KEGG   Pongo abelii (Sumatran orangutan): 100441126
Entry
100441126         CDS       T01416                                 

Gene name
TSC2
Definition
(RefSeq) tuberin isoform X1
  KO
K07207  tuberous sclerosis 2
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04072  Phospholipase D signaling pathway
pon04115  p53 signaling pathway
pon04140  Autophagy - animal
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04152  AMPK signaling pathway
pon04211  Longevity regulating pathway
pon04218  Cellular senescence
pon04714  Thermogenesis
pon04910  Insulin signaling pathway
pon04919  Thyroid hormone signaling pathway
pon05163  Human cytomegalovirus infection
pon05165  Human papillomavirus infection
pon05168  Herpes simplex virus 1 infection
pon05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    100441126 (TSC2)
   04151 PI3K-Akt signaling pathway
    100441126 (TSC2)
   04152 AMPK signaling pathway
    100441126 (TSC2)
   04150 mTOR signaling pathway
    100441126 (TSC2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100441126 (TSC2)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100441126 (TSC2)
   04218 Cellular senescence
    100441126 (TSC2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100441126 (TSC2)
   04919 Thyroid hormone signaling pathway
    100441126 (TSC2)
  09149 Aging
   04211 Longevity regulating pathway
    100441126 (TSC2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100441126 (TSC2)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    100441126 (TSC2)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    100441126 (TSC2)
   05163 Human cytomegalovirus infection
    100441126 (TSC2)
   05165 Human papillomavirus infection
    100441126 (TSC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:pon01009]
    100441126 (TSC2)
Protein phosphatases and associated proteins [BR:pon01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     100441126 (TSC2)
SSDB
Motif
Pfam: Tuberin DUF3384 Rap_GAP Telomere_reg-2 Cnd1
Other DBs
NCBI-GeneID: 100441126
NCBI-ProteinID: XP_024089853
Ensembl: ENSPPYG00000006986
LinkDB
Position
16
AA seq 1784 aa
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
MALWGAHRLYSLRNSPTSVLPSFYQAMVCPNEVVSYEIVLSITRLIKKYRKELQVVTWDI
LLNIIERLLQQLQTLDSPELRTVVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVAARSLS
PPPELEERDAAAHSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
GPLSPPSGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
ALDMPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
ARPPPLPRSNTDSAAVVEEGSPGEVPVPVEPPGLEDFEAALGMDRRTDAYSRSSSVSSQE
EKSLHAEELVARGIPIERAVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD
KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI
SDSAPSRRGKRVERDAFKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE
SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDRHRCDKKRHLGN
DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV
SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP
SLPLVHPPSHTKAPAQTPAEPTPGYEMGQRKRLVSSVEDFTEFV
NT seq 5355 nt   +upstreamnt  +downstreamnt
atggccaaaccaacaagcaaagattcaggcttgaaggagaagtttaagattctgttggga
ctgggaacaccgaggccaaatcccaggtctgcagagggtaaacagacggagtttatcatc
accgcggaaatactgagagaactgagcatggaatgtggcctcaacaatcgcatccggatg
atagggcagatttgtgaagttgcaaaaaccaagaaatttgaagagcacgcagtggaagca
ctttggaaggcggtcgcggatctgttgcagccggagcggccactggaggcccggcacgcg
gtgctggctctgctgaaggccatcgtgcagggacagggcgagcgtttgggggtcctcaga
gccctcttctttaaggtcatcaaggattacccttccaatgaagaccttcacgaaaggctg
gaagttttcaaggccctcacagacaatgggagacacatcacctacttggaggaagagctg
gctgactttgtcctgcagtggatggatgttggcttgtcctcggaattccttctggtgctg
gtgaacttggtcaaattcaatagctgttacctcgacgagtacatcgcaaggatggttcag
atgatctgtctgctctgcgtccggaccgcatcctctgtggacatagaggtctccctgcag
gtgctggacgctgtggtctgctacaactgcctgccggctgagagcctcccgctgttcatc
gttactctctgtcgcaccatcaacgtcaaggagctctgcgagccttgctggaagctgatg
cggaacctccttggcacccacctgggccacagcgccatctataacatgtgccacctcatg
gaggacagagcctacatggaggacgcgcccctgctgagaggagccgtgttttttgtgggc
atggctctctggggagcccaccggctctattctctgaggaactcgccgacatctgtgcta
ccatcattttaccaggccatggtatgtccgaacgaggtggtgtcctatgagatcgtcctg
tccatcaccaggctcatcaagaagtacaggaaggagctccaggtggtgacgtgggacatt
ctgctgaacatcatcgaacggctccttcagcagctccagaccttggacagcccggagctc
aggaccgttgtccatgacctgttgaccacggtggaggagctgtgtgaccagaacgagttc
cacgggtctcaggagagatactttgaactggtggagagatgtgcggaccagaggccggag
tcctccctcctgaacctgatctcctatagagcgcagtccatccacccggccaaggacggc
tggattcagaacctgcaggcgctgatggagagattcttcaggagcgagtcccgaggcgcc
gtgcgcatcaaggtgctggacgtgctgtcctttgtgctgctcatcaacaggcagttctat
gaggaggagctgattaactcagtggtcatctcgcagctctcccacatccccgaggataaa
gaccaccaggtccgaaagctggccacccagttgctggtggacctggcagagggctgccac
acacaccacttcaacagcctgctggacatcatcgagaaggtggcggcccgctccctctcc
ccacccccagagctggaagaaagggatgcggccgcacactcagcctccttggaggatgtg
aagacagctgtcctgggtcttctggtcatccttcagaccaagctgtacaccctgcctgca
agccacgccacgcgcgtgtatgagatgctggtcagccacattcagctccactacaagcac
agctacaccctgccaattgcgagcagcatccggctgcaggcctttgacttcctgttgctg
ctgcgggccgactcactgcaccgcctcggcctgcccaacaaggatggagtcgtgcggttc
agcccctactgcgtctgcgactacatggagccagagagaggctctgagaagaagaccagc
ggccccctttctcctccctcagggccgcctggcccggcgcctgcaggtcccgccgtgcgg
ctgggttccctgccctactccctgctcttccgtgtcctgctgcagtgcttgaagcaggag
tctgactggaaggtgctgaagctggttctgggcaggctgcccgagtccctgcgctacaaa
gtgctcatctttacttccccttgcagtgtggaccagctgtgctctgctctctgctccatg
ctttcaggcccaaagacactggagcggctccgaggcgccccagaaggcttctccagaact
gacctgcacctggctgtggttccagtgctgacagcattaatctcttaccataactacctg
gacaaaaccaaacagcgcgagatggtctactgcctggagcagggcctcatccaccgctgt
gccagccagtgcgtcgtggccttgtccatctgcagcgtggagatgcctgacatcatcatc
aaggcgctgcccgtcctggtggtgaagctcacacacatctcggccacagccagcatggcc
gtcccactgctggagttcctgtccactctggccaggctgccgcacctctacaggaacttt
gccgcggagcagtatgccagtgtgttcgccatctccctgccgtacaccaacccctccaag
tttaatcagtacatcgtgtgtctggcccatcacgtcatagccatgtggttcatcaggtgc
cgcctgcccttccggaaggatttcgtccctttcatcactaagggcctgcggtccaatgtc
ctcttgtcttttgatgacacccccgagaaggacagcttcagggcccggagtactagtctc
aacgagagacccaagagtctgaggatagccagaccccccaaacaaggcttgaataactct
ccacccgtgaaagaattcaaggagagctctgcagccgaggccttccggtgccgcagcatc
agtgtgtctgaacatgtggtccgcagcaggatacagacgtccctcaccagtgccagcttg
gggtctgcagacgagaactccgtggcccaggctgacgatagcctgaaaaacctccacctg
gagctcacggaaacctgtctggacatgatggctcgatacgtcttctccaacttcacggct
gtcccgaagaggtctcctgtgggcgagttcctcctggcgggtggcaggaccaaaacctgg
ctggttgggaacaagcttgtcactgtgacgacaagcgtgggaaccgggacccggtcgtta
ctaggcctggactcgggggagttgcagtccggcccagagtcgagctccagccccggcgtg
catgtgagacagacaaaggaggcgccggccaagctggagtcccaggctgggcagcaggtg
tcccgtggggcccgggaccgggtccgttccatgtcggggggccatggtcttcgagttggc
gccctggacatgccggcctcccagttcctgggcagtgccacttctccaggaccacggact
gcaccagccgcgaagcctgagaaggcgtcagctggcacccgggttcctgtgcaggagaag
acgaacttggcggcctacgtacccctgctgacccagggctgggcggagatcctggtccgg
aggcccacagggaacaccagctggctgatgagcctggagaacccgctcagccctttctct
tcggacatcaacaacatgcccctgcaggagctgtccaacgccctcatggcggctgagcgc
ttcaaggagcaccgggacacagccctgtacaagtcattgtcggtgccggcggccagcacg
gccagaccccctcctctgcctcgctccaacacagactccgctgcggtcgtggaggaggga
agtcctggcgaggttcctgtgccagtggagcccccaggcttggaggactttgaggcagcg
ctaggcatggacaggcgcacggatgcctacagcaggtcgtcctcagtctccagccaggag
gagaagtcgctccacgcggaggagctggttgccaggggcatccccatcgagcgagccgtc
tcctcggagggtggccggccctctgtggacctctccttccagccctcgcagcccctgagc
aagtccagctcctctcccgagctgcagaccctgcaggacatcctcggggaccctggggac
aaggccgacgtgggccggctgagccctgaggttaaggcccggtcacagtcagggaccctg
gacggggaaagtgctgcctggtcagcctcgggcgaagacagtcggggccagccggagggt
cccttgccttccagctccccccgctcgcccagtggcctccggccccgaggttacaccatc
tccgactcggccccatcacggaggggcaagagggtagagagggatgcctttaagagcaga
gccacagcctccaatgcagagaaagtgccgggcatcaaccccagtttcgtgttcctgcag
ctctaccattcccccttctttggcgacgagtcaaacaagccaatcctgctgcccaatgag
tcacagtcctttgagcggtcggtgcagctcctcgaccagatcccatcatacgacacccac
aagatcgccgtcctgtatgttggagaaggccagagcaacagcgagctcgccatcctgtcc
aacgagcatggctcctacaggtacacggagttcctgacgggcctgggccggctcatcgag
ctgaaagactgccagcccgacaaggtgtacctgggaggcctggacgtgtgtggtgaggat
ggccagttcacctactgctggcacgatgacatcatgcaagccgtcttccacatcgcgacc
ctgatgcccaccaaggacgtggacaggcaccgctgcgacaagaagcgccacctgggcaat
gactttgtgtccattgtctacaatgactccggcgaggactttaagctcggcaccatcaag
ggccagttcaactttgtccacgtgatcgtcaccccgctggactatgagtgcaacctggtg
tccctgcagtgcaggaaagacatggagggccttgtggacaccagcgtggccaagatcgtg
tctgaccgcaacctgcccttcgtggcccgccagatggccttgcacgcaaatatggcctca
caggtgcaccatagccgctccaaccccaccgacatctacccctccaagtggattgcccgg
ctccgccacatcaagaggctccgccagcggatctgtgaggaagccgcctactccaacccc
agcctgcctctggtgcaccccccgtcccataccaaagcccctgcacagactccagccgag
cccacacctggctacgagatgggccagcggaagcgcctcgtctcctccgtggaggacttc
accgagttcgtgtga

DBGET integrated database retrieval system