KEGG   PATHWAY: ray04721
Entry
ray04721                    Pathway                                
Name
Synaptic vesicle cycle - Rousettus aegyptiacus (Egyptian rousette)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
ray04721  Synaptic vesicle cycle
ray04721

Other DBs
GO: 0016079 0048488
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107512578  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
107503755  SLC18A1; chromaffin granule amine transporter [KO:K08155]
107509743  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
107508903  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
107507389  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
107498877  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
107497930  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
107503693  SYT1; synaptotagmin-1 [KO:K15290]
107515669  VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
107521651  RAB3A; ras-related protein Rab-3A [KO:K07882]
107519379  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
107511813  STX1A; syntaxin-1A [KO:K04560]
107511540  STX2; syntaxin-2 isoform X1 [KO:K08486]
107503989  STX1B; syntaxin-1B isoform X1 [KO:K08486]
107497323  STX3; syntaxin-3 [KO:K08486]
107520219  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
107502766  UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293]
107515167  UNC13C; protein unc-13 homolog C isoform X1 [KO:K15293]
107517237  UNC13A; protein unc-13 homolog A isoform X1 [KO:K15293]
107507100  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
107518030  CPLX1; complexin-1 [KO:K15294]
107515903  CPLX2; complexin-2 [KO:K15294]
107506280  CPLX4; LOW QUALITY PROTEIN: complexin-4 [KO:K15295]
107510530  CPLX3; complexin-3 [KO:K15295]
107519399  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
107505355  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
107508174  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
107516020  NAPA; alpha-soluble NSF attachment protein [KO:K15296]
107520245  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
107512046  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
107515082  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
107502826  CLTA; clathrin light chain A isoform X1 [KO:K04644]
107517505  CLTB; clathrin light chain B isoform X1 [KO:K04645]
107497861  CLTCL1; LOW QUALITY PROTEIN: clathrin heavy chain 2 [KO:K04646]
107510139  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
107506906  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
107498795  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
107499680  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
107507012  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
107516006  AP2S1; AP-2 complex subunit sigma [KO:K11827]
107513702  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107503746  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
107516231  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
107512214  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
107501201  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
107503259  ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149]
107509568  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
107500465  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
107512797  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
107513634  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
107514655  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
107498476  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
107511034  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
107500564  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
107503485  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
107504599  V-type proton ATPase 116 kDa subunit a isoform 2 isoform X1 [KO:K02154]
107519336  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154]
107513825  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]
107514921  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
107520218  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
107511566  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107506034  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
107499515  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
107498365  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
107499665  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
107499955  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
107507750  SLC6A4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
107499510  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038]
107507393  SLC6A5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
107497178  SLC6A7; sodium-dependent proline transporter [KO:K05040]
107498359  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
107509756  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
107509787  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
107507287  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
107499243  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
107509715  SLC1A3; excitatory amino acid transporter 1 [KO:K05614]
107517270  SLC1A6; LOW QUALITY PROTEIN: excitatory amino acid transporter 4 [KO:K05617]
107497956  SLC1A7; excitatory amino acid transporter 5 [KO:K05618]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
ray04144  Endocytosis
ray04724  Glutamatergic synapse
ray04725  Cholinergic synapse
ray04726  Serotonergic synapse
ray04727  GABAergic synapse
ray04728  Dopaminergic synapse
KO pathway
ko04721   
LinkDB

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