Pongo abelii (Sumatran orangutan): 100452233 Help Entry 100452233         CDS       T01416                                  Gene name IRS2 Definition (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04022   cGMP-PKG signaling pathway pon04068   FoxO signaling pathway pon04140   Autophagy - animal pon04152   AMPK signaling pathway pon04211   Longevity regulating pathway pon04213   Longevity regulating pathway - multiple species pon04910   Insulin signaling pathway pon04920   Adipocytokine signaling pathway pon04923   Regulation of lipolysis in adipocytes pon04930   Type II diabetes mellitus pon04931   Insulin resistance pon04932   Non-alcoholic fatty liver disease pon04935   Growth hormone synthesis, secretion and action pon05010   Alzheimer disease pon05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100452233 (IRS2)    04022 cGMP-PKG signaling pathway     100452233 (IRS2)    04152 AMPK signaling pathway     100452233 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100452233 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100452233 (IRS2)    04923 Regulation of lipolysis in adipocytes     100452233 (IRS2)    04920 Adipocytokine signaling pathway     100452233 (IRS2)    04935 Growth hormone synthesis, secretion and action     100452233 (IRS2)   09149 Aging    04211 Longevity regulating pathway     100452233 (IRS2)    04213 Longevity regulating pathway - multiple species     100452233 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100452233 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     100452233 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100452233 (IRS2)    04932 Non-alcoholic fatty liver disease     100452233 (IRS2)    04931 Insulin resistance     100452233 (IRS2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:pon04990]     100452233 (IRS2) Domain-containing proteins not elsewhere classified [BR:pon04990]  Phosphotyrosine binding (PTB) domain-containing proteins   IRS related family proteins    100452233 (IRS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  100452233 NCBI-ProteinID:  XP_024086711 LinkDB All DBs Position 13 AA seq 1346 aa AA seqDB search MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLISEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGEFYG YMTMDRPLSHCGRPYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLM RATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAA LAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAVAVTPAGPAGPAPTSAASRTF AASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP PDFFSAALHAGGEPLRGVPGCCYSSLPRSYKASYTCGGDSDQYVLMSSPVGRILEEERLE PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGSLGGGRPEGFLGQRGRAVRPTRLSLE GLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGAHLSPPAPPLLASAASSSSLLSASSPAS SLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEVSSLYPP LPPRPSASPSSSLQPPPPPPPPGELYRLPPASAAATAQGPGAASSSSSDTGDNGDYTEMA FGVAATPPQPIAAPPKPEAARVTSPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVI RADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGG SDEPPISPRQLQPALPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNY IAIDVREEPGLPPQPQPQPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSSGGGCGGPGPG ALPPANTYASIDFLSHHLKEATIVKE NT seq 4041 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgcggcacgggccgcccgggccggcgagcggagacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg acggcgggcggggggtcggctccgcagccgccgcggctcgagtactacgagagcgagaaa aagtggcggagcaaggcaggcgcgccgaaacgggtgatcgcgctcgactgctgcttgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgaa tacttcgccgtggccgccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctgatcagcgagggccgcgcggccgccggagacgcgccccccgccgccgcacccgcc gcgtcctgcagcgcctccctgcccggcgccctgggcggctctgccggcgccgccggggcc gaggacagctacgggctggtggcgcccgccacggccgcctaccgtgaggtgtggcaggtg aacctgaagcccaagggtctgggccagagcaagaacctgacgggcgtgtaccgtctgtgc ctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctg cagctcatgaacatccgccgctgcggccactcggacagctttttcttcatcgaggtgggc cgctcggccgtcacaggccccggcgagctgtggatgcaggcggacgactcggtggtggcg cagaacatccatgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttc cggccgcgcagcaagagccagtcgtcggggtcgtcggccacgcaccccatcagcgtcccc ggcgcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgc cgctcgcgcaccgacagcctggccgccaccccgccggcggccaagtgcagctcgtgccgg gtgcgtaccgccagcgagggcgatggcggcgcggcggcgggggcggcggccgcgggcgcc aggccggtgtcggtggccgggagccccctgagccccgggccggtgcgcgcgcccctgagc cgctcgcacaccctgagcggcggctgcggcggccgcgggagcaaggtggcgctgctgccg gcagggggcgcgttgcagcacagccgctccatgtccatgcccgtggcgcactcgccgccc gccgccaccagccccggttccctgtcgtccagcagcggccacggctcgggctcctacccg ccgccgcccggcccgcacccgcccctgccgcatccgctgcaccacggccccggccagcgg ccctccagcggcagcgcctccgcctcgggctcccccagcgaccccggcttcatgtccctg gacgagtacggttccagcccaggcgacctgcgcgccttctgcagtcaccgaagcaacacg cccgagtccatcgcggaaacgcccccggcccgagacggcggcggcggtgagttctacggg tacatgaccatggacaggcccctgagccactgtggccgcccctaccgccgggtctcgggg gacgcggcccaggacctggaccgagggctgcgcaagaggacctactccctgaccacgccg gcccggcagcggccggtgccccagccctcctctgcctcgctggatgagtacaccctgatg cgggccaccttctcgggcagcgcgggccgcctctgcccgtcctgccccgcgtcgtctccc aaggtggcttaccacccctacccggaggactacggagacatcgagatcggctcccacagg agctccagcagcaacctgggcgcagacgacggctacatgcccatgacgcccggcgcggcc ctcgcgggcagtgggagcggcagctgcaggagcgacgactacatgcccatgagccccgcc agcgtgtccgcccccaagcagatcttgcagcccagggccgccgctgccgccgccgccgtc gccgtgacccctgcggggcctgcgggaccagcgcccacctctgcggcgagcaggacattc gcggcgagtgggggcggctacaaggccagctcgcccgccgagagctcccccgaggacagt gggtacatgcgcatgtggtgcggctccaagctgtccatggagcatgcagatggcaagctg ctgcccaacggggactacctcaacgtgtcccccagcgacgcggtcaccacgggcaccccg cccgacttcttctccgcagccctgcacgccggcggggagccgctcaggggcgttcctggc tgctgctacagctccttgcctcgctcctacaaggcctcctacacctgcggcggggacagc gaccagtacgtgctcatgagctcccccgtggggcgcatcctggaggaggagcggctggag cctcaggccacgccagggcccagccaggcggccagcgccttcggggccggccccacgcag ccccctcaccccgtagtgccttcgcccgtgcggcccagcggcagcctaggcggcggccgc ccggagggcttcttgggccagcgcggccgggcggtgaggcccacgcgcctgtccctggag gggctgcccagcctgcccagcatgcacgagtacccactgccaccggagcccaagagcccc ggcgagtacatcaacatcgacttcggcgagcccggggcccacctgtcgccgcccgcgcct cccctgctggcgtcggcggcctcgtcctcctcgctcttgtccgccagcagcccggcctcg tcgctgggctcaggcaccccgggcaccagcagcgacagccggcagcgctctccgctctcc gactacatgaacctcgacttcagctcccccaagtctcctaagccgggcgccccgagcggc caccccgtgggctccttggacggcctcctgtcccccgaggtctcctccctgtatccgccg ctgcccccgcgtccgtccgcgtccccgtcgtcgtccctgcagccgccgccaccgccgccg cccccgggggagctgtaccgcctgccccccgcctcggccgccgccaccgcccagggcccg ggcgccgcctcatcgtcgtcctcggacaccggggacaatggtgactacaccgagatggct tttggtgtggccgccaccccgccgcaaccaatcgcggcccccccgaagccagaagctgcc cgcgtgaccagcccgacgtcgggcgtgaagaggctgagcctcatggagcaggtgtcaggg gtcgaggccttcctgcaggccagccagcccccggacccccaccgcggcgccaaggtcatc cgcgcagacccgcaggggggccgccgccgccacagttccgagaccttctcctccaccacg acggtcacccccgtgtccccgtccttcgcccacaaccccaagcgccacaactcggcctcc gtggaaaatgtctctctcaggaaaagcagcgagggcggcgtgggtgtcggccctggaggg agcgacgagccgcccatctccccccgacagttgcagccggcgctcccggcgccccctttg gcaccgcagggccggccgtggaccccgggtcagcccgggggcttggtcggttgtcctggg agcggtggatcgccaatgcgcagagagacctctgctggcttccagaatggtctcaactac atcgccatcgacgtaagggaggagcccgggctgccaccccagccgcagccgcagccgccg ccgccgcttcctcagccgggagacaagagctcctggggtcggacccgaagcctcgggggt ctcatcagcgctgtgggcgtcggcagcagcggcggcgggtgtggggggccgggtcccggt gccctgccccctgccaacacctacgccagcattgacttcttgtcccaccacttgaaggag gccaccattgtgaaagagtga

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