KEGG T01416: 100431600

KEGG Orthology (KO) [BR:pon00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    100431600 (MAP2K7)
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100431600 (MAP2K7)
   04012 ErbB signaling pathway
    100431600 (MAP2K7)
   04668 TNF signaling pathway
    100431600 (MAP2K7)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    100431600 (MAP2K7)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100431600 (MAP2K7)
   04660 T cell receptor signaling pathway
    100431600 (MAP2K7)
   04664 Fc epsilon RI signaling pathway
    100431600 (MAP2K7)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100431600 (MAP2K7)
   04926 Relaxin signaling pathway
    100431600 (MAP2K7)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100431600 (MAP2K7)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100431600 (MAP2K7)
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100431600 (MAP2K7)
   05016 Huntington disease
    100431600 (MAP2K7)
   05022 Pathways of neurodegeneration - multiple diseases
    100431600 (MAP2K7)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100431600 (MAP2K7)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100431600 (MAP2K7)
   05135 Yersinia infection
    100431600 (MAP2K7)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100431600 (MAP2K7)
   05161 Hepatitis B
    100431600 (MAP2K7)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100431600 (MAP2K7)
   05169 Epstein-Barr virus infection
    100431600 (MAP2K7)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100431600 (MAP2K7)
Enzymes [BR:pon01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100431600 (MAP2K7)
Protein kinases [BR:pon01001]
Serine/threonine kinases: STE group
  STE7 family
   100431600 (MAP2K7)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 Pkinase_fungal APH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

LinkDB

Position

AA seq 419 aa
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR

NT seq 1260 nt +upstreamnt +downstreamnt
atggcggcgtcctccctggagcagaagctgtcccgcctggaagcaaagctgaagcaggag
aaccgggaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccagg
cccaccctgcagctcccgctggccaacgatgggggcagccgctcgccatcctcagagagc
tccccgcagcaccccacgccccctgcccggccccgccacatgctggggctcccgtcaacc
ctgttcacaccccgcagcatggagagcattgagattgaccagaagctgcaggagatcatg
aagcagacgggctacctgaccatcgggggccagcgctaccaggcagaaatcaacgacctg
gagaacttgggcgagatgggcagcggcacctgcggccaggtgtggaagatgcgcttccgg
aagaccggccacgtcattgctgttaagcaaatgcggcgctcggggaacaaggaggagaac
aagcgcatcctcatggacctggacgtggtgctcaagagccacgactgcccctacatcgtg
cagtgctttgggacgttcatcaccaacacggatgtcttcatcgccatggagctcatgggt
acctgcgctgaaaagctgaagaagcggatgcagggccccatccccgagcgcatcctgggc
aagatgacagtggcgattgtgaaggcgctgtactacctgaaggagaagcacggtgtcatc
caccgcgacgtcaagccctccaacatcctgctggacgagcggggccagatcaagctctgt
gacttcggcatcagcggccgcctggtggactccaaagccaagacgcggagcgctggctgc
gccgcctacatggcacccgagcgcattgaccccccagaccccaccaagccggactatgac
atccgggccgacgtatggagcctgggcatctcgttggtggagctggcaacgggacagttt
ccctacaagaactgcaagacggactttgaggtcctcaccaaagtcctacaggaagagccc
ccgcttctgcccggacacatgggcttctcaggggacttccagtccttcgtcaaagactgc
cttactaaagatcacaggaagagaccaaagtataataagctacttgaacacagtttcatc
aagcgctacgagacgctggaggtggacgtggcgtcctggttcaaggatgtcatggcgaag
actgagtcaccgcggactagcggcgtcctgagccagccccacctgcccttcttcaggtag

Pongo abelii (Sumatran orangutan): 100439299

Entry

100439299 CDS T01416

Gene name

MAP2K4

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 4

K04430

mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]

Organism

pon Pongo abelii (Sumatran orangutan)

Pathway

pon04010

MAPK signaling pathway

pon04012

ErbB signaling pathway

pon04620

Toll-like receptor signaling pathway

pon04664

Fc epsilon RI signaling pathway

pon04668

TNF signaling pathway

pon04912

GnRH signaling pathway

pon04926

Relaxin signaling pathway

pon04935

Growth hormone synthesis, secretion and action

pon05132

Salmonella infection

pon05135

Yersinia infection

pon05142

Chagas disease

pon05161

Hepatitis B

pon05166

Human T-cell leukemia virus 1 infection

pon05167

Kaposi sarcoma-associated herpesvirus infection

pon05169

Epstein-Barr virus infection

pon05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:pon00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100439299 (MAP2K4)
   04012 ErbB signaling pathway
    100439299 (MAP2K4)
   04668 TNF signaling pathway
    100439299 (MAP2K4)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100439299 (MAP2K4)
   04664 Fc epsilon RI signaling pathway
    100439299 (MAP2K4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100439299 (MAP2K4)
   04926 Relaxin signaling pathway
    100439299 (MAP2K4)
   04935 Growth hormone synthesis, secretion and action
    100439299 (MAP2K4)
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100439299 (MAP2K4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100439299 (MAP2K4)
   05135 Yersinia infection
    100439299 (MAP2K4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100439299 (MAP2K4)
   05161 Hepatitis B
    100439299 (MAP2K4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100439299 (MAP2K4)
   05169 Epstein-Barr virus infection
    100439299 (MAP2K4)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    100439299 (MAP2K4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100439299 (MAP2K4)
Enzymes [BR:pon01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100439299 (MAP2K4)
Protein kinases [BR:pon01001]
Serine/threonine kinases: STE group
  STE7 family
   100439299 (MAP2K4)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Kinase-like Seadorna_VP7 Pkinase_fungal APH

Other DBs

NCBI-GeneID:

100439299

NCBI-ProteinID:

XP_002827100

LinkDB

Position

AA seq 399 aa
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD

NT seq 1200 nt +upstreamnt +downstreamnt
atggcggctccgagcccgagcggcggcggcggctccgggggcggcagcggcagcggcacc
ccgggccccgtagggtccccggcgccgggccacccggccgtcagcagcatgcagggtaaa
cgcaaagcactgaagttgaattttgcaaatccacctttcaaatctacagcaaggtttact
ctgaatcccaatcctacaggagttcaaaacccacacatagagagactgagaacacacagc
attgagtcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagag
gacttgaaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtc
cacaaaccaagtgggcaaataatggcagttaaaagaattcggtcaacagtggatgaaaaa
gaacaaaaacaacttcttatggatttggatgtagtaatgcggagtagtgattgcccatac
attgttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggaactc
atgtctacctcgtttgacaagttttacaaatatgtatatagtgtattagatgatgttatt
ccagaagaaattttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaa
gaaaacttgaaaattattcacagagatatcaaaccttccaatattcttctggacagaagt
ggaaatattaagctctgtgacttcggcatcagtggacagcttgtggactctattgccaag
acaagagatgctggctgtaggccatacatggcacctgaaagaatagacccaagcgcatca
cgacaaggatatgatgtccgctctgatgtctggagtttggggatcacattgtatgagttg
gccacgggccgatttccttatccaaagtggaatagtgtatttgatcaactaacacaagtc
gtgaaaggagatcctccgcagctgagtaattctgaggaaagggaattctccccgagtttc
atcaactttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagag
cttctgaaacatccctttattttgatgtatgaagaacgtgccgttgaggtcgcatgctat
gtttgtaaaatcctggatcaaatgccagctactcccagctctcccatgtatgtcgattga

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