttcccaacttcaccgcggaaacactcatccagaatgtcattctacatgagcat cacattttccttggtgccactaactacatttatgttttaaatgaggaagaccttcagaag gttgctgagtacaagaccgggcctgtgttggaacacccagattgtttcccatgtcaggac tgcagcagcaaagccaatttatcaggaggcgtttggaaagataacatcaacatggctcta gttgtcgacacctactatgatgatcaactcattagctgtggcagcgtcaacagagggacc tgccagcgacatgtctttccccacaatcatactgctgacatacagtcggaggttcactgc atattctccccacagatagaagagcccagccagtgtcctgactgtgtggtgagcgccctg ggagccaaagtcctttcatctgtaaaggaccggttcatcaacttctttgtaggtaatacc ataaattcttcttatttcccagatcatccattgcattcaatatcagtgagaaggctaaag gaaacgaaagatggttttatgtttttgacggaccagtcctacattgatgttttacctgag ttcagagattcttaccccattaagtatgtccatgcctttgaaagcaacaattttatttac ttcttgacggtccaaagggaaactctagatgctcagacttttcacacaagaataatcagg ttctgttccataaactctggattgcattcctacatggaaatgcctctggagtgtattctt acagaaaagagaaaaaagagatccacaaagaaggaagtgtttaatatccttcaggctgcg tatgtcagcaagcctggggcccaacttgctagacaaataggagccagcctgaatgatgac attctctttggggtgttcgcacaaagcaagccagattctgccgaaccaatggatcgatct gccatgtgtgcattccctatcaaatatgtcaacgacttcttcaacaagatcgtcaacaaa aacaatgtgagatgtctccagcatttttacggacccaatcatgagcactgttttaatagg acacttctgagaaattcatcaggctgtgaagcgcgccgtgatgaatatcgaacagagttt accacagctttgcagcgcgttgacttattcatgggtcaattcagcgaagtcctcttaaca tctatatccaccttcattaaaggagacctcaccatagctaatcttgggacatcagagggt cgcttcatgcaggttgtggtttctcgatcaggaccatcaacccctcatgtgaattttctc ctggactcccatccggtgtctccagaagtgattgtggagcatccattaaaccagaatggc tacacactggttgtcactgggaagaagatcacgaagatcccattgaatggcttgggctgc agacatttccagtcctgcagtcagtgcctctctgccccaccctttgttcagtgtggctgg tgccatgacaaatgtgtgcgatcggaggaatgctcgagcgggacatggactcaacagatc tgtctgcctgcaatctacaaggttttcccaagtagtgcaccccttgaaggagggacaagg ctgaccatatgtggctgggactttggatttcggaggaataataaatttgatttaaagaaa actagagttctccttggaaatgagagctgcaccttgactttaagtgagagcacgatgaat atattgaaatgcacagttggtcctgccatgaataagcatttcaatatgtccataattatt tcaaatggccacgggacaacacaatacagtacattctcctatgtggatcctgtaataaca ggtatttcgccgaaatatggtcctatggctggtggcactttacttactttaactggaaat tacctaaacagtgggaattccagacacatttcaattggtggaaaaacatgtactttaaaa agtgtgtcaaacagtattcttgaatgttataccccagcccaaaccatttcaactgagttt gctgttaaattgaaaattgacttagccaaccgagagacaagcatcttcagttaccgggaa gatcccattgtctacgaaattcatccaaccaaatcttttattagtggtgggagcacaata acaggtgttgggaaaaacctgaattcagttagtgtcccgaggatggtcataaatgtgcat gaagcaggaaggaactttactgtggcatgtcaacatcgctctaattcagagataatctgc tgtaccactccttccctgcaacagctgaatctgcaactccccctgaaaaccaaagccttt ttcatgttagatgggatcctttccaaatactttgatctcatttatgtacataatcctgtg tttaagccttttgaaaagccagtgatgatctcaatgggcaatgaaaatgtactggaaatt aagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaataag agctgtgagaatatacacttacattctgaagccgttttatgcacggtccccaatgacctg ctgaaattgaacagcgagctaaatatagagtggaagcaagcaatttcttcaaccgtcctt ggaaaagtaatagttcaaccagatcagaatttcacaggattgattgctggtgttgtctca atatcaatagcactgttattactacttgggtttttcctgtggctgaaaaagagaaagcaa attaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcatttg gataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaatct gtagactaccgagctacttttccagaagatcagtttcctaattcatctcagaacggttca tgccgacaagtgcagtatcctctgacagacatgtcccccatcctaactagtggggactct gatatatccagtccattactgcaaaatactgtccacattgacctcagtgccctaaatcca gagctggtccaggcagtgcaacatgtagtgattgggcccagtagcctgattgtgcatttc aatgaagtcataggaagagggcattttggttgtgtatatcatgggactttgttggacaat gatggcaagaaaattcactgtgctgtgaaatccttgaatagaatcactgacataggagaa gtttcccaatttctgaccgagggaatcatcatgaaagattttagtcatcccaatgtcctc tcgctcctgggaatctgcctgcgaagtgaagggtctccactggtggtcctaccatacatg aaacatggagatcttcgaaatttcattcgaaatgagactcataatccaactgtaaaagat cttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaagttt gtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcacagtcaaggtt gctgattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaacaaa acaggtgcaaagctgccagtgaagtggatggctttggaaagtctgcaaactcaaaagttt accaccaagtcagatgtgtggtcctttggcgtgctcctctgggagctgatgacaagagga gccccaccttatcctgacgtgaacacctttgatataactgtttacttgttgcaagggaga aggctcctacaacccgaatactgcccagaccccttatatgaagtaatgctaaaatgctgg caccctaaagccgaaatgcgcccatccttttctgaactggtgtcccggatatcagcgatc ttctctactttcattggggagcactatgtccatgtgaacgctacttatgtgaacgtaaaa tgtgtcgctccatatccttctctgttgtcatcagaagataacgctgatgatgaggtggac acacgaccagcctccttctgggagacatcatag

Pongo abelii (Sumatran orangutan): 100171540 Help Entry 100171540         CDS       T01416                                  Gene name FGFR2 Definition (RefSeq) fibroblast growth factor receptor 2   KO K05093   fibroblast growth factor receptor 2 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04144   Endocytosis pon04151   PI3K-Akt signaling pathway pon04550   Signaling pathways regulating pluripotency of stem cells pon04810   Regulation of actin cytoskeleton pon05200   Pathways in cancer pon05215   Prostate cancer pon05226   Gastric cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100171540 (FGFR2)    04014 Ras signaling pathway     100171540 (FGFR2)    04015 Rap1 signaling pathway     100171540 (FGFR2)    04020 Calcium signaling pathway     100171540 (FGFR2)    04151 PI3K-Akt signaling pathway     100171540 (FGFR2)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100171540 (FGFR2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100171540 (FGFR2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100171540 (FGFR2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100171540 (FGFR2)    05230 Central carbon metabolism in cancer     100171540 (FGFR2)   09162 Cancer: specific types    05226 Gastric cancer     100171540 (FGFR2)    05215 Prostate cancer     100171540 (FGFR2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100171540 (FGFR2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100171540 (FGFR2)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100171540 (FGFR2)    00536 Glycosaminoglycan binding proteins [BR:pon00536]     100171540 (FGFR2) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100171540 (FGFR2) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   FGFR family [OT]    100171540 (FGFR2) CD molecules [BR:pon04090]  Proteins   100171540 (FGFR2) Glycosaminoglycan binding proteins [BR:pon00536]  Heparan sulfate / Heparin   Growth factors/receptors    100171540 (FGFR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Kinase-like Pkinase_fungal DUF1615 Motif Other DBs NCBI-GeneID:  100171540 NCBI-ProteinID:  NP_001124693 UniProt:  Q5RF81 LinkDB All DBs Position 10 AA seq 384 aa AA seqDB search MNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVM AEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQD GPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYL ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMR DCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSV FSPDPMPYEPCLPQYPHINGSVKT NT seq 1155 nt NT seq  +upstreamnt  +downstreamnt atgaactccaataccccgctggtgaggataacaacacgcctctcttcaacggcagacacc cccatgctggcaggggtctccgagtatgaacttccagaggacccaaaatgggagtttcca agagataagctgacactgggcaagcccctgggagaaggttgctttgggcaagtggtcatg gcggaagcagtgggaattgacaaagacaagcccaaggaggcggtcaccgtggccgtgaag atgttgaaagatgatgccacagagaaagacctttctgatctggtgtcagagatggagatg atgaagatgattgggaaacacaagaatatcataaatcttcttggagcctgcacacaggat gggcctctctatgtcatagttgagtatgcctctaaaggcaacctccgagaatacctccga gcccggaggccacccgggatggagtactcctatgacattaaccgtgttcctgaggagcag atgaccttcaaggacttggtgtcatgcacctaccagctggccagaggcatggaatacttg gcttcccaaaaatgtattcatcgagatttagcagccagaaatgttttggtaacagaaaac aatgtgatgaaaatagcagactttggacttgccagagatatcaacaatatagactattac aaaaagaccaccaatgggcgacttccagtcaagtggatggctccagaagccctgtttgat agagtatacactcatcagagtgatgtctggtccttcggggtgttaatgtgggagatcttc actttagggggctcgccctacccagggattcccgtggaggaactttttaagctgctgaag gaaggacacagaatggataaaccagccaactgcaccaacgaactgtacatgatgatgagg gactgttggcatgcagtgccctcccagagaccaacgttcaagcagttggtagaagacttg gatcgaattctcactctcacaaccaatgaggaatacttggacctcagccaacctctcgaa cagtattcacctagttaccctgacacaagaagttcttgttcttcaggagatgattctgtt ttttctccagaccccatgccttacgaaccatgccttcctcagtatccacacataaacggc agtgttaaaacatga

Pongo abelii (Sumatran orangutan): 100172156 Help Entry 100172156         CDS       T01416                                  Gene name IGF1R Definition (RefSeq) insulin-like growth factor 1 receptor   KO K05087   insulin-like growth factor 1 receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon01522   Endocrine resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04066   HIF-1 signaling pathway pon04068   FoxO signaling pathway pon04114   Oocyte meiosis pon04140   Autophagy - animal pon04144   Endocytosis pon04150   mTOR signaling pathway pon04151   PI3K-Akt signaling pathway pon04152   AMPK signaling pathway pon04211   Longevity regulating pathway pon04213   Longevity regulating pathway - multiple species pon04510   Focal adhesion pon04520   Adherens junction pon04550   Signaling pathways regulating pluripotency of stem cells pon04730   Long-term depression pon04913   Ovarian steroidogenesis pon04914   Progesterone-mediated oocyte maturation pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05205   Proteoglycans in cancer pon05214   Glioma pon05215   Prostate cancer pon05218   Melanoma pon05224   Breast cancer pon05225   Hepatocellular carcinoma Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100172156 (IGF1R)    04014 Ras signaling pathway     100172156 (IGF1R)    04015 Rap1 signaling pathway     100172156 (IGF1R)    04066 HIF-1 signaling pathway     100172156 (IGF1R)    04068 FoxO signaling pathway     100172156 (IGF1R)    04151 PI3K-Akt signaling pathway     100172156 (IGF1R)    04152 AMPK signaling pathway     100172156 (IGF1R)    04150 mTOR signaling pathway     100172156 (IGF1R)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100172156 (IGF1R)    04140 Autophagy - animal     100172156 (IGF1R)   09143 Cell growth and death    04114 Oocyte meiosis     100172156 (IGF1R)   09144 Cellular community - eukaryotes    04510 Focal adhesion     100172156 (IGF1R)    04520 Adherens junction     100172156 (IGF1R)    04550 Signaling pathways regulating pluripotency of stem cells     100172156 (IGF1R)  09150 Organismal Systems   09152 Endocrine system    04913 Ovarian steroidogenesis     100172156 (IGF1R)    04914 Progesterone-mediated oocyte maturation     100172156 (IGF1R)   09156 Nervous system    04730 Long-term depression     100172156 (IGF1R)   09149 Aging    04211 Longevity regulating pathway     100172156 (IGF1R)    04213 Longevity regulating pathway - multiple species     100172156 (IGF1R)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100172156 (IGF1R)    05202 Transcriptional misregulation in cancer     100172156 (IGF1R)    05205 Proteoglycans in cancer     100172156 (IGF1R)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     100172156 (IGF1R)    05214 Glioma     100172156 (IGF1R)    05218 Melanoma     100172156 (IGF1R)    05215 Prostate cancer     100172156 (IGF1R)    05224 Breast cancer     100172156 (IGF1R)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100172156 (IGF1R)    01522 Endocrine resistance     100172156 (IGF1R)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100172156 (IGF1R)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100172156 (IGF1R) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100172156 (IGF1R) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100172156 (IGF1R) CD molecules [BR:pon04090]  Proteins   100172156 (IGF1R) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Recep_L_domain fn3 Furin-like Kinase-like Insulin_TMD DUF4476 Motif Other DBs NCBI-GeneID:  100172156 NCBI-ProteinID:  NP_001125259 Ensembl:  ENSPPYG00000006808 UniProt:  Q5RCL1 LinkDB All DBs Position 15 AA seq 1064 aa AA seqDB search MQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLIN IRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVL DNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNG ERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDA CGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILY IRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYC SKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFE NFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVD NKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFVRTMPAEGADDIPGPVTWEPR PENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTA RIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRN NSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVK DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT RGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLW EIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRLAFLEII SSIKDEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGH KAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC NT seq 3195 nt NT seq  +upstreamnt  +downstreamnt atgcaggagtgcccctcgggcttcatccgcaacggcagccagagcatgtactgcatccca tgtgaaggtccttgccccaaggtctgtgaggaagaaaagaaaacaaagaccattgattct gttacttctgctcagatgctccaaggatgcaccatcttcaagggcaatttgctcattaac atccgacgggggaataacattgcttcagaactggagaacttcatggggctcatcgaggtg gtgacgggctacgtgaagatccgccattctcatgccttggtctccttgtccttcctaaaa aaccttcgcctcatcttaggagaggagcagctagaagggaattactccttctacgtcctc gacaaccagaacttgcagcaactatgggactgggaccaccgcaacctgaccatcaaagca gggaaaatgtactttgctttcaatcccaaattatgtgtttctgaaatttaccgcatggag gaagtgacggggactaaaggacgccaaagcaaaggggacataaacaccaggaacaacggg gagagagcctcctgtgaaagtgatgtcctgcatttcacctccaccaccacgtcgaagaat cgcatcatcataacctggcaccggtaccggccccctgactacagggatctcatcagcttc accgtttactacaaggaagcaccctttaagaatgtcacggagtatgatgggcaggacgcc tgcggctccaacagctggaacatggtggacgtggacctcccacccaacaaggacgtggag cccggcatcttactgcatgggctgaagccctggactcagtacgccgtttacgtcaaggct gtgaccctcaccatggtggagaacgaccatatccgtggagccaagagtgagatcttgtac attcgcaccaatgcttcagttccttccattcccttggacgttctttcagcatcgaactcc tcttctcagttaatcgtgaagtggaaccctccctctctgcccaacggcaacctgagttac tacattgtgcgctggcagcggcagcctcaggacggctacctttaccggcacaattactgc tccaaagacaaaatccccatcaggaagtatgccgacggcaccatcgacattgaggaagtc acagagaaccccaagactgaggtgtgtggtggtgagaaagggccttgctgcgcctgcccc aaaactgaagccgagaagcaggctgagaaggaggaggctgagtaccgcaaagtctttgag aatttcctgcacaactccatcttcgtgcccagacctgaaaggaagcggagagatgtcatg caagtggccaacaccaccatgtccagccgaagcaggaacaccacggccgcagacacgtac aacatcaccgacccagaagagctggagacagagtaccctttctttgagagcagagtggat aacaaggagagaactgtcatttctaaccttcggcctttcacattgtaccgcatcgatatc cacagctgcaatcatgaggctgagaagctgggctgcagcgcctccaacttcgtctttgta aggactatgcccgcagaaggagcagatgacattcctgggccagtgacctgggagccaagg cctgaaaactccatctttttaaagtggccagaacctgagaatcccaatggattgattcta atgtatgaaataaaatacggatcacaagttgaggatcagcgagaatgtgtgtccagacag gaatacaggaagtatggaggggccaagctaaaccggctaaacccggggaactacacagcc cggattcaggccacatctctctctgggaatgggtcgtggacagatcctgtgttcttctat gtccaggccaaaacaggatatgaaaacttcatccatctgatcatcgctctgcccgtcgct gtcctgttgattgtgggagggttggtgattatgctgtacgtcttccatagaaagagaaat aacagcaggctggggaatggagtgctgtatgcctctgtgaacccggagtacttcagcgct gcggatgtgtacgttcctgatgagtgggaggtggctcgggagaagatcaccatgagccgg gaacttgggcaggggtcgtttgggatggtctatgaaggagttgccaagggtgtggtgaaa gatgaacctgaaaccagagtggccattaaaacagtgaacgaggccgcaagcatgcgtgaa aggatcgagtttctcaacgaagcttctgtgatgaaggagttcaattgtcaccatgtggtg cgattgctgggtgtggtgtcccaaggccagccaacactggtcatcatggaactgatgaca cggggcgatctcaaaagttatctccggtctctgaggccagaaatggagaataatccagtc ctagcacctccaagcctaagcaagatgattcagatggccggagagattgcagacggcatg gcatacctcaacgccaacaagttcgtccacagagaccttgctgcccggaattgcatggta gccgaagatttcacagtcaaaatcggagattttggtatgacgcgagatatctatgagaca gactattaccggaaaggagggaaagggctgctgcccgtgcgctggatgtctcccgagtcc ctcaaggatggagtcttcaccacttactcggacgtctggtccttcggggtcgtcctctgg gagattgccacactggccgagcagccctaccagggcttgtccaacgagcaagtccttcgc ttcgtcatggagggcggccttctggacaagccagacaactgtcctgacatgctgtttgaa ctgatgcgcatgtgctggcagtataaccccaagatgaggcttgccttcctggagatcatc agcagcatcaaagacgagatggagcctggcttccgggaggtctccttctactacagcgag gagaacaagctgcccgagccggaggaactggacctcgagccagagaacatggagagcgtc cccctggacccctcggcctcctcgtcctccctgccactgcccgacagacactcaggacac aaggccgagaacggccccggccctggagtactggtcctccgcgccagcttcgacgagaga cagccttacgcacacatgaacgggggccgcaagaacgagcgggccttgccactgccccag tcttcgacctgctga

Pongo abelii (Sumatran orangutan): 100174302 Help Entry 100174302         CDS       T01416                                  Gene name TEK Definition (RefSeq) angiopoietin-1 receptor precursor   KO K05121   endothelial-specific receptor tyrosine kinase [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04066   HIF-1 signaling pathway pon04151   PI3K-Akt signaling pathway pon05323   Rheumatoid arthritis Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100174302 (TEK)    04014 Ras signaling pathway     100174302 (TEK)    04015 Rap1 signaling pathway     100174302 (TEK)    04066 HIF-1 signaling pathway     100174302 (TEK)    04151 PI3K-Akt signaling pathway     100174302 (TEK)  09160 Human Diseases   09163 Immune disease    05323 Rheumatoid arthritis     100174302 (TEK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100174302 (TEK)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100174302 (TEK) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100174302 (TEK) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   TIE family    100174302 (TEK) CD molecules [BR:pon04090]  Proteins   100174302 (TEK) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Ig_Tie2_1 Pkinase fn3 Pur_ac_phosph_N fn3_2 hEGF EGF_2 APH DUF2369 DUF4702 Pkinase_fungal Motif Other DBs NCBI-GeneID:  100174302 NCBI-ProteinID:  NP_001127247 UniProt:  Q5RDI5 LinkDB All DBs Position 9 AA seq 1123 aa AA seqDB search MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGACHEDTGEC ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGRKGLQCNE ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLLRRGEGGEGHPGPVRRFTTAS IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT ILDGYSISSITIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR MAQAFQNREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKA RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVPCKLGHHPNIINLLGACEHRGYLYLA IEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFI HRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDV WSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYE RPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA NT seq 3372 nt NT seq  +upstreamnt  +downstreamnt atggactctttagccagcttagttctctgtggagtcagcttgctcctttctggaactgtg gaaggtgccatggacttgatcttgatcaattccctacctcttgtgtctgatgctgaaaca tctctcacctgcattgcctctgggtggcgcccccatgagcccatcaccataggaagggac tttgaagccttaatgaaccagcaccaggatccgctggaagttactcaagatgtgaccaga gaatgggctaaaaaagttgtttggaagagagaaaaggccagtaagatcaatggtgcttat ttctgtgaagggcgagttcgaggagaggcaatcaggatacgaaccatgaagatgcgtcaa caagcttccttcctaccagctactttaactatgactgtggacaagggagataatgtgaac atatctttcaaaaaggtattgattaaagaagaagatgcagtgatttacaaaaatggttcc ttcatccattcagtgccccggcatgaagtaccggatattctagaagtacacctgcctcat gctcagccccaggatgctggagtgtactcggccaggtatataggaggaaacctcttcacc tcggccttcaccaggctgatagtccggagatgtgaagctcagaagtggggacctgaatgc aaccatctctgtactgcttgtatgaacaatggtgcctgccatgaagatactggagaatgc atttgccctcctgggtttatgggaaggacatgtgagaaggcttgtgaactgcacacattt ggcagaacttgtaaagaaaggtgcagtggacaagagggatgcaagtcttatgtgttctgt ctccctgacccctatgggtgttcctgtgccacaggccggaagggtctgcagtgcaatgaa gcatgccaccctggtttttatgggccagattgtaagcttaggtgcagctgcaacaacggg gagatgtgtgatcgcttccaaggatgtctctgctctccaggatggcagggactccagtgt gagagagaaggcataccaaggatgaccccaaagatagtggatttgccagatcatatagaa gtaaacagtggtaaatttaatcccatttgcaaagcttctggctggccgctacctactaat gaagaaatgaccctggtgaagccggatgggacagtgctccatccaaaagactttaaccat acggatcatttctcagtagccatattcaccatccaccggatcctcccccctgactcagga gtttgggtctgcagtgtgaacacagtggctgggatggtggaaaagcccttcaacatttct gttaaagttcttccaaagcccctgaatgccccaaacgtcattgacactggacataacttc gctgtcatcaacatcagctctgagccttactttggggatggaccaatcaaatccaagaag cttctatacaaacccgttaatcactatgaggcttggcaacatattcaagtgacgaatgag attgttacactcaactatttggaacctcggaccgaatatgaactctgtgtgcaactgctc cgtcgtggagagggtggggaagggcatcctggacctgtgagacgcttcacaacagcttct atcggactccctcctccaagaggtctaaatctcctgcctaaaagtcagaccactctaaat ttgacctggcaaccaatatttccaagctcagaagatgacttttatgttgaagtggagaga aggtctgtgcaaaaaagtgatcagcagaatattaaagttccaggcaacttgacttcagtg ctacttaacaacttacatcccagggaacagtacgtggtccgagctagagtcaacaccaag gcccagggggaatggagtgaagatcttactgcttggacccttagtgacattcttcctcct caaccagaaaacatcaagatttccaacatcacacactcctcggctgtgatttcttggaca atattggatggctattctatttcttctattactatccgttacaaggttcaaggcaagaat gaagaccagcacattgatgtgaagataaagaatgccaccatcactcagtatcagctcaag ggcctagagcctgaaacagcataccaggtggacatttttgcagagaacaacatagggtca agcaacccagccttttctcatgaactggtgaccctcccagaatctcaagcaccagcggac ctcggaggggggaagatgctgcttatagccatccttggctctgctggaatgacctgcctg actgtgctgttggcctttctgatcatattgcaattgaagagggcaaatgtgcaaaggaga atggcccaagccttccaaaacagggaagaaccagctgtgcagttcaactcaggaactctg gccctaaacaggaaggtcaaaaacaacccagatcctacaatttatccagtgcttgactgg aatgatatcaaatttcaagatgtgattggggagggcaattttggccaagttcttaaggcg cgcatcaagaaggatgggttacggatggatgctgccatcaaaagaatgaaagaatatgcc tccaaagatgatcacagggattttgcaggagaactggaagttccttgtaaacttggacac catccaaacatcatcaacctcttaggagcatgtgaacatcgaggctacttgtacctggcc attgagtacgcgccccatggaaaccttctggactttctgcgcaagagccgtgtgctggag acggacccagcatttgccattgccaatagcactgcgtccacactgtcctcccagcagctc ctccacttcgctgccgacgtggcccggggcatggactacttgagccaaaaacagtttatc cacagggatctggctgccagaaacattttagttggtgaaaactatgtggcaaaaatagca gattttggattgtcccgaggtcaagaggtgtatgtgaaaaagacaatgggaaggctccca gtgcgctggatggccatcgagtcactgaattacagtgtgtacacaaccaacagtgatgta tggtcctatggtgtgttactatgggagattgttagcttaggaggcacaccctactgcggg atgacttgtgcagaactctacgagaagctgccccagggctacagactggagaagcccctg aactgcgatgatgaggtgtatgatctaatgagacaatgctggcgggagaagccttatgag aggccatcatttgcccagatattggtgtccttaaacagaatgttagaggagcgaaagacc tacgtgaataccacgctttatgagaagtttacttatgcaggaattgactgttctgctgaa gaagcggcctag

Pongo abelii (Sumatran orangutan): 100174431 Help Entry 100174431         CDS       T01416                                  Gene name ERBB3 Definition (RefSeq) receptor tyrosine-protein kinase erbB-3 precursor   KO K05084   receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04012   ErbB signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon05205   Proteoglycans in cancer pon05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100174431 (ERBB3)    04012 ErbB signaling pathway     100174431 (ERBB3)    04020 Calcium signaling pathway     100174431 (ERBB3)    04151 PI3K-Akt signaling pathway     100174431 (ERBB3)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100174431 (ERBB3)    05205 Proteoglycans in cancer     100174431 (ERBB3)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100174431 (ERBB3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100174431 (ERBB3) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100174431 (ERBB3) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    100174431 (ERBB3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Furin-like Pkinase Kinase-like Motif Other DBs NCBI-GeneID:  100174431 NCBI-ProteinID:  NP_001127366 Ensembl:  ENSPPYG00000004643 UniProt:  Q5RB22 LinkDB All DBs Position 12 AA seq 1342 aa AA seqDB search MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG KSCPPCHEVCKGRCWGSGPEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN LDFLITGLNGDPWHKIPALDPEKLNVFQTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELKKLKVLGSGVF GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESTVSGSNEQCPR PVSLYPMPRGCLASESSEGHVTHSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPNAGTTPDEDY EYMNRQRGGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD SAFDNPDYWHSRLFPKANAQRT NT seq 4029 nt NT seq  +upstreamnt  +downstreamnt atgagggcgaacgacgctctgcaggtgctgggcttgcttttcagcctggcccggggctcc gaggtgggcaactctcaggcagtgtgtcctgggactctgaatggcctgagtgtgaccggc gatgctgagaaccaataccagacactgtacaagctctacgagaggtgtgaggtggtgatg gggaacctcgagattgtgctcacgggacacaatgccgacctctccttcctgcagtggatt cgagaagtgacaggctatgtcctcgtggccatgaatgaattctctactctaccattgccc aacctccgcgtggtgcgagggacccaggtctacgatgggaagtttgccatctttgtcatg ttgaactataacaccaactccagccacgctctgcgccagctccgcttgactcagctcacc gagattctgtcagggggtgtttatattgagaagaacgataagctttgtcacatggacaca attgactggagggacatcgtgagggaccgagacgctgagatagtggtgaaggacaatggc aaaagctgtcccccctgtcatgaggtttgcaaggggcgatgctggggttctggaccagaa gactgccagacattgaccaagaccatctgtgctccacagtgtaatggtcactgctttggg cccaaccccaaccagtgctgccatgatgagtgtgccgggggctgctcaggccctcaggac acagactgctttgcctgccggcacttcaatgacagtggagcctgtgtacctcgctgtcca cagcctcttgtctacaacaagctaactttccagctggaacccaatccccacaccaagtat cagtatggaggagtttgtgtagccagctgtccccataactttgtggtggatcaaacatcc tgtgtcagggcctgtcctcctgacaagatggaagtagataaaaatgggctcaagatgtgt gagccttgtgggggactatgtcccaaagcctgtgaggggacaggctctgggagccgcttc cagactgtggactcgagcaacattgatggatttgtgaactgcaccaagatcctgggcaac ctggactttctgatcaccggcctcaatggagacccctggcacaagatccctgccctggac ccagagaagctcaatgtcttccagacagtacgggagatcacaggttacctgaacatccag tcctggccgccccacatgcacaacttcagtgttttttccaacttgacaaccattggaggc agaagcctctacaaccggggcttctcattgttgatcatgaagaacttgaatgtcacatct ctgggcttccgatccctgaaggaaattagtgctgggcgtatctatataagtgccaatagg cagctatgctaccaccactctttgaactggaccaaggtgcttcgggggcctacggaagag cgactagacatcaagcataatcggccacgcagagactgcgtggcagagggcaaagtgtgt gacccactgtgctcctctgggggatgctggggcccgggccctggtcagtgcttgtcctgt cgaaactacagccgaggaggtgtctgtgtgacccactgcaactttctgaatggggagcct cgagaatttgcccatgaggccgaatgcttctcctgccacccggaatgccaacccatggag ggcactgccacatgcaatggctcgggctctgatacttgtgctcaatgtgcccattttcga gatgggccccactgtgtgagcagctgcccccatggagtcctaggtgccaagggcccaatc tacaagtacccagatgttcagaatgaatgtcggccctgccatgagaactgcacccagggg tgtaaaggaccagagcttcaagactgtttaggacaaacactggtgctcatcggcaaaacc catctgacaatggctttgacagtgatagcaggattggtagtgattttcatgatgctgggt ggcacttttctctactggcgtgggcgccggattcagaataaaagggctatgaggcgatac ttggaacggggtgagagcatagagcctctggaccccagtgagaaggctaacaaagtcttg gccagaatcttcaaagagacagagctaaagaagcttaaagtgcttggctcgggtgtcttt ggaactgtgcacaaaggagtgtggatccctgagggtgaatcaatcaagattccagtctgc attaaagtcattgaggacaagagtggacggcagagttttcaagctgtgacagatcatatg ctggccattggcagcctggaccatgcccacattgtacggctgctgggactatgcccaggg tcatctctgcagcttgtcactcaatacttgcctctgggttctctgctggatcatgtgaga caacaccggggggcactggggccacagctgctgctcaactggggagtacaaattgccaag ggaatgtactaccttgaggaacatggtatggtgcatagaaacctggctgcccgaaacgtg ctactcaagtcacccagtcaggttcaggtggcagattttggtgtggctgacctgctgcct cctgatgataagcagctgctatacagtgaggccaagactccaattaagtggatggccctt gagagtatccactttgggaaatacacacaccagagtgatgtctggagctatggtgtgaca gtttgggagttgatgaccttcggggcagagccctatgcagggctgcgattggctgaagta ccagacctgctagagaagggggagcggttggcacagccacagatctgcacaattgatgtc tacatggtgatggtcaagtgttggatgattgatgagaacattcgcccaacctttaaagaa ctagccaatgagttcaccaggatggccagagacccaccacggtatctggtcataaagaga gagagtgggcctggaatagcccctgggccagagccccatggtctgacaaacaagaagcta gaggaagtagagctggagccagaactagacctagacctagacttggaagcagaggaggac aacctggcaaccaccacactgggctccgccctcagcctaccagttggaacacttaatcgg ccacgtgggagccagagccttttaagtccatcatctggatacatgcccatgaaccagggt aatcttggggagtcttgccaggagtctacagtttctgggagcaatgaacagtgcccccgt ccagtctctctatacccaatgccacgcggatgcctggcatcagagtcatcagagggccat gtaacacactctgaggctgagctccaggagaaagtgtcaatgtgtaggagccggagcagg agccggagcccacggccacgcggagatagcgcctaccattcccagcgccacagtctgctt actcctgttaccccactctccccaccagggttagaggaagaggatgtcaacggttatgtc atgccagatacacacctcaaaggtactccctcctcccgggaaggcaccctttcttcggtg ggtctcagttctgtcctgggtactgaagaagaagatgaagatgaggagtatgaatacatg aaccggaggagaaggcacagtccacctcatccccctaggccaagttcccttgaggagctg ggttatgagtacatggatgtggggtcagacctcagtgcctctctgggcagcacacagagt tgcccactccaccctgtacccatcatgcccaatgcaggcacaactccagatgaagactat gaatatatgaatcggcaacgaggtggaggtggtcctgggggtgattatgcagccatgggg gcctgcccagcatctgagcaagggtatgaagagatgagagcttttcaggggcctggacat caggccccccatgtccattatgcccgcctaaaaactctacgtagcttagaggctacagac tctgcctttgataaccctgattactggcatagcaggcttttccccaaggctaatgcccag agaacgtaa

Pongo abelii (Sumatran orangutan): 100174545 Help Entry 100174545         CDS       T01416                                  Gene name FGFR1 Definition (RefSeq) fibroblast growth factor receptor 1 precursor   KO K04362   fibroblast growth factor receptor 1 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04520   Adherens junction pon04550   Signaling pathways regulating pluripotency of stem cells pon04714   Thermogenesis pon04810   Regulation of actin cytoskeleton pon04928   Parathyroid hormone synthesis, secretion and action pon05200   Pathways in cancer pon05205   Proteoglycans in cancer pon05215   Prostate cancer pon05218   Melanoma pon05224   Breast cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100174545 (FGFR1)    04014 Ras signaling pathway     100174545 (FGFR1)    04015 Rap1 signaling pathway     100174545 (FGFR1)    04020 Calcium signaling pathway     100174545 (FGFR1)    04151 PI3K-Akt signaling pathway     100174545 (FGFR1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100174545 (FGFR1)    04550 Signaling pathways regulating pluripotency of stem cells     100174545 (FGFR1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100174545 (FGFR1)  09150 Organismal Systems   09152 Endocrine system    04928 Parathyroid hormone synthesis, secretion and action     100174545 (FGFR1)   09159 Environmental adaptation    04714 Thermogenesis     100174545 (FGFR1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100174545 (FGFR1)    05205 Proteoglycans in cancer     100174545 (FGFR1)    05230 Central carbon metabolism in cancer     100174545 (FGFR1)   09162 Cancer: specific types    05218 Melanoma     100174545 (FGFR1)    05215 Prostate cancer     100174545 (FGFR1)    05224 Breast cancer     100174545 (FGFR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100174545 (FGFR1)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100174545 (FGFR1)    00536 Glycosaminoglycan binding proteins [BR:pon00536]     100174545 (FGFR1) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100174545 (FGFR1) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   FGFR family [OT]    100174545 (FGFR1) CD molecules [BR:pon04090]  Proteins   100174545 (FGFR1) Glycosaminoglycan binding proteins [BR:pon00536]  Heparan sulfate / Heparin   Growth factors/receptors    100174545 (FGFR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase I-set Ig_3 ig Ig_2 V-set FGFR3_TM Ig_5 C2-set_2 Ig_4 Ig_6 Pkinase_fungal DUF1615 Motif Other DBs NCBI-GeneID:  100174545 NCBI-ProteinID:  NP_001127472 Ensembl:  ENSPPYG00000018526 UniProt:  Q5R8Q3 LinkDB All DBs Position 8 AA seq 820 aa AA seqDB search MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD VQSINWLRDGVQLAESNRTRITGEEVEVQDSMPADSGLYACVTSSPSGSDTTYFSVNVSD ALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL EERPAVMTSPLYLEIIIYCAGAFLISCMVGSVIVYKTKSGTKKSDFHSQMAVHKLAKSIP LRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK PLGEGCFGQVVLAEAVGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD TRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR NT seq 2463 nt NT seq  +upstreamnt  +downstreamnt atgtggagctggaagtgcctcctcttctgggctgtgctggtcacagccacactctgcacc gctaggccatccccaaccttgcctgaacaagcccagccctggggagcccctgtggaagtg gagtccttcctggtccaccccggtgacctgctgcagcttcgctgtcggctgcgggacgat gtgcagagcatcaactggctgcgggacggggtgcagctggcggaaagcaaccgcacccgc atcacaggggaggaggtggaggtgcaggactccatgcccgcagactccggcctctatgct tgcgtaaccagcagcccctcgggcagtgacaccacctacttctccgtcaatgtttcagat gctctcccctcctcggaggatgatgatgatgatgatgactcctcttcagaggagaaagaa acagataacaccaaaccaaaccccgtagctccatattggacatccccagaaaaaatggaa aagaaattgcatgcagtgccggctgccaagacagtgaagttcaaatgcccttccagtggg accccaaaccccacactgcgctggttgaaaaatggcaaagaattcaaacctgaccacaga attggaggctacaaggtccgttatgctacctggagcatcataatggactccgtggtgccc tctgacaagggcaactacacctgcattgtggagaatgagtatggcagcatcaaccacacg taccagctggatgtcgtggagcggtcccctcaccgacccatcctgcaagcagggttgccc gccaacaagacagtggccctgggtagcaacgtggagttcatgtgtaaggtgtacagtgat ccgcagccgcacatccagtggctaaagcacatcgaggtgaacgggagcaagattggtcca gacaacctgccttatgtccagatcttgaagactgctggagttaataccaccgacaaagag atggaggtgcttcacttaagaaatgtctcctttgaggacgcaggggagtatacgtgcttg gcgggtaactctatcggactctcccatcactctgcatggttgaccgttctggaagccctg gaagagaggccggcagtgatgacctcgcccctgtacctggagatcatcatctattgtgca ggggccttcctcatctcctgcatggtggggtcggtcatcgtctacaagacgaagagtggt accaagaagagcgacttccacagccagatggctgtgcacaagctggccaagagcatccct ctgcgcagacaggtaacagtgtctgctgactccagtgcatccatgaactctggagttctt ctggttcggccgtcacggctctcctccagtgggactcccatgctagcaggggtctctgag tatgagcttcccgaagaccctcgctgggagctgcctcgggacagactggtcttaggcaaa cccctgggagagggctgctttgggcaggtggtgttggcagaggctgtcgggctggacaag gacaaacccaaccgtgtgaccaaagtggctgtgaagatgttgaagtcggacgcaacagag aaagacttgtcagacctgatctcagaaatggagatgatgaagatgatcgggaagcataag aatatcatcaacctgctgggggcctgcacgcaggacggtcccttgtatgtcatcgtggag tatgcctccaagggcaacctgcgggagtacctgcaggcccggaggcccccagggctggaa tactgctacaaccccagccacaacccagaggagcagctctcctccaaggacctggtgtcc tgcgcctaccaggtggcccgaggcatggagtatctggcctccaagaagtgcatacaccga gacctggcggccaggaatgtcctggtgacagaggacaatgtgatgaagatagcagacttt ggcctcgcacgggacattcaccacatcgactactataaaaagacaaccaacggccgactg cctgtgaagtggatggcgcccgaggcattatttgaccggatctacacccaccagagtgat gtgtggtcttttggggtgctcctgtgggagatcttcactctgggtggctccccgtacccc ggtgtgcctgtggaggagcttttcaagctgctgaaggagggtcaccgcatggacaagccc agtaactgcaccaacgagctgtacatgatgatgcgggactgctggcatgcagtgccctca cagagacccaccttcaagcagctggtggaagacctggaccgcatcgtggccttgacctcc aaccaggagtacctggacctgtccatgcccctggaccagtactcccccagctttcccgac acccggagctctacgtgctcctcaggggaggattccgtcttctctcatgagccgctgccc gaggagccctgcctgccccgacacccagcccagcttgccaatggcggactcaaacgccgc tga

Pongo abelii (Sumatran orangutan): 100431735 Help Entry 100431735         CDS       T01416                                  Gene name PDGFRA Definition (RefSeq) platelet-derived growth factor receptor alpha   KO K04363   platelet-derived growth factor receptor alpha [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04072   Phospholipase D signaling pathway pon04144   Endocytosis pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon04540   Gap junction pon04630   JAK-STAT signaling pathway pon04810   Regulation of actin cytoskeleton pon05163   Human cytomegalovirus infection pon05200   Pathways in cancer pon05206   MicroRNAs in cancer pon05214   Glioma pon05215   Prostate cancer pon05218   Melanoma pon05230   Central carbon metabolism in cancer pon05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100431735 (PDGFRA)    04014 Ras signaling pathway     100431735 (PDGFRA)    04015 Rap1 signaling pathway     100431735 (PDGFRA)    04630 JAK-STAT signaling pathway     100431735 (PDGFRA)    04020 Calcium signaling pathway     100431735 (PDGFRA)    04072 Phospholipase D signaling pathway     100431735 (PDGFRA)    04151 PI3K-Akt signaling pathway     100431735 (PDGFRA)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100431735 (PDGFRA)   09144 Cellular community - eukaryotes    04510 Focal adhesion     100431735 (PDGFRA)    04540 Gap junction     100431735 (PDGFRA)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100431735 (PDGFRA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100431735 (PDGFRA)    05206 MicroRNAs in cancer     100431735 (PDGFRA)    05230 Central carbon metabolism in cancer     100431735 (PDGFRA)    05231 Choline metabolism in cancer     100431735 (PDGFRA)   09162 Cancer: specific types    05214 Glioma     100431735 (PDGFRA)    05218 Melanoma     100431735 (PDGFRA)    05215 Prostate cancer     100431735 (PDGFRA)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     100431735 (PDGFRA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100431735 (PDGFRA)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100431735 (PDGFRA)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100431735 (PDGFRA) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100431735 (PDGFRA) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    100431735 (PDGFRA) CD molecules [BR:pon04090]  Proteins   100431735 (PDGFRA) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 I-set ig Ig_2 V-set Herpes_gE C2-set_2 Kinase-like Motif Other DBs NCBI-GeneID:  100431735 NCBI-ProteinID:  XP_009238298 Ensembl:  ENSPPYG00000014767 UniProt:  H2PDE4 LinkDB All DBs Position 4 AA seq 1089 aa AA seqDB search MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGENEVSWQYP MSEEENSNVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL VDDHHGSTGGQMVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEVHPRD RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS SDLVEDSFL NT seq 3270 nt NT seq  +upstreamnt  +downstreamnt atggggacttcccatccggcgttcctggtcttaggctgtcttctcacagggctgagccta atcctctgccagctttcattaccctctatccttccaaatgaaaatgaaaaggttgtgcag ctgaattcatccttttctctgagatgctttggggagaatgaagtgagctggcagtacccc atgtctgaagaagagaactccaatgtggaaatcagaaatgaagaaaacaacagtggcctt tttgtgacggtcttggaagtgagcagtgcctcggcggcccacacagggttgtacacttgc tattacaaccacactcagacagaagagaatgagcttgaaggcaggcacatttacatctat gtgccagacccagatgtagcctttgtacctctaggaatgacggattatttagtcatcgtg gaggatgatgattctgccatcataccttgtcgcacaactgatcccgagactcctgtaacc ttacacaacagtgagggagtggtacctgcctcctacgacagcagacagggctttaatggg accttcactgtagggccctatatctgtgaggccaccgtcaaaggaaagaagttccagacc atcccatttaacgtttatgctttaaaagcaacatcagagctggatctagaaatggaagct cttaaaaccgtgtataagtcaggggaaacgattgtggtcacctgtgctgtttttaacaat gaggtggttgaccttcaatggacttaccctggagaagtgaaaggcaaaggcatcacaatg ctggaagaaatcaaagtcccatccatcaaattggtgtacactttgacggtccccgaggcc acggtgaaagacagtggagattacgaatgtgctgcccgccaggctaccagggaggtcaaa gaaatgaagaaagtcactatttctgtccatgagaaagggttcattgaaatcaaacccacc ttcagccagttggaagctgtcaacctgcatgaagtcaaacattttgttgtagaggtgcgg gcctacccacctcccaggatatcctggctgaaaaacaatctgactctgattgaaaatctc actgagatcaccactgatgtggaaaagattcaggaaataaggtatcgaagcaaattaaag ctgatccgtgctaaggaagaagacagtggccattatacaattgtagctcaaaatgaagat gctgtgaagagctatacttttgaactgttaactcaagttccttcatcaattctggacttg gtcgatgatcaccatggctcaactgggggacagatggtgagatgcacagctgaaggcacg ccgcttcctgatattgagtggatgatatgcaaggatattaagaaatgtaataatgaaact tcctggacgattttggccaacaatgtctcaaacatcatcacggaggtccacccccgagac aggagtaccgtggagggccgtgtgactttcgccaaagtggaggagaccattgcggtgcga tgcctggctaagaatctccttggagctgagaaccgagagctgaagctggtggctcccacc ctgcgttctgaactcacggtggctgctgcagtcctggtgctgttggtgattgtgatcatc tcactcattgtcctggttgtcatttggaaacagaaaccgaggtatgaaattcgctggagg gtcattgaatcaatcagcccggatggacatgaatatatttatgtggacccgatgcagctg ccttatgactcaagatgggagtttccaagagatggactagtgcttggtcgggtcttgggg tctggagcatttgggaaggtggttgaaggaacagcctatggattaagtcggtcccaacct gtcatgaaagttgcagtgaagatgctaaaacccacggccagatccagtgaaaaacaagct ctcatgtctgaactgaagataatgactcacctggggccacatttgaacattgtaaacttg ctgggagcctgcaccaagtcaggccccatttacatcatcacggagtactgcttctatgga gatttggtcaactatttgcataagaatagggatagcttcctgagccaccacccagagaag ccaaagaaagagctggatatctttggattgaaccctgctgatgaaagcacacggagctat gttattttatcttttgaaaacaatggtgactacatggacatgaagcaggctgatactaca cagtatgtccccatgctagaaagaaaagaggtttctaaatattccgacatccagagatca ctctatgatcgtccagcctcatataagaagaaatctatgttagactcagaagtcaaaaac ctcctttcagatgataactcagaaggccttactttattggatttgttgagcttcacctat caagttgcccgaggaatggagtttttggcttcaaaaaattgtgtccaccgtgatctggct gctcgcaacgtcctcctggcacaaggaaaaatcgtgaagatctgtgactttggcctggcc agagacatcatgcatgattcaaactatgtgtcaaaaggcagtacctttctgcccgtgaag tggatggctcctgagagcatctttgacaacctctacaccacactgagtgatgtctggtct tacggcattctgctctgggagatcttttcccttggtggcaccccttaccccggcatgatg gtggattctactttctacaataagatcaagagtgggtaccggatggctaagcctgaccat gctaccagtgaagtctacgagatcatggtgaaatgctggaacagtgagccggagaagaga ccctccttttaccacctgagtgagattgtggagaatctgctgcctggacaatataaaaag agttatgaaaaaattcacctggacttcctgaagagtgaccatcctgctgtggcacgcatg cgtgtggactcagacaatgcgtacattggtgtcacctacaaaaacgaggaagacaagctg aaggactgggagggtggtctggatgagcagagactgagcgctgacagtggctacatcatt cctctgcctgacattgaccctgtccctgaggaggaggacctgggcaagaggaacagacac agctcgcagacctctgaagagagtgccattgagacgggttccagcagttccaccttcatc aagagagaggacgagaccattgaagacatcgacatgatggacgacatcggcatagactct tcagacctggtagaagacagcttcctgtaa

Pongo abelii (Sumatran orangutan): 100433126 Help Entry 100433126         CDS       T01416                                  Gene name FGFR3 Definition (RefSeq) LOW QUALITY PROTEIN: fibroblast growth factor receptor 3   KO K05094   fibroblast growth factor receptor 3 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04144   Endocytosis pon04151   PI3K-Akt signaling pathway pon04550   Signaling pathways regulating pluripotency of stem cells pon04810   Regulation of actin cytoskeleton pon05200   Pathways in cancer pon05206   MicroRNAs in cancer pon05219   Bladder cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100433126 (FGFR3)    04014 Ras signaling pathway     100433126 (FGFR3)    04015 Rap1 signaling pathway     100433126 (FGFR3)    04020 Calcium signaling pathway     100433126 (FGFR3)    04151 PI3K-Akt signaling pathway     100433126 (FGFR3)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100433126 (FGFR3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100433126 (FGFR3)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100433126 (FGFR3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100433126 (FGFR3)    05206 MicroRNAs in cancer     100433126 (FGFR3)    05230 Central carbon metabolism in cancer     100433126 (FGFR3)   09162 Cancer: specific types    05219 Bladder cancer     100433126 (FGFR3)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100433126 (FGFR3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100433126 (FGFR3)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100433126 (FGFR3) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100433126 (FGFR3) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   FGFR family [OT]    100433126 (FGFR3) CD molecules [BR:pon04090]  Proteins   100433126 (FGFR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase I-set Ig_3 Ig_2 ig FGFR3_TM V-set C2-set_2 Pkinase_fungal DUF1533 Motif Other DBs NCBI-GeneID:  100433126 NCBI-ProteinID:  XP_024102130 LinkDB All DBs Position 4 AA seq 806 aa AA seqDB search MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVLGPEPGQQEQLVFGSGDAVELS CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG NPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRXPPKKGLGSPTVHKISRFPLK RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE GCFGQVVMAEAVGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSC SSSGDDSVFAHDLLPPAPPSSGGSRT NT seq 2421 nt NT seq  +upstreamnt  +downstreamnt atgggcgcccctgcctgcgccctcgcgctctgcgtggccgtggccatcgtggccggcgcc tcctcggagtccttggggacggagcagcgcgtcgtggggcgagcggcagaagtcctgggc ccagagcccggccagcaggagcagttggtcttcggcagcggggatgctgtggagctgagc tgtcccccgcccgggggtggtcccatggggcccactgtctgggtcaaggatggcacaggg ctggtgccctcggagcgtgtcctggtggggccccagcggctgcaggtgctgaatgcctcc cacgaggactccggggcctacagctgccggcagcggctcacgcagcgcgtactgtgccac ttcagtgtgcgggtgacagacgctccatcctcaggagatgacgaagacggggaggacgag gctgaggacacaggtgtggacacaggggccccttactggactcggcccgagcggatggac aagaagctgctggccgtgccggccgccaacaccgtccgcttccgctgcccggccgccggc aaccccactccctccatctcctggctgaagaatggcaaggagttccgcggcgagcaccgc atcggaggcatcaagctgcggcaccagcagtggagcctggtcatggaaagcgtggtgccc tcagaccgcggcaactacacctgcgtagtggagaacaagtttggcagcatccggcagaca tacacgctggatgtgctggagcgctccccgcaccggcccatcctgcaggcggggctgccg gccaaccagacggcggtgctgggcagcgatgtggagttccactgcaaggtgtacagtgac gcacagccccacatccagtggctcaagcacgtggaggtgaacggcagcaaggtgggcccg gacggcacaccctacgttaccgtgctcaagacggcgggcgctaacaccaccgacaaggag ctagaggttctgtccttgcacaacgtcacctttgaggacgccggggagtacacctgcctg gcgggcaattctattgggttttctcatcactctgcgtggctggtggtgctgccagctgag gaggagctggtggaggctgacgaggcgggcagtgtgtatgcaggcatcctcagctacggg gtgggcttcttcttgttcatcctggtggtggcggctgtgacgctctgccgcctacgcnag ccccccaagaaaggcctgggctcccccaccgtgcacaagatctcccgcttcccgctcaag cgacaggtgtccctggagtccaacgcgtccatgagctccaacacaccgctggtgcgcatc gcaaggctgtcctcaggggagggccccacgctggccaatgtctccgagcttgagctgcct gccgaccccaaatgggagctgtctcgggcccggctgaccctgggcaagccccttggggag ggctgcttcggtcaggtggtcatggcagaggccgtcggcattgacaaggaccgggccgcc aagcctgtcaccgtagccgtgaagatgctgaaagacgatgccactgacaaggacctgtcg gacctggtgtctgagatggagatgatgaagatgattggcaaacacaagaacatcatcaac ctgctgggcgcctgcacgcagggtgggcccctgtacgtgctggtggagtacgcggctaag ggtaacttgcgggagttcctgcgggcgcggcggcccccgggcctggactactccttcgac acctgcaagccacccgaggagcagctcaccttcaaggacctggtgtcctgtgcctaccag gtggcccggggcatggagtacctggcctcccagaagtgcatccacagggacctggctgcc cgcaatgtgctggtgaccgaggacaatgtgatgaagatcgcagacttcgggctggcccgg gacgtgcacaacctcgactactacaagaagacaaccaacggccggctgcccgtgaagtgg atggcgcctgaggccttgtttgaccgagtctacactcaccagagtgacgtctggtccttt ggggtcctgctctgggagatcttcacgctagggggctccccgtaccccggtatccctgtg gaggagctcttcaagctgctgaaggagggacaccgcatggacaagcccgccaactgcaca cacgacctgtacatgatcatgcgggagtgctggcatgctgcaccctcccagaggcccacc ttcaagcagctggtggaggacctggaccgtgtccttaccgtgacatccaccgatgagtac ctggacctgtcggcgcctttcgagcagtactctcctggtggccaggacacccccagctgc agctcctcaggggatgactccgtgtttgcccacgacctgctgcccccggccccacccagc agtgggggctcgcggacgtga

Pongo abelii (Sumatran orangutan): 100433386 Help Entry 100433386         CDS       T01416                                  Gene name CSF1R Definition (RefSeq) macrophage colony-stimulating factor 1 receptor   KO K05090   macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04060   Cytokine-cytokine receptor interaction pon04061   Viral protein interaction with cytokine and cytokine receptor pon04151   PI3K-Akt signaling pathway pon04380   Osteoclast differentiation pon04640   Hematopoietic cell lineage pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05221   Acute myeloid leukemia Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100433386 (CSF1R)    04014 Ras signaling pathway     100433386 (CSF1R)    04015 Rap1 signaling pathway     100433386 (CSF1R)    04151 PI3K-Akt signaling pathway     100433386 (CSF1R)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     100433386 (CSF1R)    04061 Viral protein interaction with cytokine and cytokine receptor     100433386 (CSF1R)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     100433386 (CSF1R)   09158 Development and regeneration    04380 Osteoclast differentiation     100433386 (CSF1R)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100433386 (CSF1R)    05202 Transcriptional misregulation in cancer     100433386 (CSF1R)   09162 Cancer: specific types    05221 Acute myeloid leukemia     100433386 (CSF1R)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100433386 (CSF1R)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100433386 (CSF1R) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100433386 (CSF1R) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    100433386 (CSF1R) CD molecules [BR:pon04090]  Proteins   100433386 (CSF1R) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 ig I-set Ig_2 Izumo-Ig Serglycin C2-set_2 AF-4 Motif Other DBs NCBI-GeneID:  100433386 NCBI-ProteinID:  XP_024103185 Ensembl:  ENSPPYG00000015942 LinkDB All DBs Position 5 AA seq 983 aa AA seqDB search MGPGVLLLLLVATAWHGQGIPVIEPSGPELVVKPGAMVTLRCVGNGSVEWDGSVEWDGPV SPHWTLHSDGSSSVLTNNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQE VVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQD YQCSALMGGRKVMSISIRLKVQKVIPGPPALTLAPAELVRIRGEAAQIVCSASNVDVNFD VFLQHNDTKLTIPQQSDFHNNRYQKVLTFNLDQVDFQHAGNYSCVANNVQGKHSTSMFFR VVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANA TIKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGS GTLVCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTV ETLEHNQTYECRAHNSVGSGSWAFIPISAGARTHPPDEFLFTPVVVACMSIMALLLLLLL LLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPKGGVDYKNIHLEKKYVHRDSG FSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELWDLLHFSSQVAQGMAFLASKNC IHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCIYTV QSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWA LEPTHRPTFQQICSFLQEQAQEDRRQQDYTNLPSSSRSGGSGSGSGSGSSSELEEESASE HLTCCEQGDIAQPLLQPNNYQFC NT seq 2952 nt NT seq  +upstreamnt  +downstreamnt atgggcccaggagttctgctgctcctgctggtggccacagcttggcatggtcagggaatc ccagtgatagagcccagtggccctgagctggtcgtgaagccaggagcaatggtgaccctg cgatgtgtgggcaatggcagcgtggaatgggatggcagcgtggaatgggatggccccgta tcacctcactggaccctgcactctgatggctccagcagcgtcctcaccaacaacaacgct accttccaaaacacggggacctatcgctgcactgagcctggagaccccctgggaggcagt gctgccatccacctctatgtcaaagaccctgcccggccctggaacgtgctagcacaggag gtggtcgtgttcgaggaccaggacgcactgctgccctgtctgctcacagacccggtgctg gaagcaggcgtctcgctggtgcgtgtgcgtggccggcccctcatgcgccacaccaactac tccttctcgccttggcatggcttcaccatccacagggccaagttcattcagagccaggac tatcaatgcagtgccctgatgggtggcaggaaggtgatgtccatcagcatccggctgaaa gtgcagaaagtcatcccagggcccccagccttgacactggcgcctgcagagctggtgcgg attcgaggggaggctgcccagatcgtgtgctcagccagcaacgttgatgttaactttgat gtcttcctccaacacaacgacactaagctcacaatccctcaacaatctgactttcataat aaccgttaccaaaaagtcctgaccttcaacctcgatcaagtagatttccaacatgccggc aactactcctgcgtggccaacaatgtgcagggcaagcactccacctccatgttcttccgg gtggtagagagtgcctacttgaacttgagctctgagcagaacctcatccaggaggtgacc gtgggggaggggctcaacctcaaagtcatggtggaggcctacccaggcctgcaaggtttt aactggacctacctgggacccttttctgaccaccagcctgagcccaagcttgctaatgct accatcaaggacacatacaggcacaccttcaccctctctctgccccgcctgaagccctct gaggctggccgctactccttcctagccagaaacccaggaggctggagagctctgacgttt gagctcacccttcgataccccccagaggtaagtgtcatatggaccttcatcaatggctct ggcacccttgtgtgtgctgcctccgggtacccccagcccaacgtgacatggctgcagtgc agtggccacactgataggtgtgatgaggcccaagtgctgcaggtctgggatgacccatac cctgaggtcctgagccaggagcccttccacaaggtgaccgtgcaaagcctgctgactgtt gagaccttagagcacaaccaaacctacgagtgcagggcccacaacagcgtggggagtggc tcctgggccttcatacccatctctgcaggagcccgcacgcatcccccagatgagttcctc ttcacaccagtggtggtcgcctgcatgtccatcatggccttactgctgctgctgctcctg ctgctattgtacaagtataagcagaagcccaagtaccaggtccgctggaagatcatcgag agctatgagggcaacagttacactttcatcgaccccacacagctgccttacaacgagaag tgggagttcccccggaacaacctgcagtttggtaagaccctcggagctggcgcctttggg aaggtggtggaggccacggcctttggtctgggcaaagaggatgctgtcctgaaggtggct gtgaagatgctgaagtccacggcccatgctgatgagaaggaggccctcatgtccgagctg aagatcatgagccacctgggccagcacgagaacatcgtcaaccttctgggagcctgcacc catggaggccctgtactggtcatcacggagtactgttgctatggcgacctgctcaacttt ctgcgaaggaaggctgaggccatgctgggacccagcctgagccccggccaggaccccaag ggaggcgtcgactataagaacatccacctcgagaagaaatatgtccacagggacagtggc ttctccagccagggtgtggacacctatgtggagatgaggcctgtctccacttcttcaaat gactccttctctgagcaagacctggacaaggaggatggacggcccctggagctctgggac ctgcttcacttctccagccaagtagcccagggcatggccttcctcgcttctaagaattgc atccaccgggatgtggcagcacgtaacgtgctgttgaccaatggtcatgtggccaagatt ggggacttcgggctggctagggacatcatgaatgactccaactacatcgtcaagggcaat gcccgcctgcctgtgaagtggatggccccagagagcatctttgactgtatctacacggtt cagagcgacgtctggtcctatggcatcctcctctgggagatcttctcgcttgggctgaat ccctaccctggcatcctggtgaacagcaagttctataaactggtgaaggatggataccaa atggcccagcctgcatttgccccaaagaatatatacagcatcatgcaggcctgctgggcc ttggagcccacccacagacccaccttccagcagatctgctccttccttcaggagcaggcc caagaggacaggagacagcaggactataccaatctgccgagcagcagcagaagcggtggc agcggcagcggcagcggcagcggcagcagcagtgaactggaggaggagagcgctagtgag cacctgacctgctgcgagcaaggggatatcgcccagcccttgctgcagcccaacaactat cagttctgctga

Pongo abelii (Sumatran orangutan): 100437110 Help Entry 100437110         CDS       T01416                                  Gene name KIT Definition (RefSeq) mast/stem cell growth factor receptor Kit isoform X1   KO K05091   proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04072   Phospholipase D signaling pathway pon04151   PI3K-Akt signaling pathway pon04640   Hematopoietic cell lineage pon04916   Melanogenesis pon05200   Pathways in cancer pon05221   Acute myeloid leukemia pon05224   Breast cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100437110 (KIT)    04014 Ras signaling pathway     100437110 (KIT)    04015 Rap1 signaling pathway     100437110 (KIT)    04072 Phospholipase D signaling pathway     100437110 (KIT)    04151 PI3K-Akt signaling pathway     100437110 (KIT)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     100437110 (KIT)   09152 Endocrine system    04916 Melanogenesis     100437110 (KIT)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100437110 (KIT)    05230 Central carbon metabolism in cancer     100437110 (KIT)   09162 Cancer: specific types    05221 Acute myeloid leukemia     100437110 (KIT)    05224 Breast cancer     100437110 (KIT)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100437110 (KIT)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100437110 (KIT) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100437110 (KIT) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    100437110 (KIT) CD molecules [BR:pon04090]  Proteins   100437110 (KIT) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 ig I-set Ig_2 Ig_6 Ig_4 V-set Pkinase_fungal APH Motif Other DBs NCBI-GeneID:  100437110 NCBI-ProteinID:  XP_024102193 LinkDB All DBs Position 4 AA seq 977 aa AA seqDB search MRGARGAWDFLCVLLLLLRVQTGSSQPSASPGEPSPPSIHPAKSELIVRVGDEIRLLCTD TGFVKWTFEILDEMNENKQNEWITEKAEATNTGKYTCTNKHGLSSSIYVFVRDPAKLFLV DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFVPDPKAGIMIKSVKRAYH RLCLHCSADQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS SVYSTWKRENSQQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSA NVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPRPEHQHWIYMNRTFTDKW EDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNASIAFNVYVNTKPEILTYD RLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSVD SSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCII VMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGA FGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA CTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTN EYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKG MAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPE SIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM YDIMKTCWDVDPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINS VGSTASSSQPLLVHDDV NT seq 2934 nt NT seq  +upstreamnt  +downstreamnt atgagaggcgctcgcggcgcctgggattttctctgcgttctgctcctactgcttcgcgtc cagacaggctcttctcaaccatctgcgagtccaggggaaccgtctccaccatccatccat ccagcaaaatcagagttaatagtccgcgtgggcgatgagattaggctgttatgcactgat acgggctttgtcaaatggacttttgagatcctcgatgaaatgaatgagaataagcagaat gaatggatcacagaaaaggcagaagccaccaacaccggcaaatacacctgcaccaacaaa cacggcttaagcagttccatttatgtgtttgttagagatcctgccaagcttttccttgtt gaccgctccttgtatgggaaagaagacaacgacacgctggtccgctgtcctctcacagac ccagaagtgaccaattattccctcaaggggtgccaggggaagcctcttcccaaggacttg aggtttgttcctgaccccaaggcgggcatcatgatcaaaagtgtgaaacgcgcctaccat cggctctgtctgcattgttccgcggaccaggagggcaagtcagtgctgtcggaaaaattc atcctgaaagtgaggccagccttcaaagctgtgcctgttgtgtctgtgtccaaagcaagc tatcttcttagggaaggggaagaattcacagtgacgtgcacaataaaagatgtgtctagt tctgtgtactcaacgtggaaaagagaaaacagtcagcagactaaactacaggagaaatat aatagctggcatcacggtgacttcaattatgaacgtcaggcaacgttgactatcagttca gcgagagttaatgattctggagtgttcatgtgttatgccaataatacttttggatcagca aatgtcacaacaaccttggaagtagtagataaaggattcattaatatcttccccatgata aacactacagtatttgtaaacgatggagaaaatgtagatttgattgttgaatatgaggca ttccccagacctgaacaccagcactggatctatatgaacagaaccttcactgataaatgg gaagattatcccaagtctgagaatgaaagtaatatcagatacgtaagtgaacttcatcta accagattaaaaggcaccgaaggaggcacttacacattcctagtgtccaattctgacgtc aatgcttccatagcatttaatgtttatgtgaatacaaaaccagaaatcctgacttacgac aggctcgtgaatggcatgctccaatgtgtggcagcaggattcccagagcccacaatagat tggtatttttgtccaggaactgagcagagatgctctgcttctgtactgccagtggatgtg cagacactaaactcatctgggccaccgtttggaaagctagtggttcagagttctgtagat tctagtgcattcaagcacaatggcacggttgaatgtaaggcttacaacgatgtgggcaag acttctgcctattttaactttgcatttaaaggtaacaacaaagagcaaatccatccccac accctgttcactcctttgctgattggtttcgtaatcgtagctggcatgatgtgcattatt gtgatgattctgacctacaaatatttacagaaacccatgtatgaagtacagtggaaggtt gttgaggagataaatggaaacaattatgtttacatagacccaacacaacttccttatgat cacaaatgggagtttcccagaaacaggctgagttttgggaaaaccctgggtgctggtgct ttcgggaaagttgttgaggcaactgcttatggcttaattaagtcagatgcggctatgact gtagctgtaaagatgctcaaaccaagtgcccatttaacagaacgggaagccctcatgtct gaactcaaagtcttgagttaccttggtaatcatatgaatattgtgaatcttcttggagcc tgcaccattggagggcccaccttggtcattacagaatattgttgctatggtgatcttttg aattttttgagaagaaaacgtgattcatttatttgttcaaagcaggaagatcatgcagaa gctgcactttataagaatcttctgcattcaaaggagtcttcctgcagcgatagtaccaat gagtacatggacatgaaacctggagtctcttatgttgtcccaaccaaggccgacaaaagg agatctgcgagaataggctcatacatagaaagagatgtgactcctgccatcatggaggat gatgagttggccctagacttagaagacttgctgagcttttcttaccaggtggcaaagggc atggccttcctcgcctccaagaattgtattcacagagacttggcagccagaaatatcctc cttactcatggtcggatcacaaagatttgtgattttggtctagccagagacatcaagaat gattctaattatgtggttaaaggaaacgctcgactacctgtgaagtggatggcacctgaa agcattttcaactgtgtatacacgtttgaaagtgacgtctggtcctatggtatttttctt tgggagctgttctctttaggaagcagcccctatcctggaatgccggtcgattctaagttc tacaagatgatcaaggaaggcttccggatgctcagccctgaacatgcacctgctgaaatg tatgacataatgaagacttgctgggatgtggatcccctaaaaagaccaacattcaagcaa attgttcagctaattgagaagcagatttcagagagcactaatcacatttactccaactta gcaaactgcagccccaaccgacagaagcccgtggtggaccattctgtgcggatcaattct gtcggcagcaccgcttcctcctcccagcctctgcttgtgcacgatgacgtctga

Pongo abelii (Sumatran orangutan): 100441207 Help Entry 100441207         CDS       T01416                                  Gene name NTRK2 Definition (RefSeq) BDNF/NT-3 growth factors receptor isoform X2   KO K04360   neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04722   Neurotrophin signaling pathway pon05034   Alcoholism Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100441207 (NTRK2)    04014 Ras signaling pathway     100441207 (NTRK2)    04020 Calcium signaling pathway     100441207 (NTRK2)    04151 PI3K-Akt signaling pathway     100441207 (NTRK2)  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     100441207 (NTRK2)  09160 Human Diseases   09165 Substance dependence    05034 Alcoholism     100441207 (NTRK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100441207 (NTRK2) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100441207 (NTRK2) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   TRK family [OT]    100441207 (NTRK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 TPKR_C2 Ig_2 ig LRR_8 LRRNT V-set LRR_5 Ig_C17orf99 Motif Other DBs NCBI-GeneID:  100441207 NCBI-ProteinID:  XP_009242828 Ensembl:  ENSPPYG00000019331 LinkDB All DBs Position 9 AA seq 553 aa AA seqDB search MSSWIRWHGPAMTRLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL KPDTWPRGSPKIA NT seq 1662 nt NT seq  +upstreamnt  +downstreamnt atgtcgtcctggataaggtggcatggacccgccatgacgcggctctggggcttctgctgg ctggttgtgggcttctggagggccgctttcgcctgtcctacgtcctgcaaatgcagtgcc tctcggatctggtgcagcgacccttctcctggcatcgtggcatttccgagattggagcct aacagtgtagatcctgagaacatcaccgaaattttcatcgcaaaccagaaaaggttagaa atcatcaacgaagatgatgttgaagcttatgtgggactgagaaatctgacaattgtggat tctggattaaaatttgtggctcataaagcatttctgaaaaacagcaacctgcagcacatc aattttactcgaaacaaactgacgagtttgtctaggaaacatttccgtcaccttgacttg tctgaactgatcctggtgggcaatccatttacatgctcctgtgacattatgtggatcaag actctccaagaggctaaatccagtccagacactcaagatttgtactgcctgaatgaaagc agcaagaatattcccctggcaaacctgcagatacccaattgtggtttgccatctgcaaat ttggccgcacctaacctcactgtggaggaaggaaagtctatcacattatcctgtagtgtg gcaggcgatccggttcctaatatgtattgggatgttggtaatctggtttccaaacatatg aatgaaacaagccacacacagggctccttaaggataactaacatttcatccgatgacagt gggaagcagatctcttgtgtggcggaaaatcttgtaggagaagatcaagattctgtcaac ctcactgtgcattttgcaccaactatcacatttctcgaatctccaacctcagaccaccac tggtgcattccattcactgtgaaaggcaaccccaaaccagcgcttcagtggttctataac ggggcaatattgaatgagtccaaatacatctgtactaaaatacatgttaccaatcacacg gagtaccacggctgcctccagctggataatcccactcacatgaacaatggggactacact ctaatagccaagaatgagtatgggaaggatgagaaacagatttctgctcacttcatgggc tggcctggaattgacgatggtgcaaacccaaattatcctgatgtaatttatgaagattat ggaactgcagcgaatgacatcggggacaccacgaacagaagtaatgaaatcccttccaca gacgtcactgataaaaccggtcgggaacatctctcggtctatgctgtggtggtgattgcg tctgtggtgggattttgccttttggtaatgctgtttctgcttaagttggcaagacactcc aagtttggcatgaaagatttctcatggtttggatttgggaaagtaaaatcaagacaaggt gttggcccagcttccgttatcagcaatgatgatgactctgccagcccactccatcacatc tccaatgggagtaacactccatcttcttcagaaggtggcccagatgctgtcattattgga atgaccaagatccctgtcatagaaaatccccagtactttggcatcaccaacagtcagctc aagccagacacatggcccagaggttcccccaagatcgcctga

Pongo abelii (Sumatran orangutan): 100450307 Help Entry 100450307         CDS       T01416                                  Gene name ERBB2 Definition (RefSeq) receptor tyrosine-protein kinase erbB-2 isoform X1   KO K05083   receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon01522   Endocrine resistance pon01524   Platinum drug resistance pon04010   MAPK signaling pathway pon04012   ErbB signaling pathway pon04020   Calcium signaling pathway pon04066   HIF-1 signaling pathway pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon04520   Adherens junction pon04530   Tight junction pon05200   Pathways in cancer pon05205   Proteoglycans in cancer pon05206   MicroRNAs in cancer pon05212   Pancreatic cancer pon05213   Endometrial cancer pon05215   Prostate cancer pon05219   Bladder cancer pon05223   Non-small cell lung cancer pon05224   Breast cancer pon05226   Gastric cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100450307 (ERBB2)    04012 ErbB signaling pathway     100450307 (ERBB2)    04066 HIF-1 signaling pathway     100450307 (ERBB2)    04020 Calcium signaling pathway     100450307 (ERBB2)    04151 PI3K-Akt signaling pathway     100450307 (ERBB2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100450307 (ERBB2)    04520 Adherens junction     100450307 (ERBB2)    04530 Tight junction     100450307 (ERBB2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100450307 (ERBB2)    05206 MicroRNAs in cancer     100450307 (ERBB2)    05205 Proteoglycans in cancer     100450307 (ERBB2)    05230 Central carbon metabolism in cancer     100450307 (ERBB2)   09162 Cancer: specific types    05212 Pancreatic cancer     100450307 (ERBB2)    05226 Gastric cancer     100450307 (ERBB2)    05219 Bladder cancer     100450307 (ERBB2)    05215 Prostate cancer     100450307 (ERBB2)    05213 Endometrial cancer     100450307 (ERBB2)    05224 Breast cancer     100450307 (ERBB2)    05223 Non-small cell lung cancer     100450307 (ERBB2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100450307 (ERBB2)    01524 Platinum drug resistance     100450307 (ERBB2)    01522 Endocrine resistance     100450307 (ERBB2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100450307 (ERBB2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pon04147]     100450307 (ERBB2)    04090 CD molecules [BR:pon04090]     100450307 (ERBB2) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100450307 (ERBB2) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    100450307 (ERBB2) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of breast cancer cells    100450307 (ERBB2) CD molecules [BR:pon04090]  Proteins   100450307 (ERBB2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Kinase-like Motif Other DBs NCBI-GeneID:  100450307 NCBI-ProteinID:  XP_024090162 Ensembl:  ENSPPYG00000008479 LinkDB All DBs Position 17 AA seq 1267 aa AA seqDB search MARTNAVQHRDSDPDSHACAGSDESDMYCCGHAQKRVCTGTDMKLRLPASPETHLDMLRH LYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLF EDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIERNPQLCYQDTIL WKDIFHKNNQLAVTLIDTNRSRACHPCSSVCKGSRCWGESSEDCQSLTRTVCAGGCARCK GPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGR YTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGME HLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITG YLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALI HHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQC VNCSQFLRGQECVEECRVLQGLPREYVNARYCLPCHPECQPQNGSVTCFGPEADQCVACA HYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQPCPINCTHSCVDLDDKGCPAEQRA SPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPN QAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL DEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ IAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW MALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICT IDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSL LEDDDMGDLVDAEEYLVPQQGFFCPDPAPGVGGMVHHRHRSSSTRSGGGDLTLGLEPSEE EAPRSPLAPSDGAGSDVFDGDLGMGAAKGLQSLPAHDPSPLQRYSEDPTVPLPSETDGYV APLTCSPQPEYVNQPDVRPQPPSPREGPLPPARPAGATLERPKTLSPGKNGVVKDVFAFG GAVENPEYLAPRGGAAPQPHPPPAFSPAFDNLYYWDQDPSERGAPPSTFKGTPTAENPEY LGLDVPV NT seq 3804 nt NT seq  +upstreamnt  +downstreamnt atggccaggacaaacgcagtgcagcacagagactcagaccctgacagccatgcctgcgca ggcagtgatgagagtgacatgtactgttgtggacacgcacaaaagcgagtgtgcaccggc acagacatgaagctgcggctccctgccagtcccgagacccacctggacatgctccgccac ctctaccagggctgccaggtggtgcaaggaaacctggaactcacctacctgcccaccaat gccagcctctccttcctgcaggatatccaggaggtgcagggctacgtgctcatcgctcac aaccaagtgaggcaggtcccactgcagaggctgcggattgtgcgaggcacccagctcttt gaggacaactatgccctggccgtgctagacaatggagacccgctgaacaataccacccct gtcacaggggcctccccaggaggcctgcgggagctgcagcttcgaagcctcacagagatc ttgaaaggaggggtcttgatcgagcggaacccccagctctgctaccaggacacgattttg tggaaggacatcttccacaagaacaaccagctggctgtcacactgatagacaccaaccgc tctcgggcctgccacccctgttcttcggtgtgtaagggctcccgctgctggggagagagt tctgaggattgtcagagcctgacgcgcactgtctgtgccggtggctgtgcccgctgcaag gggccactgcccactgactgctgccatgagcagtgtgctgccggctgcacgggccccaag cactctgactgcctggcctgcctccacttcaaccacagtggcatctgtgagctgcactgc ccagccctggtcacctacaacacagacacctttgagtccatgcccaatcccgagggccga tatacattcggcgccagctgtgtgactgcctgtccctacaactacctttctacggacgtg ggatcctgcaccctcgtctgccccctgcacaaccaagaggtgacagcagaggacggaaca cagcggtgtgagaagtgcagcaagccctgtgcccgagtgtgctatggtctgggcatggag cacttgcgagaggtgagggcagtcaccagtgccaatatccaggagtttgctggctgcaag aagatctttgggagcctggcatttctgccggagagctttgatggggacccagcctccaac accgccccgctccagccagagcagctccgagtgtttgagactctggaagagatcacaggt tacctatacatctcagcatggccagacagcctgcctgacctcagcgtcttccagaacctg caagtaatccggggacgaattctgcacaatggcgcctactcgctgaccctgcaagggctg ggcatcagctggctggggctgcgctcgctgcgggaactgggcagtggactggccctcatc caccataacacccgcctctgcttcgtgcacacggtgccctgggaccagctcttccggaac ccgcaccaagctctgctccacactgccaaccggccagaggacgagtgtgtgggcgagggc ctggcctgccaccagctgtgcgcccgagggcactgctggggtccagggcccacccagtgt gtcaactgcagccagttccttcggggccaggagtgcgtggaggaatgccgagtactgcag gggctccccagggagtatgtgaatgccaggtactgtttgccgtgccaccctgagtgtcag ccccagaatggctcagtgacctgttttggaccggaggctgaccagtgtgtggcctgtgcc cactataaggaccctcccttctgcgtggcccgctgccccagcggtgtgaaacctgacctc tcctacatgcccatctggaagtttccagatgaggagggcacgtgccagccttgccccatc aactgcacccactcctgtgtggacctggatgacaagggctgccccgccgagcagagagcc agccctctgacgtccatcatctctgcggtggtgggcattctgctggtcgtggtcttgggg gtggtctttgggatcctcatcaagcgacggcagcagaagatccggaagtacacgatgcgg aggctgctgcaggaaacggagctggtggagccgctgacacctagcggagcgatgcccaac caggcgcagatgcgtatcctgaaagagacggagctgaggaaggtgaaggtgcttggatct ggcgcttttggcacagtctacaagggcatctggatccctgatggggaaaatgtgaaaatt ccagtggccatcaaagtgttgagggaaaacacatcccccaaagccaacaaagaaatctta gacgaagcatacgtgatggctggtgtgggctccccatatgtctcccgcctcctgggcatc tgcctgacatccacggtgcagctggtgacacagcttatgccctatggctgcctcttagac catgtccgggaaaaccgcggacgcctgggctcccaggacctgctgaactggtgtatgcag attgccaaggggatgagctacctggaggatgtgcggctcgtacacagggacttggctgct cggaacgtgctggtcaagagtcccaaccatgtcaaaattacagacttcgggctggctcgg ctgctggacattgacgagacagagtaccatgcagatgggggcaaggtgcccatcaagtgg atggcgctggagtccattctccgccggcggttcacccaccagagtgatgtgtggagttat ggtgtgactgtgtgggagctgatgacttttggggccaaaccttacgatgggatcccagcc cgggagatccctgacctgctggaaaagggggagcggctgccccagcctcccatctgcacc attgatgtctacatgatcatggtcaaatgttggatgattgactctgaatgtcggccgaga ttccgggagttggtgtctgaattctcccgcatggccagggacccccagcgctttgtggtc atccagaatgaggacttgggcccagccagtcccttggacagcaccttctaccgctcactg ctggaggacgatgacatgggggacctggtggatgctgaggagtatctggtaccccagcag ggcttcttctgtccagaccctgccccgggagttgggggcatggtccaccacaggcaccgc agctcatctaccaggagtggcggtggggacctgacgctagggctggagccctctgaagag gaggcccccaggtctccactggcaccctccgatggggctggctccgatgtatttgatggt gacctgggaatgggggcagccaaggggctgcaaagcctccccgcacatgaccccagccct ctacagcggtacagtgaggaccccacagtacccctgccctctgagactgatggctacgtt gcccccctgacctgcagcccccagcccgaatatgtgaaccagccagatgttcggccacag cctccttcgccccgagagggccctctgcctcctgcccgacctgctggtgccactctggaa aggcctaagactctctccccagggaagaatggggttgtcaaagacgtttttgcctttggg ggtgccgtggagaaccccgagtacttggcaccccggggaggagctgcccctcagccccac cctcctcctgccttcagcccagccttcgacaacctctattactgggaccaggacccatca gagcggggggctccacccagcaccttcaaagggacacctacggcagaaaacccagagtac ctgggtctggacgtgccagtgtga

Pongo abelii (Sumatran orangutan): 100451422 Help Entry 100451422         CDS       T01416                                  Gene name INSR Definition (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04022   cGMP-PKG signaling pathway pon04066   HIF-1 signaling pathway pon04068   FoxO signaling pathway pon04072   Phospholipase D signaling pathway pon04150   mTOR signaling pathway pon04151   PI3K-Akt signaling pathway pon04152   AMPK signaling pathway pon04211   Longevity regulating pathway pon04213   Longevity regulating pathway - multiple species pon04520   Adherens junction pon04910   Insulin signaling pathway pon04913   Ovarian steroidogenesis pon04923   Regulation of lipolysis in adipocytes pon04930   Type II diabetes mellitus pon04931   Insulin resistance pon04932   Non-alcoholic fatty liver disease pon04960   Aldosterone-regulated sodium reabsorption pon05010   Alzheimer disease Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100451422 (INSR)    04014 Ras signaling pathway     100451422 (INSR)    04015 Rap1 signaling pathway     100451422 (INSR)    04066 HIF-1 signaling pathway     100451422 (INSR)    04068 FoxO signaling pathway     100451422 (INSR)    04072 Phospholipase D signaling pathway     100451422 (INSR)    04022 cGMP-PKG signaling pathway     100451422 (INSR)    04151 PI3K-Akt signaling pathway     100451422 (INSR)    04152 AMPK signaling pathway     100451422 (INSR)    04150 mTOR signaling pathway     100451422 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100451422 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100451422 (INSR)    04923 Regulation of lipolysis in adipocytes     100451422 (INSR)    04913 Ovarian steroidogenesis     100451422 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100451422 (INSR)   09149 Aging    04211 Longevity regulating pathway     100451422 (INSR)    04213 Longevity regulating pathway - multiple species     100451422 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100451422 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100451422 (INSR)    04932 Non-alcoholic fatty liver disease     100451422 (INSR)    04931 Insulin resistance     100451422 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100451422 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100451422 (INSR) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100451422 (INSR) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100451422 (INSR) CD molecules [BR:pon04090]  Proteins   100451422 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  100451422 NCBI-ProteinID:  XP_024092866 LinkDB All DBs Position 19 AA seq 1370 aa AA seqDB search MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTAAVPTVAAFPNTSSTSVPTSP EEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADD IVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR LRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVI GSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQG SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMC WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS SHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4113 nt NT seq  +upstreamnt  +downstreamnt atgggcaccgggggccggcggggggcggcggccgcgccgctgctggtggcggtggccgcg ctgctattgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cggaacaacctcactaggttgcatgagctggagaattgctctgtcatcgaaggacacttg cagatactcttaatgttcaaaacgaggcccgaagatttccgagacctcagtttccccaaa ctcataatgatcactgattacttgctgctcttccgggtctatgggctcgagagcctgaag gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactacgcgctg gtcatcttcgagatggttcacctcaaggaactcggcctctacaacctgatgaacatcacc cggggttctgtccgcatcgagaagaacaatgagctctgttacttggccactatcgactgg tcccgtatcctggattccgtggaggataattacatcgtattgaacaaagatgacaatgag gagtgtggagacatctgtccgggtaccgcaaagggcaagaccaactgccccgccactgtc atcaatgggcagtttgtcgaacgctgttggactcatagtcactgccagaaagtttgcccg accatctgtaagtcacacggctgcaccgccgaaggcctctgttgccacagcgagtgcctg ggcaactgttctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggc tgccaccagtacgtcattcacaacaacaagtgcatccctgagtgtccctccgggtacacg atgaattccagcaacttgctgtgcaccccatgcctgggtccctgtcccaaggtgtgccac ctcctagaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggatgc accgtcatcaacgggagtctgatcatcaacattcgaggaggcaacaatctggcagctgag ctagaagccaacctcggcctcattgaagaaatttcagggtatctaaaaatccgccgatcc tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg gaaatcgggaactactccttctatgccttggacaaccagaacctaaggcagctctgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag agaaacgacattgccctgaagaccaatggggaccaggcatcctgtgaaaatgagttactt aaattttcttacattcggacatcttttgacaagatcttgctgagatgggagccgtactgg ccccccgacttccgagacctcttggggttcatgctgttctacaaagaggccccttatcag aatgtgacggagttcgacgggcaggatgcgtgtggttccaacagctggacggtggtagac attgacccacccctgaggtccaacgaccccaaatcacagaaccacccaggatggctgatg cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg gatgaacgccggacctatggggccaagagtgacatcatttatgtccagacagatgccacc aacccctctgtgcccctggatccaatctcagtgtctaactcatcatcccagattattttg aagtggaaacccccctccgaccccaatggcaacatcacccactacctggttttctgggag aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaagggctgaagctg ccctcgaggacctggtctccaccattcgagtctgaagattctcagaagcacaaccagagt gagtatgaggattcggccggcgaatgctgctcctgtccaaagacagactctcagatcctg aaggagctggaggagtcctcgtttaggaagacgtttgaggattacctgcacaacgtggtt tttgtccccaggccatctcggaaacgcaggtcccttggcgatgttgggaatgtgacagcg gctgtgcccacggtggcagctttccccaacacttcctcaaccagcgtgcccacgagtccg gaggagcacaggccctttgagaaggtggtaaacaaggagtcgctggtcatctctggcttg cgacacttcacaggctatcgcatcgagctgcaggcttgcaaccaagacacccctgaggaa cggtgcagtgtggcagcctacgtcagtgccaggaccatgcctgaagccaaggctgatgac atcgtcggccctgtgacgcacgaaatctttgagaacaacgttgtccacttgatgtggcag gagccgaaggagcccaatggtctgatcgtgctgtatgaagtgagttatcggcgatatggc gatgaggagctgcatctctgcgtctcccgcaagcacttcgctctggaacggggctgcagg ctgcgtgggctgtcgccggggaactacagcgtgcgagtccgggccacctcccttgcgggc aacggctcctggacggaacccacctatttctacgtgacagactatttagatgtcccgtca aatattgcaaaaattatcatcggccccctcatctttgtctttctcttcagtgttgtgatt ggaagtatttatctattcctgagaaagaggcagccagatgggccgctgggaccgctttac gcttcttcaaaccctgagtatctcagtgccagtgatgtgtttccatgctctgtgtacgtg ccggacgagtgggaggtgcctcgagagaagataaccctccttcgagagctggggcagggc tccttcggcatggtatatgagggcaacgccagggacatcatcaagggtgaggcagagacc cgtgtggcggtgaagacggtcaacgagtcagccagtctccgagagcggattgaattcctc aatgaggcctcggtcatgaagggcttcacctgccatcacgtggtgcgcctcctgggagtg gtgtccaagggccagcccacgctggtggtgatggagctgatggctcatggagacctgaag agctacctccgttctctgcggccagaggctgagaataatcctggccgccctccgcctacc ctgcaagagatgattcagatggcggcagagattgctgacgggatggcctacctgaacgcc aagaagtttgtgcatcgggacctggcagcgagaaactgcatggtcgcccatgattttact gtcaaaattggagactttggaatgaccagagacatctatgaaacggattactaccggaaa gggggtaagggtctgctccctgtacggtggatggcgccggagtccctgaaggatggggtc tttaccacttcttctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttg gcagaacagccttaccaaggcctgtctaatgaacaggtgttgaaatttgtcatggatgga gggtatctggatcaacccgacaactgtccagagagagtcactgacctcatgcgcatgtgc tggcaattcaaccccaagatgaggccaaccttcctggagattgtcaacctgctcaaggac gacctgcaccccagctttccggaggtgtcgttcttccacagcgaggagaacaaggctccc gagagtgaggagctggagatggagtttgaggacatggagaatgtgcccctggaccgttcc tcgcactgtcagagggaggaggcggggggccgggatggagggtcctcgctaggtttcaag cggagctacgaggaacacatcccttacacacacatgaacggaggcaagaaaaacgggcgg attctgaccttgcctcggtccaatccttcctaa

Pongo abelii (Sumatran orangutan): 100451664 Help Entry 100451664         CDS       T01416                                  Gene name EPHA2 Definition (RefSeq) ephrin type-A receptor 2   KO K05103   Eph receptor A2 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04151   PI3K-Akt signaling pathway pon04360   Axon guidance Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100451664 (EPHA2)    04014 Ras signaling pathway     100451664 (EPHA2)    04015 Rap1 signaling pathway     100451664 (EPHA2)    04151 PI3K-Akt signaling pathway     100451664 (EPHA2)  09150 Organismal Systems   09158 Development and regeneration    04360 Axon guidance     100451664 (EPHA2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100451664 (EPHA2) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100451664 (EPHA2) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   EPH family [OT]    100451664 (EPHA2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Ephrin_lbd Pkinase fn3 SAM_1 EphA2_TM SAM_2 Pur_ac_phosph_N Interfer-bind Ephrin_rec_like SKG6 Pkinase_fungal Motif Other DBs NCBI-GeneID:  100451664 NCBI-ProteinID:  XP_024087413 LinkDB All DBs Position 1 AA seq 976 aa AA seqDB search MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVISG VAVGVVLLLVLAGVGFFIHRRRKNLRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGTLKTSSGKKEVPVAIKTLKAGYTEKQRVDF LGEAGIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY SLLGLKDQVNTVGIPI NT seq 2931 nt NT seq  +upstreamnt  +downstreamnt atggagctccaggcagcccgcgcctgcttcgccctgctgtggggctgtgcgctggccgcg gccgcggcggcacagggcaaggaagtggtactgctggactttgctgcagctggaggggag ctcggctggctcacacacccgtatggcaaagggtgggacctgatgcagaacatcatgaat gacatgccgatctacatgtactccgtgtgcaacgtgatgtctggtgaccaggacaactgg ctccgcaccaactgggtgtaccgaggagaggctgagcgtatcttcattgagctcaagttt actgtacgtgactgcaacagcttccctggcggcgccagctcctgcaaggagactttcaac ctctactatgccgagtcggacctggactatggcaccaacttccagaagcgcctgttcacc aagattgacaccattgcgcccgatgagatcaccgtcagcagcgacttcgaggcacgccac gtgaagctgaacgtggaggagcgctccgtggggccgctcacccgcaaaggcttctacctg gccttccaggatatcggtgcctgtgtggcgctgctctccgtccgtgtctactacaagaag tgccccgagctgctgcagggcctggcccacttccctgagaccatcgccggctctgatgca ccctccctggccactgtggccggcacctgtgtggaccatgccgtggtgccaccgggcggt gaagagccccgtatgcactgtgcagtggacggcgagtggctggtgcccattgggcagtgc ctgtgccaggcaggctacgagaaggtggaggatgcctgccaggcctgctctcctggattc tttaagtttgaggcatctgagagcccctgcttggagtgccctgagcacacgctgccatcc cctgagggtgccacctcctgcgagtgtgaggaaggcttcttccgggcacctcaggaccca gcgtcgatgccttgcacacgacccccctccgccccacactacctcacggccgtgggcatg ggtgccaaggtggagctgcgctggacgccccctcaggacagcggaggccgcgaggacatt gtctacagcgtcacctgtgaacagtgctggcccgagtctggggagtgcgggccgtgtgag gccagtgtgcgctactcggagcctccgcacggattgacccgaaccagtgtgacagtcagc gacctggagccccacatgaactacacctttaccgtggaggcccgcaatggcgtctcaggc ctggtgaccagccgcagcttccgtactgccagtgtcagcatcaaccagacagagcccccc aaggtgaggctggagggccgcagcaccacctctcttagcgtctcctggagcatccccccg ccgcagcagagccgcgtgtggaagtacgaggtcacctaccgcaagaagggagactccaac agctacaacgtgcgccgcactgagggtttctccgtgaccctggatgacctggctccggac accacctacctggtccaggtgcaggcactgacgcaggagggccagggggccggcagcaag gtgcacgaattccagacgctgtccccggagggatctggcaacttggcggtgattagcggc gtggctgtcggtgtggtcctgcttctggtgctggcaggagttggcttctttatccaccgc aggaggaagaacctgcgtgcccgccagtccccagaggacgtttacttctccaagtcagaa caactgaagcccctgaagacatacgtggacccccacacatatgaggaccccaaccaggct gtgttgaagttcactaccgagatccatccatcctgtgtcactcggcagaaggtgattgga gcaggagagtttggggaggtgtacaagggcacgctgaagacatcctcggggaagaaggag gtgccggtggccatcaagacgctgaaagccggctacacagaaaagcagcgagtggacttc cttggcgaggccggcatcatgggccagttcagccaccacaacatcattcgcctggagggc gtcgtctccaaatacaagcccatgatgatcatcactgagtacatggagaatggggccctg gacaagttccttcgggagaaggatggtgagttcagcgtgctgcagctggtgggcatgctg cggggcattgcagctggcatgaagtacctggccaacatgaactatgtgcaccgtgacctg gctgcccgcaacatcctcgtcaacagcaacctggtctgcaaggtgtctgactttggcctg tcccgcgtgctggaggacgaccccgaggccacctacaccaccagtggcggcaagatcccc atccgctggaccgccccagaggccatttcctaccgcaagttcacctctgccagcgacgtg tggagctttggcattgtcatgtgggaggtgatgacctacggcgagcggccctactgggag ctgtccaaccacgaggtgatgaaagccatcaatgatggcttccggctccccacgcccatg gactgcccctccgccatctaccagctcatgatgcagtgctggcagcaggagcgtgcccgc cgccccaagttcgctgacatcgtcagcatcctggacaagctcattcgtgcccctgactcc ctcaagaccctggctgacttcgacccccgggtgtctatccggctccccagcacgagcggc tcagagggggtgcctttccgcacggtgtccgagtggctggagtccatcaagatgcagcag tatacggagcacttcatggcggccggctacactgccatcgagaaggtggtgcagatgacc aacgacgacatcaagaggattggggtgcggctgcccggccaccagaagcgcatcgcctac agcctgctgggactcaaggaccaggtgaacactgtgggaatccccatctga

Pongo abelii (Sumatran orangutan): 100452269 Help Entry 100452269         CDS       T01416                                  Gene name NTRK1 Definition (RefSeq) high affinity nerve growth factor receptor isoform X2   KO K03176   neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04210   Apoptosis pon04722   Neurotrophin signaling pathway pon04750   Inflammatory mediator regulation of TRP channels pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05216   Thyroid cancer pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100452269 (NTRK1)    04014 Ras signaling pathway     100452269 (NTRK1)    04020 Calcium signaling pathway     100452269 (NTRK1)    04151 PI3K-Akt signaling pathway     100452269 (NTRK1)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     100452269 (NTRK1)  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     100452269 (NTRK1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100452269 (NTRK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100452269 (NTRK1)    05202 Transcriptional misregulation in cancer     100452269 (NTRK1)    05230 Central carbon metabolism in cancer     100452269 (NTRK1)   09162 Cancer: specific types    05216 Thyroid cancer     100452269 (NTRK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100452269 (NTRK1) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100452269 (NTRK1) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   TRK family [OT]    100452269 (NTRK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase TPKR_C2 I-set LRR_8 TrkA_TMD Ig_3 Ig_2 LRR_4 Motif Other DBs NCBI-GeneID:  100452269 NCBI-ProteinID:  XP_002810050 Ensembl:  ENSPPYG00000000698 UniProt:  H2N5B2 LinkDB All DBs Position 1 AA seq 796 aa AA seqDB search MLRGGRRGQLGWHSWAEGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH HLPSAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ GHLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML VAVKALKEVSESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR LQALAQAPPVYLDVLG NT seq 2391 nt NT seq  +upstreamnt  +downstreamnt atgctgcgaggaggacggcgcgggcagcttggctggcacagctgggctgaggggccgggc agcctgctggcttggctgatactggcatctgcgggcgccgcaccctgccccgatgcctgc tgcccccacggctcctcgggactgcgatgcacccgggatggggccctggatagcctccac cacctgcccagcgcagagaacctgactgagctctacatcgagaaccagcagcatctgcag catctggagctccgtgacctgaggggcctgggggagctgagaaacctcaccatcgtgaag agtggtctccgtttcgtggcgccagacgccttccatttcactcctcggctcagtcgcctg aatctctccttcaacgctctggagtctctctcctggaaaactgtgcagggcctctcctta caggaactggtcctgtcggggaaccctctgcactgttcctgtgccctgcgctggctacag cgctgggaggaggagggactgggcggagtgcctgaacagaagctgcagtgtcacgggcaa gggcacctggcccatatgcccaatgccagctgtggtgtgcccacgctgaaggtccaggtg cccaatgcctcggtggatgtgggggacgacgtgctgctgcggtgccaggtggaggggcgg ggcctggagcaggccggctggatcctcacggagctggagcagtcagccacagtgatgaaa tctgggggtctgccatccctggggctgaccctggccaatgtcaccagtgacctcaacagg aagaatgtgacgtgctgggcagagaacgatgtgggccgggcagaggtctctgttcaggtc aacgtctccttcccggccagtgtgcagctgcacacagcggtggagatgcaccactggtgc atccccttctctgtggatgggcagccggcaccatctctgcgctggctcttcaatggctcc gtgctcaatgagaccagcttcatcttcaccgagttcctggagccggcggccaatgagacc gtgcggcacgggtgtctgcgcctcaaccagcccacccacgtcaacaacggcaactacacg ctgctggctgccaaccccttcggccaggcctccgcctccatcatggctgccttcatggac aaccctttcgagttcaaccccgaggaccccatccctgtctccttctcgccagtggacact aacagcacatctggagacccggtggagaagaaggacgaaacaccttttggggtctcggtg gctgtgggcctggccgtctttgcctgcctcttcctttctacgctgctccttgtgctcaac aaatgcggacggagaaacaagtttgggatcaaccgcccggctgtgctggctccagaggac gggctggccatgtccctgcatttcatgacattgggtggcagctccctgtcccccaccgag ggcaaaggctctgggctccaaggccacatcatcgagaacccacaatacttcagtgatgcc tgtgttcaccacatcaagcgccgggacatcgtgctcaagtgggagctgggggagggcgcc tttgggaaggtcttccttgctgagtgccacaacctcctgcctgagcaggacaagatgctg gtggctgtcaaggcattgaaggaggtgtccgagagtgctcggcaggacttccagcgtgag gctgagctgctcaccatgctgcagcaccagcacattgtgcgcttcttcggcgtctgcacc gagggccgccccctgctcatggtctttgagtatatgcggcatggggacctcaaccgcttc ctccgatcccatgggcctgatgccaagctgctggctggtggggaggatgtggctccaggc cccctgggtctggggcagctgctggccgtggctagccaggtcgctgcggggatggtgtac ctggcgggtctgcattttgtgcaccgggacctggccacacgcaactgtctggtgggccag ggactggtggtcaagattggtgattttggcatgagcagggatatctacagcaccgactat taccgtgtgggaggccgcaccatgctgcccattcgctggatgccgcccgagagcatcctg taccgcaagttcaccaccgagagcgacgtgtggagcttcggcgtggtcctctgggagatc ttcacctacggcaagcagccctggtaccagctctccaacacggaggcaatcgactgcatc acgcagggacgtgagttggagcggccacgtgcctgcccaccagaggtctacgccatcatg cggggctgctggcagcgggagccccagcaacgccacagcatcaaggatgtgcacgcccgg ctgcaagccctggcccaggcacctcctgtctacctggatgtcctgggctag

Pongo abelii (Sumatran orangutan): 100454731 Help Entry 100454731         CDS       T01416                                  Gene name FLT3 Definition (RefSeq) receptor-type tyrosine-protein kinase FLT3 isoform X1   KO K05092   fms-related tyrosine kinase 3 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04151   PI3K-Akt signaling pathway pon04640   Hematopoietic cell lineage pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05221   Acute myeloid leukemia pon05230   Central carbon metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100454731 (FLT3)    04014 Ras signaling pathway     100454731 (FLT3)    04151 PI3K-Akt signaling pathway     100454731 (FLT3)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     100454731 (FLT3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100454731 (FLT3)    05202 Transcriptional misregulation in cancer     100454731 (FLT3)    05230 Central carbon metabolism in cancer     100454731 (FLT3)   09162 Cancer: specific types    05221 Acute myeloid leukemia     100454731 (FLT3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100454731 (FLT3)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100454731 (FLT3) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100454731 (FLT3) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    100454731 (FLT3) CD molecules [BR:pon04090]  Proteins   100454731 (FLT3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase ig I-set Ig_3 Ig_2 APH Motif Other DBs NCBI-GeneID:  100454731 NCBI-ProteinID:  XP_024086677 Ensembl:  ENSPPYG00000005244 LinkDB All DBs Position 13 AA seq 993 aa AA seqDB search MPALARGGGRLPLLVVLSAIIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP EDLGCALRPQSAGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDDGYSISKFCNHKHQPGEYIFHA ENDDAQLTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITQ GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIDYENQKRLEEEEDL NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK LIQNGFKMDQPFYATEEIYIIMQACWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG RVSERPHTYQNRRPFSREMDSGPLSPQTQVEDS NT seq 2982 nt NT seq  +upstreamnt  +downstreamnt atgccggcgttggcgcgcggcggcggccggctgccgctgctcgttgttttgtctgcaatc atatttgggactattacaaatcaagatctgcctgtgatcaagtgtgttttaatcaatcat aagaacaatgattcatcagtggggaagtcatcatcatatcccatggtgtcagaatcccca gaagacctcgggtgtgcattgagaccccagagcgcagggacagtgtacgaagctgccgct gtggaagtggatgtatctgcttccatcacattgcaagtgctggttgacgccccagggaac atttcctgtctctgggtctttaagcacagctccctgaattgccagccacattttgattta caaaacagaggagttgtttccatggtcattttgaaaatgacagaaacccaagctggagaa tacctactttttattcagagtgaagctaccaattacacaatattgtttacagtgagtata agaaataccctgctttacacattaagaagaccttactttagaaaaatggaaaaccaggac gccctggtctgcatatctgagagcgttccagagccgatcgtggaatgggtgctttgcgat tcacagggggaaagctgtaaagaagaaagtccagctgttgttaaaaaggaggaaaaagtg cttcatgaattatttgggacggacataaggtgctgtgccagaaatgaactgggcagggaa tgcaccaggctcttcacaatagatctaaatcaaactcctcagaccacattgccacaatta tttcttaaagtaggggaacccttatggataaggtgcaaagctgttcatgtgaaccatgga ttcgggctcacctgggaattagaaaacaaagcactcgaggagggcaactactttgagatg agtacctattcaacaaacagaactatgatacggattctgtttgcttttgtatcatcagtg gcaagaaacgacaccggatactacacttgttcctcttcaaagcatcccagtcaatcagct ttggttaccatcgtagaaaagggatttataaatgctaccaattcaagtgaagattatgaa attgaccaatatgaagagttttgtttttctgtcaggtttaaagcctacccacaaatcaga tgtacgtggaccttctctcgaaaatcatttccttgtgagcaaaagggtctcgatgacgga tacagcatatccaagttttgcaatcataagcaccagccaggagaatatatattccatgca gaaaatgatgatgcccaattgaccaaaatgttcacgctgaatataagaaggaaacctcaa gtgctcgcagaagcatcagcaagtcaggcgtcctgtttctcggatggatacccattacca tcttggacctggaagaagtgttcagacaagtctcccaactgcacagaagagatcacacaa ggagtctggaatagaaaggctaacagaaaagtatttggacagtgggtgtcgagcagtact ctaaacatgagtgaagccataaaagggttcctggtcaagtgctgtgcatacaattccctt ggcacatcttgtgagacgatccttttaaactctccaggccccttccctttcatccaagac aacatctcattctatgcaacaattggtgtttgtctcctcttcattgtcgttttaaccctg ctaatttgtcacaagtacaaaaagcaatttaggtatgaaagccagctacagatggtacag gtgaccggctcctcagataatgagtacttctacgttgatttcagagaatatgaatatgat ctcaaatgggagtttccaagagaaaatttagagtttgggaaggtactaggatcaggtgct tttggaaaagtgatgaacgcaacagcttatggaattagcaaaacaggagtctcaatccag gttgccgtcaaaatgctgaaagaaaaagcagacagctctgaaagagaggcactcatgtca gaactcaagatgatgacccagctgggaagccacgagaatattgtgaatctgctgggggcg tgcacactgtcaggaccaatttacttgatttttgaatactgttgctatggtgatcttctc aactatctaagaagtaaaagagaaaaatttcacaggacttggacagagattttcaaggaa cacaatttcagtttttaccccactttccaatcacatccaaattccagcatgcctggttca agagaagttcagatacacccggactcggatcaaatctcagggcttcatgggaattcattt cactctgaagatgaaattgattatgaaaaccaaaaaaggctggaagaagaggaagacttg aatgtgcttacatttgaagatcttctttgctttgcatatcaagttgccaaaggaatggaa tttctggaatttaagtcgtgtgttcacagagacctggccgccaggaacgtgctcgtcacc cacgggaaggtggtgaagatatgtgactttggattggctcgagatatcatgagtgattcc aactatgttgtcaggggcaatgcccgtctgcctgtaaaatggatggcccctgaaagcctg tttgaaggcatctacaccattaagagtgatgtctggtcatacggaatattactgtgggaa atattctcacttggtgtgaatccttaccctggcattccggttgatgctaacttctacaaa ctgattcaaaatggatttaaaatggatcagccattttatgctacagaagaaatatacatt ataatgcaagcctgctgggcttttgactcaaggaaacggccatccttccctaatttgact tcatttttaggatgtcagctggcagatgcagaagaagcgatgtatcagaatgtggatggt cgtgtttcggaacgtcctcacacctaccaaaacaggcgacctttcagcagagagatggat tcggggccactctctccgcagactcaggtcgaagattcctag

Pongo abelii (Sumatran orangutan): 100456038 Help Entry 100456038         CDS       T01416                                  Gene name NGFR Definition (RefSeq) tumor necrosis factor receptor superfamily member 16   KO K02583   tumor necrosis factor receptor superfamily member 16 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04060   Cytokine-cytokine receptor interaction pon04151   PI3K-Akt signaling pathway pon04215   Apoptosis - multiple species pon04722   Neurotrophin signaling pathway pon05202   Transcriptional misregulation in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100456038 (NGFR)    04014 Ras signaling pathway     100456038 (NGFR)    04015 Rap1 signaling pathway     100456038 (NGFR)    04151 PI3K-Akt signaling pathway     100456038 (NGFR)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     100456038 (NGFR)  09140 Cellular Processes   09143 Cell growth and death    04215 Apoptosis - multiple species     100456038 (NGFR)  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     100456038 (NGFR)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     100456038 (NGFR)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04050 Cytokine receptors [BR:pon04050]     100456038 (NGFR)    04090 CD molecules [BR:pon04090]     100456038 (NGFR) Cytokine receptors [BR:pon04050]  Tumor necrosis factor receptors   TNF receptor superfamily    100456038 (NGFR) CD molecules [BR:pon04090]  Proteins   100456038 (NGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TNFR_16_TM TNFR_c6 Death TPR_21 Motif Other DBs NCBI-GeneID:  100456038 NCBI-ProteinID:  XP_024091423 LinkDB All DBs Position 17 AA seq 427 aa AA seqDB search MEAGATGLAMDGPRLLLLLLLGVSLGGAKEACPTSLYTHSGECCKACNLGEGVAQPCGAN QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVADVVTTVMGSSQ PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE STATSPV NT seq 1284 nt NT seq  +upstreamnt  +downstreamnt atggaggcaggtgccaccggcctcgccatggacgggccgcgcctgctgctgttgctgctt ctgggggtgtcccttggaggtgccaaggaggcatgccccacaagcctgtacacacacagc ggcgagtgctgcaaagcctgcaacctgggcgagggtgtggcccagccttgtggagccaac cagaccgtgtgtgagccctgcctggacagcgtgacgttctccgacgtggtgagcgcaacc gagccgtgcaagccgtgcaccgagtgcgtggggcttcagagcatgtcggcgccgtgcgtg gaggccgacgacgccgtgtgccgctgcgcctacggctactaccaggatgagacgactggg cgctgcgaggcgtgccgcgtgtgcgaggcgggctcgggcctcgtgttctcgtgccaagac aagcagaacaccgtgtgcgaggagtgccccgacggcacgtattccgacgaggccaaccac gtggacccgtgcctgccctgcaccgtgtgcgaggacaccgagcgccagctccgcgagtgc acacgctgggccgacgccgagtgcgaggagatccctggccgttggattacacggtccaca cccccggagggctcggacagcacagcccccagcacccaggagcctgaggcacctccagaa caagacctcatagccagcacggtggcagatgtggtgaccacagtgatgggcagctcccag cctgtggtgacccgaggcaccaccgacaacctcatccctgtctattgctccatcctggct gctgtggttgtgggccttgtggcctacatagccttcaagaggtggaacagctgcaagcaa aacaagcaaggagccaacagccggccagtgaaccagacgcccccaccagagggagaaaaa ctccacagcgacagtggcatctccgtggacagccagagcctgcatgaccagcagccccat acgcagacagcctcgggccaggccctcaagggtgacggaggcctctacagcagcctgccc ccagccaagcgggaggaggtggagaagcttctcaacggctctgcaggggacacctggcgg cacctggcgggcgaactgggctaccagcccgagcacatagactcctttacccatgaggcc tgccccgttcgtgccctgcttgcaagctgggccacccaggacagcgccacactggacgcc ctcctggccgccctgcgccgcatccagcgagccgaccttgtggagagtctgtgcagtgag tccactgccacgtccccggtgtga

Pongo abelii (Sumatran orangutan): 100456061 Help Entry 100456061         CDS       T01416                                  Gene name FLT1 Definition (RefSeq) vascular endothelial growth factor receptor 1 isoform X1   KO K05096   FMS-like tyrosine kinase 1 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04066   HIF-1 signaling pathway pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon05202   Transcriptional misregulation in cancer pon05323   Rheumatoid arthritis Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100456061 (FLT1)    04014 Ras signaling pathway     100456061 (FLT1)    04015 Rap1 signaling pathway     100456061 (FLT1)    04066 HIF-1 signaling pathway     100456061 (FLT1)    04020 Calcium signaling pathway     100456061 (FLT1)    04151 PI3K-Akt signaling pathway     100456061 (FLT1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100456061 (FLT1)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     100456061 (FLT1)   09163 Immune disease    05323 Rheumatoid arthritis     100456061 (FLT1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100456061 (FLT1) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100456061 (FLT1) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   VEGFR family [OT]    100456061 (FLT1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Ig_3 I-set Pkinase ig Ig_2 V-set VEGFR-2_TMD Ig_6 Ig_4 C1-set Ig_5 Herpes_gE Adeno_E3_CR1 Marek_A Motif Other DBs NCBI-GeneID:  100456061 NCBI-ProteinID:  XP_024086675 Ensembl:  ENSPPYG00000005246 LinkDB All DBs Position 13 AA seq 1338 aa AA seqDB search MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHVMQAGQTLHLQCRGEAAHK WSLPETVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK VQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKHQVLETVAGKRSYRLSMKVK AFPSPEVVWLKEGLPATEKSARYLTRGYSLIIKDLTEEDAGNYTILLSIKQSNVFKNLTA TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKTASTLVVADSRISGIYICIASNK VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDITWILLRTVNNRTM HYSISKQKMAITKEHSITLNLTIMNVSLEDSGTYACRARNVYTGEEILQKKEITIRDQEA PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIER VTEDDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK QGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSV TSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIH RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD PKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKEGISA PKFNSGSSDDVRYVNAFKFMSLERIKTVEELLPNATSMFDDYQGDSSTLLASPMLKRFTW TDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHISEGKRRFTYDNAELERKIAC CSPPPDYNSVVLYSTPPI NT seq 4017 nt NT seq  +upstreamnt  +downstreamnt atggtcagctactgggacaccggggtcctgctgtgcgcgctgctcagctgtttgcttctc acaggatctagttcaggttcaaaattaaaagatcctgaactgagtttaaaaggcacccag cacgtcatgcaagcaggccagacactgcatctccaatgcaggggggaagcagcccataaa tggtctttgcctgaaacggtgagtaaggaaagcgaaaggctgagcataactaaatctgcc tgtggaagaaatggcaaacaattctgcagtactttaaccttgaacacagctcaagcaaac cacactggcttctacagctgcaaatatctagctgtacctacttcaaagaagaaggaaaca gaatctgcaatctatatatttattagtgatacaggtagacctttcgtagagatgtacagt gaaatccccgaaattatacacatgactgaaggaagggagctcgtcattccctgccgggtt acgtcacctaacatcactgttactttaaaaaagtttccacttgacactttgatccctgat ggaaaacgcatcatctgggacagtagaaagggcttcatcatatcaaatgcaacgtacaaa gaaatagggcttctgacctgtgaagcaacagtcaatgggcatttgtataagacaaactat ctcacacatcgacaaaccaatacaatcatagatgtccaaataagcacaccacgcccagtc aaattacttagaggccatactcttgtcctcaattgtactgctaccactcccttgaacacg agagttcaaatgacctggagttaccctgatgaaaaaaataagagagcttctgtaaggcga cgaattgaccaaagcaattcccatgccaacatattctacagtgttcttactattgacaaa gtgcagaacaaagacaaaggactttatacttgtcgtgtaaggagtggaccatcattcaaa tctgttaacacctcagtgcatatatatgataaagcattcatcactgtgaaacatcgaaaa catcaggtgctcgaaaccgtagctggcaagcggtcttaccggctctctatgaaagtgaag gcatttccctcgccggaagttgtatggttaaaagaggggttacctgcaactgagaaatct gctcgctatttgactcgtggctactcgttaattatcaaggacttaactgaagaggatgca gggaattatacaatcttgctgagcataaaacagtcaaatgtgttcaaaaacctcactgcc actctaattgtcaatgtgaaaccccagatttacgaaaaggccgtgtcatcgtttccagac ccagctctctacccactgggcagcagacaaatcctgacttgtaccgcatatggtatccct caacctacaatcaagtggttctggcacccctgtaaccataatcattccgaagcaaggtgt gacttttgttccaataatgaagagtcctttatcctggatgctgacagcaacatgggaaac agaattgagagcatcactcagcgcatggcaataatagaaggaaagaataagacggctagc accttggttgtggctgactctagaatttctggaatctacatttgcatagcttccaataaa gttgggactgtgggaagaaacataagcttttatatcacagatgtgccaaatgggtttcat gttaacttggaaaaaatgccgacggaaggagaggacctgaaactgtcttgcacagttaac aagttcttatacagagacatcacttggattttactgcgcacagttaataacagaacaatg cactacagtattagcaagcaaaaaatggccatcactaaggagcactccatcactcttaat cttaccatcatgaatgtttccctggaagattcaggcacctatgcctgcagagccaggaat gtatacacaggggaagaaatcctccagaagaaagaaattacaatcagagatcaggaagca ccatacctcctgcgaaacctcagtgatcacacagtggccatcagcagttctaccacttta gactgtcatgctaatggtgtccccgagcctcagatcacttggtttaaaaacaaccacaaa atacaacaagagcctggaattattttaggaccaggaagcagcacgctgtttattgaaaga gtcacagaagatgatgaaggtgtctatcactgcaaagccaccaaccagaagggctctgtg gaaagttcagcatacctcactgttcaaggaacctcggacaagtctaatctggagctgatc actctaacatgcacctgtgtggctgcgactctcttctggctgctattaaccctctttatc cgaaaaatgaaaaggtcttcttctgaaataaagactgactacctatcaattataatggac ccagatgaagttcccttggatgagcagtgtgagcggctcccttatgatgccagcaagtgg gagtttgcccgggagagacttaaactgggcaaatcacttggaagaggggcttttggaaaa gtggttcaagcatcagcatttggcattaagaaatcacctacgtgccggactgtggctgtg aaaatgctgaaagagggggccacggccagcgagtacaaagctctgatgactgagctcaaa atcttgacccacattggccaccatctgaacgtggttaacctgctgggagcctgcaccaag caaggagggcctctgatggtgattgttgaatactgcaaatatggaaatctctccaactac ctcaagagcaaacgtgacttattttttctcaacaaggatgcagcattacacatggagcct aagaaagaaaaaatggagccaggcctggaacaaggcaagaaaccaagactagatagcgtc accagcagcgagagctttgcgagctccgggtttcaggaagataaaagtctgagtgatgtt gaggaagaggaggattctgacggtttctacaaggagcccatcactatggaagatctgatt tcttacagttttcaagtggccagaggcatggagttcctgtcttctagaaagtgcattcat cgggacctggcagcgagaaacattcttttatctgagaacaacgtggtgaagatttgtgat tttggcctcgcccgggatatttataagaaccccgattatgtgagaaaaggagatactcga cttcctctgaaatggatggctcctgaatctatctttgacaaaatctacagcaccaagagc gacgtgtggtcttacggagtattgctgtgggaaatcttctccttaggtgggtctccatac ccaggagtacaaatggatgaggacttttgcagtcgcctgagggaaggcatgaggatgaga gctcctgagtactctactcctgaaatctatcagatcatgctggactgctggcacagagac ccaaaagaaaggccaagatttgcagaacttgtggaaaaactaggtgatttgcttcaagca aatgtacaacaggatggtaaagactacatcccaatcaatgccatactgacaggaaatagt gggtttacatactcaactcctgccttctctgaggacttcttcaaggaaggtatttcagct ccgaagtttaattcaggaagctctgatgatgtcagatatgtaaatgctttcaagttcatg agcctggaaagaatcaaaaccgttgaagaacttttaccaaatgccacctccatgtttgat gactaccagggggacagcagcactctgttggcctctcccatgctgaagcgcttcacctgg actgacagcaaacccaaggcctcgctcaagattgacttgagagtaaccagtaagagtaag gagtcggggctatctgatgtcagcaggcccagtttctgccattccagctgtgggcacatc agcgaaggcaagcgcaggttcacctacgacaacgctgagctggaaaggaaaatcgcgtgc tgctccccacccccagactacaactcggtggtcctgtactccaccccacccatctag

Pongo abelii (Sumatran orangutan): 100459280 Help Entry 100459280         CDS       T01416                                  Gene name EGFR Definition (RefSeq) epidermal growth factor receptor isoform X2   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon01522   Endocrine resistance pon04010   MAPK signaling pathway pon04012   ErbB signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04066   HIF-1 signaling pathway pon04068   FoxO signaling pathway pon04072   Phospholipase D signaling pathway pon04144   Endocytosis pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon04520   Adherens junction pon04540   Gap junction pon04630   JAK-STAT signaling pathway pon04810   Regulation of actin cytoskeleton pon04912   GnRH signaling pathway pon04915   Estrogen signaling pathway pon04921   Oxytocin signaling pathway pon04926   Relaxin signaling pathway pon04928   Parathyroid hormone synthesis, secretion and action pon04934   Cushing syndrome pon05160   Hepatitis C pon05163   Human cytomegalovirus infection pon05165   Human papillomavirus infection pon05171   Coronavirus disease - COVID-19 pon05200   Pathways in cancer pon05205   Proteoglycans in cancer pon05206   MicroRNAs in cancer pon05210   Colorectal cancer pon05212   Pancreatic cancer pon05213   Endometrial cancer pon05214   Glioma pon05215   Prostate cancer pon05218   Melanoma pon05219   Bladder cancer pon05223   Non-small cell lung cancer pon05224   Breast cancer pon05225   Hepatocellular carcinoma pon05226   Gastric cancer pon05230   Central carbon metabolism in cancer pon05231   Choline metabolism in cancer pon05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100459280 (EGFR)    04012 ErbB signaling pathway     100459280 (EGFR)    04014 Ras signaling pathway     100459280 (EGFR)    04015 Rap1 signaling pathway     100459280 (EGFR)    04630 JAK-STAT signaling pathway     100459280 (EGFR)    04066 HIF-1 signaling pathway     100459280 (EGFR)    04068 FoxO signaling pathway     100459280 (EGFR)    04020 Calcium signaling pathway     100459280 (EGFR)    04072 Phospholipase D signaling pathway     100459280 (EGFR)    04151 PI3K-Akt signaling pathway     100459280 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100459280 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     100459280 (EGFR)    04520 Adherens junction     100459280 (EGFR)    04540 Gap junction     100459280 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100459280 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     100459280 (EGFR)    04915 Estrogen signaling pathway     100459280 (EGFR)    04921 Oxytocin signaling pathway     100459280 (EGFR)    04926 Relaxin signaling pathway     100459280 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     100459280 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100459280 (EGFR)    05206 MicroRNAs in cancer     100459280 (EGFR)    05205 Proteoglycans in cancer     100459280 (EGFR)    05230 Central carbon metabolism in cancer     100459280 (EGFR)    05231 Choline metabolism in cancer     100459280 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100459280 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     100459280 (EGFR)    05212 Pancreatic cancer     100459280 (EGFR)    05225 Hepatocellular carcinoma     100459280 (EGFR)    05226 Gastric cancer     100459280 (EGFR)    05214 Glioma     100459280 (EGFR)    05218 Melanoma     100459280 (EGFR)    05219 Bladder cancer     100459280 (EGFR)    05215 Prostate cancer     100459280 (EGFR)    05213 Endometrial cancer     100459280 (EGFR)    05224 Breast cancer     100459280 (EGFR)    05223 Non-small cell lung cancer     100459280 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100459280 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     100459280 (EGFR)    05171 Coronavirus disease - COVID-19     100459280 (EGFR)    05163 Human cytomegalovirus infection     100459280 (EGFR)    05165 Human papillomavirus infection     100459280 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100459280 (EGFR)    01522 Endocrine resistance     100459280 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100459280 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pon04147]     100459280 (EGFR) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100459280 (EGFR) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    100459280 (EGFR) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    100459280 (EGFR)   Exosomal proteins of pancreatic cancer cells    100459280 (EGFR)   Exosomal proteins of bladder cancer cells    100459280 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Recep_L_domain GF_recep_IV Furin-like Motif Other DBs NCBI-GeneID:  100459280 NCBI-ProteinID:  XP_002817983 LinkDB All DBs Position 7 AA seq 628 aa AA seqDB search MRSSRTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN ILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM GENNTLVWKYADAGHVCHLCHPNCTYGS NT seq 1887 nt NT seq  +upstreamnt  +downstreamnt atgcgatcctcccggacggccggggcagcgctcctggcgctgctagctgcgctctgcccg gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg gtccttgggaatctggaaattacctatgtacagaggaattatgatctttccttcttaaag accatccaggaggtggctggttatgtcctcatcgccctcaacacagtggagcggattcct ttggaaaacctgcagatcatcagaggaaatatgtactatgaaaattcctatgccttagca gtcttatctaactatgatgcaaataaaaccggactaaaggagctgcccatgagaaattta caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag agcatccagtggcgggacatagtcagcagcgactttctcagcaacatgtcgatggacttc cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctct gggcgctgccgcggcaaatcccccagtgactgctgccacaaccagtgtgccgctggctgc acgggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc aaggacacctgccccccactcatgctctacaaccccaccacataccagatggatgtgaac cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata ggtattggtgaatttaaagacacactctccataaatgctacgaatattaaacacttcaaa aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc ttcacacacactccacctctggatccacaggaactggatattctgaaaaccgtaaaggaa atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgctttt gagaacctagaaatcatacgcggcaggaccaagcaacatgggcagttttctcttgcagtc gtcagcctgaacataacatccttgggattacgctccctcaaggagataagcgatggagat gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc agggactgcgtctcctgccggaatgtcagccgaggcagagaatgcgtggacaagtgcaac attctggagggcgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca gaatgcctgccccaggccatgaacatcacctgcacgggacggggaccagacaactgtatc cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg ggagaaaacaacaccctggtctggaagtacgcagacgccggccacgtgtgccacctgtgc catccaaactgcacctacgggtcctaa

Pongo abelii (Sumatran orangutan): 100460001 Help Entry 100460001         CDS       T01416                                  Gene name PDGFRB Definition (RefSeq) platelet-derived growth factor receptor beta isoform X1   KO K05089   platelet-derived growth factor receptor beta [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04072   Phospholipase D signaling pathway pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon04540   Gap junction pon04630   JAK-STAT signaling pathway pon04810   Regulation of actin cytoskeleton pon05165   Human papillomavirus infection pon05200   Pathways in cancer pon05206   MicroRNAs in cancer pon05214   Glioma pon05215   Prostate cancer pon05218   Melanoma pon05230   Central carbon metabolism in cancer pon05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100460001 (PDGFRB)    04014 Ras signaling pathway     100460001 (PDGFRB)    04015 Rap1 signaling pathway     100460001 (PDGFRB)    04630 JAK-STAT signaling pathway     100460001 (PDGFRB)    04020 Calcium signaling pathway     100460001 (PDGFRB)    04072 Phospholipase D signaling pathway     100460001 (PDGFRB)    04151 PI3K-Akt signaling pathway     100460001 (PDGFRB)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100460001 (PDGFRB)    04540 Gap junction     100460001 (PDGFRB)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100460001 (PDGFRB)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100460001 (PDGFRB)    05206 MicroRNAs in cancer     100460001 (PDGFRB)    05230 Central carbon metabolism in cancer     100460001 (PDGFRB)    05231 Choline metabolism in cancer     100460001 (PDGFRB)   09162 Cancer: specific types    05214 Glioma     100460001 (PDGFRB)    05218 Melanoma     100460001 (PDGFRB)    05215 Prostate cancer     100460001 (PDGFRB)   09172 Infectious disease: viral    05165 Human papillomavirus infection     100460001 (PDGFRB)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100460001 (PDGFRB)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100460001 (PDGFRB)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100460001 (PDGFRB) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100460001 (PDGFRB) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   PDGFR family [OT]    100460001 (PDGFRB) CD molecules [BR:pon04090]  Proteins   100460001 (PDGFRB) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase ig Ig_3 I-set Ig_2 V-set C1-set Ig_6 TrmE_N Motif Other DBs NCBI-GeneID:  100460001 NCBI-ProteinID:  XP_002816120 Ensembl:  ENSPPYG00000015943 UniProt:  A0A663D6Y7 H2PH25 LinkDB All DBs Position 5 AA seq 1106 aa AA seqDB search MRLLGAMPALALKGQLLLLPLLLLLEPQVSQGLVITPPGPELVLNVSSTFVLTCSGSAPV VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLEPDERKRLYIFV PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDIALPVPYDHQRGFS GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV EPEPELEQLPDSGCPAPRVEAEDSFL NT seq 3321 nt NT seq  +upstreamnt  +downstreamnt atgcggcttctgggtgcgatgccagctctggccctcaaaggccagctgctgttgctgccc ctcctgttactgctggaaccacaggtctctcagggcctggtcatcacacccccagggcca gagcttgtcctcaatgtctccagcaccttcgttctgacctgctctggttcagctccggtg gtgtgggaacggatgtcccaggagcccccacaggaaatggccaaggcccaggatggcacc ttctccagcgtgctgacactgaccaacctcactgggctagacacgggagaatacttttgc acccacaatgactcccgtggactggagcctgatgagcggaaacggctctacatctttgtg ccagatcccactgtgggcttcctccctaatgatgccgaggaactattcatctttctcacg gaaataactgagatcaccattccatgccgagtaacagacccacagctggtggtgacactg cacgagaagaaaggggacattgcactgcctgtcccctatgatcaccaacgtggcttttct ggtatctttgaggacagaagctacatctgcaaaaccaccattggggacagggaggtggat tccgatgcctactatgtctacagactccaggtgtcatctatcaacgtctctgtgaacgca gtgcagactgtggtccgccagggtgagaacatcaccctcatgtgcattgtgatcgggaat gaggtggtcaacttcgagtggacatacccccgcaaagaaagtgggcggctggtggagccg gtgaccgacttcctcttggatatgccttaccacatccgctccatcctgcacatccccagt gccgagttagaagactcggggacctacacctgcaatgtgacggagagtgtgaatgaccat caggatgaaaaggccatcaacatcaccgtggttgagagtggctacgtgcggctcctggga gaagtgggcacactgcaatttgctgagctgcatcggagccggacactgcaggtagtattc gaggcctacccaccgcccaccgtcctgtggtttaaagacaaccgcaccctgggcgactcc agcgctggcgagatcgccctgtccacgcgcaacgtgtcggagacccggtatgtgtcagag ctgacactggttcgcgtgaaggtggcagaggctggccactacaccatgcgggccttccat gaggacgctgaggtccagctctccttccagctacagatcaatgtccctgtccgagtgctg gagctaagtgagagccaccctgacagcggggaacagacagtccgctgtcgtggccggggc atgccccagccgaacatcatctggtccgcctgcagagacctcaaaaggtgtccacgcgag ctgccgcccacgctgctggggaacagttccgaagaggagagccagctggagacgaacgtg acgtactgggaggaggagcaggagtttgaggtggtgagcacactgcgtctgcagcacgtg gatcggccgctgtcggtgcgctgcacgctgcgcaacgctgtgggccaggacacgcaggag gtcatcgtggtgccacactccttgccctttaaggtggtggtgatctcagccatcctggcc ctggtggtgctcaccatcatctcccttatcatcctcatcatgctttggcagaagaagcca cgttacgagatccgatggaaggtgattgagtctgtgagctctgacggccatgagtacatc tacgtggaccccatgcagctgccctatgactccacgtgggagctgccgcgggaccagctt gtgctgggacgcaccctcggctctggggcctttgggcaggtggtggaggccacggctcat ggcctgagccattctcaggccacgatgaaagtggccgtcaagatgcttaaatccacagcc cgcagcagtgagaagcaagcccttatgtcggagctgaagatcatgagtcaccttgggccc cacctgaacgtggtcaacctgttgggggcctgcaccaaaggaggacccatctatatcatc actgagtactgccgctacggagacctggtggactacctgcaccgcaacaaacacaccttc ctgcagcaccactctgacaagcgccgcccgcccagcgcggagctctacagcaatgcactg cccgttgggctccccctgcccagccatgtgtccttgactggggagagcgacggtggctac atggacatgagcaaggacgagtcggtggactacgtacccatgctggacatgaaaggagac gtcaaatatgcagacatcgagtcctccaattacatggccccttacgataactacgttccc tctgcccctgagaggacctgtcgggcaactttgatcaacgagtctccagtgctaagctac atggacctcgtgggcttcagctaccaggtggccaatggcatggagtttctggcctccaag aactgcgtccacagagacctggcggctaggaacgtgctcatctgtgaaggcaagctggtc aagatctgtgactttggcctggctcgagacatcatgcgggactcgaattacatctccaaa ggcagcacctttttgcctttgaagtggatggctccggagagcatcttcaacagcctctac accaccctgagcgacgtgtggtccttcgggatcctgctctgggagatcttcaccttgggt ggcaccccttacccagagctgcccatgaatgaacagttctacaatgccatcaaacggggt taccgcatggcccagcctgcccatgcctccgatgagatctatgagatcatgcagaagtgc tgggaagagaagtttgagattcggccccccttctcccagctggtgctgcttctcgagaga ctgttgggcgaaggttacaaaaagaagtaccagcaggtggatgaggagtttctgaggagt gaccacccagccatccttcggtcccaggcccgcttgcctgggttccatggcctccgatct cccctggacaccagctccgtcctctatactgccgtgcagcccaatgagggtgacaacgac tatatcatccccctgcccgaccccaaacccgaggttgctgacgagggcccactggagggt tcccccagcctagccagctccaccctgaatgaagtcaacacctcctcaaccatctcctgt gacagccccctggagccccaggatgaaccagagccagagccccagcttgagctccaggtg gagccagagccggagctggaacagctgccggattcagggtgccctgcgcctcgggtggaa gcagaggacagcttcctgtag

Pongo abelii (Sumatran orangutan): 100461105 Help Entry 100461105         CDS       T01416                                  Gene name FGFR4 Definition (RefSeq) fibroblast growth factor receptor 4 isoform X1   KO K05095   fibroblast growth factor receptor 4 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04144   Endocytosis pon04151   PI3K-Akt signaling pathway pon04550   Signaling pathways regulating pluripotency of stem cells pon04810   Regulation of actin cytoskeleton pon05200   Pathways in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100461105 (FGFR4)    04014 Ras signaling pathway     100461105 (FGFR4)    04015 Rap1 signaling pathway     100461105 (FGFR4)    04020 Calcium signaling pathway     100461105 (FGFR4)    04151 PI3K-Akt signaling pathway     100461105 (FGFR4)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100461105 (FGFR4)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100461105 (FGFR4)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100461105 (FGFR4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100461105 (FGFR4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100461105 (FGFR4)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100461105 (FGFR4) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100461105 (FGFR4) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   FGFR family [OT]    100461105 (FGFR4) CD molecules [BR:pon04090]  Proteins   100461105 (FGFR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Ig_3 I-set Ig_2 ig V-set C2-set_2 Kinase-like Motif Other DBs NCBI-GeneID:  100461105 NCBI-ProteinID:  XP_024103320 Ensembl:  ENSPPYG00000016083 LinkDB All DBs Position 5 AA seq 802 aa AA seqDB search MWLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLSEDAGRYLCLARGSMIVLQNLTLIIDDS LTSSNDDKDPKSHMDSSNRHIYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMP TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHDRHPRPPATVQKLSRFPLARQFSL ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS VFSHDPLPLGSSSFPFGSGVQT NT seq 2409 nt NT seq  +upstreamnt  +downstreamnt atgtggctgctgctggccctgttgggggtcctgctgagtgtgcctgggcctccagtcttg tccctggaggcctctgaggaagtggagctggagccctgcctggctcccagcctggagcag caagagcaggagctgacagtagcccttgggcagcctgtgcggctgtgctgtgggcgggct gagcgtggtggccactggtacaaggagggcagtcgcctggcacctgccggccgtgtacgg ggctggaggggccgcctagagattgccagcttcctatctgaggatgctggccgctacctc tgcctggcacgaggctccatgatcgtcctgcagaatctcaccttgattatagatgactcc ttgacctccagcaacgatgataaggaccccaagtcccatatggactcctcgaataggcac atttacccccagcaagcaccttactggacacacccccagcgcatggagaagaaactgcat gcagtacctgcggggaacaccgtcaagttccgctgtccagctgcaggcaaccccatgccc accatccgctggcttaaggatggacaggcctttcatggggagaaccgcattggaggcatt cggctgcgccatcagcactggagtctcgtgatggagagcgtggtaccctcggaccgcggc acgtacacctgcctggtagagaatgctgtgggcagcatccgctataactacctgctagat gtgctggagcggtccccgcaccggcccatcctgcaggccgggctcccggccaacaccaca gccgtggtgggcagtgacgtggagctgctgtgtaaggtgtacagcgatgcccagccccac atccagtggctgaagcacatcgtcatcaacggcagcagcttcggagccgacggtttcccc tatgtgcaagtcctaaagactgcagacatcaatagctcagaggtggaggtcctgtacctg cggaacgtgtcagccgaggatgcaggcgagtacacctgcctcgcaggcaattccatcggc ctctcctaccagtctgcctggctcacggtgctgccagaggaggaccccacatggaccgca gcagcgcccgaggccaggtatacggacatcatcctgtacgcgtcgggctccctggccttg gctgtgctcctactgctggccgggctgtatcgagggcaggcgctccacgaccggcacccc cgcccgcccgccactgtgcagaagctctcccgcttccctctggcccgacagttctccctg gagtcaggctcttccggcaagtcaagctcatccctagtacgaggcgtgcgtctctcctcc agcggccccgccttgctcgccggcctcgtgagtctagatctacctctcgacccactatgg gagttcccccgggacaggctggtgcttggaaagcccctgggcgagggctgctttggccag gtagtacgtgcagaggcctttggcatggaccctgcccggcctgaccaagccagcactgtg gccgtcaagatgctcaaagacaacgcctccgacaaggacctggccgacctggtctcggag atggaggtgatgaagctgattggccgacacaagaacatcatcaacctgctgggtgtctgc acccaggaagggcccctgtatgtgatcgtggagtgcgccgccaagggaaacctgcgggag ttcctgcgggcccggcgccccccaggccccgacctcagccctgacggtcctcggagcagt gaggggccgctctccttcccagtcctggtctcctgcgcctaccaggtggcccgaggcatg cagtatctggagtcccggaagtgtatccaccgggacctggctgcccgcaatgtgctggtg accgaggacaatgtgatgaagattgctgactttgggctggcccgcggcgtccaccacatt gactactataagaaaaccagcaatggccgcctgcctgtcaagtggatggcgcccgaggcc ttgtttgaccgggtgtacacacaccagagtgacgtgtggtcttttgggatcctactgtgg gagatcttcaccctcgggggctccccgtatcctggcatcccggtggaggagctgttctcg ctgctgcgggagggacatcggatggaccgacccccacactgccccccagagctgtacggg ttgatgcgtgagtgctggcacgcggcaccctcccagaggcctaccttcaagcaactggtg gaggcgctggacaaggtcctgctggccgtctctgaggagtacctcgacctccgcctgacc ttcggaccctattccccctctggtggggacgccagcagcacctgctcctccagcgattct gtcttcagccacgaccccctgccactgggatccagctccttccccttcgggtctggggtg cagacatga

Pongo abelii (Sumatran orangutan): 100462098 Help Entry 100462098         CDS       T01416                                  Gene name FLT4 Definition (RefSeq) vascular endothelial growth factor receptor 3 isoform X1   KO K05097   FMS-like tyrosine kinase 4 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04510   Focal adhesion pon05200   Pathways in cancer pon05224   Breast cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100462098 (FLT4)    04014 Ras signaling pathway     100462098 (FLT4)    04015 Rap1 signaling pathway     100462098 (FLT4)    04020 Calcium signaling pathway     100462098 (FLT4)    04151 PI3K-Akt signaling pathway     100462098 (FLT4)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100462098 (FLT4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100462098 (FLT4)   09162 Cancer: specific types    05224 Breast cancer     100462098 (FLT4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100462098 (FLT4) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100462098 (FLT4) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   VEGFR family [OT]    100462098 (FLT4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Ig_3 I-set Pkinase Ig_2 ig VEGFR-2_TMD V-set Ig_6 C1-set Motif Other DBs NCBI-GeneID:  100462098 NCBI-ProteinID:  XP_024102878 Ensembl:  ENSPPYG00000016139 LinkDB All DBs Position 5 AA seq 1363 aa AA seqDB search MQRGAALCLQLWLCLGLLDGLASGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLREVHANDTGSYVCYYKYIKARI EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG QEVVWDDRRGMLVSTPLLRDALYLQCETTWGDRDFLSNPFLVHITGNELYDIQLLPRKSL ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV SQHDLGSYVCEANNGIQRFRESTEVIVHEKPFINVEWLKGPILEATAGDELVKLPVKLAA YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQR DLMPQCRDWRVVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV GQDERLIYFYVTTIPDGFSIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF PRERLHLGRVLGYGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKIL IHIGNHLNVVNLLGACTKPKGPLMVIVEYCKYGNLSNFLRAKRETFRPYAEKSPEQRGRF RAMVELARLDRRRPGSSDRVLFARFSKNQGGARRASPDQEAEDLWLSPLTLEDLVCYSFQ VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQQLRDGTRMRAPELA TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEDEVCMAPRGSQSSEEGSFS QVSTMALHIVQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAQTRGSSRMKTFEEFPM TPTTYKASVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVDVTRAHPDSQGRRR RPDRGARGGQVFYNSEYGELSEPSKEDHCSPSARVTFFTDNSY NT seq 4092 nt NT seq  +upstreamnt  +downstreamnt atgcagcggggcgccgcgctgtgcctgcaactgtggctgtgcctgggactcctggacggc ctggcgagtggctactccatgacccccccaaccttgaacatcacggaggagtcacacgtc atcgacaccggtgacagcctgtccatctcctgcaggggacagcaccccctcgagtgggcc tggccaggagctcaggaggcaccagccactggggacaaggacagcgaggacacgggggtg gtgcgagactgcgagggcacagacgccaggccctactgcaaggtgttgctgctgcgcgag gtgcacgccaacgacacaggcagctacgtctgctactacaagtacatcaaggcccgcatc gagggcaccacggctgccagctcctacgtgttcgtgagagactttgagcagccattcatc aacaagcctgacacgctcttggtcaacaggaaggacgccatgtgggtgccctgtctggtg tccatccccggcctcaatgtcacgctgcgctcgcaaagctcggtgctgtggccagacggg caggaggtggtgtgggacgaccggcggggcatgctggtgtccacaccgctgctgcgcgac gccctgtacctgcagtgcgagaccacctggggggaccgggacttcctttccaaccccttc ctggtacacatcacaggcaacgagctctatgacatccagctgttgcccaggaagtcgctg gagctgctggtaggggagaagctggtcctgaactgcaccgtgtgggctgagttcaactcg ggtgtcacctttgactgggactacccggggaagcaggcagagcggggtaagtgggtgccc gagcgacgctcccagcagacccacacagaactctccagcatcctgaccatccacaacgtc agccagcacgacctgggctcgtatgtgtgcgaggccaacaacggcatccagcgatttcgg gagagcaccgaggtcattgtgcatgaaaagcccttcatcaacgtcgagtggctcaaagga cccatcctggaggccacggcaggagacgagctggtgaagctgcccgtgaagctggcagcg taccccccgcccgagttccagtggtacaaggatggaaaggcactgtccgggcgccacagt ccacatgccctggtgctcaaggaggtgacagaggccagcacgggcacctacaccctcgcc ttgtggaactccgctgctggcctgaggcgcaacatcagcctggagctggtggtgaatgtg cccccccagatacacgagaaggaggcctcctcccccagcatctactcgcgtcacagccgc caggccctcacctgcacggcctacggggtgcccctgcctctcagcatccagtggcactgg cggccctggacaccctgcaagatgtttgcccagcgcagtctccggcggcggcagcagcga gacctcatgccacagtgccgcgactggagggtggtgaccacgcaggatgccgtgaacccc atcgagagcctggacacctggaccgagtttgtggagggaaagaataagactgtgagcaag ctggtgatccagaatgccaacgtgtccgccatgtacaagtgtgtggtctccaacaaggtg ggccaggatgagcggctcatctacttctatgtgaccaccatccccgacggcttcagcatc gaatccaagccatccgaggaactactagagggccagcccgtgctcctgagctgccaagcc gacagctacaagtacgagcatctgcgctggtaccgcctcaacctgtccacgctgcacgat gcgcacgggaacccgctgctgctagactgcaagaacgtgcatctgttcgccacccctctg gccgccagcctggaggaggtggcgcctggggcgcgccacgccacgctcagcctgagtatc ccccgcgtcgcgcccgagcacgagggccactatgtgtgcgaagtgcaagaccggcgcagc catgacaagcactgccacaagaagtacctgtcggtgcaggccctggaagcccctcggctc acgcagaacttgaccgatctcctggtgaacgtgagcgactcactggagatgcagtgcttg gtggccggagcgcacgcgcccagcatcgtgtggtacaaagacgagaggctgctggaggaa aagtctggagtcgacttggcggactccaaccagaagctgagcatccagcgcgtgcgcgag gaggatgcgggacgctatctgtgcagcgtgtgcaacgccaagggctgcgtcaactcctcc gccagcgtggccgtggaaggctccgaggataaaggcagcatggagatcgtgatccttgtc ggtaccggcgtcatcgctgtcttcttctgggtcctcctcctcctcatcttctgtaacatg aggaggccggcccacgcagacatcaagacgggctacctgtccatcatcatggaccccggg gaggtgcctctggaggagcaatgcgaatacctgtcctacgacgccagccagtgggaattc ccccgagagcggctgcacctggggagagtgctcggctacggcgccttcgggaaggtggtg gaagcctccgctttcggcatcaacaagggcagcagctgtgacaccgtggccgtgaaaatg ctgaaagagggcgccacagccagcgagcaccgcgcgctgatgtcggagctcaagatccta attcacatcggcaaccacctcaacgtggtcaacctcctgggggcgtgcaccaagccgaag ggccccctcatggtgatcgtggagtattgcaagtacggcaacctctccaacttcctgcgc gccaagcgggagaccttcaggccctatgcagagaagtctcccgagcagcgcggacgcttc cgcgccatggtggagctcgccaggctggatcggaggaggccagggagcagcgacagggtc ctcttcgcacggttctcgaagaaccagggcggagcgaggcgggcttctccagaccaagaa gctgaggacctgtggctgagcccgctgaccttggaagaccttgtctgctacagcttccag gtggccagaggaatggagttcctggcttcccgaaagtgcatccacagagacctggctgct cggaacattctgctgtcagaaagcgacgtggtgaagatctgtgactttggccttgcccgg gacatctacaaagaccctgactacgtccgcaagggcagtgcccggctgcccctgaagtgg atggcccctgaaagcatcttcgacaaggtgtacaccacgcagagtgacgtgtggtccttt ggggtgcttctctgggagatcttctctctgggggcctccccataccctggggtgcagatc aatgaggagttctgtcagcagctgagagacggcacaaggatgagggccccggagctggcc actcccgccatacgccgcatcatgctgaactgctggtccggagaccccaaggcgagacct gcattctcggagctggtggagatcctgggggacctgctccagggcaggggtctgcaagag gaagacgaggtctgcatggccccgcgcggctctcagagctcagaagagggcagcttctcg caggtgtccaccatggccctacacatcgtccaggctgacgctgaggacagcccaccaagc ctgcagcgccacagcctggccgccaggtattacaactgggtgtcctttcccgggtgcctg gccagaggggctcagacccgtggttcctccaggatgaagacatttgaggaattccccatg accccaacaacctacaaagcctctgtggacaaccagacagacagtgggatggtgctggcc tcggaggagtttgagcagatagagagcaggcatagacaagaaagcggcttcagctgtaaa ggacctggccagaatgtggatgtgaccagggcacaccctgactcccaagggaggcggcgg cggcctgaccggggggcccgaggaggccaggtgttttacaacagcgagtatggggagctg tcggagccaagcaaggaggaccactgctccccatctgcccgcgtgactttcttcacagac aacagctactaa

Pongo abelii (Sumatran orangutan): 100462446 Help Entry 100462446         CDS       T01416                                  Gene name KDR Definition (RefSeq) vascular endothelial growth factor receptor 2   KO K05098   kinase insert domain protein receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01521   EGFR tyrosine kinase inhibitor resistance pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon04370   VEGF signaling pathway pon04510   Focal adhesion pon05205   Proteoglycans in cancer pon05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100462446 (KDR)    04014 Ras signaling pathway     100462446 (KDR)    04015 Rap1 signaling pathway     100462446 (KDR)    04370 VEGF signaling pathway     100462446 (KDR)    04020 Calcium signaling pathway     100462446 (KDR)    04151 PI3K-Akt signaling pathway     100462446 (KDR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100462446 (KDR)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100462446 (KDR)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     100462446 (KDR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100462446 (KDR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100462446 (KDR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100462446 (KDR) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100462446 (KDR) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   VEGFR family [OT]    100462446 (KDR) CD molecules [BR:pon04090]  Proteins   100462446 (KDR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Ig_3 I-set Pkinase Ig_2 ig VEGFR-2_TMD V-set C2-set_2 Ig_4 Motif Other DBs NCBI-GeneID:  100462446 NCBI-ProteinID:  XP_002814831 Ensembl:  ENSPPYG00000014765 UniProt:  H2PDE2 A0A663DHE2 LinkDB All DBs Position 4 AA seq 1356 aa AA seqDB search MESKVLLAVALWLCVGTRAAFVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPVKYLGYPPP EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECPNEPSQAVSVTNPY PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQVANVSALYKCEAVNKVGRGE RVISFHVTRGPEITLQPDMQPTEQESVSLWCAADRSTFENLTWYKLGPQPLPIHMGELPT PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT VLERVAPMITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS GMVLASEELKTLEDRTKLAPSFSGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV NT seq 4071 nt NT seq  +upstreamnt  +downstreamnt atggagagcaaggtgctgctggccgtcgccctgtggctctgcgtggggacccgggccgcc tttgtgggtttgcctagtgtttctcttgatctgcccaggctcagcatacaaaaagacata cttacaattaaggctaatacaactcttcaaattacttgcaggggacagagggacttggac tggctttggcccaataatcagagtggcagtgagcaaagggtggaggtgactgagtgcagc gatggcctcttctgtaagacactcacaattccaaaagtgatcggaaatgacactggagcc tacaagtgcttctaccgggaaactgacttggcctcggtcatttatgtctatgttcaagat tacagatctccatttattgcttctgttagtgaccaacatggagtcgtgtacattacagag aacaaaaacaaaactgtggtgattccatgtctcgggtccatttcaaatctcaacgtgtca ctttgtgcaaggtacccagaaaagagatttgttcctgatggaaacagaatttcctgggac agcaagaagggctttactattcccagctacatgatcagctatgctggcatggtcttctgt gaagcaaaaattaatgatgaaagttaccagtctattatgtacatagttgtcgttgtaggg tataggatttatgatgtggttctgagtccgtctcacggaattgaactatctgttggagaa aagcttgtcttaaattgtacagcaagaactgaactaaatgtggggattgacttcaactgg gaatacccttcttcgaagcatcagcataagaaacttgtaaaccgagacctaaaaacccag tctgggagtgagatgaagaaatttttgagcaccttaactatagatggtgtaacccggagt gaccaaggattgtacacctgtgcagcgtccagtgggctgatgaccaagaagaacagcact tttgtcagggtccatgaaaaaccttttgttgcttttggaagtggcatggaatctctggtg gaagccacggtgggggagcgtgtcagaatccctgtgaagtaccttggttacccaccccca gaaataaaatggtataaaaatggaataccccttgagtccaatcacacaattaaagcgggg catgtactgacgattatggaagtgagtgaaagagacacagggaattacactgtcatcctt accaatcccatttcaaaggagaagcagagccacgtggtctctctggttgtgtatgtccca ccccagattggtgagaaatcgctgatctctcctgtggattcctaccagtatggcaccact caaacgctgacgtgtacggtctatgccattcctcccccgcatcacatccactggtattgg cagttggaggaagagtgccccaacgagcccagccaagctgtctcagtgacaaacccatac ccttgtgaagaatggagaagtgtggaggactttcagggaggaaataaaattgaagtcaat aaaaatcaatttgctctaattgaaggaaaaaacaaaactgtaagtacccttgttatccaa gtggcaaatgtgtcagctttgtacaaatgtgaagcggtcaacaaagtcgggagaggagag agggtgatctccttccacgtgaccaggggtcctgaaattactttgcaacctgacatgcag cccactgagcaggagagcgtgtctttgtggtgcgctgcagacagatctacatttgagaac ctcacatggtacaagcttggcccacagcctctgccaatccacatgggagagttgcccaca cctgtttgcaagaacttggatactctttggaaattgaatgccaccatgttctctaatagc acaaatgacattttgatcatggagcttaagaatgcatccttgcaggaccaaggagactat gtctgccttgctcaagacaggaagaccaagaaaagacattgcgtggtcagacagctcaca gtcctagagcgtgtggcacccatgatcacaggaaacctggagaatcagacgacaagtatt ggggaaagcatcgaagtctcatgcacggcatctgggaatccccctccacagatcatgtgg tttaaagataatgagacccttgtagaagactcaggcattgtattgaaggatgggaaccgg aacctcactatccgcagagtgagaaaggaggacgaaggcctctacacctgccaggcatgc agtgttcttggctgtgcaaaagtggaggcattcttcataatagaaggtgcccaggaaaag acgaacttggaaatcattattctagtaggcacagcggtgattgccatgttcttctggcta cttcttgtcatcatcctacggaccgttaagcgggctaatggaggggaactgaagacaggc tacttgtccatcgtcatggatccagatgaactcccattggacgaacattgtgaacgactg ccttatgatgccagcaaatgggaattccccagagaccggctgaagctaggtaagcctctt ggccgtggtgcctttggccaagtgattgaagcagatgcctttggaattgacaagacagca acttgcaggacagtagctgtcaaaatgttgaaagaaggagcaacacacagtgagcatcga gccctcatgtctgaactcaagatcctcattcatattggtcaccatctcaatgtggtcaac cttctaggtgcctgtaccaagccaggagggccactcatggtgattgtggaattctgcaaa tttggaaacctatccacttacctgaggagcaagagaaatgaatttgtcccctacaagacc aaaggggcacgattccgtcaagggaaagactacgttggagcaatccctgtggatctgaaa cggcgcttggacagcatcaccagtagccagagctcagctagctctggatttgtggaggag aagtccctcagtgatgtagaagaagaggaagctcctgaagatctgtataaggacttcctg accttggagcatctcatctgttacagcttccaagtggctaagggcatggagttcttggca tcgcgaaagtgtatccacagggacctggcggcacgaaatatcctcttatcggagaagaac gtggttaaaatctgtgactttggcttggcccgggatatttataaagatccagattatgtc agaaaaggagatgctcgcctccctttgaaatggatggccccagaaacaatttttgacaga gtgtacacaatccagagtgacgtctggtcttttggtgttttgctgtgggaaatattttcc ttaggtgcttctccatatcctggggtaaagattgatgaagaattttgtaggcgactgaaa gaaggaactagaatgagggcccccgattatactacaccagaaatgtaccagaccatgctg gactgctggcacggggagcccagtcagagacccacgttttcagagttggtggaacatttg ggaaatctcttgcaagctaatgctcagcaggatggcaaagactacattgttcttccgata tcagagactttgagcatggaagaggattctggactctctctgcctacctcacctgtttcc tgtatggaggaggaggaagtatgtgaccccaaattccattatgacaacacagcaggaatc agtcagtatctgcagaacagtaagcgaaagagcaggcctgtgagtgtaaaaacatttgaa gatatcccattagaagaaccagaagtaaaagtaatcccagatgacaaccagacggacagt ggtatggttcttgcctcagaagagctgaaaactttggaagacagaaccaaattagctcca tcttttagtggaatggtgcccagcaaaagcagggagtctgtggcatctgaaggctcaaac cagacaagcggctaccagtccggatatcactccgatgacacagacaccactgtgtactcc agtgaggaagcagaacttttaaagctgatagagattggagtgcaaaccggcagcacagcc cagattctccagcctgactcggggaccacactgagctctcctcctgtttaa

Pongo abelii (Sumatran orangutan): 100938677 Help Entry 100938677         CDS       T01416                                  Gene name ERBB4 Definition (RefSeq) receptor tyrosine-protein kinase erbB-4 isoform X1   KO K05085   receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04012   ErbB signaling pathway pon04020   Calcium signaling pathway pon04151   PI3K-Akt signaling pathway pon05014   Amyotrophic lateral sclerosis pon05205   Proteoglycans in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100938677 (ERBB4)    04012 ErbB signaling pathway     100938677 (ERBB4)    04020 Calcium signaling pathway     100938677 (ERBB4)    04151 PI3K-Akt signaling pathway     100938677 (ERBB4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100938677 (ERBB4)   09164 Neurodegenerative disease    05014 Amyotrophic lateral sclerosis     100938677 (ERBB4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100938677 (ERBB4) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100938677 (ERBB4) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    100938677 (ERBB4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like Kinase-like APH DUF3951 Motif Other DBs NCBI-GeneID:  100938677 NCBI-ProteinID:  XP_024099518 Ensembl:  ENSPPYG00000013138 LinkDB All DBs Position 2B AA seq 1308 aa AA seqDB search MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED EYVNEPLYLNTFANTLGKAEYLKNNVLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV NT seq 3927 nt NT seq  +upstreamnt  +downstreamnt atgaagccggcgacaggactttgggtctgggtgagccttctcgtggcggcggggaccgtc cagcccagcgattctcagtcagtgtgtgcaggaacggagaataaactgagctctctctct gacttggaacagcagtaccgagccttgcgcaagtactatgaaaactgtgaggttgtcatg ggcaacctggagataaccagcattgagcacaaccgggacctctccttcctgcggtctgtt cgagaagtcacaggctacgtgttagtggctcttaatcagtttcgttacctgcctctggag aatttacgcattattcgtgggacaaaactttatgaggatcgatatgccttggcaatattt ttaaactacagaaaagatggaaactttggacttcaagaacttggattaaagaacttgaca gaaatcctaaatggtggagtctatgtagaccagaacaaattcctttgttatgcggacacc attcattggcaagatattgttcggaacccatggccttccaacttgactcttgtgtcaaca aatggtagttcaggatgtggacgttgccataagtcctgtactggccgttgctggggaccc acagaaaatcattgccagactttgacaaggacggtgtgtgcagaacaatgtgacggcaga tgctacggaccttacgtcagtgactgctgccatcgagaatgtgctggaggctgctcagga cctaaggatacagactgctttgcctgcatgaatttcaatgacagtggagcatgtgttact cagtgtccccaaacctttgtctacaatccaaccacttttcaactggagcacaatttcaat gcaaagtacacatatggagcattctgtgtcaagaagtgtccacataactttgtggtagat tccagttcttgtgtgcgtgcctgccctagttccaagatggaagtagaagaaaatgggatt aaaatgtgtaaaccttgcactgacatttgcccaaaagcttgtgatggcattggcacagga tcattgatgtcagctcagactgtggattccagtaacattgacaaattcataaactgtacc aagatcaatgggaatttgatctttctggtcactggtattcatggggacccttacaatgca attgaagccatagacccagagaaactgaatgtctttcggacagtcagagagataacaggt ttcctgaacatacagtcatggccaccaaacatgactgacttcagtgttttttctaacctg gtgacaattggtggaagagtactctatagtggcctgtccttgcttatcctcaagcaacag ggcatcacctctctacagttccagtccctgaaggaaatcagcgcaggaaacatctatatt actgacaacagcaacctgtgttattatcataccattaactggacaacactcttcagcaca atcaaccaaagaatagtaatccgggacaatagaaaagctgaaaactgtactgctgaagga atggtgtgcaaccatctgtgttccagtgatggctgttggggacctgggccagaccagtgt ctgtcgtgtcgccgcttcagtagaggaaggatctgcatagagtcttgtaacctctatgat ggtgaatttcgggagtttgagaatggctccatctgtgtggagtgtgacccccagtgtgag aagatggaagatggcctcctcacatgccatggaccgggtcctgacaactgtacaaagtgc tctcattttaaagatggcccaaactgtgtggaaaaatgtccagatggcttacagggggca aacagtttcattttcaagtatgctgatccggatcgggagtgccacccatgccatccaaac tgcacccaagggtgtaacggtcccactagtcatgactgcatttactacccatggacgggc cattccactttaccacaacatgctagaactcccctgattgcagctggagtaattggtggg ctcttcattctggtcattgtgggtctgacatttgctgtttatgttagaaggaagagcatc aaaaagaaaagagccttgagaagattcttggaaacagagttggtggaaccattaactccc agtggcacagcacccaatcaagctcaacttcgtattttgaaagaaactgagctgaagagg gtaaaagtccttggctcaggtgcttttggaacggtttataaaggtatttgggtacctgaa ggagaaactgtgaagattcctgtggctattaagattcttaatgagacaactggtcccaag gcaaatgtggagttcatggatgaagctctgatcatggcaagtatggatcatccacaccta gtacggttgctgggtgtgtgtctgagcccaaccatccagctggttactcaacttatgccc catggctgcctgttggagtatgtccacgagcacaaggataacattggatcacaactgctg cttaactggtgtgtccagatagctaagggaatgatgtacctggaagaaagacgactcgtt catcgggatttggcagcccgtaatgtcttagtgaaatctccaaaccatgtgaaaatcaca gattttgggctagccagactcttggaaggagatgaaaaggagtacaatgctgatggagga aagatgccaattaaatggatggctctggagtgtatacattacaggaaattcacccatcag agtgacgtttggagctatggagttactatatgggaactgatgacctttggaggaaaaccc tatgatggaattccaacgcgagaaatccctgatttattagagaaaggagaacgtttgcct cagcctcccatctgcactattgacgtttacatggtcatggtcaaatgttggatgattgat gctgacagtagacctaaatttaaggaactggctgctgagttttcaaggatggctcgagac cctcaaagatacctagttattcagggtgatgatcgtatgaagcttcccagtccaaatgac agcaagttctttcagaatctcttggatgaagaggatttggaagatatgatggatgctgag gagtacttggtccctcaggctttcaacatcccacctcccatctatacttccagagcaaga attgactcaaataggagtgaaattggacacagccctcctcctgcctacacccccatgtca ggaaaccagtttgtataccgagatggaggttttgctgcagaacaaggagtgtctgtgccc tacagagccccaactagcacaattccagaagctcctgtggcacagggtgctactgctgag atttttgatgactcctgctgtaatggcaccctacgcaagccagtggcaccccatgtccaa gaggacagtagcacccagaggtacagcgctgaccccaccgtgtttgccccagaacggagc ccacgaggcgagctggatgaggagggttacatgactcctatgcgagacaaacccaaacaa gaatacctgaatccagtggaggagaacccttttgtttctcggagaaaaaatggagacctt caagcattggataatcccgaatatcacaatgcatccaatggtccacccaaggccgaggat gagtatgtgaatgagccactgtacctcaacacctttgccaacaccttgggaaaagctgag tacctgaagaacaacgtactgtcagtgccagagaaggccaagaaagcgtttgacaaccct gactactggaaccacagcctgccacctcggagcacccttcagcacccagactacctgcag gagtacagcacaaaatatttttataaacagaatgggcggatccggcctattgtggcagag aatcctgaatacctctctgagttctccctgaagccaggcactgtgctgccgcctccacct tacagacaccggaatactgtggtgtaa

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