Entry
Name
Synaptic vesicle cycle - Rousettus aegyptiacus (Egyptian rousette)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:
ray ]
Gene
107515669 VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504 ]
107519379 RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291 ]
107507100 SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211 ]
107519399 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
107505355 CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
107503746 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
107516231 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
107501201 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
107503259 ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149 ]
107503485 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154 ]
107504599 V-type proton ATPase 116 kDa subunit a isoform 2 isoform X1 [KO:K02154 ]
107519336 ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154 ]
107513825 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154 ]
107514921 ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146 ]
107506034 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155 ]
107499515 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661 ]
107498365 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
107507750 SLC6A4; sodium-dependent serotonin transporter isoform X1 [KO:K05037 ]
107499510 SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038 ]
107507393 SLC6A5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038 ]
107498359 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
107509756 SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045 ]
107509787 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046 ]
107499243 SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613 ]
107517270 SLC1A6; LOW QUALITY PROTEIN: excitatory amino acid transporter 4 [KO:K05617 ]
Compound
Reference
Authors
Li L, Chin LS
Title
The molecular machinery of synaptic vesicle exocytosis.
Journal
Reference
Authors
Nestler EJ, Hyman SE, Malenka RC.
Title
Molecular neuropharmacology: A foundation for clinical neuroscience
Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
Authors
Chapman ER
Title
How does synaptotagmin trigger neurotransmitter release?
Journal
Reference
Authors
Benfenati F, Onofri F, Giovedi S
Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
Journal
Reference
Authors
de Saint Basile G, Menasche G, Fischer A
Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
Journal
Reference
Authors
Carr CM, Munson M
Title
Tag team action at the synapse.
Journal
Reference
Authors
Sudhof TC
Title
The synaptic vesicle cycle.
Journal
Reference
Authors
Gundelfinger ED, Kessels MM, Qualmann B
Title
Temporal and spatial coordination of exocytosis and endocytosis.
Journal
Reference
Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Journal
Reference
Authors
Chapman ER
Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Journal
Reference
Authors
Sudhof TC
Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
Journal
Reference
Authors
Rizo J, Sudhof TC
Title
Snares and Munc18 in synaptic vesicle fusion.
Journal
Reference
Authors
Malsam J, Kreye S, Sollner TH
Title
Membrane fusion: SNAREs and regulation.
Journal
Related pathway
KO pathway
LinkDB
All DBs