Rhinopithecus bieti (black snub-nosed monkey): 108532525 Help Entry 108532525         CDS       T04641                                  Gene name NOS3 Definition (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism rbb  Rhinopithecus bieti (black snub-nosed monkey) Pathway rbb00220   Arginine biosynthesis rbb00330   Arginine and proline metabolism rbb01100   Metabolic pathways rbb04020   Calcium signaling pathway rbb04022   cGMP-PKG signaling pathway rbb04066   HIF-1 signaling pathway rbb04071   Sphingolipid signaling pathway rbb04151   PI3K-Akt signaling pathway rbb04370   VEGF signaling pathway rbb04371   Apelin signaling pathway rbb04611   Platelet activation rbb04915   Estrogen signaling pathway rbb04921   Oxytocin signaling pathway rbb04926   Relaxin signaling pathway rbb04931   Insulin resistance rbb04933   AGE-RAGE signaling pathway in diabetic complications rbb05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:rbb00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     108532525 (NOS3)    00330 Arginine and proline metabolism     108532525 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     108532525 (NOS3)    04371 Apelin signaling pathway     108532525 (NOS3)    04066 HIF-1 signaling pathway     108532525 (NOS3)    04020 Calcium signaling pathway     108532525 (NOS3)    04071 Sphingolipid signaling pathway     108532525 (NOS3)    04022 cGMP-PKG signaling pathway     108532525 (NOS3)    04151 PI3K-Akt signaling pathway     108532525 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     108532525 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     108532525 (NOS3)    04921 Oxytocin signaling pathway     108532525 (NOS3)    04926 Relaxin signaling pathway     108532525 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     108532525 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     108532525 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     108532525 (NOS3) Enzymes [BR:rbb01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      108532525 (NOS3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 HTH_15 Motif Other DBs NCBI-GeneID:  108532525 NCBI-ProteinID:  XP_017732105 UniProt:  A0A2K6MEG7 LinkDB All DBs Position Un AA seq 1205 aa AA seqDB search MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATSAPEPSRAPASLPPPAPEHSPPSSPLT QPPEGPKFPRVKNWEVGSIAYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPTP EQLLSQARDFINQYYSSIKRSGSQAHQQRLQEVEAEVAATGTYQLRENELVFGAKQAWRN APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA RDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATILSVENLQSSKSTRATIL VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP PPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEMHLTVAVL AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPSSDT TTNGP NT seq 3618 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagcgtggcccaggaacctgggccaccctgtggcctggggctgggg ctgggccttgggctgtgcggcaagcagggcccagccacctctgcccctgagcccagccgg gccccggcatccctacccccgccagcgccagaacacagccctccgagctccccgctaacc cagcccccagaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcgcc tatgacaccctcagcgcccaggcgcagcaggatgggccctgcaccccaagacgctgcctg ggctccctggtatttccacggaaactacagggccggccctcccccggccccccgacccct gagcagctgctgagtcaggcccgggacttcatcaaccagtactacagctccatcaagagg agcggctctcaggcccaccaacagcggcttcaagaggtggaagccgaggtggcagccaca ggcacctaccagcttagggagaatgagctggtgttcggggccaagcaggcctggcgcaac gctccccgctgtgtgggccggatccagtgggggaagctgcaggtgttcgatgcccgggac tgcaggtctgcacaggaaatgttcacctacatctgcaaccacatcaaatacgccaccaac cggggcaaccttcgctcggccatcacagtgttcccgcagcgctgccctggccgaggagac ttccgaatctggaacagccagctggtgcgctatgcgggctaccggcagcaggatggctct gtgcggggggacccagccaacgtcgagatcaccgagctctgcattcagcacggctggacc ccaggaaacggtcgctttgacgtgctgcccctgctgctccaggccccggatgagccccca gaactcttccttctgccccctgagctggtccttgaggtgccactggagcaccccacgctg gagtggtttgcagctctgggcctgcgctggtacgccctcccagcagtgtccaacatgctg ctggaaattgggggcctggagttccccgcagcccccttcagtggctggtacatgagcact gagatcggcacgaggaacctgtgtgaccctcaccgctacaacatcctggaggacgtggct gtctgcatggacctggacacccggacaacttcgtccctatggaaagacaaggcagcggtg gaaatcaacgtggccgtgctgcacagttaccagctggccaaagtcaccattgtggaccac cacgccgccacagcctccttcatgaagcacctggagaatgagcagaaggccagggggggc tgccctgcagactgggcctggatcgtgccccccatctcaggcagcctcactcctgtcttc catcaggagatggtcaactatttcctgtccccagccttccgctaccagccagacccctgg aaggggagtgcggccaagggcactggcatcaccaggaagaagacctttaaagaagtggcc aatgccgtgaagatctccgcctcactcatgggcaccgtgatggcgaagcgagtgaaggcg acaatcctgtacggctccgagaccggccgggcccagagctacgcacagcagctggggaga cttttccggaaggcttttgatccccgggtcctgtgtatggatgagtacgatgtggtgtcc cttgaacacgagacgctggtgctggtggtaaccagcacattcgggaatggggatcccccg gagaatggagagagctttgcagctgccctgatggagatgtctggtccctacaacagctcc cctcggccagaacagcacaagagttataagatccgcttcaacagcatctcctgctcagac ccactggtgtcctcttggcggcggaagaggaaggagtccagtaacacagacagtgcaggg gccctgggcacactcaggttctgtgtgttcgggctgggctcccgggcgtacccccatttc tgtgcctttgctcgtgcggtggacacgcggctggaggaactgggcggggagcggctgctg cagctgggccagggtgacgagctgtgtggccaggaggaggccttccgcggctgggcccag gctgccttccaggccgcctgtgagaccttctgtgtgggagaggatgccaaggctgccgcc cgagacatcttcagccccaaaaggagttggaagcgccagaggtaccggctgagcacccag gccgagggcctgcagttgctgccaggcctgatccacgtgcacaggcggaagatgttccag gctacaattctctcagtggaaaacctacaaagcagcaagtccacgagggccaccatcctg gtgcgcctggacactggaggccaggaggggctgcagtaccagccgggggaccacataggt gtctgcccacccaaccggcccggccttgtggaggcgctgctgagccgcgtggaggacccg cctgcgcccaccgaacccgtggcagtagagcaactggagaagggcagccctggtggccct ccccccagctgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctcacc ttcttcctggacatcacctccccgcccagccctcagctcttgcggctgctcagcaccttg gcagaagagcccagggaacagcaggagctggaggccctcagtcaggatccccgacgctat gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccttcg gtggcactgcctgccccactgctcctcacccagctgcctctgcttcaaccccggtactac tcagtcagctcagcacccagcacccacccaggagagatgcacctcactgtagctgtgctg gcatacaggacccaggatgggctgggccccctgcactatggagtctgctccacgtggcta agccaactcaagcccggagaccctgtgccctgcttcatccggggggctccctccttccgg ctgccacccgatcccagcttgccctgcatcctggtgggcccaggcactggcattgccccc ttccggggattctggcaggagcggctgcatgacattgagagcaaagggctgcagcccact cccatgactttggtgtttggctgccgatgctcccaactcgaccatctctaccgcgacgag gtgcagaacgcccagcagcgcggggtgtttggccgagtcctcaccgccttctcccgggaa cctgacaaccccaagacctacgtgcaggacatcctgagaacggagctggctgcagaggtg caccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcaccatggca accaacgtcctgcagaccgtgcagcgcatcttggcgacggagggcgacatggagctggac gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaagacattttc gggctcacgctgcgcacccaagaggtgacaagccgcatacgcacccagagcttttccttg caggagcggcagctgcggggcgcagtgccctgggcgttcgacccgcccagctccgacacc accaccaacggcccctga

Rhinopithecus bieti (black snub-nosed monkey): 108539288 Help Entry 108539288         CDS       T04641                                  Gene name NOS1 Definition (RefSeq) nitric oxide synthase 1   KO K13240   nitric-oxide synthase, brain [EC:1.14.13.39] Organism rbb  Rhinopithecus bieti (black snub-nosed monkey) Pathway rbb00220   Arginine biosynthesis rbb00330   Arginine and proline metabolism rbb01100   Metabolic pathways rbb04020   Calcium signaling pathway rbb04145   Phagosome rbb04371   Apelin signaling pathway rbb04713   Circadian entrainment rbb04730   Long-term depression rbb04926   Relaxin signaling pathway rbb04970   Salivary secretion rbb05010   Alzheimer disease rbb05014   Amyotrophic lateral sclerosis rbb05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:rbb00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     108539288 (NOS1)    00330 Arginine and proline metabolism     108539288 (NOS1)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108539288 (NOS1)    04020 Calcium signaling pathway     108539288 (NOS1)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     108539288 (NOS1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     108539288 (NOS1)   09154 Digestive system    04970 Salivary secretion     108539288 (NOS1)   09156 Nervous system    04730 Long-term depression     108539288 (NOS1)   09159 Environmental adaptation    04713 Circadian entrainment     108539288 (NOS1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     108539288 (NOS1)    05014 Amyotrophic lateral sclerosis     108539288 (NOS1)    05022 Pathways of neurodegeneration - multiple diseases     108539288 (NOS1) Enzymes [BR:rbb01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      108539288 (NOS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 PDZ PDZ_6 NAD_binding_1 PDZ_2 Motif Other DBs NCBI-GeneID:  108539288 NCBI-ProteinID:  XP_017743361 LinkDB All DBs Position Un AA seq 1337 aa AA seqDB search MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI RVTQPLGPPTKAVDLSHQPSAGKEQPLAVDGASGPGNGPQHAQDDGQEAGSLPHANGLAP XAPGQDPAKKAARVGLQGRGENNELLKEIEPVLNLLTSGSRGVKGGAPAKTEMKDMGIQV DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPASGKQSPTKNGSPS KCPRFLKVKNWETDVVLTDTLHLNSTLETGCTEYICMGSIMLPSQHLRRPEDVRTKEQLF PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIETTSTYQLKDTELIYGAKHAWRNASRC VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ EERKYPEPLRFFPRKGPPLPHGDTEVHGLAAARDSQHRSYKVRFNSVSSYSDSQKSSGDG PDLRHNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELC GQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELT QGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHE DLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDEHRLPPCTIFQAFKYYLDIT TPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPAT LLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQAD EVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGGLQSSGCLLP TPRPGELQLCLSSPREQ NT seq 4014 nt NT seq  +upstreamnt  +downstreamnt atggaggatcacatgttcggtgttcagcaaatccagcccaatgtcatttctgttcgtctt ttcaagcgcaaagttgggggcctgggattcctggtgaaggagcgggtcagtaagccaccc gtgatcatctccgacctgattcgtgggggcgccgcggagcagagtggcctcatccaggct ggagacatcattcttgcggtcaacggccggcccttggtggacctgagctatgacagcgcc ctggaggtactcagaggcattgcctccgagacccacgtggtcctcattctgaggggccct gaaggcttcaccacgcacctggagaccacctttacaggtgatgggacccccaaaaccatc cgggtgacacagcccctgggtcccccaaccaaagctgtggatctgtcccaccagccatcg gccggcaaagaacaacccctggcagtggatggggcctcgggtcctgggaatgggcctcag catgcccaagacgatgggcaggaggctggctcgctcccccatgccaacggcctggcccca nnggccccaggccaggaccctgcaaagaaagcagccagagtcggcctccaaggcagaggg gagaacaatgaactgctcaaggagatagagcctgtgctgaaccttctcaccagtgggagc agaggggtcaagggaggggcacctgccaagacagagatgaaagatatgggaatccaggtg gacagagatttggacggcaaatcacacaaacctctgcccctcggtgtggagaacgaccga gtcttcaatgacctatgggggaagggcaatgtgcctgtcgtcctcaacaacccatattca gagaaggagcagccccctgcctcaggaaaacagtcccccacaaagaatggcagcccctcc aagtgtccacgcttcctcaaagtcaagaactgggagactgacgtggttctcactgacacc ctccaccttaacagcacattggaaacgggatgcactgagtacatctgcatgggctccatc atgcttccttctcagcatctacggaggcctgaagatgtccgcacaaaagaacagctcttc cctctcgccaaagagtttattgatcaatactattcttcaattaaaagatttggctccaaa gcccacatggaaaggctggaagaggtgaacaaagagatcgaaaccactagcacctaccaa ctcaaggacacagagctcatctacggggccaagcatgcctggcggaatgcctcgcgctgt gtgggcaggatccagtggtccaagctgcaggtattcgatgctcgcgactgcaccacagcc cacgggatgttcaactacatctgcaaccacgtcaagtatgccaccaataaagggaacctc aggtctgccatcaccatattcccccagaggacagacggcaagcacgacttccgagtctgg aactcccagctcatccgctacgctggctacaagcagcccgacggctccaccctgggggac ccggccaacgtgcagttcacagagatttgcatacagcagggctggaaacccccgagaggc cgcttcgatgtcctgccgctcctgcttcaggccaacggcaatgaccctgagctcttccag attcctccagagctggtgttggaagttcccatcaggcaccccaagtttgagtggttcaag gacctggggctgaagtggtacggcctccctgccgtgtccaacatgctcctggagattggc ggcctggagttcagcgcctgtcccttcagtggctggtacatgggcacagagattggtgtc cgcgactactgtgacaactcccgctacaatatcctggaggaagtggccaagaagatgaac ttagacatgaggaagacgtcctccctgtggaaggaccaggcgctggtggagatcaatatc gcggttctctatagcttccagagtgacaaagtgaccattgttgaccatcactccgccacc gagtccttcattaagcacatggagaatgagtaccgctgccggggaggctgccctgccgac tgggtgtggattgtgccccccatgtccggaagcatcacccctgtgttccaccaggagatg ctcaactaccggctcaccccctccttcgaataccagcctgatccctggaacacccacgtc tggaaaggcaccaacgggacccccacaaagcggcgagccattggcttcaagaagctggca gaagctgtcaagttctcggccaagctaatggggcaggctatggccaagagggtcaaagca accatcctctatgccacggagacaggcaaatcacaagcttatgccaagaccttgtgtgag atcttcaaacacgcctttgatgccaaggtgatgtccatggaagaatatgacatcgtgcac ctggaacatgaaactctggtcctcgtggttaccagcacctttggcaacggagatccccct gagaatggggagaaatttggctgtgctttgatggaaatgaggcaccccaactctgtgcag gaagaaaggaagtacccggaacccttgcgtttctttccccgtaaagggcctcccctcccc catggtgacacagaagtccacggtctggctgcagcccgtgacagccagcacaggagctac aaggtccgattcaatagcgtctcctcctactctgactcccaaaaatcatcaggcgatggg cccgacctcagacacaactttgagagtgctggacccctggccaatgtgaggttctcagtg tttggtcttggctcacgagcgtaccctcacttttgcgccttcggacatgctgtggacact ctcctggaagaactgggaggggagaggatcctgaagatgagggaaggggatgagctctgt gggcaggaagaggctttcaggacctgggccaagaaggtcttcaaggcagcctgtgatgtc ttctgtgtgggagatgatgtcaacattgaaaaggcgaacaattccctcatcagcaatgac cgcagctggaagagaaacaagttccgcctcacctatgtggccgaagctccagaactcacg caaggtctatccaatgtccacaaaaagcgagtctcagctgcccgactccttagccgtcaa aacctccagagccctaaatccagtcggtcaactatcttcgtgcgtctccacaccaacggg agtcaggagctgcagtaccagcctggggaccacctgggtgtcttccctggcaaccacgag gacctcgtgaatgccctgatcgagcggctggaggacgcaccccctgtcaaccagatggtg aaagtggagctgctggaggagcggaacacggctttaggcgtcatcagtaactggacagac gagcaccgcctcccaccctgcaccatcttccaggccttcaagtactacctggacatcacc acgccaccaacgcccctgcagctgcagcagtttgcctccctagccaccaacgagaaggag aagcagcgtctgctggtcctcagcaagggtttgcaggagtacgaggaatggaaatggggc aagaaccccaccatcgtggaggtgctggaggagttcccatccatccagatgccggccacc ttgctcctgacccagctgtccctgctgcagccccgctactattccatcagctcctcccca gacatgtaccctgatgaagtgcacctcactgtggccatcgtttcctaccgcactcgagat ggagaaggaccaattcaccacggcgtgtgctcctcctggctcaaccggatacaggctgac gaagtggtcccctgtttcgtgagaggagcacccagcttccacctgccccggaacccccaa gtcccttgcatccttgttggaccgggcaccggcattgcgcctttccgaagcttctggcaa cagcggcaatttgatatccaacacaaaggtgggttacagtccagcggctgcctgcttccc acccccagacctggggagctccagctgtgtctcagcagccctagagaacagtga

Rhinopithecus bieti (black snub-nosed monkey): 108539959 Help Entry 108539959         CDS       T04641                                  Gene name NOS2 Definition (RefSeq) nitric oxide synthase 2   KO K13241   nitric-oxide synthase, inducible [EC:1.14.13.39] Organism rbb  Rhinopithecus bieti (black snub-nosed monkey) Pathway rbb00220   Arginine biosynthesis rbb00330   Arginine and proline metabolism rbb01100   Metabolic pathways rbb04020   Calcium signaling pathway rbb04066   HIF-1 signaling pathway rbb04146   Peroxisome rbb04371   Apelin signaling pathway rbb04926   Relaxin signaling pathway rbb05010   Alzheimer disease rbb05014   Amyotrophic lateral sclerosis rbb05022   Pathways of neurodegeneration - multiple diseases rbb05133   Pertussis rbb05140   Leishmaniasis rbb05142   Chagas disease rbb05145   Toxoplasmosis rbb05146   Amoebiasis rbb05152   Tuberculosis rbb05200   Pathways in cancer rbb05222   Small cell lung cancer Brite KEGG Orthology (KO) [BR:rbb00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     108539959 (NOS2)    00330 Arginine and proline metabolism     108539959 (NOS2)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108539959 (NOS2)    04066 HIF-1 signaling pathway     108539959 (NOS2)    04020 Calcium signaling pathway     108539959 (NOS2)  09140 Cellular Processes   09141 Transport and catabolism    04146 Peroxisome     108539959 (NOS2)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     108539959 (NOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     108539959 (NOS2)   09162 Cancer: specific types    05222 Small cell lung cancer     108539959 (NOS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     108539959 (NOS2)    05014 Amyotrophic lateral sclerosis     108539959 (NOS2)    05022 Pathways of neurodegeneration - multiple diseases     108539959 (NOS2)   09171 Infectious disease: bacterial    05133 Pertussis     108539959 (NOS2)    05152 Tuberculosis     108539959 (NOS2)   09174 Infectious disease: parasitic    05146 Amoebiasis     108539959 (NOS2)    05145 Toxoplasmosis     108539959 (NOS2)    05140 Leishmaniasis     108539959 (NOS2)    05142 Chagas disease     108539959 (NOS2) Enzymes [BR:rbb01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      108539959 (NOS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 Motif Other DBs NCBI-GeneID:  108539959 NCBI-ProteinID:  XP_017744419 LinkDB All DBs Position Un AA seq 901 aa AA seqDB search MREGLGAACEAAGPRLCRLLCRILRPKPACCLRGASPVTQDDLQYHSLSKQQNESLQPLV GTGKKSPESLVKPDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMT PKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQL TGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARNCSTAREMFEHICRHVRYSTNNGNIR SAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGR FDVVPLVLQADGHDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGG LEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDRAVVEINIA VLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEML NYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKMMASRVRVTI LFATETGKSEALAWDLGALFSCAFNPKVVCMDKYSLSCLEEERLLLVVTSTFGNGDCPGN GEKLKKSLFMLKELTNKFRYAVFGLGSSMYPRFCAFARDIDQKLSHLGASQLTPMGEGDE LSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSSVTWDPHHYRLVQDSQPLDLS KALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGICPGNQP ALVQGILERVVDSPAPHQIVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQL LLQKLAQVATEVTERQRLEALCQVKIRVGGQCGYVGGLRMWGAGAQSWSLTSKRDPPRFP K NT seq 2706 nt NT seq  +upstreamnt  +downstreamnt atgcgcgaggggttgggcgcggcgtgcgaggccgctgggccccggctttgccggctgctt tgcaggatcctccggccgaagcccgcctgctgcctgcgcggagccagtccagtgacacag gatgaccttcagtatcacagcctcagcaagcagcagaatgagtccctgcagcccctcgtg gggacaggaaagaagtctccagaatctctggtcaagccggatgcaaccccattgtcctcc ccacgacatgtgaggatcaaaaactggggcagcgggatgactttccaggacacacttcac cacaaggccaaagggattttgacttgcaggtccaaatcttgcttgggatccattatgact cccaaaagtttgaccagaggacccagggacaagcctacccctccagatgagcttctacct caagctatcgaatttgtcaaccaatattacggctccttcaaagaggcaaaaatagaggaa catctggccagggtggaagcggtaacaaaggagatagaaacaacaggaacctaccaactg acgggagatgagctcatcttcgctaccaagcaggcctggcgcaatgccccacgctgcatt gggaggatccagtggtccaacctgcaggtctttgatgcccgcaactgttccaccgcccgg gaaatgtttgaacacatctgcagacacgtgcgttactccaccaacaatggcaacatcagg tcggccatcaccgtgttcccccagcggagcgatggtaagcacgacttccgggtgtggaat gctcagctcatccgctacgcgggctaccagatgccagatggcagcatcagaggggaccct gccaacgtggaattcactcagctgtgcatcgacctgggctggaagcccaagtatggccgc ttcgatgtggtccccctggtcctacaggctgacggccatgaccctgagctcttcgaaatc ccacctgaccttgtgcttgaggtggccatggaacatcccaaatatgagtggtttcgggaa ctggagctaaagtggtacgccctgcctgcagtggccaacatgctgctcgaggtgggcggc ctggagttcccagggtgccccttcaatggctggtacatgggcacagagatcggagtccgg gacttctgtgacgtccagcgctacaacatcctggaggaagtgggcaggagaatgggcttg gaaacgcacaagctggcctcgctctggaaagaccgggctgttgttgagatcaacattgct gtgctccatagtttccagaagcaaaacgtgaccatcatggaccaccactcagctgcagaa tccttcatgaagtacatgcagaatgaataccggtcccgtgggggctgcccggcagactgg atttggctggtccctcccatgtctgggagcatcactcccgtgtttcaccaggagatgctg aactacgtcctgtcccctttctactactatcaggtagaggcctggaaaacccatgtctgg caggacgagaagcggagacccaagagaagagagattccgttgaaagtcttggtcaaagct gtgctcttcgcctgtatgctgatgcgcaagatgatggcgtcccgagtcagagtcaccatc ctctttgcgacagagacaggaaaatcagaggcgctggcctgggacctgggggccttgttc agctgtgccttcaaccccaaggttgtctgcatggataagtacagcctgagctgcctggag gaggagcggctgctgttggtggtgaccagtacgtttggcaatggagactgccccggcaac ggagagaaactgaagaaatcgctcttcatgctgaaagagctcaccaacaaattcaggtat gctgtgtttggccttggctccagcatgtaccctcggttctgcgcctttgctcgtgacatc gatcagaagctgtcccacctgggggcctctcagctcacccccatgggagaaggggatgag ctcagtgggcaggaggacgccttccgcagctgggccgtgcaaaccttcaaggcagcctgt gagacgtttgatgtccgaggcaaacagcacattcagatccccaagctctacacctccagt gtgacctgggacccacaccactacaggctcgtgcaggactcacagcctttggacctcagc aaagccctcagcagcatgcacgccaagaacgtgttcaccatgaggctcaaatctcggcag aacctacagagtccgacatccagccgtgccaccatcctggtggaactctcctgtgaggac ggccaaggcctgaactacttgccaggggagcaccttgggatttgcccaggcaaccagccg gccctggtccaaggcatcctggagcgagtggtggacagccccgcgccccaccagatagtg cgcctggaggccctggacgagagcggcagctactgggtcagtgacaagaggctgcccccc tgctcactcagccaggccctcacctacttcctggatatcaccacccccccaacccagctg ctgctccaaaagctggcccaggtggccacagaagtgactgagagacagaggctggaggcc ctgtgccaggtgaagatcagggttggtgggcagtgcgggtatgtggggggtctcagaatg tggggagctggagctcagagctggtctttaacttccaagagggatccacccaggttccca aagtga

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