Panthera pardus (leopard): 109269114
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Entry
109269114 CDS
T06062
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad01521
EGFR tyrosine kinase inhibitor resistance
ppad01522
Endocrine resistance
ppad04010
MAPK signaling pathway
ppad04012
ErbB signaling pathway
ppad04015
Rap1 signaling pathway
ppad04024
cAMP signaling pathway
ppad04062
Chemokine signaling pathway
ppad04068
FoxO signaling pathway
ppad04150
mTOR signaling pathway
ppad04270
Vascular smooth muscle contraction
ppad04510
Focal adhesion
ppad04650
Natural killer cell mediated cytotoxicity
ppad04720
Long-term potentiation
ppad04722
Neurotrophin signaling pathway
ppad04726
Serotonergic synapse
ppad04730
Long-term depression
ppad04810
Regulation of actin cytoskeleton
ppad04910
Insulin signaling pathway
ppad04914
Progesterone-mediated oocyte maturation
ppad04928
Parathyroid hormone synthesis, secretion and action
ppad04934
Cushing syndrome
ppad05010
Alzheimer disease
ppad05022
Pathways of neurodegeneration - multiple diseases
ppad05034
Alcoholism
ppad05160
Hepatitis C
ppad05161
Hepatitis B
ppad05200
Pathways in cancer
ppad05205
Proteoglycans in cancer
ppad05208
Chemical carcinogenesis - reactive oxygen species
ppad05210
Colorectal cancer
ppad05211
Renal cell carcinoma
ppad05212
Pancreatic cancer
ppad05213
Endometrial cancer
ppad05214
Glioma
ppad05215
Prostate cancer
ppad05216
Thyroid cancer
ppad05218
Melanoma
ppad05219
Bladder cancer
ppad05220
Chronic myeloid leukemia
ppad05221
Acute myeloid leukemia
ppad05223
Non-small cell lung cancer
ppad05224
Breast cancer
ppad05225
Hepatocellular carcinoma
ppad05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109269114 (BRAF)
04012 ErbB signaling pathway
109269114 (BRAF)
04015 Rap1 signaling pathway
109269114 (BRAF)
04068 FoxO signaling pathway
109269114 (BRAF)
04024 cAMP signaling pathway
109269114 (BRAF)
04150 mTOR signaling pathway
109269114 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
109269114 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
109269114 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
109269114 (BRAF)
04062 Chemokine signaling pathway
109269114 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
109269114 (BRAF)
04914 Progesterone-mediated oocyte maturation
109269114 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
109269114 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
109269114 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
109269114 (BRAF)
04720 Long-term potentiation
109269114 (BRAF)
04730 Long-term depression
109269114 (BRAF)
04722 Neurotrophin signaling pathway
109269114 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109269114 (BRAF)
05205 Proteoglycans in cancer
109269114 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
109269114 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
109269114 (BRAF)
05212 Pancreatic cancer
109269114 (BRAF)
05225 Hepatocellular carcinoma
109269114 (BRAF)
05226 Gastric cancer
109269114 (BRAF)
05214 Glioma
109269114 (BRAF)
05216 Thyroid cancer
109269114 (BRAF)
05221 Acute myeloid leukemia
109269114 (BRAF)
05220 Chronic myeloid leukemia
109269114 (BRAF)
05218 Melanoma
109269114 (BRAF)
05211 Renal cell carcinoma
109269114 (BRAF)
05219 Bladder cancer
109269114 (BRAF)
05215 Prostate cancer
109269114 (BRAF)
05213 Endometrial cancer
109269114 (BRAF)
05224 Breast cancer
109269114 (BRAF)
05223 Non-small cell lung cancer
109269114 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
109269114 (BRAF)
05160 Hepatitis C
109269114 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
109269114 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
109269114 (BRAF)
09165 Substance dependence
05034 Alcoholism
109269114 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
109269114 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109269114 (BRAF)
01522 Endocrine resistance
109269114 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppad01001
]
109269114 (BRAF)
Enzymes [BR:
ppad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
109269114 (BRAF)
Protein kinases [BR:
ppad01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
109269114 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Kdo
Motif
Other DBs
NCBI-GeneID:
109269114
NCBI-ProteinID:
XP_019308495
Ensembl:
ENSPPRG00000024821
UniProt:
A0A9V1FSQ7
LinkDB
All DBs
Position
Unknown
AA seq
821 aa
AA seq
DB search
MAALSGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQE
EASIAETALTSGSSPSAPPSDSPGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGAPLNQLMRGLRKYQSRTPSPLLHSVPSEIVF
DFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVG
VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG
MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS
NCPKAMKRLMAECLKKKRDERPLFPQERSRRKYRLFNSGYPWKILASIELLARSLPKIHR
SASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2466 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggcggcggcggcggcggtggcgcggagcagggccaggctctgttc
aacggggacatggagcccgaagccggcgccgcggcctcttcggctgcggaccctgccatt
cccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcc
ctattggacaaatttggtggggagcataatccgccatcaatatatctagaggcctatgaa
gaatacaccagcaagctagatgccctccaacagagagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagctctgcatccacggacaccgttacatcttcc
tcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaaccccacagat
gtatcacggagcaatcccaagtcaccacagaaacctatcgttagagtcttcctgcctaat
aaacagaggacagtggtacctgcaagatgtggagttacagtccgggacagtctaaagaaa
gctctgatgatgagaggtctaatccctgagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccaattggctgggacactgatatctcctggctcaccggagaggaattgcat
gtagaagtgttggaaaatgttccgcttacaactcacaactttgtacggaaaacgtttttc
accttagcattttgtgacttttgtcgaaagctgcttttccaaggttttcgctgtcaaacg
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggag
gaggcctccatagcagagactgccctaacgtctggatcgtccccttctgcccccccctcc
gattctcctgggccccaaattctcaccagtccgtctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcaatttggacagcgagaccggtcc
tcatcagctccaaatgtgcatataaatacaatagaacctgtcaatattgatgacttgatt
agagaccaggggtttcgtagtgatggagcccctttgaaccagctgatgcgtggtcttcgg
aaataccaatcccggactcccagtcccctcctacattctgtccccagtgaaatagtgttt
gattttgagcctggcccagtgttcagaggatcaaccacaggcttgtctgccaccccccct
gcctcattgccgggctctctcactaatgtaaaagcattacagaaatctccagggcctcag
cgggaaaggaaatcttcttcatcctcagaagataggaatcgaatgaaaacacttggtaga
agggattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaatt
ggatccgggtcatttgggacagtctataagggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcggcatgtgaacatcctgctcttcatgggctattcaacaaagccc
cagctggctattgtcacccagtggtgtgagggctccagcttataccaccatctccacatc
atcgagaccaaattcgagatgatcaagctgatagatattgctcggcagactgcgcagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtaattcgaatgcaagataaaaacccatatagctttcagtcagatgtatatgcatttgga
attgttctctatgaattgatgactggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggtgggacgaggatatctttctccagatctcagtaaggtacgaagt
aactgtccgaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgag
aggccactgtttccccaagaaaggtccagaagaaagtatagactctttaacagtggttac
ccctggaagattcttgcctctattgagctgctggcccgctcattgccaaaaattcaccgc
agtgcatcagaaccctccttgaatcgggctggcttccagacagaggattttagtctctat
gcttgtgcttctccaaaaacacccatccaggcagggggatatggagaatttgcagccttc
aagtag
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integrated database retrieval system
