Rhinopithecus bieti (black snub-nosed monkey): 108517986
Help
Entry
108517986 CDS
T04641
Gene name
RAF1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rbb
Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01521
EGFR tyrosine kinase inhibitor resistance
rbb01522
Endocrine resistance
rbb04010
MAPK signaling pathway
rbb04012
ErbB signaling pathway
rbb04014
Ras signaling pathway
rbb04015
Rap1 signaling pathway
rbb04022
cGMP-PKG signaling pathway
rbb04024
cAMP signaling pathway
rbb04062
Chemokine signaling pathway
rbb04068
FoxO signaling pathway
rbb04071
Sphingolipid signaling pathway
rbb04072
Phospholipase D signaling pathway
rbb04140
Autophagy - animal
rbb04150
mTOR signaling pathway
rbb04151
PI3K-Akt signaling pathway
rbb04210
Apoptosis
rbb04218
Cellular senescence
rbb04270
Vascular smooth muscle contraction
rbb04360
Axon guidance
rbb04370
VEGF signaling pathway
rbb04371
Apelin signaling pathway
rbb04510
Focal adhesion
rbb04540
Gap junction
rbb04550
Signaling pathways regulating pluripotency of stem cells
rbb04613
Neutrophil extracellular trap formation
rbb04625
C-type lectin receptor signaling pathway
rbb04630
JAK-STAT signaling pathway
rbb04650
Natural killer cell mediated cytotoxicity
rbb04660
T cell receptor signaling pathway
rbb04662
B cell receptor signaling pathway
rbb04664
Fc epsilon RI signaling pathway
rbb04666
Fc gamma R-mediated phagocytosis
rbb04720
Long-term potentiation
rbb04722
Neurotrophin signaling pathway
rbb04726
Serotonergic synapse
rbb04730
Long-term depression
rbb04810
Regulation of actin cytoskeleton
rbb04910
Insulin signaling pathway
rbb04912
GnRH signaling pathway
rbb04914
Progesterone-mediated oocyte maturation
rbb04915
Estrogen signaling pathway
rbb04916
Melanogenesis
rbb04917
Prolactin signaling pathway
rbb04919
Thyroid hormone signaling pathway
rbb04921
Oxytocin signaling pathway
rbb04926
Relaxin signaling pathway
rbb04928
Parathyroid hormone synthesis, secretion and action
rbb04929
GnRH secretion
rbb04935
Growth hormone synthesis, secretion and action
rbb05010
Alzheimer disease
rbb05022
Pathways of neurodegeneration - multiple diseases
rbb05034
Alcoholism
rbb05132
Salmonella infection
rbb05152
Tuberculosis
rbb05160
Hepatitis C
rbb05161
Hepatitis B
rbb05163
Human cytomegalovirus infection
rbb05164
Influenza A
rbb05165
Human papillomavirus infection
rbb05167
Kaposi sarcoma-associated herpesvirus infection
rbb05170
Human immunodeficiency virus 1 infection
rbb05200
Pathways in cancer
rbb05205
Proteoglycans in cancer
rbb05206
MicroRNAs in cancer
rbb05210
Colorectal cancer
rbb05211
Renal cell carcinoma
rbb05212
Pancreatic cancer
rbb05213
Endometrial cancer
rbb05214
Glioma
rbb05215
Prostate cancer
rbb05218
Melanoma
rbb05219
Bladder cancer
rbb05220
Chronic myeloid leukemia
rbb05221
Acute myeloid leukemia
rbb05223
Non-small cell lung cancer
rbb05224
Breast cancer
rbb05225
Hepatocellular carcinoma
rbb05226
Gastric cancer
rbb05230
Central carbon metabolism in cancer
rbb05231
Choline metabolism in cancer
rbb05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
rbb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
108517986 (RAF1)
04012 ErbB signaling pathway
108517986 (RAF1)
04014 Ras signaling pathway
108517986 (RAF1)
04015 Rap1 signaling pathway
108517986 (RAF1)
04370 VEGF signaling pathway
108517986 (RAF1)
04371 Apelin signaling pathway
108517986 (RAF1)
04630 JAK-STAT signaling pathway
108517986 (RAF1)
04068 FoxO signaling pathway
108517986 (RAF1)
04072 Phospholipase D signaling pathway
108517986 (RAF1)
04071 Sphingolipid signaling pathway
108517986 (RAF1)
04024 cAMP signaling pathway
108517986 (RAF1)
04022 cGMP-PKG signaling pathway
108517986 (RAF1)
04151 PI3K-Akt signaling pathway
108517986 (RAF1)
04150 mTOR signaling pathway
108517986 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
108517986 (RAF1)
09143 Cell growth and death
04210 Apoptosis
108517986 (RAF1)
04218 Cellular senescence
108517986 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
108517986 (RAF1)
04540 Gap junction
108517986 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
108517986 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
108517986 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
108517986 (RAF1)
04625 C-type lectin receptor signaling pathway
108517986 (RAF1)
04650 Natural killer cell mediated cytotoxicity
108517986 (RAF1)
04660 T cell receptor signaling pathway
108517986 (RAF1)
04662 B cell receptor signaling pathway
108517986 (RAF1)
04664 Fc epsilon RI signaling pathway
108517986 (RAF1)
04666 Fc gamma R-mediated phagocytosis
108517986 (RAF1)
04062 Chemokine signaling pathway
108517986 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
108517986 (RAF1)
04929 GnRH secretion
108517986 (RAF1)
04912 GnRH signaling pathway
108517986 (RAF1)
04915 Estrogen signaling pathway
108517986 (RAF1)
04914 Progesterone-mediated oocyte maturation
108517986 (RAF1)
04917 Prolactin signaling pathway
108517986 (RAF1)
04921 Oxytocin signaling pathway
108517986 (RAF1)
04926 Relaxin signaling pathway
108517986 (RAF1)
04935 Growth hormone synthesis, secretion and action
108517986 (RAF1)
04919 Thyroid hormone signaling pathway
108517986 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
108517986 (RAF1)
04916 Melanogenesis
108517986 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
108517986 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
108517986 (RAF1)
04720 Long-term potentiation
108517986 (RAF1)
04730 Long-term depression
108517986 (RAF1)
04722 Neurotrophin signaling pathway
108517986 (RAF1)
09158 Development and regeneration
04360 Axon guidance
108517986 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108517986 (RAF1)
05206 MicroRNAs in cancer
108517986 (RAF1)
05205 Proteoglycans in cancer
108517986 (RAF1)
05230 Central carbon metabolism in cancer
108517986 (RAF1)
05231 Choline metabolism in cancer
108517986 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
108517986 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
108517986 (RAF1)
05212 Pancreatic cancer
108517986 (RAF1)
05225 Hepatocellular carcinoma
108517986 (RAF1)
05226 Gastric cancer
108517986 (RAF1)
05214 Glioma
108517986 (RAF1)
05221 Acute myeloid leukemia
108517986 (RAF1)
05220 Chronic myeloid leukemia
108517986 (RAF1)
05218 Melanoma
108517986 (RAF1)
05211 Renal cell carcinoma
108517986 (RAF1)
05219 Bladder cancer
108517986 (RAF1)
05215 Prostate cancer
108517986 (RAF1)
05213 Endometrial cancer
108517986 (RAF1)
05224 Breast cancer
108517986 (RAF1)
05223 Non-small cell lung cancer
108517986 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
108517986 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
108517986 (RAF1)
09165 Substance dependence
05034 Alcoholism
108517986 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
108517986 (RAF1)
05152 Tuberculosis
108517986 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
108517986 (RAF1)
05161 Hepatitis B
108517986 (RAF1)
05160 Hepatitis C
108517986 (RAF1)
05164 Influenza A
108517986 (RAF1)
05163 Human cytomegalovirus infection
108517986 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
108517986 (RAF1)
05165 Human papillomavirus infection
108517986 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108517986 (RAF1)
01522 Endocrine resistance
108517986 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rbb01001
]
108517986 (RAF1)
Enzymes [BR:
rbb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
108517986 (RAF1)
Protein kinases [BR:
rbb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
108517986 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
108517986
NCBI-ProteinID:
XP_017711600
UniProt:
A0A2K6KHX9
LinkDB
All DBs
Position
Un
AA seq
668 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTLVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVNPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq
2007 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacattagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggccttcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcctct
ttgattggggaagaacttcaagtagatttcctggatcatgttccgcttacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcaaacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacaggtattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctgtcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
aacctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacacccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggcaaatggcatggagacgttgcagtaaagatcctaaaggttgtc
aacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccgacagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggccta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattatatgag
ctgatgacgggggaacttccttactctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgagggtatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtcccctaggctgcctgtcttctag
Rhinopithecus bieti (black snub-nosed monkey): 108530908
Help
Entry
108530908 CDS
T04641
Gene name
ARAF
Definition
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rbb
Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01521
EGFR tyrosine kinase inhibitor resistance
rbb01522
Endocrine resistance
rbb04010
MAPK signaling pathway
rbb04012
ErbB signaling pathway
rbb04068
FoxO signaling pathway
rbb04270
Vascular smooth muscle contraction
rbb04650
Natural killer cell mediated cytotoxicity
rbb04720
Long-term potentiation
rbb04726
Serotonergic synapse
rbb04730
Long-term depression
rbb04810
Regulation of actin cytoskeleton
rbb04910
Insulin signaling pathway
rbb04914
Progesterone-mediated oocyte maturation
rbb04928
Parathyroid hormone synthesis, secretion and action
rbb05010
Alzheimer disease
rbb05022
Pathways of neurodegeneration - multiple diseases
rbb05034
Alcoholism
rbb05160
Hepatitis C
rbb05161
Hepatitis B
rbb05200
Pathways in cancer
rbb05205
Proteoglycans in cancer
rbb05210
Colorectal cancer
rbb05211
Renal cell carcinoma
rbb05212
Pancreatic cancer
rbb05213
Endometrial cancer
rbb05214
Glioma
rbb05215
Prostate cancer
rbb05218
Melanoma
rbb05219
Bladder cancer
rbb05220
Chronic myeloid leukemia
rbb05221
Acute myeloid leukemia
rbb05223
Non-small cell lung cancer
rbb05224
Breast cancer
rbb05225
Hepatocellular carcinoma
rbb05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rbb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
108530908 (ARAF)
04012 ErbB signaling pathway
108530908 (ARAF)
04068 FoxO signaling pathway
108530908 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
108530908 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
108530908 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
108530908 (ARAF)
04914 Progesterone-mediated oocyte maturation
108530908 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
108530908 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
108530908 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
108530908 (ARAF)
04720 Long-term potentiation
108530908 (ARAF)
04730 Long-term depression
108530908 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108530908 (ARAF)
05205 Proteoglycans in cancer
108530908 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
108530908 (ARAF)
05212 Pancreatic cancer
108530908 (ARAF)
05225 Hepatocellular carcinoma
108530908 (ARAF)
05226 Gastric cancer
108530908 (ARAF)
05214 Glioma
108530908 (ARAF)
05221 Acute myeloid leukemia
108530908 (ARAF)
05220 Chronic myeloid leukemia
108530908 (ARAF)
05218 Melanoma
108530908 (ARAF)
05211 Renal cell carcinoma
108530908 (ARAF)
05219 Bladder cancer
108530908 (ARAF)
05215 Prostate cancer
108530908 (ARAF)
05213 Endometrial cancer
108530908 (ARAF)
05224 Breast cancer
108530908 (ARAF)
05223 Non-small cell lung cancer
108530908 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
108530908 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
108530908 (ARAF)
09165 Substance dependence
05034 Alcoholism
108530908 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
108530908 (ARAF)
05160 Hepatitis C
108530908 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108530908 (ARAF)
01522 Endocrine resistance
108530908 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rbb01001
]
108530908 (ARAF)
Enzymes [BR:
rbb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
108530908 (ARAF)
Protein kinases [BR:
rbb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
108530908 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
108530908
NCBI-ProteinID:
XP_017729524
UniProt:
A0A2K6KC69
LinkDB
All DBs
Position
Un
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPRPHTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGGDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaatggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacagtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccaggccccacactcagcactgtgacccggagcacttccccttccct
gccccggccaacgcccccctgcagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtggtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaaatccccacattccaagtcaccagcagagcagcgtgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccaccgctgagcaggcccaagctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgaaggctccagcctctaccatcacctgcatgtggctgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctatgcctacggggttgtgctctac
gagctcatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctctagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgtcttgtgccttag
Rhinopithecus bieti (black snub-nosed monkey): 108541537
Help
Entry
108541537 CDS
T04641
Gene name
BRAF
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rbb
Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01521
EGFR tyrosine kinase inhibitor resistance
rbb01522
Endocrine resistance
rbb04010
MAPK signaling pathway
rbb04012
ErbB signaling pathway
rbb04015
Rap1 signaling pathway
rbb04024
cAMP signaling pathway
rbb04062
Chemokine signaling pathway
rbb04068
FoxO signaling pathway
rbb04150
mTOR signaling pathway
rbb04270
Vascular smooth muscle contraction
rbb04510
Focal adhesion
rbb04650
Natural killer cell mediated cytotoxicity
rbb04720
Long-term potentiation
rbb04722
Neurotrophin signaling pathway
rbb04726
Serotonergic synapse
rbb04730
Long-term depression
rbb04810
Regulation of actin cytoskeleton
rbb04910
Insulin signaling pathway
rbb04914
Progesterone-mediated oocyte maturation
rbb04928
Parathyroid hormone synthesis, secretion and action
rbb04934
Cushing syndrome
rbb05010
Alzheimer disease
rbb05022
Pathways of neurodegeneration - multiple diseases
rbb05034
Alcoholism
rbb05160
Hepatitis C
rbb05161
Hepatitis B
rbb05200
Pathways in cancer
rbb05205
Proteoglycans in cancer
rbb05210
Colorectal cancer
rbb05211
Renal cell carcinoma
rbb05212
Pancreatic cancer
rbb05213
Endometrial cancer
rbb05214
Glioma
rbb05215
Prostate cancer
rbb05216
Thyroid cancer
rbb05218
Melanoma
rbb05219
Bladder cancer
rbb05220
Chronic myeloid leukemia
rbb05221
Acute myeloid leukemia
rbb05223
Non-small cell lung cancer
rbb05224
Breast cancer
rbb05225
Hepatocellular carcinoma
rbb05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rbb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
108541537 (BRAF)
04012 ErbB signaling pathway
108541537 (BRAF)
04015 Rap1 signaling pathway
108541537 (BRAF)
04068 FoxO signaling pathway
108541537 (BRAF)
04024 cAMP signaling pathway
108541537 (BRAF)
04150 mTOR signaling pathway
108541537 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
108541537 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
108541537 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
108541537 (BRAF)
04062 Chemokine signaling pathway
108541537 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
108541537 (BRAF)
04914 Progesterone-mediated oocyte maturation
108541537 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
108541537 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
108541537 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
108541537 (BRAF)
04720 Long-term potentiation
108541537 (BRAF)
04730 Long-term depression
108541537 (BRAF)
04722 Neurotrophin signaling pathway
108541537 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108541537 (BRAF)
05205 Proteoglycans in cancer
108541537 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
108541537 (BRAF)
05212 Pancreatic cancer
108541537 (BRAF)
05225 Hepatocellular carcinoma
108541537 (BRAF)
05226 Gastric cancer
108541537 (BRAF)
05214 Glioma
108541537 (BRAF)
05216 Thyroid cancer
108541537 (BRAF)
05221 Acute myeloid leukemia
108541537 (BRAF)
05220 Chronic myeloid leukemia
108541537 (BRAF)
05218 Melanoma
108541537 (BRAF)
05211 Renal cell carcinoma
108541537 (BRAF)
05219 Bladder cancer
108541537 (BRAF)
05215 Prostate cancer
108541537 (BRAF)
05213 Endometrial cancer
108541537 (BRAF)
05224 Breast cancer
108541537 (BRAF)
05223 Non-small cell lung cancer
108541537 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
108541537 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
108541537 (BRAF)
09165 Substance dependence
05034 Alcoholism
108541537 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
108541537 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
108541537 (BRAF)
05160 Hepatitis C
108541537 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108541537 (BRAF)
01522 Endocrine resistance
108541537 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rbb01001
]
108541537 (BRAF)
Enzymes [BR:
rbb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
108541537 (BRAF)
Protein kinases [BR:
rbb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
108541537 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
108541537
NCBI-ProteinID:
XP_017746540
LinkDB
All DBs
Position
Un
AA seq
753 aa
AA seq
DB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAAASSAADPAVPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLEYLGNGTDFSVSSSASMDTVTSSS
SSSLSVLQSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKAL
MMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTL
AFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEA
SLAETALTSGSSPSAPTSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSS
APNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKML
NVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE
TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS
GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI
IFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQENLQPSSSHHHGSICS
YFLSLVFVQFVNIKTQFCSSNFFLKIQNFQCIS
NT seq
2262 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccgcggcctcttcggctgcggaccctgccgttccg
gaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcccta
ttggacaaatttggtggggagcataatccaccatcaatatatctggaggcctatgaagaa
tacaccagcaagctagatgcactccaacaaagagaacaacagttattggaatatctgggg
aacggaactgatttttctgtttctagctctgcatcaatggacaccgttacatcttcttcc
tcttctagcctttcagtgctacaatctctttcagtttttcaaaatcccacagatgtggca
cggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctacccaacaaacag
aggacagtggtacctgcaaggtgtggagttacagtccgagacagtctaaagaaagcactg
atgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggatggagagaag
aaaccaattggctgggacactgatatttcctggcttactggagaagaattgcatgtggaa
gtgttggagaatgttccacttacaacacacaactttgtacgaaaaacatttttcacctta
gcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaacatgtggt
tataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgaccaa
cttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggaagaggcc
tccttagcagagactgccctaacatctggatcatccccttccgcacccacctcagactct
attgggccccaaattctcaccagtccgtctccttcaaaatccattccaattccacagccc
ttccgaccagcagatgaagatcatcgaaatcaatttgggcaacgagaccggtcctcatca
gctcccaatgtgcatataaacacaatagaacctgtcaatattgatgacttgattagagac
caaggatttcgtggtgatggaggatcaaccacaggtttgtctgccaccccccctgcctca
ttacctggctcactcactaacgtgaaagccttacagaaatctccaggacctcagcgagaa
aggaagtcatcttcatcctcagaagacaggaatcggatgaaaacacttggtagacgggac
tcgagtgatgattgggagattcctgatgggcagattacagtgggacaaagaattggatct
gggtcatttggaacagtctacaagggaaagtggcatggtgatgtggcagtgaaaatgttg
aatgtgacagcacctacacctcagcagttacaagccttcaaaaatgaagtaggagtactc
aggaaaacacgacacgtgaatatcctactcttcatgggctattccacaaagccacaacta
gctattgttacccagtggtgcgagggctccagcttgtatcaccatctccatatcattgag
accaaatttgagatgatcaaacttatagatattgcacgacagactgcacagggcatggat
tacttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttcttcat
gaagacctcacagtaaaaataggtgattttggtctagctacagtgaaatctcgatggagt
gggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagtcatc
agaatgcaagataaaaatccatacagctttcagtcggatgtatatgcctttgggattgtt
ctgtatgaattgatgactggacagttaccttattcaaacatcaataacagggaccagata
atttttatggtgggacgaggatacctatctccagatctcagtaaggtacggagtaactgt
ccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagatgaaagacca
ctctttccccaagagaatttgcagccttcaagtagccaccatcatggcagcatctgctct
tatttcttaagtcttgtgttcgtacaatttgttaacatcaaaacacagttctgttcctca
aatttttttttaaagatacaaaatttccaatgcataagctga
DBGET
integrated database retrieval system
