KEGG   Pongo abelii (Sumatran orangutan): 100172517
Entry
100172517         CDS       T01416                                 

Gene name
JAK2
Definition
(RefSeq) tyrosine-protein kinase JAK2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon04062  Chemokine signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04217  Necroptosis
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04630  JAK-STAT signaling pathway
pon04658  Th1 and Th2 cell differentiation
pon04659  Th17 cell differentiation
pon04725  Cholinergic synapse
pon04917  Prolactin signaling pathway
pon04920  Adipocytokine signaling pathway
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04935  Growth hormone synthesis, secretion and action
pon05140  Leishmaniasis
pon05145  Toxoplasmosis
pon05152  Tuberculosis
pon05161  Hepatitis B
pon05164  Influenza A
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05168  Herpes simplex virus 1 infection
pon05200  Pathways in cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100172517 (JAK2)
   04151 PI3K-Akt signaling pathway
    100172517 (JAK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    100172517 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100172517 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    100172517 (JAK2)
   04659 Th17 cell differentiation
    100172517 (JAK2)
   04062 Chemokine signaling pathway
    100172517 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100172517 (JAK2)
   04917 Prolactin signaling pathway
    100172517 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    100172517 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    100172517 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100172517 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100172517 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100172517 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100172517 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100172517 (JAK2)
   05164 Influenza A
    100172517 (JAK2)
   05168 Herpes simplex virus 1 infection
    100172517 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100172517 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100172517 (JAK2)
   05140 Leishmaniasis
    100172517 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100172517 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100172517 (JAK2)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100172517 (JAK2)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100172517 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like
Other DBs
NCBI-GeneID: 100172517
NCBI-ProteinID: NP_001125600
Ensembl: ENSPPYG00000019243
UniProt: Q5RB23
LinkDB
Position
9
AA seq 1132 aa
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLLVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcctgccttacgatgacagaaatggagggaacatccacctcttctatatat
cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagttcttctg
gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatccggg
gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt
cctcgttggtattgcagtggcagcaacagagcctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat
tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaacgatcaaaccccactggccatt
tataactctatcagctacaagacattcttaccaaaatgtattcgagcaaagatccaagac
tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcaattc
agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
ctacagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt
cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcaaatgaaagccga
gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg
gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccaacagtgcttgaaaatatacaaagcaactgt
catggcccaatttcgatggattttgccattagcaaactgaagaaggcaggtaatcagact
ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttttgacttttgct
gtcgagcgagaaaatgtcattgaatataaacactgtttaattacaaaaaatgagaatgaa
gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt
taccagatggaaactgttcgctcagacaatataattttccagtttactaaatgctgtccc
ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgacgta
ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaagattttt
aaaggcgtacgaagagaagtaggagactacggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagac
gaaaatattctggttcaggagtttgtaaaatttggatcactagatacatatctgaaaaag
aataaaaattgtataaatatattatggaaacttgaagttgctaaacagttggcatgggcc
atgcattttctagaagaaaacacccttattcatgggaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataaacctctaagtgctctggattctcaa
agaaagctacaattttatgaagataggcatcagcttcctgcaccaaagtgggcagaatta
gcaaaccttataaataattgtatggattatgaaccagatttcaggccttctttcagagcc
atcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagaccgggat
cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct
gtaaaaaagcttcagcatagtactgaagagcacctaagagactttgaaagggaaattgaa
atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaaaattaattatggaatatttaccatatgggagtttacgagactat
cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacgaga
aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactataaagtaaaagagcctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa
tttatgcgtatgattggcaacgacaaacaaggacagatgatcgtgttccatttgatagaa
cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatatg
atcatgacagaatgctggaacaataatgtaaatcagcgcccctcctttagggatctagct
cttcgagtggatcaaataagggataacatggctggatga

KEGG   Pongo abelii (Sumatran orangutan): 100433477
Entry
100433477         CDS       T01416                                 

Gene name
JAK1
Definition
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon04151  PI3K-Akt signaling pathway
pon04217  Necroptosis
pon04380  Osteoclast differentiation
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04621  NOD-like receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04658  Th1 and Th2 cell differentiation
pon04659  Th17 cell differentiation
pon05140  Leishmaniasis
pon05145  Toxoplasmosis
pon05152  Tuberculosis
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05162  Measles
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05168  Herpes simplex virus 1 infection
pon05169  Epstein-Barr virus infection
pon05171  Coronavirus disease - COVID-19
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05212  Pancreatic cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100433477 (JAK1)
   04151 PI3K-Akt signaling pathway
    100433477 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    100433477 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100433477 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    100433477 (JAK1)
   04658 Th1 and Th2 cell differentiation
    100433477 (JAK1)
   04659 Th17 cell differentiation
    100433477 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100433477 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100433477 (JAK1)
   05203 Viral carcinogenesis
    100433477 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100433477 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100433477 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100433477 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100433477 (JAK1)
   05161 Hepatitis B
    100433477 (JAK1)
   05160 Hepatitis C
    100433477 (JAK1)
   05171 Coronavirus disease - COVID-19
    100433477 (JAK1)
   05164 Influenza A
    100433477 (JAK1)
   05162 Measles
    100433477 (JAK1)
   05168 Herpes simplex virus 1 infection
    100433477 (JAK1)
   05163 Human cytomegalovirus infection
    100433477 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100433477 (JAK1)
   05169 Epstein-Barr virus infection
    100433477 (JAK1)
   05165 Human papillomavirus infection
    100433477 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100433477 (JAK1)
   05140 Leishmaniasis
    100433477 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100433477 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100433477 (JAK1)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100433477 (JAK1)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100433477 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2
Other DBs
NCBI-GeneID: 100433477
NCBI-ProteinID: XP_002810775
Ensembl: ENSPPYG00000001270
UniProt: H2N755 A0A6D2XH65
LinkDB
Position
1
AA seq 1154 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDIGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
NT seq 3465 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagactgaggtgaacctggaggcccctgagccaggggtggaagtgatcttc
tatctgtcggacagggagcccctccggctgggcagtggagagtacacagcagaggaactg
tgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg
tatgacgagaacaccaagctctggtatgctccaaatcgcaccatcaccgttgatgacaag
atgtccctccggctccactaccggatgaggttctatttcaccaattggcatggaaccaac
gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa
aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct
cagggacagtatgatttggtgaaatgcctggctcctattcgagaccccaagaccgagcag
gatggacatgatattgagaatgagtgtctagggatggctgtcctggccatctcacactat
gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgaggata
aataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgacagcagc
gtgtccacgcatgacctgaaggtgaaatacttggctactttggaaactttgacaaaacat
tacggtgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat
tggtttcattcgaatgacattggaaacgttctgtactacgaagtgatggtgactgggaat
cttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaaaataaa
ctgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgg
gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctctcttcccacgag
gaggccttgtcctttgtgtccctggtagatggctacttccggctcacagcagacgcccat
cattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgt
catggtccaatctgtacagaatacgccatcaataaattgcggcaagaaggaagcgaggag
gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgaccgtcacc
tgctttgagaagtctgagcaggtgcagggtgcccagaagcagttcaagaactttcaaatc
gaggtgcagaagggccgctacagtctgcacggttcagaccgcagcttccccagcttggga
gacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttcatgcta
aaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaa
gctcaggagtggcagcctgtctaccccatgagccagctgagtttcgatcggatcctcaag
aaggatctggtgcagggcgagcaccttgggagaggcacaagaacacacatctactctggg
accctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatc
ctcaaagtcttagaccccagccacagggatatttccctggccttcttcgaggcagccagc
atgatgagacaggtctcccacaaacacatcgtgtacctctacggcgtctgtgtccgcgac
gtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcac
cggaaaagcgatgtccttaccacaccatggaaattcaaagttgccaaacagctggccagt
gccctgagctacttggaggataaagacctggtccatggaaatgtgtgtactaaaaacctc
ctcctggcccgtgaaggcatcgacagtgagtgtggcccgttcatcaagctcagtgaccct
ggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccatggattgct
cccgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagctttgga
accacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgatt
gagaaagagagattctatgaaagccggtgcaggccggtgacaccatcgtgtaaggagctg
gctgacctcatgacccgctgcatgaactacgaccccaatcagaggcctttcttccgagct
atcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaaa
ccagcaactgaagtggaccccacacattttgaaaagcgcttcctaaagaggatccgtgac
ttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaat
acaggggagcaggtggctgttaagtctctgaagcctgagagtggaggtaaccacatagct
gatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtgaagtac
aaaggaatctgcacagaagacggaggaaatggtattaagctcatcatggaatttctgcct
tcgggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcag
ctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatacgtt
caccgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattgga
gactttggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgac
cgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatatt
gcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgattca
gattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgaca
gtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccacctaactgt
ccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggaca
agctttcagaaccttattgaaggatttgaagcacttttaaaataa

KEGG   Pongo abelii (Sumatran orangutan): 100433988
Entry
100433988         CDS       T01416                                 

Gene name
JAK3
Definition
(RefSeq) tyrosine-protein kinase JAK3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04062  Chemokine signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04217  Necroptosis
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04630  JAK-STAT signaling pathway
pon04658  Th1 and Th2 cell differentiation
pon04659  Th17 cell differentiation
pon05161  Hepatitis B
pon05162  Measles
pon05166  Human T-cell leukemia virus 1 infection
pon05169  Epstein-Barr virus infection
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05223  Non-small cell lung cancer
pon05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100433988 (JAK3)
   04151 PI3K-Akt signaling pathway
    100433988 (JAK3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    100433988 (JAK3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100433988 (JAK3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    100433988 (JAK3)
   04659 Th17 cell differentiation
    100433988 (JAK3)
   04062 Chemokine signaling pathway
    100433988 (JAK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100433988 (JAK3)
   05203 Viral carcinogenesis
    100433988 (JAK3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    100433988 (JAK3)
  09163 Immune disease
   05340 Primary immunodeficiency
    100433988 (JAK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100433988 (JAK3)
   05161 Hepatitis B
    100433988 (JAK3)
   05162 Measles
    100433988 (JAK3)
   05169 Epstein-Barr virus infection
    100433988 (JAK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100433988 (JAK3)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100433988 (JAK3)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100433988 (JAK3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo Kinase-like APH SH2 LRR_RI_capping
Other DBs
NCBI-GeneID: 100433988
NCBI-ProteinID: XP_024092214
Ensembl: ENSPPYG00000009724
LinkDB
Position
19
AA seq 1124 aa
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQHLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQSQR
PGELLKTISYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
DLERLDPAGAAETFHVGLPGALGGQDGLGLLRVAGDSGISWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTLTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSHPGSYVLRRSPQDFDSFLLTVCVQTP
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDQQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSTLGPQLDMLWSGSRGCETHAFTAHPEGKPHSLSFL
NT seq 3375 nt   +upstreamnt  +downstreamnt
atggcacctccaagtgaagagacgcccctgatccctcagcgttcatgcagcctcttgtcc
acggaggctggtgccctgcatgtgctgctgcccgctcggggccccgggcccccccagcac
ctatctttctcctttggggaccacttggctgaggacctgtgcgtgcaggctgccaaggcc
agcggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc
tggttccccccgagccacatcttttcagtggaggatgccagcacccaagtcctgctctac
aggattcgcttttacttccccaattggtttgggctggagaagtgccaccgctttgggcta
cgcaaggatttggccagcgctatccttgacctgccagtcctggagcacctctttgcccag
caccgcagtgacctggtgagtgggcgcctccccgtgggcctcagtctcaaggagcagggt
gagtgtctcagcctggccgtgttggacctggcccggatggcgcgagagcagtcccagcgg
ccgggagagctgctgaagactatcagctacaaggcctgcctacccccaagcctgcgcgac
ctgatccagggcctgagcttcgtgacgcggaggcgtattcggaggacggtgcgcagggcc
ctgcgccgcgtggccgcctgccaggcagaccggcactcgctcatggccaagtacatcatg
gacctggagcggctggatccagccggggccgccgagaccttccacgtgggcctccctggg
gcccttggtggccaggacgggctggggctgctccgcgtggctggtgacagcggcatctcc
tggacccagggagaacaggaggtcctccagcccttctgcgactttccagaaatcgtagac
attagcatcaagcaggccccgcgcgttggcccggccggggagcaccgcctggtcactctt
accaggacagacaaccagattttggaggccgagttcccagggctgcccgaggctctgtcg
ttcgtggcgctcgtggacggctacttccggctgaccacggactcccagcacttcttctgc
aaggaggtggcaccgccgaggctgctggaggaagtggccgagcagtgccacggccccatc
actctggactttgccatcaacaagcttaagactgggggctcacatcctggctcctatgtt
ctccgccgcagcccccaggactttgacagcttcctcctcactgtctgtgtccagaccccc
cttggtcctgattataagggctgcctcatccggcgcagccccacaggaaccttccttctg
gttggcctcagccgaccccacagcagtcttcgagagctcctggcaacgtgctgggatggg
gggctgcacgtagatggggtggcagtgaccctcacctcctgctgtatccccagacccaaa
gaaaagtccaacctgatcgtggtccagagaggtcacagcccacccacatcatccttggtt
cagccccaatcccaataccagctgagtcagatgacatttcacaagatccctgctgacagc
ctggagtggcatgagaacctgggccatgggtccttcaccaagatttaccggggctgtcgc
catgaggtggtggatggggaggcccgaaagacagaggtgctgctgaaggtgatggatgct
aagcacaagaactgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtcg
taccggcatctcgtgctgctccacggcgtgtgcatggctggagacagcaccatggtgcag
gaatttgtacacctgggggcgatagacatgtatcttcgaaaacgtggccacctggtgcca
gccagctggaagctgcaggtggtcaaacagctggcctacgccctcaactatctggaggac
aaaggcctcccccatggcaatgtctctgcccggaaggtgctcctggctcgggagggggct
gatgggagcccgcccttcatcaagctgagtgaccctggggtcagccccgctgtgttaagc
ctggagatgctcactgacaggatcccctgggtggcccccgagtgtctccgggaggcccag
acacttagcttggaagctgacaagtggggcttcggcgccacggtctgggaagtgtttagt
ggcgtcaccatgcccatcagcgccctggatcctgctaagaaactccaattttatgaggac
cagcagcagctgccggcccccaagtggacagagctggccctgctgattcaacagtgcatg
gcctatgagccagtccagaggccctccttccgagccgtcattcgtgacctaaatagcctc
atctcttcagactatgagctcctctcagaccccacacctggagccctggcacctcgtgat
gggctgtggaatggtgcccagctctatgcctgccaagaccccacgatctttgaggagaga
cacctcaagtacatctcacagctgggcaagggcaactttggcagcgtggagctgtgccgc
tatgacccgctaggtgacaatacaggtgccctggtggccgtgaaacagctgcagcacagc
gggccagaccagcagagggactttcagcgggagattcagatcctcaaagcactgcacagt
gatttcattgtcaagtatcgtggtgtcagctacggcccgggccgccagagcctgcggctg
gtcatggagtacctgcccagcggctgcttgcgcgacttcctgcagcggcaccgtgcgcgc
ctcgatgccagccgcctccttctctattcctcacagatctgcaagggcatggagtaccta
ggctcccgccgctgcgtgcaccgcgacctggccgcccgaaacatcctcgtggagagcgag
gcacacgtcaagatcgctgacttcggcctagctaagctgctgccgcttgacaaagactac
tacgtcgtccgcgagccgggccagagccccattttctggtatgcccccgaatccctctcg
gacaatatcttctctcgccagtcagacgtctggagcttcggggtcgtcctgtacgagctc
ttcacctactgcgacaaaagctgcagtccctcggccgagttcctgcggatgatgggatgt
gagcgggatgtccccgccctctgccgcctcctggaactgctggaggagggccagaggctg
ccggcgcctcctgcctgccctgcagaggttcacgagctcatgaagctgtgctgggcccct
agcccacaggaccggccatcattcagcaccctgggcccccagctggacatgctgtggagc
ggaagccgggggtgtgagactcatgccttcactgctcacccagagggcaaaccccactcc
ctgtcctttttatag

KEGG   Pongo abelii (Sumatran orangutan): 100439493
Entry
100439493         CDS       T01416                                 

Gene name
TYK2
Definition
(RefSeq) LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04217  Necroptosis
pon04380  Osteoclast differentiation
pon04621  NOD-like receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04658  Th1 and Th2 cell differentiation
pon04659  Th17 cell differentiation
pon05145  Toxoplasmosis
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05162  Measles
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05168  Herpes simplex virus 1 infection
pon05169  Epstein-Barr virus infection
pon05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100439493 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    100439493 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    100439493 (TYK2)
   04658 Th1 and Th2 cell differentiation
    100439493 (TYK2)
   04659 Th17 cell differentiation
    100439493 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100439493 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    100439493 (TYK2)
   05160 Hepatitis C
    100439493 (TYK2)
   05171 Coronavirus disease - COVID-19
    100439493 (TYK2)
   05164 Influenza A
    100439493 (TYK2)
   05162 Measles
    100439493 (TYK2)
   05168 Herpes simplex virus 1 infection
    100439493 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100439493 (TYK2)
   05169 Epstein-Barr virus infection
    100439493 (TYK2)
   05165 Human papillomavirus infection
    100439493 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100439493 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100439493 (TYK2)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100439493 (TYK2)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100439493 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo APH
Other DBs
NCBI-GeneID: 100439493
NCBI-ProteinID: XP_024093477
LinkDB
Position
19
AA seq 1186 aa
MPLRHWGTARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESLLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPQEP
AVYRCGPPGTEASSDQTAQGMQLLDPGSFEYLFEQGKHEFVNDVASLWDLSSEEEIHHFK
NESLGMAFLHLCHLALRHGISLEEVAKKTSFKDCIPRSFRRHIQQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESGAGPPTHEVLVTGTGGIQWWPVQEEVNKEEGSSGSSGNPQASLSGKKAKAHKA
VGQPADRPREPLWAYFCDFRDITHVVLKERCVSIHRQDNKCLELSLPSRAAALSFVSLVD
GYFRLTADSNHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPY
RLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAG
DDCFSLRRCCLPQPGETSNLIIMRGARASTRTLNLSQLSFHRVDQKEITQLSHLGQGTRT
NVYEGRLRVEGSRDTEEGKMDDEDPXVPGREHGQELRVVLKVLDPSHHDIALAFYETASL
MSQVSHAHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASA
LSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWMAP
ECLTGGPNSLSTAMDKWGFGATLLEICFDGEAPLQNRSPSEKEHFYQRQHRLPEPSCPEL
ATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIR
DLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCAPQHRSGWKQEIDILRTLYHEHIVK
YKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQHYIH
RDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYA
SDVWSFGVTLYELLTHCDSNQSPPTKFLELIGVAQGQMTVLRLTELLERGERLPRPDKCP
CEVYHFMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
NT seq 3561 nt   +upstreamnt  +downstreamnt
atgcctctgcgccactgggggacggccaggggcagtaagcccgttggggatggagcccag
cccatggctgccatgggaggcctgaaggtgcttctgcactgggctggtccaggcggcggg
gagccctgggtcactttcagtgagtcattgctgacagctgaggaagtctgcatccatatt
gcacataaagttggtatcactcctccttgtttcaatctcttcgccctcttcgatgctcag
gcccaagtctggttgcccccaaaccacatcctagagatccccagagatgcaagcctgatg
ctatatttccgcataaggttttatttccggaactggcatggcatgaatcctcaggaaccg
gctgtgtaccgttgtgggcccccaggaaccgaggcatcctcagatcagacagcacagggg
atgcaactcctggacccaggctcatttgagtacctctttgagcagggcaagcatgagttt
gtgaatgacgtggcatcactgtgggatctgtcgagcgaggaggagatccaccactttaag
aatgagagcctgggcatggcctttctgcacctctgtcacctcgctctccgccatggcatc
tccctggaggaggtggccaagaagaccagcttcaaggactgcatcccacgctccttccgt
cggcatatccagcagcacagtgccctgacccggctgcgccttcggaacgtcttccgcagg
ttcctgcgggacttccagccgggccgactctcccagcagatggtcatggttaaataccta
gccacacttgagcggctggcaccccgcttcggcacagagcgtgtgcccgtgtgccacctg
aggctactggcccaggccgagggggagccctgctacatccgggacagcggggtggcccct
acagaccctggccccgagtctggtgctgggcccccaacccatgaggtgctggtgactggc
actggtggcatccagtggtggccagtacaggaggaggtgaacaaggaggagggttctagt
ggcagcagtggcaaccctcaagccagcctgtctgggaagaaggccaaggctcacaaggca
gtcggccagccggcggacaggccgcgggagccactgtgggcctacttctgtgacttccgg
gacatcacccacgtggtgctgaaagagcgctgtgtcagcatccaccggcaggacaacaag
tgcctggagctgagcctgccttcccgggctgcggcgctgtccttcgtgtcgctggtggac
ggctatttccgcctgacggccgactccaaccactacctgtgccacgaggtggctccccca
cggctggtgatgagcatccgggatgggatccacggacccctgctggagccatttgtgcag
gccaagctgcggcccgaggacggcctgtacctcattcactggagcaccagccacccctac
cgcctgatcctcacagtggcccagcgtagccaggcaccagacggcatgcagagcttgcgg
ctccggaagttccccattgagcagcaggacggggccttcgtgctggagggctggggccgg
tccttccccagcgttcgggaacttggggctgccttgcagggctgcttgctgagggctggg
gacgactgcttctctctgcgtcgctgttgcctgccccaaccaggagaaacctccaatctc
atcatcatgcggggggctcgggccagcaccaggacactcaacctcagccagctcagcttc
caccgcgttgaccagaaggagatcacccagctgtcccacttgggccagggcacaaggacc
aatgtgtatgagggccgcctgcgagtggagggcagcagggacactgaggagggcaagatg
gatgacgaggaccccntcgtgcctggcagggagcatgggcaggagctacgagtggtgctc
aaagtgctggaccctagtcaccatgacatcgccctggccttctacgagacagccagcctc
atgagccaggtctcccacgcacacctggccttcgtgcatggcgtctgtgtgcgcggccct
gaaaatatcatggtgacagagtatgtggagcacggacccctggatgtgtggctgcggagg
gagcggggccatgtgcccatggcttggaagatggtggtggcccagcaactggccagcgcc
ctcagctacctggagaacaagaacctggttcatggtaatgtgtgtggccggaacatcctg
ctggcccgactggggctggcagagggcaccagccccttcatcaagctgagtgatcccggc
gtgggcctgggcgccctctccagggaggagcgggtggagaggatcccctggatggccccc
gaatgcctaacaggtgggcccaacagcctaagcaccgccatggacaagtgggggtttggc
gccaccctcttggagatctgctttgacggagaggcccctctgcagaaccgcagcccctcc
gagaaggagcatttctaccaaaggcagcaccggctgcccgagccctcctgcccagagctg
gccacactcaccagccagtgtctgacctatgagccgacccagaggccatcattccgcacc
atcctgcgtgacctcacccggctgcagccccacaatcttgctgacgtcttgactgtgaac
ccggactcaccagcctcagaccctacggttttccacaagcgctatttgaaaaagatccga
gatctgggcgagggtcacttcggcaaggtcagcttgtactgctacgatccgaccaacgac
ggcactggcgagatggtggcggtgaaagccctcaaggcagactgcgctccccagcaccgc
tccggctggaagcaggagattgacattctgcgcacgctctatcacgagcacatcgtcaag
tacaagggctgctgcgaggaccaaggcgagaagtctctgcagctggtcatggagtacgtg
cccctgggcagcctccgagactacctgccccggcacagcgtcgggctggcccagctgctg
ctcttcgcccagcagatctgcgagggcatggcctatctgcacgcgcagcactacatccac
cgagacttagccgcgcgcaacgtgctgctggacaacgacaggctggtcaagatcggggac
tttggcctagccaaggccgtgcccgaaggccacgagtactaccgcgtgcgcgaggatggg
gacagccctgtgttctggtatgccccagagtgcctgaaggagtataagttctactatgcg
tccgatgtctggtccttcggggtgaccctgtatgagctgctgacgcactgtgactccaac
cagagcccccccacgaaattccttgagctcataggcgttgctcagggtcagatgacagtt
ctgagactcaccgagttgctggaacgaggggagaggctgccacggcccgacaaatgtccc
tgtgaggtctatcatttcatgaagaactgctgggagacagaggcgtccttccgcccaacc
ttcgagaacctcatacccatcctgaagacagtccatgagaagtaccaaggccaggcccct
tcagtgttcagcgtgtgctga

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