KEGG   PATHWAY: ray04540
Entry
ray04540                    Pathway                                

Name
Gap junction - Rousettus aegyptiacus (Egyptian rousette)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ray04540  Gap junction
ray04540

Other DBs
GO: 0005921
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107515269  GJA1; gap junction alpha-1 protein [KO:K07372]
107508082  GJD2; gap junction delta-2 protein [KO:K07373]
107502626  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107516134  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107518173  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107513376  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107497394  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
107502078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
107507553  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107520204  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107508819  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
107499793  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107497163  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107498193  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
107503781  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
107519446  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107511436  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
107507127  HRAS; GTPase HRas isoform X1 [KO:K02833]
107497434  KRAS; GTPase KRas isoform X1 [KO:K07827]
107499847  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
107519729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107508942  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
107510634  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
107515836  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
107497830  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107512598  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107516884  MAP3K2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
107508930  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
107511070  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
107516782  tubulin alpha-1B chain-like [KO:K07374]
107500328  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107497847  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
107497857  tubulin alpha-3 chain-like [KO:K07374]
107514242  tubulin alpha-1A chain isoform X1 [KO:K07374]
107514243  tubulin alpha-1C chain [KO:K07374]
107516732  tubulin alpha-4A chain isoform X1 [KO:K07374]
107502098  tubulin beta-3 chain [KO:K07375]
107503105  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
107511148  TUBB4A; tubulin beta-4A chain [KO:K07375]
107521721  TUBB2A; tubulin beta-2A chain [KO:K07375]
107521722  tubulin beta-2B chain [KO:K07375]
107500090  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
107497724  TUBB6; tubulin beta-6 chain [KO:K07375]
107498082  TUBB; tubulin beta chain [KO:K07375]
107504039  CSNK1D; casein kinase I isoform delta isoform X1 [KO:K08959] [EC:2.7.11.1]
107501476  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
107515774  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
107511714  ADRB1; beta-1 adrenergic receptor [KO:K04141]
107515942  DRD1; D(1A) dopamine receptor [KO:K04144]
107500068  neuroendocrine secretory protein 55-like [KO:K04632]
107500067  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
107512952  DRD2; D(2) dopamine receptor [KO:K04145]
107512406  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107502700  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107498506  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107498014  ADCY4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107518038  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
107514224  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107512248  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107497689  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107521680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107502272  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
107503628  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
107504978  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
107518526  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
107514938  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
107520124  GNA11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107517194  GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107506114  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107519930  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107497081  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
107514464  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
107504134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107497427  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
107511965  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107510307  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107516091  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107503061  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
107507549  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
107518221  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
107507550  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
107509998  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
107515478  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
107516479  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
ray04010  MAPK signaling pathway
ray04020  Calcium signaling pathway
ray04060  Cytokine-cytokine receptor interaction
ray04070  Phosphatidylinositol signaling system
ray04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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