Panthera tigris altaica (Amur tiger): 102959529 Help Entry 102959529         CDS       T02988                                  Gene name TLR4 Definition (RefSeq) toll like receptor 4   KO K10160   toll-like receptor 4 Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg04064   NF-kappa B signaling pathway ptg04066   HIF-1 signaling pathway ptg04145   Phagosome ptg04151   PI3K-Akt signaling pathway ptg04217   Necroptosis ptg04613   Neutrophil extracellular trap formation ptg04620   Toll-like receptor signaling pathway ptg04621   NOD-like receptor signaling pathway ptg05132   Salmonella infection ptg05133   Pertussis ptg05134   Legionellosis ptg05135   Yersinia infection ptg05140   Leishmaniasis ptg05142   Chagas disease ptg05144   Malaria ptg05145   Toxoplasmosis ptg05146   Amoebiasis ptg05152   Tuberculosis ptg05161   Hepatitis B ptg05162   Measles ptg05164   Influenza A ptg05170   Human immunodeficiency virus 1 infection ptg05171   Coronavirus disease - COVID-19 ptg05205   Proteoglycans in cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ptg05321   Inflammatory bowel disease ptg05323   Rheumatoid arthritis Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     102959529 (TLR4)    04066 HIF-1 signaling pathway     102959529 (TLR4)    04151 PI3K-Akt signaling pathway     102959529 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     102959529 (TLR4)   09143 Cell growth and death    04217 Necroptosis     102959529 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102959529 (TLR4)    04620 Toll-like receptor signaling pathway     102959529 (TLR4)    04621 NOD-like receptor signaling pathway     102959529 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     102959529 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102959529 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     102959529 (TLR4)    05321 Inflammatory bowel disease     102959529 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     102959529 (TLR4)    05135 Yersinia infection     102959529 (TLR4)    05133 Pertussis     102959529 (TLR4)    05134 Legionellosis     102959529 (TLR4)    05152 Tuberculosis     102959529 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102959529 (TLR4)    05161 Hepatitis B     102959529 (TLR4)    05171 Coronavirus disease - COVID-19     102959529 (TLR4)    05164 Influenza A     102959529 (TLR4)    05162 Measles     102959529 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     102959529 (TLR4)    05144 Malaria     102959529 (TLR4)    05145 Toxoplasmosis     102959529 (TLR4)    05140 Leishmaniasis     102959529 (TLR4)    05142 Chagas disease     102959529 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ptg04131]     102959529 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:ptg04054]     102959529 (TLR4)    04090 CD molecules [BR:ptg04090]     102959529 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:ptg00536]     102959529 (TLR4) Membrane trafficking [BR:ptg04131]  Endocytosis   Phagocytosis    Toll-like receptors     102959529 (TLR4) Pattern recognition receptors [BR:ptg04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    102959529 (TLR4) CD molecules [BR:ptg04090]  Proteins   102959529 (TLR4) Glycosaminoglycan binding proteins [BR:ptg00536]  Hyaluronan   Cell surface receptors    102959529 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_5 LRR_9 LRR_6 DUF1863 Motif Other DBs NCBI-GeneID:  102959529 NCBI-ProteinID:  XP_007094399 LinkDB All DBs Position Un AA seq 833 aa AA seqDB search MMPPTRLAGTLIPAMAFLSCLRPESWDPCVEVVPNITYQCMDLNLHKIPDNIPSSTKDLD MSFNPLSHLGSHSFSNFPELQVLDLSRCEIQIIEDDAYQGLNHLSILILTGNPIQRLFPG AFSGLSSLQTLVAVETNIASLEDFPIGHLKMLKELNVAHNLIHSFKLPEYFSNMPNLEYL DLSNNKIQNIYHKDLQVLHQKPLLNLSLDLSLNPLDSIQPGAFKEIKLRELTLRSNFNST DVMKASIQGLAGLQVHQLVLGEFKNERNLERFDKSILEGLCNLTIEKFRIAYFDKFSEDA IDSFDCLANVSTISLVHLYFNGPKQLPKNLGWQRLELVNCEFEQFPTWKLDSLKELVFSA NEVGNTFTQVKLESLEFLDLSRNDFSFKSCCSERDLGTTRLKHLDLSFNNIITISSNFLG LEQLEYLDFQRSSLKQVSDFSVFLPLKNLRYLDISYTHTQVAFHGIFNGLISLQILKMAG NSFQDNFLPNIFMELTNLTILDLSDCQLEQVSQVAFNSLPKLQLLNMSHNHLLSLDTLPY EPLHSLQTLDCSFNRIVASKEQELRHFPSNLSSLNLTRNDFACVCEHQSFLQWVKDQRQL LVEVEQMVCAKPLDMQGMPMLNFRNATCQVSKTIITVSVFTALLVSLVVVLVYKFYFHLM LLAGCKKYSRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKLEKSLL RQQVELYRLLNRNTYLEWEDSVLGRHIFWRRLRKALLDGKPRSPEGMADAEGS NT seq 2502 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcctacccgcctggctgggactctgatcccagccatggccttcctctcctgc ctgagacctgagagctgggacccttgtgtggaggtggttcctaacattacttaccaatgc atggacctgaatcttcacaaaatccccgacaacatcccctcatcaaccaaggacctggac atgagctttaaccccctgagtcatttaggcagccatagtttctccaacttcccagaactg caggtgctggatttatccaggtgtgaaattcaaataattgaagatgatgcatatcagggc ctaaaccacctctccatcttgatattgacaggaaatcctatccagaggttattcccagga gctttttctggactatcgagtttacagacgctggtggctgtggagacaaatatagcatct ctagaggacttccccattggacatctcaaaatgttgaaggagcttaatgtggctcacaat cttatccattccttcaaattacctgaatatttttctaacatgcccaaccttgagtatttg gatctttccaataacaagatccaaaatatttatcataaagacttacaggttctacatcaa aagcctctactcaacctttctttagacttgtccctaaaccctttagactctatccaacca ggtgcctttaaagaaattaagctccgtgaactgactttgagaagtaattttaatagtaca gatgtaatgaaagcttctattcaaggtctggcaggcttacaggtccatcagttggttctg ggagaatttaaaaatgaaaggaacttggaaagatttgacaaatctatcctggagggactg tgcaatttgaccatagaaaaattccggatagcatactttgacaagttctcagaggatgct attgactcatttgattgtttggcaaacgtttctaccatttctctggtgcatctgtatttc aacgggccaaaacagctccctaaaaatctcggatggcaacggttagaattggttaactgt gaatttgaacaatttcccacatggaagctggactctctcaaggagcttgttttctctgcc aacgaagttgggaacacttttactcaggttaagttggaaagccttgagtttctagatctc agtagaaatgactttagtttcaagagttgctgttctgagagagatttggggacaaccaga ctgaagcatttagatctaagcttcaacaatattattaccataagttcaaacttcttgggc ttagaacagttagaatatctagatttccagcgttccagtttgaaacaggtcagtgatttt tcagtattcctacccctcaaaaacctccgttaccttgatatttcttacactcacacccaa gttgccttccatggcatcttcaatggcttgatcagcctccaaatcttaaaaatggctggc aattctttccaggacaacttccttccaaatattttcatggagctgactaacttgaccatt ctagacctctctgattgtcagctggaacaggtgtcccaagtggcatttaactcactccct aaacttcagttgctaaatatgagtcacaaccacctcttatcattggatacacttccttat gaaccacttcactccctccagactctggactgcagttttaaccgtatagtggcctctaag gagcaagaactacggcattttccaagtaatctatcttccttaaatcttactcggaatgat tttgcttgtgtttgtgaacaccagagtttcctgcagtgggtcaaggaccagaggcagctc ttggtggaagttgaacagatggtgtgtgcaaaacctttggacatgcagggcatgcccatg ctgaattttaggaatgctacctgtcaggtgagcaagaccatcattactgtgtcggttttc actgcactcttggtttctctggtggtggttctggtgtataagttctatttccacctgatg cttcttgctggctgtaaaaagtatagcagaggtgaaagcacctatgacgccttcgttatc tactcaagccaggatgaagattgggtgaggaatgaattggtaaagaacttggaggagggg gtgcccccttttcagctctgccttcactacagagactttattcctggtgtggccatcgcc gccaacatcatccaggaaggtttccataaaagccggaaggttatcgtcgtggtgtcccag cactttatccagagtcgatggtgcatctttgagtatgagattgcccagacttggcagttt ctgagcagccgtgccggcatcatcttcatcgtcctgcagaagttggagaagtccctgctg cggcagcaggtggagctgtatcgccttctcaacaggaacacctacctggagtgggaggac agtgtcctggggaggcacatcttctggagacgactcagaaaagccttgctggatggtaaa ccacgcagtccagaaggaatggcagatgcagaaggcagctag

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