KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108531435Help
Entry
108531435         CDS       T04641                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb00310  Lysine degradation
rbb05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    108531435 (DOT1L)
 09160 Human Diseases
  09161 Cancers
   05202 Transcriptional misregulation in cancers
    108531435 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:rbb03036]
    108531435 (DOT1L)
Enzymes [BR:rbb01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     108531435 (DOT1L)
Chromosome and associated proteins [BR:rbb03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     108531435 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1
Motif
Other DBs
NCBI-GeneID: 108531435
NCBI-ProteinID: XP_017730366
LinkDB All DBs
Position
Un
AA seq 1732 aa AA seqDB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKLAGPTDAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKNQTALDVLHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNTQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRSQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKGALGRELEPDAGRLHLELDCAKFSLPHLSSMSPELSMNGQAAGY
ELCSALSRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHTVPSRPAASELHPRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSGGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA
ELATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL
TEASKGDLPSDSGFSDPESEAKRRIVFTIATGAGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRKRGRRKRASTGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPTPASEPVNNSKWKSTFSPISDIGLAKSADSP
LQASSALSQNSLFTFRPALEEPPADAKLATHPRKGFPSSLSGADGLSPSTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAASLSSPLSFPSQRGKEASDANPFLSKRQLDGLAGLK
GEGSRSKEAGEGGLQLCGPTDKTPLLTGKAAKARDRELDLKNGHNLFISAAAVPPGSLLS
GPGLAPVASSAGGAASSTQTHRPFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGSTVGGVFNHAVPSASAHPFGARVGRGAAC
GSATLGPSPLQAAASSFQAPASVETRPPPPPPPPPXAPPAHQGRPPAGPPVLHAPPPPNA
ALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARP
SFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR
NT seq 5199 nt NT seq  +upstreamnt  +downstreamnt
atgggggagaagctggagctgagactcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgttgccggtctacgacaaacatcacgatgctgctcatgaaatcatcgagacc
atccgatgggtgtgtgaagaaatcccggatctcaagctcgctatggagaattacgtttta
attgactatgacaccaaaagcttcgagagcatgcagaggctctgcgacaagtacaaccgc
gccatcgatagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
cggccgtccaccgggctcctgcgccatatcctgcagcaggtctacaaccactcggtgact
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
ttcgacctggtggcccaaatgatcgacgagatcaagatgaccgacgacgacctgtttgtg
gacttggggagcggtgtgggccaggtcgtgctccaggttgccgctgccaccaactgcaaa
catcactatggcgtcgagaaagcagacatcccggccaagtatgcggagaccatggaccgc
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacattggagaga
ggcgatttcctctcagaagagtggagggagcggattgccaacacgagtgttatatttgtg
aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaaaccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtggtggagctgtcgcccctgaag
ggctcggtgtcgtggacagggaagccagtctcctactacctgcacactatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaggaggca
gcccggcgccgccagcagcgcgagagcaagagcaacgcggccacgcccaccaagggcccc
gagggcaagctggccggccccactgacgcccccatggactctggtgctgaggaagagaag
gcaggagcagccaccgtgaagaagccgtctccctccaaagcccgcaagaagaagctcaac
aagaaggggaggaagatggctggccgcaagcgcgggcgccccaagaagatgagcactgcg
aaccccgagcggaagcccaagaagaaccaaactgcactggatgtcctgcacgctcagacc
gtgtctcagacggcagcctcctcgccccaggatgcctacaggtcccctcacagcccgttc
taccagctacctccgagcgtgcagcggcactcccccaacccgctgctggtggcgcccacc
ccgcccgcgttgcagaagctgctagagtctttcaagatccagtacctgcagttcctggca
tacacaaagaccccccagtacaaggccagcctacaggagctgctgggccaggagaaggag
aagaacacccagctcctgggcgcggctcagcagctcctcagccactgccaggcccagaag
gaggagatcaggaggctgttccagcaaaaattggatgagctgggcgtgaaggcgctgacc
tacaacgacctgattcaggcgcagaaggagatctccgcccacaaccagcagctgcgggag
cagtcggagcagctggagcaggacaaccgtgcgctgcgcagccagagcttgcagctgctc
aaggctcgctgtgaggagctgcagctagactgggccacgctgtccctggagaagctgctg
aaggagaagcaggccctgaagagccagatctcggagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgtgtgccgcctgatgacgccctgtctctgcacctacgcgggaagggtgctctgggc
cgcgagctggagcctgacgccggccggctgcacctggagctggactgcgccaagttctcg
ctgcctcacttgagcagcatgagcccagagctctccatgaacggccaggctgccggctat
gagctctgcagtgcgctgagccggccgtcatccaagcagaacacaccccagtacctggcc
tcacccctagaccaggaggtggtgccctgcacccccagccacagcggccggccacgcctg
gagaagctgtctggcctggctgcacccgactacaccaggctgtccccggccaagattgtg
ctgaggcggcacctgagccaggaccacacggtgcccagcaggccggccgccagtgagctg
cacccaagagctgagcacaccaaggagaacggccttccctaccagagccccagcgtgcct
ggcagcatgaagctgagtccccaggacccgcggcccctgtcacctggggccttgcagctt
gctggagagaagagcagtgagaagggcctgagagagcgcgcctatggcagcggcggggag
ctcatcaccagcctgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccg
gtcagcatccccctggccagcgtggtgctgcccagccgcgctgagagggcgaggagcacc
cccagtcctgtgctgcagccccgcgacccctcatccacacttgaaaagcagattggtgct
aatgcccacggtgctgggagcagaagccttgccctggcccccgcaggcttctcctatgct
ggctctgtggccatcagcggggccttggcgggcagcccggcctctctcacacctggagcc
gagctggccaccttggatgagtcctccagctctgggagcctttttgccactgtggggtcc
cgcagctccacaccacagcaccccctgctgctggcacagccccggaactcgctcccggcc
tctcccgcccaccagctctcctccagcccccggcttggtggggctgcccagggcccgctc
actgaggccagcaagggggacttgccctcagattccggtttctcagatcctgagagtgag
gccaagaggaggatcgtgttcaccatcgccactggtgcgggcagtgccaaacagtcgccc
tccagcaagcacagccccctgaccgccagcgcccgtggggactgtgtgccgagccacggg
caggacagccgcaagcgcgggcggcggaagcgagcatcgacggggacgcccagcttgagc
gcaggcgtgtcccccaagcgccgagccctgccgtccgtcgctggccttttcacacaacct
tcagggtctcccctcaacctcaactccatggtcagtaacatcaaccagcccctggagatt
acagccatctcgtcccccgagacctccctgaagagctcccctgtgccctaccaggaccac
gaccagccccccgtgctcaagaaggagcggcctctgagccagaccaatggggcacactac
tccccgctcacctcggacgaggagccaggctctgaggacgagcccagcagcgcccgaatt
gagagaaaaattgcaacaatctccttagaaagcaaatctcccccgaaaactttggaaaat
ggtggtggtttggcgggaaggaagcccacgcccgcgagcgagccagtcaacaacagcaag
tggaagtccactttctcgcccatctctgacattggcctggccaagtctgcagacagcccg
ctgcaggccagctctgccctcagccagaactccctgttcacgttccggcccgccctggag
gagccccctgccgatgccaagctggccacccaccccaggaaaggctttcccagctctctg
tcgggggctgacggactcagcccgagcaccaaccctgccaacggctgcacctttggcggg
ggcctggccgcggacctgagtttacacagcttcagcgatggtgcttcccttccccacaag
ggccccgaggcggccagcctgagctccccgctgagcttcccctcgcagcgtggcaaggag
gcctcggacgccaaccctttcctgagcaagaggcagctggatggcctggctgggctgaag
ggcgagggcagccgcagcaaggaggcaggggagggcggcctgcagctgtgcgggcccacg
gacaagaccccactgctgactggcaaggccgccaaggcccgagaccgcgagctcgacctc
aagaatggccacaacctcttcatctccgctgcggccgtgcctcccggaagcctcctcagc
ggccccggcctggccccggtggcgtcctccgcaggcggcgcggcgtcctccacccagacg
caccggcccttcttgggccccttcccgccgggaccgcagtttgcgctcggccccatgtcc
ctgcaggccaacctcggctccgtggccggctcctccgtgctgcagtcgctgttcagctct
gtgccggccgccgcaggcctggtgcacgtgtcgtccgctgccaccagactgaccaactcg
cacgccatgggcagcttttccggggtggcaggcagcacagttggaggtgtctttaaccac
gcggtgccttccgcctctgctcatccgtttggagcccgtgtcggccgcggggctgcatgt
ggcagtgccacgctgggcccgagcccgctgcaggcggcggcctcttcctttcaggccccg
gcctcggttgagacccggccgccccctccgcctccgcctcccccgnctgccccgcctgcg
caccagggccggccccccgcggggcctcccgtcctccacgccccgcctccacctaacgcc
gccttgcctcctcccccaacgctgctggcctctaaccctgagcccgcgcttctgcagagc
ctcgcgtccctcccgcctaaccaagctttcttgccccccacctctgctgcctctctgccg
cctgctaacgcctctttgtctatcaagctcacctccctcccgcacaagggcgctcgcccc
tccttcacggtgcaccaccagcccctgccccggctggccctggcccaggccgcgcccggg
atcccgcaggccagcgccacggggccgtccgcggtgtgggtgtccctcggcatgccgcct
ccctatgccgcgcacctttcgggggttaagccgcgataa

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