KEGG   Pongo abelii (Sumatran orangutan): 100443314
Entry
100443314         CDS       T01416                                 

Gene name
CDK4
Definition
(RefSeq) cyclin-dependent kinase 4 isoform X2
  KO
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01522  Endocrine resistance
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04218  Cellular senescence
pon04530  Tight junction
pon04660  T cell receptor signaling pathway
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04934  Cushing syndrome
pon05160  Hepatitis C
pon05162  Measles
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05169  Epstein-Barr virus infection
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05212  Pancreatic cancer
pon05214  Glioma
pon05218  Melanoma
pon05219  Bladder cancer
pon05220  Chronic myeloid leukemia
pon05222  Small cell lung cancer
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    100443314 (CDK4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100443314 (CDK4)
   04115 p53 signaling pathway
    100443314 (CDK4)
   04218 Cellular senescence
    100443314 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    100443314 (CDK4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    100443314 (CDK4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100443314 (CDK4)
   05203 Viral carcinogenesis
    100443314 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100443314 (CDK4)
   05225 Hepatocellular carcinoma
    100443314 (CDK4)
   05214 Glioma
    100443314 (CDK4)
   05220 Chronic myeloid leukemia
    100443314 (CDK4)
   05218 Melanoma
    100443314 (CDK4)
   05219 Bladder cancer
    100443314 (CDK4)
   05224 Breast cancer
    100443314 (CDK4)
   05222 Small cell lung cancer
    100443314 (CDK4)
   05223 Non-small cell lung cancer
    100443314 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100443314 (CDK4)
   04934 Cushing syndrome
    100443314 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100443314 (CDK4)
   05160 Hepatitis C
    100443314 (CDK4)
   05164 Influenza A
    100443314 (CDK4)
   05162 Measles
    100443314 (CDK4)
   05163 Human cytomegalovirus infection
    100443314 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100443314 (CDK4)
   05169 Epstein-Barr virus infection
    100443314 (CDK4)
   05165 Human papillomavirus infection
    100443314 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100443314 (CDK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100443314 (CDK4)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100443314 (CDK4)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100443314 (CDK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like FTA2
Other DBs
NCBI-GeneID: 100443314
NCBI-ProteinID: XP_002823486
Ensembl: ENSPPYG00000004703
UniProt: A0A2J8UGT3
LinkDB
Position
12
AA seq 303 aa
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
NT seq 912 nt   +upstreamnt  +downstreamnt
atggctacctctcgatatgagccagtggctgaaattggtgtcggtgcctatgggacagtg
tacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtcccc
aatggaggaggagctggaggaggccttcccatcagcacagttcgtgaggtggctttactg
aggcgactggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccaca
tcccgaactgaccgggagatcaaggtaaccctggtgtttgagcatgtagaccaggaccta
aggacgtatctggacaaggcacccccaccaggcttgccagccgaaaccatcaaggatctg
atgcgccagtttctaagaggcctagatttccttcatgccaattgcatcgttcaccgagat
ctgaagccagagaacattctggtgacaagtggtggaacagtcaagctggctgactttggc
ctggccagaatctacagctaccagatggcacttacacccgtggttgttacactctggtac
cgagctcccgaagttcttctgcagtccacatatgcaacacctgtggacatgtggagtgtt
ggctgtatctttgcagagatgtttcgtcgaaagcctctcttctgtggaaactctgaagcc
gaccagttgggcaaaatctttgacctgattgggctgcctccagaggatgactggcctcga
gatgtatccctgccccgtggagcctttccccccagagggccccgcccagtgcagtcggtg
gtacctgagatggaggagtcgggagcgcagctgctgctggaaatgctgacttttaaccca
cacaagcgaatctctgcctttcgagctctgcagcactcttatctacataaggatgaaggt
aatccggagtga

KEGG   Pongo abelii (Sumatran orangutan): 100446748
Entry
100446748         CDS       T01416                                 

Gene name
CDK2
Definition
(RefSeq) cyclin-dependent kinase 2
  KO
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04068  FoxO signaling pathway
pon04110  Cell cycle
pon04114  Oocyte meiosis
pon04115  p53 signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04218  Cellular senescence
pon04914  Progesterone-mediated oocyte maturation
pon04934  Cushing syndrome
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05162  Measles
pon05165  Human papillomavirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05169  Epstein-Barr virus infection
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05215  Prostate cancer
pon05222  Small cell lung cancer
pon05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100446748 (CDK2)
   04151 PI3K-Akt signaling pathway
    100446748 (CDK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100446748 (CDK2)
   04114 Oocyte meiosis
    100446748 (CDK2)
   04115 p53 signaling pathway
    100446748 (CDK2)
   04218 Cellular senescence
    100446748 (CDK2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    100446748 (CDK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100446748 (CDK2)
   05203 Viral carcinogenesis
    100446748 (CDK2)
  09162 Cancer: specific types
   05226 Gastric cancer
    100446748 (CDK2)
   05215 Prostate cancer
    100446748 (CDK2)
   05222 Small cell lung cancer
    100446748 (CDK2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100446748 (CDK2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100446748 (CDK2)
   05161 Hepatitis B
    100446748 (CDK2)
   05160 Hepatitis C
    100446748 (CDK2)
   05162 Measles
    100446748 (CDK2)
   05169 Epstein-Barr virus infection
    100446748 (CDK2)
   05165 Human papillomavirus infection
    100446748 (CDK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100446748 (CDK2)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:pon03032]
    100446748 (CDK2)
   03036 Chromosome and associated proteins [BR:pon03036]
    100446748 (CDK2)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100446748 (CDK2)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100446748 (CDK2)
DNA replication proteins [BR:pon03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    100446748 (CDK2)
Chromosome and associated proteins [BR:pon03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    100446748 (CDK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 100446748
NCBI-ProteinID: XP_002823433
Ensembl: ENSPPYG00000004638
UniProt: A0A6D2W5S7 H2NHM8
LinkDB
Position
12
AA seq 298 aa
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
NT seq 897 nt   +upstreamnt  +downstreamnt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaagtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattac
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga

KEGG   Pongo abelii (Sumatran orangutan): 100454924
Entry
100454924         CDS       T01416                                 

Gene name
CDK6
Definition
(RefSeq) cyclin-dependent kinase 6
  KO
K02091  cyclin-dependent kinase 6 [EC:2.7.11.22]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04218  Cellular senescence
pon04934  Cushing syndrome
pon05160  Hepatitis C
pon05162  Measles
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05169  Epstein-Barr virus infection
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05206  MicroRNAs in cancer
pon05212  Pancreatic cancer
pon05214  Glioma
pon05218  Melanoma
pon05220  Chronic myeloid leukemia
pon05222  Small cell lung cancer
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    100454924 (CDK6)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100454924 (CDK6)
   04115 p53 signaling pathway
    100454924 (CDK6)
   04218 Cellular senescence
    100454924 (CDK6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100454924 (CDK6)
   05206 MicroRNAs in cancer
    100454924 (CDK6)
   05203 Viral carcinogenesis
    100454924 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100454924 (CDK6)
   05225 Hepatocellular carcinoma
    100454924 (CDK6)
   05214 Glioma
    100454924 (CDK6)
   05220 Chronic myeloid leukemia
    100454924 (CDK6)
   05218 Melanoma
    100454924 (CDK6)
   05224 Breast cancer
    100454924 (CDK6)
   05222 Small cell lung cancer
    100454924 (CDK6)
   05223 Non-small cell lung cancer
    100454924 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100454924 (CDK6)
  09172 Infectious disease: viral
   05160 Hepatitis C
    100454924 (CDK6)
   05164 Influenza A
    100454924 (CDK6)
   05162 Measles
    100454924 (CDK6)
   05163 Human cytomegalovirus infection
    100454924 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100454924 (CDK6)
   05169 Epstein-Barr virus infection
    100454924 (CDK6)
   05165 Human papillomavirus infection
    100454924 (CDK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100454924 (CDK6)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100454924 (CDK6)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100454924 (CDK6)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like RIO1 FTA2
Other DBs
NCBI-GeneID: 100454924
NCBI-ProteinID: XP_002818259
Ensembl: ENSPPYG00000017818
UniProt: A0A6D2X0V6 A0A2J8WJX0
LinkDB
Position
7
AA seq 326 aa
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
NT seq 981 nt   +upstreamnt  +downstreamnt
atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg
gagggcgcctatggaaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg
gcgttgaagcgtgtgcgggtgcagacgggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat
gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa
ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc
gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcttggacgtaattggactcccaggagaa
gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa
ccaattgagaagtttgtaacagatatcgatgaactaggcaaagacctacttctgaagtgt
ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc
caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc
tcggagctgaatacagcctga

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