KEGG   Rousettus aegyptiacus (Egyptian rousette): 107503781
Entry
107503781         CDS       T06036                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray01521  EGFR tyrosine kinase inhibitor resistance
ray01522  Endocrine resistance
ray04010  MAPK signaling pathway
ray04012  ErbB signaling pathway
ray04014  Ras signaling pathway
ray04062  Chemokine signaling pathway
ray04068  FoxO signaling pathway
ray04072  Phospholipase D signaling pathway
ray04150  mTOR signaling pathway
ray04151  PI3K-Akt signaling pathway
ray04380  Osteoclast differentiation
ray04510  Focal adhesion
ray04540  Gap junction
ray04550  Signaling pathways regulating pluripotency of stem cells
ray04630  JAK-STAT signaling pathway
ray04650  Natural killer cell mediated cytotoxicity
ray04660  T cell receptor signaling pathway
ray04662  B cell receptor signaling pathway
ray04664  Fc epsilon RI signaling pathway
ray04714  Thermogenesis
ray04722  Neurotrophin signaling pathway
ray04910  Insulin signaling pathway
ray04912  GnRH signaling pathway
ray04915  Estrogen signaling pathway
ray04917  Prolactin signaling pathway
ray04926  Relaxin signaling pathway
ray04935  Growth hormone synthesis, secretion and action
ray05034  Alcoholism
ray05160  Hepatitis C
ray05161  Hepatitis B
ray05163  Human cytomegalovirus infection
ray05165  Human papillomavirus infection
ray05200  Pathways in cancer
ray05203  Viral carcinogenesis
ray05205  Proteoglycans in cancer
ray05206  MicroRNAs in cancer
ray05210  Colorectal cancer
ray05211  Renal cell carcinoma
ray05213  Endometrial cancer
ray05214  Glioma
ray05215  Prostate cancer
ray05220  Chronic myeloid leukemia
ray05221  Acute myeloid leukemia
ray05223  Non-small cell lung cancer
ray05224  Breast cancer
ray05225  Hepatocellular carcinoma
ray05226  Gastric cancer
ray05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ray00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107503781 (GRB2)
   04012 ErbB signaling pathway
    107503781 (GRB2)
   04014 Ras signaling pathway
    107503781 (GRB2)
   04630 JAK-STAT signaling pathway
    107503781 (GRB2)
   04068 FoxO signaling pathway
    107503781 (GRB2)
   04072 Phospholipase D signaling pathway
    107503781 (GRB2)
   04151 PI3K-Akt signaling pathway
    107503781 (GRB2)
   04150 mTOR signaling pathway
    107503781 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107503781 (GRB2)
   04540 Gap junction
    107503781 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    107503781 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    107503781 (GRB2)
   04660 T cell receptor signaling pathway
    107503781 (GRB2)
   04662 B cell receptor signaling pathway
    107503781 (GRB2)
   04664 Fc epsilon RI signaling pathway
    107503781 (GRB2)
   04062 Chemokine signaling pathway
    107503781 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107503781 (GRB2)
   04912 GnRH signaling pathway
    107503781 (GRB2)
   04915 Estrogen signaling pathway
    107503781 (GRB2)
   04917 Prolactin signaling pathway
    107503781 (GRB2)
   04926 Relaxin signaling pathway
    107503781 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    107503781 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    107503781 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    107503781 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    107503781 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107503781 (GRB2)
   05206 MicroRNAs in cancer
    107503781 (GRB2)
   05205 Proteoglycans in cancer
    107503781 (GRB2)
   05203 Viral carcinogenesis
    107503781 (GRB2)
   05231 Choline metabolism in cancer
    107503781 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107503781 (GRB2)
   05225 Hepatocellular carcinoma
    107503781 (GRB2)
   05226 Gastric cancer
    107503781 (GRB2)
   05214 Glioma
    107503781 (GRB2)
   05221 Acute myeloid leukemia
    107503781 (GRB2)
   05220 Chronic myeloid leukemia
    107503781 (GRB2)
   05211 Renal cell carcinoma
    107503781 (GRB2)
   05215 Prostate cancer
    107503781 (GRB2)
   05213 Endometrial cancer
    107503781 (GRB2)
   05224 Breast cancer
    107503781 (GRB2)
   05223 Non-small cell lung cancer
    107503781 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    107503781 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    107503781 (GRB2)
   05160 Hepatitis C
    107503781 (GRB2)
   05163 Human cytomegalovirus infection
    107503781 (GRB2)
   05165 Human papillomavirus infection
    107503781 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107503781 (GRB2)
   01522 Endocrine resistance
    107503781 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ray04131]
    107503781 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:ray04990]
    107503781 (GRB2)
Membrane trafficking [BR:ray04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    107503781 (GRB2)
Domain-containing proteins not elsewhere classified [BR:ray04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   107503781 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 107503781
NCBI-ProteinID: XP_015988019
LinkDB
Position
Unknown
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagaa
ctcaatgggaaagatggcttcattcccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcatgat
ggagccttccttatccgagagagcgagagtgctcctggggatttctccctctcggtcaag
tttggaaacgacgtgcagcacttcaaggtgctccgggacggagccgggaagtacttcctc
tgggtggtgaagttcaattctttgaacgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatattcctccgggacatagagcaggtgccacagcagccgacgtac
gtccaagccctctttgactttgacccccaggaggatggagagctggggttccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaagggggcgtgccacggg
cagaccggcatgttcccccgcaattacgtcacccccgtgaaccggaacgtgtag

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