KEGG   Pongo abelii (Sumatran orangutan): 100437449
Entry
100437449         CDS       T01416                                 

Gene name
ABL2
Definition
(RefSeq) Abelson tyrosine-protein kinase 2 isoform X2
  KO
K08887  abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100437449 (ABL2)
   04014 Ras signaling pathway
    100437449 (ABL2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05416 Viral myocarditis
    100437449 (ABL2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100437449 (ABL2)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100437449 (ABL2)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  ABL family
   100437449 (ABL2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 SH3_3 NHS SH3_6 RGS12_us1
Other DBs
NCBI-GeneID: 100437449
NCBI-ProteinID: XP_002809798
Ensembl: ENSPPYG00000000464
UniProt: A0A2J8UC56
LinkDB
Position
1
AA seq 1167 aa
MVLGTVLLQPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA
LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
LVRESESSPGQLSISLRYEGRVYHYRINTTTDGKVYVTAESRFSTLAELVHHHSTVADGL
VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG
GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD
RMAMTLPRNCQRSKLHLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR
GAAALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS
PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP
RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK
AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL
LSSAITEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA
AAGVPGTNPVLNNLLSCVQEISDVVQR
NT seq 3504 nt   +upstreamnt  +downstreamnt
atggtccttgggacagttctccttcaacctaatagttatggcagagatcaggacacttct
ctttgctgcctgtgcactgaggcctcagaatctgctctacccgacttgacagatcacttt
gccagctgtgtggaggatggatttgagggagacaagactggaggcagtagtccagaagct
ttgcatcgtccctatggttgtgatgttgaaccccaggcactaaatgaggctatcaggtgg
agctccaaggagaacttgctcggagccaccgagagtgaccctaatctcttcgttgcactt
tatgattttgtagcaagtggtgataacacactcagcatcactaaaggtgaaaagctacga
gtccttggttacaaccagaatggcgagtggagtgaagttcgctctaagaacgggcagggc
tgggtgccaagcaactacatcaccccagtgaacagtctggaaaaacactcctggtaccat
ggacctgtgtcacgcagtgcagctgagtatctgctcagcagtctaatcaatggcagcttc
ctggtacgagaaagtgagagtagccctgggcagctgtccatctcgctcaggtacgaggga
cgtgtgtatcactacaggatcaataccaccacagatggcaaggtgtatgtgactgctgag
agccgcttcagcaccttggcagagcttgtacaccatcactccacagtggctgatgggctg
gtgacaacattacactacccagcacccaagtgtaataagcctacagtctatggtgtgtcc
cccatccacgacaaatgggaaatggagcgaacagatattaccatgaagcacaaacttggg
ggcggtcagtatggagaggtttacgttggcgtctggaagaaatacagccttacagttgct
gtgaaaacattgaaggaagataccatggaggtagaagaattcctgaaagaagctgcggta
atgaaggaaatcaagcatcctaatctggtacaacttttaggtgtgtgtactttggagcca
ccattttacattgtgactgaatacatgccatacgggaatttgctggattacctccgagaa
tgcaaccgagaagaggtgactgcagttgtgctgctctacatggccactcagatttcttct
gcaatggagtacttagagaagaagaatttcatccatagagatcttgcagctcgtaactgc
ctagtgggagaaaaccatgtggtaaaagtggctgactttggcttaagtagattgatgact
ggagacacttatactgctcatgctggagccaaatttcctattaagtggacagcaccagag
agtcttgcctacaataccttctcaattaaatctgacgtctgggcttttggggtactgttg
tgggaaatcgctacctatggaatgtcaccatatccaggtattgacctgtctcaggtctac
gacctcctagaaaaaggatatcgaatggaacagcctgagggatgcccccctaaggtttat
gaacttatgagagcatgctggaagtggagccctgccgataggccctcttttgctgaaaca
caccaagcttttgaaaccatgttccatgactccagcatttctgaagaggtagctgaggag
cttgggagagctgcctcctcatcatctgttgttccatacctgccccggctacctatactt
ccttccaagactcggacactgaagaaacaggtggagaacaaggagaacattgaaggggca
caagatgccacagaaaattctgcttccagtttagcaccagggttcatcagaggtgcgcag
gcctccagtggatccccagcactgcctcgaaagcaaagagacaagtcacccagcagcctc
ttggaagatgccaaagagacatgcttcaccagggataggaaggggggcttcttcagctcc
ttcatgaaaaagagaaatgctcctacaccccctaaacgcagcagctccttccgagaaatg
gagaatcagccccataagaaatacgaactcacgggtaacttctcatctgttgcttctcta
cagcatgctgatgggttctctttcactcctgcccagcaagaggcgaatctggtgccaccc
aagtgctatggggggagctttgcacagaggaacctctgtaatgacgacggtggtgggggt
gggggcagtggcactgctgggggtgggtggtctggcatcacaggcttctttacaccacgc
ttaatcaaaaagacactgggcttacgagcaggtaaacccacagccagtgatgacacttcc
aagccttttccaaggtcaaactctacatcttccatgtcctcagggcttccagagcaggat
aggatggcaatgacccttcccaggaactgccagaggtccaaactccacctggaaaggaca
gtgtccacctcttctcagccagaagagaatgtggacagggccaatgacatgcttccaaaa
aaatcagaggaaagtgctgctccaagcagggagagaccaaaagccaagttattgcccaga
ggagccgcagctcttcctctcagaacaccctctggggatctagccattacagagaaggac
cctccaggggtgggagtggctggagtggcagctgcccccaagggcaaagagaagaatggt
ggggcacgacttgggatggctggagttccagaggatggagagcagccgggctggccttct
ccagccaaggctgcccctgtcctcccaaccactcacaaccacaaagtgccagtccttatc
tcacccaccctgaaacacactccagctgatgtgcagctcattggcacagactctcagggg
aataaattcaagctcttatctgagcatcaggtcacatcctctggagacaaggaccgaccc
cgacgggtaaaaccaaagtgtgccccacccccaccaccagtgatgagactactgcagcat
ccgtccatctgctcagaccctacagaagagccgactgccctaactgcaggacagtccacg
tcagaaacacaggaaggaggaaagaaggcagctctgggcgcagtgcccatcagtgggaaa
gctgggaggccagtgatgcctccacctcaagtgcctctgcccacatcttccatctcgcca
gccaaaatggccaacggcacagcaggtactaaagtggctctgagaaaaaccaaacaggcc
gctgagaaaatctcagcagacaaaatcagcaaagaggccctgctggaatgtgctgaccta
ctgtccagtgcaatcacggaacctgtgcccaacagccagctggtagacactggacaccag
ctgcttgactactgctcaggctatgtggactgcatccctcaaactcgcaacaaatttgcc
ttccgagaggctgtgagcaaactggaactcagcctgcaggagctacaggtttcttcagca
gctgctggtgtgcccgggacaaaccctgtccttaataacttattgtcatgtgtacaggaa
atcagtgatgtggtgcagaggtag

KEGG   Pongo abelii (Sumatran orangutan): 100453216
Entry
100453216         CDS       T01416                                 

Gene name
ABL1
Definition
(RefSeq) tyrosine-protein kinase ABL1 isoform X1
  KO
K06619  abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04110  Cell cycle
pon04360  Axon guidance
pon04722  Neurotrophin signaling pathway
pon05200  Pathways in cancer
pon05206  MicroRNAs in cancer
pon05220  Chronic myeloid leukemia
pon05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100453216 (ABL1)
   04014 Ras signaling pathway
    100453216 (ABL1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100453216 (ABL1)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100453216 (ABL1)
  09158 Development and regeneration
   04360 Axon guidance
    100453216 (ABL1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100453216 (ABL1)
   05206 MicroRNAs in cancer
    100453216 (ABL1)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    100453216 (ABL1)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    100453216 (ABL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100453216 (ABL1)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100453216 (ABL1)
Protein kinases [BR:pon01001]
 Non-receptor tyrosine kinases
  ABL family
   100453216 (ABL1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 SH3_3 Kinase-like SH3_6
Other DBs
NCBI-GeneID: 100453216
NCBI-ProteinID: XP_024107872
LinkDB
Position
9
AA seq 1149 aa
MGQQPGKVLGDQRRPSLPALHFIKGAGRKESSRHGGPHCNVFVEHEALQRPVASDFEPQG
LSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCE
AQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR
SISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRN
KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE
EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL
YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKF
PIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP
EGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSA
LLQAPELPTKTRTSRRAAEHRDATDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPE
GGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDI
SNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATG
EEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPA
LPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQ
VTVASASGLPYKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHS
SESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPLQSPSQEVAGEAVLGAKTKASSLVDAV
NSDAAKPSQPGESLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTA
FIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGK
NLYTFCVSYVDSIQQMRNKFAFREAINKLENHLRELQICPATAGSGPAATQDFSKLLSSV
KEISDIVQR
NT seq 3450 nt   +upstreamnt  +downstreamnt
atggggcagcagcctggaaaagttcttggggaccaaagaaggccaagcttgcctgccctg
cattttatcaaaggagcagggaggaaggaatcatcgaggcatgggggtccacactgcaat
gtttttgtggaacatgaagcccttcagcggccagtagcatctgactttgagcctcagggt
ctgagtgaagccgctcgttggaactccaaggaaaaccttctcgctggacccagtgaaaat
gaccccaaccttttcgttgcactgtatgattttgtggccagtggagataacactctaagc
ataactaaaggtgaaaagctccgggtcttaggctataatcacaatggggaatggtgtgaa
gcccaaaccaaaaatggccaaggctgggtcccaagcaactacatcacgccagtcaacagt
ctggagaaacactcctggtaccatgggcctgtgtcccgcaatgctgctgagtatctgctg
agcagcgggatcaatggcagcttcttggtgcgtgagagtgagagcagtcctggccagagg
tccatctcgctgagatacgaagggagggtgtaccattacaggatcaacactgcttctgat
ggcaagctctacgtctcctccgagagccgcttcaacaccctggccgagctggttcatcat
cattcaacagtggccgatgggctcatcaccacgctccattatccagcccccaagcgcaac
aagcccactgtctacggtgtgtcgcccaactacgacaagtgggagatggaacgcacggac
atcaccatgaagcacaagctgggcgggggccagtatggggaggtgtacgagggcgtgtgg
aagaaatacagcctgacggtggccgtgaagaccttgaaggaggacaccatggaggtggaa
gagttcttgaaagaagctgcagtcatgaaagagatcaaacaccctaacctggtgcagctc
cttggggtctgcacgcgggagcccccgttctatatcatcactgagttcatgacctacggg
aacctcctggactacctgagggagtgcaaccggcaggaggtgaacgccgtggtgctgctg
tacatggccactcagatctcgtcagccatggagtacctggagaagaaaaacttcatccac
agagatcttgctgcccgaaactgcctggtaggggagaaccacttggtgaaggtagctgat
tttggcctgagcaggttgatgacaggggacacctacacagcccatgctggagccaagttc
cccatcaaatggactgcacccgagagcctggcctacaacaagttctccatcaagtctgac
gtctgggcatttggagtcttgctttgggaaattgctacctatggcatgtccccttacccg
ggaattgacctgtcccaggtgtatgagctgctagagaaggactaccgcatggagcgccca
gaaggctgcccagagaaggtctatgaactcatgcgagcatgttggcagtggaatccctct
gaccggccctcctttgctgaaatccaccaagcctttgaaacaatgttccaggaatccagt
atctcagacgaagtggaaaaggagctggggaaacaaggcgtccgtggggctgtgagtgcc
ttgctgcaggccccagagctgcccaccaagacaaggacctccaggagagctgcggagcac
agagacgctactgacgtgcctgagatgcctcactccaagggccagggagagagcgatcct
ctggaccatgagcctgccgtgtctccattgctccctcgaaaagagcgaggtcccccggag
ggtggcctgaatgaagatgagcgccttctccccaaagacaaaaagaccaacttgttcagc
gccttgatcaagaagaagaagaagacagccccaacccctcccaaacgcagcagctccttc
cgggagatggacggccagccggagcgcagaggagccggcgaggaagagggccgagacatc
agcaacggggctctggctttcacccccttggacacagctgacccagccaagtccccaaag
cccagcaatggggctggggtccccaatggagccctccgggagtccgggggctcaggcttc
cggtctccccacctgtggaagaagtccagcacgctgaccagcagccgcctagccactggc
gaggaagagggtggtggcagctccagcaagcgcttcctgcgctcctgctccgcttcctgc
gttccccacggggccaaggacacggagtggaggtcagtcacgctgcctcgggacttgcag
tccacgggaagacagtttgactcgtccacatttggagggcacaaaagtgagaagccggct
ctgcctcggaagagggcaggggagaacaggtctgaccaggtgacccgaggcacagtaacg
cccccccccaggctggtgaaaaagaacgaggaagctgctgatgaggtcttcaaagacatc
atggagtccagcccgggttccagcccacccaacctgactccaaaacccctccggcggcag
gtcaccgtggcctctgcctcgggcctcccctacaaggaagaagctggaaagggcagtgcc
ttagggacccctgctgcagctgagccagtgacccccaccagcaaagcaggctcaggtgca
ccagggggcaccagcaagggccccgccgaggagtccagagtgaggaggcacaagcactcc
tctgagtcgccagggagggacaaggggaaattgtccaggctcaaacctgccccgccgccc
ccaccagcagcctctgcagggaaggctggaggaaagcccttgcagagcccgagccaggag
gtggccggggaggcggtcctgggcgcaaagacaaaagcctcaagtctggttgatgctgtg
aacagtgacgctgccaagcccagccagccgggagagagcctcaaaaagcccgtgctccca
gccactccaaagccacagtccgccaagccatcggggacccccatcagcccagcccctgtt
ccctccacgttgccatcagcatcctcggccctggcaggggaccagccatcttccaccgcc
ttcatccctctcatatcgacccgagtgtctcttcggaaaacccgccagcctccagagcgg
atcgccagtggcgccatcactaagggcgtggtcctggacagcaccgaggcgctgtgcctc
gccatctctaggaactccgagcagatggccagccacagcgcagtgctcgaggcaggcaaa
aacctctacacattctgcgtgagctacgtggattccatccagcaaatgaggaacaagttt
gccttccgagaggccatcaacaaactggagaatcatctccgggagcttcagatctgcccg
gcgacagcaggcagtggtccggcggccactcaggacttcagcaagctcctcagttcggtg
aaggaaatcagtgacatagtgcagaggtag

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