KEGG   Pongo abelii (Sumatran orangutan): 100173972
Entry
100173972         CDS       T01416                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon04010  MAPK signaling pathway
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04062  Chemokine signaling pathway
pon04068  FoxO signaling pathway
pon04072  Phospholipase D signaling pathway
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04380  Osteoclast differentiation
pon04510  Focal adhesion
pon04540  Gap junction
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04630  JAK-STAT signaling pathway
pon04650  Natural killer cell mediated cytotoxicity
pon04660  T cell receptor signaling pathway
pon04662  B cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04714  Thermogenesis
pon04722  Neurotrophin signaling pathway
pon04910  Insulin signaling pathway
pon04912  GnRH signaling pathway
pon04915  Estrogen signaling pathway
pon04917  Prolactin signaling pathway
pon04926  Relaxin signaling pathway
pon04935  Growth hormone synthesis, secretion and action
pon05034  Alcoholism
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05163  Human cytomegalovirus infection
pon05165  Human papillomavirus infection
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05205  Proteoglycans in cancer
pon05206  MicroRNAs in cancer
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
pon05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100173972 (GRB2)
   04012 ErbB signaling pathway
    100173972 (GRB2)
   04014 Ras signaling pathway
    100173972 (GRB2)
   04630 JAK-STAT signaling pathway
    100173972 (GRB2)
   04068 FoxO signaling pathway
    100173972 (GRB2)
   04072 Phospholipase D signaling pathway
    100173972 (GRB2)
   04151 PI3K-Akt signaling pathway
    100173972 (GRB2)
   04150 mTOR signaling pathway
    100173972 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100173972 (GRB2)
   04540 Gap junction
    100173972 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100173972 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100173972 (GRB2)
   04660 T cell receptor signaling pathway
    100173972 (GRB2)
   04662 B cell receptor signaling pathway
    100173972 (GRB2)
   04664 Fc epsilon RI signaling pathway
    100173972 (GRB2)
   04062 Chemokine signaling pathway
    100173972 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100173972 (GRB2)
   04912 GnRH signaling pathway
    100173972 (GRB2)
   04915 Estrogen signaling pathway
    100173972 (GRB2)
   04917 Prolactin signaling pathway
    100173972 (GRB2)
   04926 Relaxin signaling pathway
    100173972 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    100173972 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100173972 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100173972 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100173972 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100173972 (GRB2)
   05206 MicroRNAs in cancer
    100173972 (GRB2)
   05205 Proteoglycans in cancer
    100173972 (GRB2)
   05203 Viral carcinogenesis
    100173972 (GRB2)
   05231 Choline metabolism in cancer
    100173972 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100173972 (GRB2)
   05225 Hepatocellular carcinoma
    100173972 (GRB2)
   05226 Gastric cancer
    100173972 (GRB2)
   05214 Glioma
    100173972 (GRB2)
   05221 Acute myeloid leukemia
    100173972 (GRB2)
   05220 Chronic myeloid leukemia
    100173972 (GRB2)
   05211 Renal cell carcinoma
    100173972 (GRB2)
   05215 Prostate cancer
    100173972 (GRB2)
   05213 Endometrial cancer
    100173972 (GRB2)
   05224 Breast cancer
    100173972 (GRB2)
   05223 Non-small cell lung cancer
    100173972 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    100173972 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100173972 (GRB2)
   05160 Hepatitis C
    100173972 (GRB2)
   05163 Human cytomegalovirus infection
    100173972 (GRB2)
   05165 Human papillomavirus infection
    100173972 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100173972 (GRB2)
   01522 Endocrine resistance
    100173972 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100173972 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:pon04990]
    100173972 (GRB2)
Membrane trafficking [BR:pon04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    100173972 (GRB2)
Domain-containing proteins not elsewhere classified [BR:pon04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   100173972 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 100173972
NCBI-ProteinID: NP_001126954
UniProt: Q5R4J7 A0A2J8Y0M0
LinkDB
Position
17
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagccgggaagtacttcctc
tgggtggtgaagttcaattctctgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattacgtcacccccgtgaaccggaacgtctaa

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