Pan troglodytes (chimpanzee): 100614256
Help
Entry
100614256 CDS
T01005
Gene name
ARAF
Definition
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr01521
EGFR tyrosine kinase inhibitor resistance
ptr01522
Endocrine resistance
ptr04010
MAPK signaling pathway
ptr04012
ErbB signaling pathway
ptr04068
FoxO signaling pathway
ptr04270
Vascular smooth muscle contraction
ptr04650
Natural killer cell mediated cytotoxicity
ptr04720
Long-term potentiation
ptr04726
Serotonergic synapse
ptr04730
Long-term depression
ptr04810
Regulation of actin cytoskeleton
ptr04910
Insulin signaling pathway
ptr04914
Progesterone-mediated oocyte maturation
ptr04928
Parathyroid hormone synthesis, secretion and action
ptr05010
Alzheimer disease
ptr05022
Pathways of neurodegeneration - multiple diseases
ptr05034
Alcoholism
ptr05160
Hepatitis C
ptr05161
Hepatitis B
ptr05200
Pathways in cancer
ptr05205
Proteoglycans in cancer
ptr05210
Colorectal cancer
ptr05211
Renal cell carcinoma
ptr05212
Pancreatic cancer
ptr05213
Endometrial cancer
ptr05214
Glioma
ptr05215
Prostate cancer
ptr05218
Melanoma
ptr05219
Bladder cancer
ptr05220
Chronic myeloid leukemia
ptr05221
Acute myeloid leukemia
ptr05223
Non-small cell lung cancer
ptr05224
Breast cancer
ptr05225
Hepatocellular carcinoma
ptr05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100614256 (ARAF)
04012 ErbB signaling pathway
100614256 (ARAF)
04068 FoxO signaling pathway
100614256 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100614256 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100614256 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100614256 (ARAF)
04914 Progesterone-mediated oocyte maturation
100614256 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100614256 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100614256 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100614256 (ARAF)
04720 Long-term potentiation
100614256 (ARAF)
04730 Long-term depression
100614256 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100614256 (ARAF)
05205 Proteoglycans in cancer
100614256 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100614256 (ARAF)
05212 Pancreatic cancer
100614256 (ARAF)
05225 Hepatocellular carcinoma
100614256 (ARAF)
05226 Gastric cancer
100614256 (ARAF)
05214 Glioma
100614256 (ARAF)
05221 Acute myeloid leukemia
100614256 (ARAF)
05220 Chronic myeloid leukemia
100614256 (ARAF)
05218 Melanoma
100614256 (ARAF)
05211 Renal cell carcinoma
100614256 (ARAF)
05219 Bladder cancer
100614256 (ARAF)
05215 Prostate cancer
100614256 (ARAF)
05213 Endometrial cancer
100614256 (ARAF)
05224 Breast cancer
100614256 (ARAF)
05223 Non-small cell lung cancer
100614256 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100614256 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100614256 (ARAF)
09165 Substance dependence
05034 Alcoholism
100614256 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100614256 (ARAF)
05160 Hepatitis C
100614256 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100614256 (ARAF)
01522 Endocrine resistance
100614256 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ptr01001
]
100614256 (ARAF)
Enzymes [BR:
ptr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100614256 (ARAF)
Protein kinases [BR:
ptr01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100614256 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100614256
NCBI-ProteinID:
XP_016798738
LinkDB
All DBs
Position
X
AA seq
611 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSLSPGSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLT
GQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq
1836 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcctttcccctggcagcccccgcacccagcactgtgacccggag
cacttccccttccctgccccagccaatgcccccctacagcgcatccgctccacgtccact
cccaacgtccatatggtcagcaccacggcccccatggactccaacctcatccagctcact
ggccagagtttcagcactgatgctgccggtagtagaggaggtagtgatggaaccccccgg
gggagccccagcccagccagcgtgtcctcggggaggaagtccccacattccaagtcacca
gcagagcagcgcgagcggaagtccttggccgatgacaagaagaaagtgaagaacctgggg
taccgggactcaggctattactgggaggtaccacccagtgaggtgcagctgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtg
aaggtgctcaaggtgtcccagcccacagctgagcaggcccaggctttcaagaatgagatg
caggtgctcaggaagacgagacatgtcaacatcttgctgtttatgggcttcatgacccgg
ccgggatttgccatcatcacacagtggtgtgagggctccagcctctaccatcacctgcat
gtggccgacacacgcttcgacatggtccagctcatcgacgtggcccggcagactgcccag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctacatgaggggctcacggtgaagatcggtgactttggcttggccacagtgaagact
cgatggagcggggcccagcccttggagcagccctcaggatctgtgctgtggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcagacgtctatgcctac
ggggttgtgctctacgagcttatgactggctcactgccttacagccacattggctgccgt
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgggag
gagcggcccctcttcccccagatcctggccacaattgagctgctgcaacggtcactcccc
aagattgagcggagtgcctcggaaccctccttgcaccgcacccaggccgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag
Pan troglodytes (chimpanzee): 460182
Help
Entry
460182 CDS
T01005
Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X2
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr01521
EGFR tyrosine kinase inhibitor resistance
ptr01522
Endocrine resistance
ptr04010
MAPK signaling pathway
ptr04012
ErbB signaling pathway
ptr04014
Ras signaling pathway
ptr04015
Rap1 signaling pathway
ptr04022
cGMP-PKG signaling pathway
ptr04024
cAMP signaling pathway
ptr04062
Chemokine signaling pathway
ptr04068
FoxO signaling pathway
ptr04071
Sphingolipid signaling pathway
ptr04072
Phospholipase D signaling pathway
ptr04140
Autophagy - animal
ptr04150
mTOR signaling pathway
ptr04151
PI3K-Akt signaling pathway
ptr04210
Apoptosis
ptr04218
Cellular senescence
ptr04270
Vascular smooth muscle contraction
ptr04360
Axon guidance
ptr04370
VEGF signaling pathway
ptr04371
Apelin signaling pathway
ptr04510
Focal adhesion
ptr04540
Gap junction
ptr04550
Signaling pathways regulating pluripotency of stem cells
ptr04625
C-type lectin receptor signaling pathway
ptr04630
JAK-STAT signaling pathway
ptr04650
Natural killer cell mediated cytotoxicity
ptr04660
T cell receptor signaling pathway
ptr04662
B cell receptor signaling pathway
ptr04664
Fc epsilon RI signaling pathway
ptr04666
Fc gamma R-mediated phagocytosis
ptr04720
Long-term potentiation
ptr04722
Neurotrophin signaling pathway
ptr04726
Serotonergic synapse
ptr04730
Long-term depression
ptr04810
Regulation of actin cytoskeleton
ptr04910
Insulin signaling pathway
ptr04912
GnRH signaling pathway
ptr04914
Progesterone-mediated oocyte maturation
ptr04915
Estrogen signaling pathway
ptr04916
Melanogenesis
ptr04917
Prolactin signaling pathway
ptr04919
Thyroid hormone signaling pathway
ptr04921
Oxytocin signaling pathway
ptr04926
Relaxin signaling pathway
ptr04928
Parathyroid hormone synthesis, secretion and action
ptr04929
GnRH secretion
ptr04935
Growth hormone synthesis, secretion and action
ptr05010
Alzheimer disease
ptr05022
Pathways of neurodegeneration - multiple diseases
ptr05034
Alcoholism
ptr05132
Salmonella infection
ptr05152
Tuberculosis
ptr05160
Hepatitis C
ptr05161
Hepatitis B
ptr05163
Human cytomegalovirus infection
ptr05164
Influenza A
ptr05165
Human papillomavirus infection
ptr05167
Kaposi sarcoma-associated herpesvirus infection
ptr05170
Human immunodeficiency virus 1 infection
ptr05200
Pathways in cancer
ptr05205
Proteoglycans in cancer
ptr05206
MicroRNAs in cancer
ptr05210
Colorectal cancer
ptr05211
Renal cell carcinoma
ptr05212
Pancreatic cancer
ptr05213
Endometrial cancer
ptr05214
Glioma
ptr05215
Prostate cancer
ptr05218
Melanoma
ptr05219
Bladder cancer
ptr05220
Chronic myeloid leukemia
ptr05221
Acute myeloid leukemia
ptr05223
Non-small cell lung cancer
ptr05224
Breast cancer
ptr05225
Hepatocellular carcinoma
ptr05226
Gastric cancer
ptr05230
Central carbon metabolism in cancer
ptr05231
Choline metabolism in cancer
ptr05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
460182 (RAF1)
04012 ErbB signaling pathway
460182 (RAF1)
04014 Ras signaling pathway
460182 (RAF1)
04015 Rap1 signaling pathway
460182 (RAF1)
04370 VEGF signaling pathway
460182 (RAF1)
04371 Apelin signaling pathway
460182 (RAF1)
04630 JAK-STAT signaling pathway
460182 (RAF1)
04068 FoxO signaling pathway
460182 (RAF1)
04072 Phospholipase D signaling pathway
460182 (RAF1)
04071 Sphingolipid signaling pathway
460182 (RAF1)
04024 cAMP signaling pathway
460182 (RAF1)
04022 cGMP-PKG signaling pathway
460182 (RAF1)
04151 PI3K-Akt signaling pathway
460182 (RAF1)
04150 mTOR signaling pathway
460182 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
460182 (RAF1)
09143 Cell growth and death
04210 Apoptosis
460182 (RAF1)
04218 Cellular senescence
460182 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
460182 (RAF1)
04540 Gap junction
460182 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
460182 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
460182 (RAF1)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
460182 (RAF1)
04650 Natural killer cell mediated cytotoxicity
460182 (RAF1)
04660 T cell receptor signaling pathway
460182 (RAF1)
04662 B cell receptor signaling pathway
460182 (RAF1)
04664 Fc epsilon RI signaling pathway
460182 (RAF1)
04666 Fc gamma R-mediated phagocytosis
460182 (RAF1)
04062 Chemokine signaling pathway
460182 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
460182 (RAF1)
04929 GnRH secretion
460182 (RAF1)
04912 GnRH signaling pathway
460182 (RAF1)
04915 Estrogen signaling pathway
460182 (RAF1)
04914 Progesterone-mediated oocyte maturation
460182 (RAF1)
04917 Prolactin signaling pathway
460182 (RAF1)
04921 Oxytocin signaling pathway
460182 (RAF1)
04926 Relaxin signaling pathway
460182 (RAF1)
04935 Growth hormone synthesis, secretion and action
460182 (RAF1)
04919 Thyroid hormone signaling pathway
460182 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
460182 (RAF1)
04916 Melanogenesis
460182 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
460182 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
460182 (RAF1)
04720 Long-term potentiation
460182 (RAF1)
04730 Long-term depression
460182 (RAF1)
04722 Neurotrophin signaling pathway
460182 (RAF1)
09158 Development and regeneration
04360 Axon guidance
460182 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
460182 (RAF1)
05206 MicroRNAs in cancer
460182 (RAF1)
05205 Proteoglycans in cancer
460182 (RAF1)
05230 Central carbon metabolism in cancer
460182 (RAF1)
05231 Choline metabolism in cancer
460182 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
460182 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
460182 (RAF1)
05212 Pancreatic cancer
460182 (RAF1)
05225 Hepatocellular carcinoma
460182 (RAF1)
05226 Gastric cancer
460182 (RAF1)
05214 Glioma
460182 (RAF1)
05221 Acute myeloid leukemia
460182 (RAF1)
05220 Chronic myeloid leukemia
460182 (RAF1)
05218 Melanoma
460182 (RAF1)
05211 Renal cell carcinoma
460182 (RAF1)
05219 Bladder cancer
460182 (RAF1)
05215 Prostate cancer
460182 (RAF1)
05213 Endometrial cancer
460182 (RAF1)
05224 Breast cancer
460182 (RAF1)
05223 Non-small cell lung cancer
460182 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
460182 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
460182 (RAF1)
09165 Substance dependence
05034 Alcoholism
460182 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
460182 (RAF1)
05152 Tuberculosis
460182 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
460182 (RAF1)
05161 Hepatitis B
460182 (RAF1)
05160 Hepatitis C
460182 (RAF1)
05164 Influenza A
460182 (RAF1)
05163 Human cytomegalovirus infection
460182 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
460182 (RAF1)
05165 Human papillomavirus infection
460182 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
460182 (RAF1)
01522 Endocrine resistance
460182 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ptr01001
]
460182 (RAF1)
Enzymes [BR:
ptr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
460182 (RAF1)
Protein kinases [BR:
ptr01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
460182 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
460182
NCBI-ProteinID:
XP_009443195
Ensembl:
ENSPTRG00000014635
VGNC:
12161
LinkDB
All DBs
Position
3
AA seq
615 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVD
SRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPR
GQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVNPTPEQFQAFRNE
VAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTA
QGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMA
PEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL
YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTED
INACTLTTSPRLPVF
NT seq
1848 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttaattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacagctcttttctcagcacagatattct
acacctcacgccttcacctttaacacctccagtccctcatctgaaggttccctctcccag
aggcagaggtcgacgtccacacctaatgtccacatggtcagcaccaccctgcctgtggac
agcaggatgattgaggatgcaattcgaagtcacagcgaatcagcctcaccttcagccctg
tccagtagtcccaacaatctgagcccaacaggctggtcacagccgaaaacccccgtgcca
gcacaaagagagcgggcaccagtatctgggacccaggagaaaaacaaaattaggcctcgt
ggacagagagattcaagctattattgggaaatagaagccagtgaagtgatgctgtccact
cggattgggtcaggctcttttggaactgtttataagggtaaatggcacggagatgttgca
gtaaagatcctaaaggttgtcaacccaaccccagagcaattccaggccttcaggaatgag
gtggctgttctgcgcaaaacacggcatgtgaacattctgcttttcatggggtacatgaca
aaggacaacctggcaattgtgacccagtggtgcgagggcagcagcctctacaaacacctg
catgtccaggagaccaagtttcagatgttccagctaattgacattgcccggcagacggct
cagggaatggactatttgcatgcaaagaacatcatccatagagacatgaaatccaacaat
atatttctccatgaaggcttaacagtgaaaattggagattttggtttggcaacagtaaag
tcacgctggagtggttctcagcaggttgaacaacctactggctctgtcctctggatggcc
ccagaggtgatccgaatgcaggataacaacccattcagtttccagtcggatgtctactcc
tatggcatcgtattgtatgaactgatgacgggggagcttccttattctcacatcaacaac
cgagatcagatcatcttcatggtgggccgaggatatgcctccccagatcttagtaagcta
tataagaactgccccaaagcaatgaagaggctggtagctgactgtgtgaagaaagtaaag
gaagagaggcctctttttccccagatcctgtcttccattgagctgctccaacactctcta
ccgaagatcaaccggagcgcttccgagccatccttgcatcgggcagcccacactgaggat
atcaatgcttgcacgctgaccacgtccccgaggctgcctgtcttctag
Pan troglodytes (chimpanzee): 463781
Help
Entry
463781 CDS
T01005
Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr01521
EGFR tyrosine kinase inhibitor resistance
ptr01522
Endocrine resistance
ptr04010
MAPK signaling pathway
ptr04012
ErbB signaling pathway
ptr04015
Rap1 signaling pathway
ptr04024
cAMP signaling pathway
ptr04062
Chemokine signaling pathway
ptr04068
FoxO signaling pathway
ptr04150
mTOR signaling pathway
ptr04270
Vascular smooth muscle contraction
ptr04510
Focal adhesion
ptr04650
Natural killer cell mediated cytotoxicity
ptr04720
Long-term potentiation
ptr04722
Neurotrophin signaling pathway
ptr04726
Serotonergic synapse
ptr04730
Long-term depression
ptr04810
Regulation of actin cytoskeleton
ptr04910
Insulin signaling pathway
ptr04914
Progesterone-mediated oocyte maturation
ptr04928
Parathyroid hormone synthesis, secretion and action
ptr04934
Cushing syndrome
ptr05010
Alzheimer disease
ptr05022
Pathways of neurodegeneration - multiple diseases
ptr05034
Alcoholism
ptr05160
Hepatitis C
ptr05161
Hepatitis B
ptr05200
Pathways in cancer
ptr05205
Proteoglycans in cancer
ptr05210
Colorectal cancer
ptr05211
Renal cell carcinoma
ptr05212
Pancreatic cancer
ptr05213
Endometrial cancer
ptr05214
Glioma
ptr05215
Prostate cancer
ptr05216
Thyroid cancer
ptr05218
Melanoma
ptr05219
Bladder cancer
ptr05220
Chronic myeloid leukemia
ptr05221
Acute myeloid leukemia
ptr05223
Non-small cell lung cancer
ptr05224
Breast cancer
ptr05225
Hepatocellular carcinoma
ptr05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
463781 (BRAF)
04012 ErbB signaling pathway
463781 (BRAF)
04015 Rap1 signaling pathway
463781 (BRAF)
04068 FoxO signaling pathway
463781 (BRAF)
04024 cAMP signaling pathway
463781 (BRAF)
04150 mTOR signaling pathway
463781 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
463781 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
463781 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
463781 (BRAF)
04062 Chemokine signaling pathway
463781 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
463781 (BRAF)
04914 Progesterone-mediated oocyte maturation
463781 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
463781 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
463781 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
463781 (BRAF)
04720 Long-term potentiation
463781 (BRAF)
04730 Long-term depression
463781 (BRAF)
04722 Neurotrophin signaling pathway
463781 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
463781 (BRAF)
05205 Proteoglycans in cancer
463781 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
463781 (BRAF)
05212 Pancreatic cancer
463781 (BRAF)
05225 Hepatocellular carcinoma
463781 (BRAF)
05226 Gastric cancer
463781 (BRAF)
05214 Glioma
463781 (BRAF)
05216 Thyroid cancer
463781 (BRAF)
05221 Acute myeloid leukemia
463781 (BRAF)
05220 Chronic myeloid leukemia
463781 (BRAF)
05218 Melanoma
463781 (BRAF)
05211 Renal cell carcinoma
463781 (BRAF)
05219 Bladder cancer
463781 (BRAF)
05215 Prostate cancer
463781 (BRAF)
05213 Endometrial cancer
463781 (BRAF)
05224 Breast cancer
463781 (BRAF)
05223 Non-small cell lung cancer
463781 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
463781 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
463781 (BRAF)
09165 Substance dependence
05034 Alcoholism
463781 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
463781 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
463781 (BRAF)
05160 Hepatitis C
463781 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
463781 (BRAF)
01522 Endocrine resistance
463781 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ptr01001
]
463781 (BRAF)
Enzymes [BR:
ptr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
463781 (BRAF)
Protein kinases [BR:
ptr01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
463781 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
463781
NCBI-ProteinID:
XP_009452635
Ensembl:
ENSPTRG00000019769
VGNC:
14003
LinkDB
All DBs
Position
7
AA seq
756 aa
AA seq
DB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIE
ALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTS
SSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLK
KALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTF
FTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQ
EEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDR
SSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP
QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQENLQPSSSHHHGS
ICSYFLSLVFVQFVNIKTQFCSSNLFLKIQNFQCIS
NT seq
2271 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgcc
attccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagag
gccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctat
gaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattggaatct
ctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgttacatct
tcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccaca
gatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgccc
aacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagtctaaag
aaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggat
ggagagaagaaaccaattggctgggacactgatatttcctggcttactggagaagaattg
catgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaaacgttt
ttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaa
acatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgtgttaat
tatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacag
gaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgcacccgcc
tcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccattccaatt
ccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacgagaccga
tcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgatgacttg
attagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgctaccccc
cctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctccaggacct
cagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaacacttggt
agacgggactcgagtgatgattgggagattcctgatgggcagattacagtgggacaaaga
attggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtggcagtg
aaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaatgaagta
ggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattccacaaag
ccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccatctccat
atcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtgaaatct
cgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcacca
gaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatatgcattt
gggattgttctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagg
gaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagat
gagagaccactctttccccaagagaatttgcagccttcaagtagccaccatcatggcagc
atctgctcttatttcttaagtcttgtgttcgtacaatttgttaacatcaaaacacagttc
tgttcctcaaatctttttttaaagatacaaaatttccaatgcataagctga
DBGET
integrated database retrieval system
