KEGG   PATHWAY: ptg05330
Entry
ptg05330                    Pathway                                

Name
Allograft rejection - Panthera tigris altaica (Amur tiger)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
Pathway map
ptg05330  Allograft rejection
ptg05330

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102959211  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
102970351  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102970631  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102958279  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102965588  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102965871  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102961195  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
102965184  CD80; CD80 molecule [KO:K05412]
102954528  CD86; CD86 molecule [KO:K05413]
102954958  CD28; CD28 molecule [KO:K06470]
102971802  IL12A; interleukin 12A [KO:K05406]
102959546  IL12B; interleukin 12B [KO:K05425]
102953222  FASLG; Fas ligand [KO:K04389]
102958442  FAS; Fas cell surface death receptor [KO:K04390]
102954346  PRF1; perforin 1 [KO:K07818]
102967670  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
102957957  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
102958869  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
102954326  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
102961248  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
102959725  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102966781  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102956510  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102956041  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102960386  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107178930  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102954602  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102966493  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
102957506  IL2; interleukin 2 [KO:K05429]
102969350  CD40LG; CD40 ligand [KO:K03161]
102972342  CD40; CD40 molecule [KO:K03160]
102963756  IFNG; interferon gamma [KO:K04687]
102958919  TNF; tumor necrosis factor [KO:K03156]
102963113  IL4; interleukin 4 [KO:K05430]
102964358  IL5; interleukin 5 [KO:K05428]
102957558  IL10; interleukin 10 [KO:K05443]
Compound
C00533  Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
Related
pathway
ptg04210  Apoptosis
ptg04514  Cell adhesion molecules
ptg04610  Complement and coagulation cascades
ptg04612  Antigen processing and presentation
ptg04660  T cell receptor signaling pathway
ptg04662  B cell receptor signaling pathway
KO pathway
ko05330   
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