KEGG   PATHWAY: ptr04664
Entry
ptr04664                    Pathway                                

Name
Fc epsilon RI signaling pathway - Pan troglodytes (chimpanzee)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
Pathway map
ptr04664  Fc epsilon RI signaling pathway
ptr04664

Other DBs
GO: 0045576
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
100608894  immunoglobulin heavy variable 3-23 [KO:K06856]
104002202  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
104002200  immunoglobulin heavy variable 6-1 [KO:K06856]
469538  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
736459  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
100612300  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
464586  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
472771  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
465759  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
470683  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
458253  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
454268  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
460858  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
457922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
471079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
456565  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
461836  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
455855  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
467875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112205915  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
742575  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
747131  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
455065  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
743199  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
107972404  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112206088  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
468310  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
449565  IL4; interleukin-4 isoform 1 precursor [KO:K05430]
449564  IL13; interleukin-13 precursor [KO:K05435]
471626  IL3; interleukin-3 precursor [KO:K04736]
743963  IL5; interleukin-5 [KO:K05428]
471627  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
494186  TNF; tumor necrosis factor [KO:K03156]
471734  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
455647  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
473114  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
457076  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
462944  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
748918  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
743295  LAT; linker for activation of T-cells family member 1 isoform X5 [KO:K07362]
737245  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
459171  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
452897  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
473387  KRAS; GTPase KRas isoform X1 [KO:K07827]
742713  NRAS; GTPase NRas [KO:K07828]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
456390  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
467664  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
469617  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
747584  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
468935  PLA2G4C; cytosolic phospholipase A2 gamma isoform X4 [KO:K16342] [EC:3.1.1.4]
100610135  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
453356  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
450428  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
452520  ALOX5AP; arachidonate 5-lipoxygenase-activating protein isoform X1 [KO:K20735]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00374  Heparin
C00388  Histamine
C00696  Prostaglandin D2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02166  Leukotriene C4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
DOI:10.1038/nri914
Reference
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
DOI:10.1016/j.coi.2003.09.010
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
DOI:10.1038/35037021
Reference
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
DOI:10.1038/nri1782
Reference
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
DOI:10.1016/S0065-2776(01)76022-1
Reference
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
DOI:10.1038/35084076
Reference
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
DOI:10.1038/ni0802-707
Related
pathway
ptr00590  Arachidonic acid metabolism
ptr04010  MAPK signaling pathway
ptr04070  Phosphatidylinositol signaling system
KO pathway
ko04664   
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