KEGG   Rousettus aegyptiacus (Egyptian rousette): 107498193
Entry
107498193         CDS       T06036                                 

Gene name
EGFR
Definition
(RefSeq) epidermal growth factor receptor
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray01521  EGFR tyrosine kinase inhibitor resistance
ray01522  Endocrine resistance
ray04010  MAPK signaling pathway
ray04012  ErbB signaling pathway
ray04014  Ras signaling pathway
ray04015  Rap1 signaling pathway
ray04020  Calcium signaling pathway
ray04066  HIF-1 signaling pathway
ray04068  FoxO signaling pathway
ray04072  Phospholipase D signaling pathway
ray04144  Endocytosis
ray04151  PI3K-Akt signaling pathway
ray04510  Focal adhesion
ray04520  Adherens junction
ray04540  Gap junction
ray04630  JAK-STAT signaling pathway
ray04810  Regulation of actin cytoskeleton
ray04912  GnRH signaling pathway
ray04915  Estrogen signaling pathway
ray04921  Oxytocin signaling pathway
ray04926  Relaxin signaling pathway
ray04928  Parathyroid hormone synthesis, secretion and action
ray04934  Cushing syndrome
ray05160  Hepatitis C
ray05163  Human cytomegalovirus infection
ray05165  Human papillomavirus infection
ray05171  Coronavirus disease - COVID-19
ray05200  Pathways in cancer
ray05205  Proteoglycans in cancer
ray05206  MicroRNAs in cancer
ray05210  Colorectal cancer
ray05212  Pancreatic cancer
ray05213  Endometrial cancer
ray05214  Glioma
ray05215  Prostate cancer
ray05218  Melanoma
ray05219  Bladder cancer
ray05223  Non-small cell lung cancer
ray05224  Breast cancer
ray05225  Hepatocellular carcinoma
ray05226  Gastric cancer
ray05230  Central carbon metabolism in cancer
ray05231  Choline metabolism in cancer
ray05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ray00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107498193 (EGFR)
   04012 ErbB signaling pathway
    107498193 (EGFR)
   04014 Ras signaling pathway
    107498193 (EGFR)
   04015 Rap1 signaling pathway
    107498193 (EGFR)
   04630 JAK-STAT signaling pathway
    107498193 (EGFR)
   04066 HIF-1 signaling pathway
    107498193 (EGFR)
   04068 FoxO signaling pathway
    107498193 (EGFR)
   04020 Calcium signaling pathway
    107498193 (EGFR)
   04072 Phospholipase D signaling pathway
    107498193 (EGFR)
   04151 PI3K-Akt signaling pathway
    107498193 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    107498193 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107498193 (EGFR)
   04520 Adherens junction
    107498193 (EGFR)
   04540 Gap junction
    107498193 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107498193 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    107498193 (EGFR)
   04915 Estrogen signaling pathway
    107498193 (EGFR)
   04921 Oxytocin signaling pathway
    107498193 (EGFR)
   04926 Relaxin signaling pathway
    107498193 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    107498193 (EGFR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107498193 (EGFR)
   05206 MicroRNAs in cancer
    107498193 (EGFR)
   05205 Proteoglycans in cancer
    107498193 (EGFR)
   05230 Central carbon metabolism in cancer
    107498193 (EGFR)
   05231 Choline metabolism in cancer
    107498193 (EGFR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107498193 (EGFR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107498193 (EGFR)
   05212 Pancreatic cancer
    107498193 (EGFR)
   05225 Hepatocellular carcinoma
    107498193 (EGFR)
   05226 Gastric cancer
    107498193 (EGFR)
   05214 Glioma
    107498193 (EGFR)
   05218 Melanoma
    107498193 (EGFR)
   05219 Bladder cancer
    107498193 (EGFR)
   05215 Prostate cancer
    107498193 (EGFR)
   05213 Endometrial cancer
    107498193 (EGFR)
   05224 Breast cancer
    107498193 (EGFR)
   05223 Non-small cell lung cancer
    107498193 (EGFR)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    107498193 (EGFR)
  09172 Infectious disease: viral
   05160 Hepatitis C
    107498193 (EGFR)
   05171 Coronavirus disease - COVID-19
    107498193 (EGFR)
   05163 Human cytomegalovirus infection
    107498193 (EGFR)
   05165 Human papillomavirus infection
    107498193 (EGFR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107498193 (EGFR)
   01522 Endocrine resistance
    107498193 (EGFR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ray01001]
    107498193 (EGFR)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ray04147]
    107498193 (EGFR)
Enzymes [BR:ray01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     107498193 (EGFR)
Protein kinases [BR:ray01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   107498193 (EGFR)
Exosome [BR:ray04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   107498193 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   107498193 (EGFR)
  Exosomal proteins of bladder cancer cells
   107498193 (EGFR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Kinase-like Kdo
Other DBs
NCBI-GeneID: 107498193
NCBI-ProteinID: XP_015976470
LinkDB
Position
Unknown
AA seq 1188 aa
MAATSAGRRRVTGVCQGTNNKLTQLGSFEDHFLSLQRMLNNCEVVLGNLEITYMRRNYDL
SFLKTIQEVAGYVLIALNVAETIPLENLQIIRGNVLFENTHALSVLSNYGENRTGLRELP
MRNLQEILHGAVRFNNNPVLCNVETIQWRDIVDSAFLSNMSMDFQSRMGSCPKCDPSCPN
GSCWGAGQENCQKLTRILCAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHKFRD
EATCKDTCPPLMLYNPTTYEMDVNPEGKYSFGATCVKKCPHNYVVTDHGSCVRACSSDSY
EVEEDGVRKCKKCEGPCRKVCNGIGTGEFKDTLSINATNIKHFKNCTSISGDLHILPVAF
KGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQF
SLAVVGLHITSLGLRSLKEISDGDVVISGNQKLCYADTIRWQNLFGTVSQKTKIMKNRSA
RDCQAAGHVCHPLCSPEGCWGPEPKDCVSCRNVSRDRECVEKCHLLEGEPREFVENSECV
QCHPECLPQAMNVTCTGRGPDKCVKCAHYVDGPHCVKTCPSGIMGENNTLVWKFSDADHV
CRLCHPNCTYGCMGPGLEGCQERPGISSIATGIVGGLLLLVVLALGVILFLRRRHIVRKR
TLRRLLQERELVEPLTPSGEAPNQALLRVLKETEFKKIKVLGSGAFGTVYKGLWNPEGEK
VKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLVTQLMPFGC
LLDYVREHKDNIGSQCLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG
LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG
IPASEISTVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELVLEFCKMARDPQR
YLVIQGDERMDLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQHGFFHSPATSRTPLLSS
LSATSNASTVACIDRNGQSCPLQEDSFLQRYSSDPTGALTEDNINDTFLPAPEYINQSIP
KRPAGSVQNPVYHSQPLSPAAGREPHYQNPHSNAVGNPEYLNTTRPACGDGPVLWVQKGG
HHISLDNPDYQQDFLPKEATSNGTFKGPAAENAEYLRVAPASREFTGA
NT seq 3567 nt   +upstreamnt  +downstreamnt
atggcagcgacttccgcgggccggcgccgcgtcacaggcgtttgccaaggcacaaacaac
aagctcacgcagctgggctcgtttgaggaccacttcctgagcctgcagaggatgctgaac
aactgcgaggtggtccttgggaacctggaaatcacctacatgcgaaggaactacgacctt
tccttcttaaagaccatccaggaggtggccggctacgtcctcatcgccctcaacgtggcg
gagacgatcccgctggaaaacctgcagatcatcaggggcaacgtgctcttcgaaaacacg
cacgccttgtcggtcctgtccaactacggggaaaacagaaccgggctgcgggagctgccc
atgagaaacctgcaggaaatcctgcacggcgccgtgcgcttcaacaacaaccccgtcctc
tgcaacgtggagaccatccagtggcgagacatcgtggacagcgccttcctgagcaacatg
tcgatggactttcagagccggatgggcagctgcccgaagtgtgacccgagctgtcccaac
gggagctgctggggtgcggggcaggagaactgccagaaactgaccaggatcctctgcgcc
cagcagtgctccaggcgctgccgcggccggtcgcccagcgactgctgccacaaccagtgt
gccgccggctgcacgggcccgcgcgagagcgactgcctggtctgccacaagttccgggac
gaagccacgtgcaaggacacctgcccgccgctcatgctgtacaacccgaccacgtacgag
atggacgtcaacccggagggcaaatacagcttcggcgccacctgcgtgaagaagtgcccc
cataactacgtggtgacagaccacggctcgtgcgtccgcgcctgcagctccgacagctac
gaggtggaggaggacggggttcgcaagtgtaagaagtgcgaaggcccctgtcgcaaagtt
tgtaacggaataggaactggtgaatttaaagacacgctttccataaatgccacaaatatc
aaacacttcaaaaactgcacctccatcagtggggaccttcacatcctgccggtcgcgttt
aagggcgactccttcactcgcaccccgcctctggacccgaaggaactggacattctgaaa
accgtaaaggagataacagggtttttgctgattcaggcctggccggaaaacaggactgac
ctccacgctttcgagaacctggaaatcatacgcggcagaacaaagcaacacggccagttt
tcccttgcggtcgtcggcctgcacataacgtcgctgggactgcgctccctcaaggagata
agcgacggagacgtcgtcatctcggggaaccagaagttgtgctacgcggacaccatacgc
tggcaaaacctgtttgggaccgtcagtcagaaaaccaagattatgaagaataggagtgca
cgagactgccaggccgcgggccacgtctgtcacccgctctgctcgccagagggctgctgg
ggcccagagccaaaggactgcgtgtcctgcaggaatgtcagccgtgaccgggagtgcgtg
gagaagtgccacctcctggagggtgagcccagggagttcgtggagaactccgagtgcgtg
cagtgccatccggaatgcctgccccaggccatgaacgtgacctgcacgggacgcggacca
gacaagtgtgtgaagtgtgcgcactacgtcgacggcccgcactgcgtcaagacctgcccg
tccggcatcatgggagaaaacaacacgctggtctggaagttctcggacgccgaccacgtg
tgtcgcctgtgccaccccaactgcacctacggctgcatggggcccggtctggaaggctgc
caggagaggcccgggatctcgtccatcgccaccggcatcgtgggcggcctgctgctgctg
gtggtgctggccctcggggtcatcctgtttctgcgccggcgccacatcgtccgcaagcgc
acgctgcgccggctgctgcaggagagagagctcgtggagcccctcacacccagtggggag
gcccccaaccaggcgctcctgagggtcttgaaggagacggagttcaaaaagatcaaggtg
ctcggctccggcgcattcggcacggtgtacaagggactctggaacccggaaggcgagaag
gtcaaaatccccgtggctatcaaggaattaagagaggccacgtctccgaaagccaacaag
gagattctcgatgaggcgtacgtgatggccagcgtggacaacccgcacgtgtgccggctg
ctgggcatctgcctgacctccacggtgcagctggtcacgcagctcatgcccttcggctgc
ctgctggactacgtccgcgagcacaaggacaacatcggctcccagtgcctgctcaactgg
tgtgtgcagatcgccaagggcatgaactacctggaggaccggcgtctggtgcatcgcgac
ctggccgccaggaacgtcctggtgaagacgccgcagcacgtcaagatcacagactttggg
ctggccaagctgctgggcgccgaggagaaggagtaccacgcggagggaggcaaggtgcct
atcaagtggatggctttggaatcgattttacaccgaatctacacccaccaaagtgacgtc
tggagctacggcgtcactgtttgggagctgatgacgttcgggtccaagccctatgacgga
atcccggcgagcgagatctcgaccgtgctggagaagggagagcgcctcccgcagccgccc
atatgcaccatcgacgtctacatgatcatggtcaagtgctggatgatagatgcagacagt
cgcccaaagttccgtgagttggtcctcgaattctgcaaaatggcccgagacccccagcgc
taccttgtcatccagggcgacgagcggatggacttgcccagccccacggactcgaacttc
taccgcgccctcatggaagaggaggacatggaggacgtggtggacgcggacgagtacctg
atcccgcagcacggcttcttccacagcccagccacgtcccgcacgccgctcctcagctcc
ctgagcgccaccagcaacgcctccaccgtggcgtgcatcgacagaaacgggcagagctgt
cccctccaggaagacagcttcttacagcgctacagctcagaccccaccggcgccttgacc
gaggacaacatcaacgacactttcctgccggcgcccgaatacataaaccagtccatcccc
aaaaggcccgcgggctcggtgcagaacccggtgtaccacagtcagcccctgagtcccgcc
gcgggcagagagccgcactaccagaacccccacagcaacgccgtgggcaaccccgagtat
ctcaacaccacccgccccgcctgcggcgacggccctgtcctctgggtgcagaagggcggc
caccacatcagcctggacaaccctgactaccagcaggacttcctgcccaaggaagccacg
tcgaacggcacgttcaagggccctgccgccgagaacgcagagtacttgcgggtagcccca
gcgagccgcgagttcactggcgcgtga

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