KEGG   Panthera tigris altaica (Amur tiger): 102962460
Entry
102962460         CDS       T02988                                 

Gene name
CASP8
Definition
(RefSeq) caspase 8
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg01524  Platinum drug resistance
ptg04115  p53 signaling pathway
ptg04210  Apoptosis
ptg04215  Apoptosis - multiple species
ptg04217  Necroptosis
ptg04620  Toll-like receptor signaling pathway
ptg04621  NOD-like receptor signaling pathway
ptg04622  RIG-I-like receptor signaling pathway
ptg04625  C-type lectin receptor signaling pathway
ptg04657  IL-17 signaling pathway
ptg04668  TNF signaling pathway
ptg04932  Non-alcoholic fatty liver disease
ptg05010  Alzheimer disease
ptg05016  Huntington disease
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05132  Salmonella infection
ptg05134  Legionellosis
ptg05142  Chagas disease
ptg05145  Toxoplasmosis
ptg05152  Tuberculosis
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05162  Measles
ptg05163  Human cytomegalovirus infection
ptg05164  Influenza A
ptg05165  Human papillomavirus infection
ptg05167  Kaposi sarcoma-associated herpesvirus infection
ptg05168  Herpes simplex virus 1 infection
ptg05169  Epstein-Barr virus infection
ptg05170  Human immunodeficiency virus 1 infection
ptg05200  Pathways in cancer
ptg05203  Viral carcinogenesis
ptg05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    102962460 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    102962460 (CASP8)
   04215 Apoptosis - multiple species
    102962460 (CASP8)
   04217 Necroptosis
    102962460 (CASP8)
   04115 p53 signaling pathway
    102962460 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102962460 (CASP8)
   04621 NOD-like receptor signaling pathway
    102962460 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    102962460 (CASP8)
   04625 C-type lectin receptor signaling pathway
    102962460 (CASP8)
   04657 IL-17 signaling pathway
    102962460 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102962460 (CASP8)
   05203 Viral carcinogenesis
    102962460 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102962460 (CASP8)
   05016 Huntington disease
    102962460 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    102962460 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    102962460 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    102962460 (CASP8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102962460 (CASP8)
   05134 Legionellosis
    102962460 (CASP8)
   05152 Tuberculosis
    102962460 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102962460 (CASP8)
   05161 Hepatitis B
    102962460 (CASP8)
   05160 Hepatitis C
    102962460 (CASP8)
   05164 Influenza A
    102962460 (CASP8)
   05162 Measles
    102962460 (CASP8)
   05168 Herpes simplex virus 1 infection
    102962460 (CASP8)
   05163 Human cytomegalovirus infection
    102962460 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102962460 (CASP8)
   05169 Epstein-Barr virus infection
    102962460 (CASP8)
   05165 Human papillomavirus infection
    102962460 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102962460 (CASP8)
   05142 Chagas disease
    102962460 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    102962460 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:ptg01002]
    102962460 (CASP8)
Enzymes [BR:ptg01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     102962460 (CASP8)
Peptidases and inhibitors [BR:ptg01002]
 Cysteine peptidases
  Family C14: caspase family
   102962460 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED PYRIN
Other DBs
NCBI-GeneID: 102962460
NCBI-ProteinID: XP_007090057
LinkDB
Position
Un
AA seq 479 aa
MDFSKCLYNIGEQLGSDELASLKFLSLDYIPQKKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLFNYLNTSKEAMEQELQIPGRAQIPPYRVMLFQISEDVNKLELRSF
KFLLSQEISRCKVDDDMNLLDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE
LSREGRMSLQRSPDELSNGEESLAMMALSDSLEEQDSESQTSDKVYRMKSKPRGYCLIFN
NYDFSRARKDVPKLQNIKDRNGTNFDAEALSKTFSELHFEIVNFKDSTAKTICEVLKSYQ
RMDHNNKDCFICCILSHGDKGIIYGSDGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQAC
QGDNYQRGIAVETDSEQKEDYLEMDSSFQKRYIPDEADFLLGMATVNNCVSYRNPTEGTW
YIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDKKNMGKQMPQPTFTLRKKLFFPLN
NT seq 1440 nt   +upstreamnt  +downstreamnt
atggatttcagtaaatgtctgtataatattggggaacagctgggcagtgatgagctggcc
tccctcaaattcctgagcctggactacatcccacaaaagaagcaagaacccatcaaagat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc
ttcttgaaggagctgcttttccgaattaatagactggacctgctgttcaactacctgaac
accagcaaggaagcaatggagcaggagcttcagataccaggcagagcccagatccctccc
tacagggtcatgctttttcagatttcagaagatgtaaacaaattggaattgaggtcgttt
aagtttcttttgagccaggagatctccagatgtaaagtggatgatgatatgaacttgctt
gatattttcatagagatggaaaagagggtcatcctaggggaaagaaatttggacactctg
aaaagaatctgtgaccaaatcaacaagagcctgctgaagaaaatcactgattatgaagaa
ttaagcagagagggaagaatgagccttcaaagaagtccagatgaattgtcaaatggggag
gaatccctggcaatgatggcattatcggactctctagaagaacaggacagtgagtcacag
acatcggacaaagtttaccgaatgaaaagcaaacctcgcggatattgtttgatctttaac
aattatgattttagcagagcacggaaggatgtgcccaaacttcagaacattaaggatagg
aatggaacaaactttgatgcagaagctttgagtaagacctttagtgagcttcattttgag
attgtgaatttcaaagactctacagcaaagacaatctgtgaagttctgaaatcctaccaa
agaatggaccataataacaaagattgcttcatctgctgtatcctctcccatggagacaaa
ggcattatttatggctctgatgggcaggaagcccccatctatgagctgacttcttacttc
actggttcaaagtgcccttcccttgcaggcaagcccaaaatcttttttattcaggcttgt
caaggggataactaccagagaggtatagctgttgagactgactctgaacagaaggaagac
tacttagaaatggactcatcatttcagaagagatatatcccagatgaggctgattttctg
ctggggatggccactgtgaacaactgtgtttcctaccgaaaccctacggaggggacctgg
tatatccagtcactttgccagagcctaagagaaagatgtcctaggggcgaagatatcctc
accatccttactgaggtgaactttgaagtgagcaataaggatgacaagaaaaacatgggg
aaacaaatgccacaacctactttcacactgaggaaaaaactcttcttccctcttaattga

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