KEGG   Pan paniscus (bonobo): 100978497
Entry
100978497         CDS       T02283                                 

Gene name
CASP8
Definition
(RefSeq) caspase 8
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01524  Platinum drug resistance
pps04115  p53 signaling pathway
pps04210  Apoptosis
pps04215  Apoptosis - multiple species
pps04217  Necroptosis
pps04620  Toll-like receptor signaling pathway
pps04621  NOD-like receptor signaling pathway
pps04622  RIG-I-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04657  IL-17 signaling pathway
pps04668  TNF signaling pathway
pps04932  Non-alcoholic fatty liver disease
pps05010  Alzheimer disease
pps05016  Huntington disease
pps05022  Pathways of neurodegeneration - multiple diseases
pps05132  Salmonella infection
pps05134  Legionellosis
pps05142  Chagas disease
pps05145  Toxoplasmosis
pps05152  Tuberculosis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    100978497 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100978497 (CASP8)
   04215 Apoptosis - multiple species
    100978497 (CASP8)
   04217 Necroptosis
    100978497 (CASP8)
   04115 p53 signaling pathway
    100978497 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100978497 (CASP8)
   04621 NOD-like receptor signaling pathway
    100978497 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    100978497 (CASP8)
   04625 C-type lectin receptor signaling pathway
    100978497 (CASP8)
   04657 IL-17 signaling pathway
    100978497 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100978497 (CASP8)
   05203 Viral carcinogenesis
    100978497 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100978497 (CASP8)
   05016 Huntington disease
    100978497 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    100978497 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    100978497 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    100978497 (CASP8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100978497 (CASP8)
   05134 Legionellosis
    100978497 (CASP8)
   05152 Tuberculosis
    100978497 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100978497 (CASP8)
   05161 Hepatitis B
    100978497 (CASP8)
   05160 Hepatitis C
    100978497 (CASP8)
   05164 Influenza A
    100978497 (CASP8)
   05162 Measles
    100978497 (CASP8)
   05168 Herpes simplex virus 1 infection
    100978497 (CASP8)
   05163 Human cytomegalovirus infection
    100978497 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100978497 (CASP8)
   05169 Epstein-Barr virus infection
    100978497 (CASP8)
   05165 Human papillomavirus infection
    100978497 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100978497 (CASP8)
   05142 Chagas disease
    100978497 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100978497 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:pps01002]
    100978497 (CASP8)
Enzymes [BR:pps01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     100978497 (CASP8)
Peptidases and inhibitors [BR:pps01002]
 Cysteine peptidases
  Family C14: caspase family
   100978497 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED PYRIN
Other DBs
NCBI-GeneID: 100978497
NCBI-ProteinID: XP_003820791
UniProt: A0A2R9AJC1
LinkDB
Position
2B
AA seq 464 aa
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINRSLLKIINDYEE
FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVQQIYEILKIYQLMDHSNMDCFICCIL
SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
NT seq 1395 nt   +upstreamnt  +downstreamnt
atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc
tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc
ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac
actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc
tacagggtcatgctgtatcagatttcagaagaagtgagcagatcagaattgaggtctttt
aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg
gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg
aaaagagtctgtgcccaaatcaacaggagcctgctgaagataatcaacgactatgaagaa
ttcagcaaaggggaggagttgtgtggggtaatgacaatctcggactctccaagagaacag
gatagtgaatcacagactttggacaaagtttaccaaatgaaaagcaaacctcggggatac
tgtctgatcatcaacaatcacaattttgcaaaagcacgggagaaagtgcccaaacttcac
agtattagggacaggaatggaacacacttggatgcaggggctttgaccacgacctttgaa
gagcttcattttgagatcaagccccacgatgactgcacggtacagcaaatctatgagatt
ttgaaaatctaccaactcatggaccacagtaacatggactgcttcatctgctgtatcctc
tcccatggagacaagggcatcatctacggcactgatggacaggaggcccccatctatgag
ctgacatctcagttcactggtttgaagtgcccttcccttgctggaaaacccaaagtgttt
tttattcaggcttgtcagggggataactaccagaaaggtatacctgttgagactgattca
gaggagcaaccctatttagaaatggatttatcatcacctcaaacgagatatatcccggat
gaggctgactttctgctggggatggccactgtgaataactgtgtttcctaccgaaaccct
gcagagggaacctggtacatccagtcactttgccagagcctgagagagcgatgtcctcga
ggcgatgatattctcaccatcctgactgaagtgaactatgaagtaagcaacaaggatgac
aagaaaaacatggggaaacagatgcctcagcctactttcacattaagaaaaaaacttgtc
ttcccttctgattga

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