KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108537414
Entry
108537414         CDS       T04641                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01521  EGFR tyrosine kinase inhibitor resistance
rbb01522  Endocrine resistance
rbb04010  MAPK signaling pathway
rbb04012  ErbB signaling pathway
rbb04014  Ras signaling pathway
rbb04062  Chemokine signaling pathway
rbb04068  FoxO signaling pathway
rbb04072  Phospholipase D signaling pathway
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04380  Osteoclast differentiation
rbb04510  Focal adhesion
rbb04540  Gap junction
rbb04550  Signaling pathways regulating pluripotency of stem cells
rbb04630  JAK-STAT signaling pathway
rbb04650  Natural killer cell mediated cytotoxicity
rbb04660  T cell receptor signaling pathway
rbb04662  B cell receptor signaling pathway
rbb04664  Fc epsilon RI signaling pathway
rbb04714  Thermogenesis
rbb04722  Neurotrophin signaling pathway
rbb04910  Insulin signaling pathway
rbb04912  GnRH signaling pathway
rbb04915  Estrogen signaling pathway
rbb04917  Prolactin signaling pathway
rbb04926  Relaxin signaling pathway
rbb04935  Growth hormone synthesis, secretion and action
rbb05034  Alcoholism
rbb05160  Hepatitis C
rbb05161  Hepatitis B
rbb05163  Human cytomegalovirus infection
rbb05165  Human papillomavirus infection
rbb05200  Pathways in cancer
rbb05203  Viral carcinogenesis
rbb05205  Proteoglycans in cancer
rbb05206  MicroRNAs in cancer
rbb05210  Colorectal cancer
rbb05211  Renal cell carcinoma
rbb05213  Endometrial cancer
rbb05214  Glioma
rbb05215  Prostate cancer
rbb05220  Chronic myeloid leukemia
rbb05221  Acute myeloid leukemia
rbb05223  Non-small cell lung cancer
rbb05224  Breast cancer
rbb05225  Hepatocellular carcinoma
rbb05226  Gastric cancer
rbb05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108537414 (GRB2)
   04012 ErbB signaling pathway
    108537414 (GRB2)
   04014 Ras signaling pathway
    108537414 (GRB2)
   04630 JAK-STAT signaling pathway
    108537414 (GRB2)
   04068 FoxO signaling pathway
    108537414 (GRB2)
   04072 Phospholipase D signaling pathway
    108537414 (GRB2)
   04151 PI3K-Akt signaling pathway
    108537414 (GRB2)
   04150 mTOR signaling pathway
    108537414 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108537414 (GRB2)
   04540 Gap junction
    108537414 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    108537414 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    108537414 (GRB2)
   04660 T cell receptor signaling pathway
    108537414 (GRB2)
   04662 B cell receptor signaling pathway
    108537414 (GRB2)
   04664 Fc epsilon RI signaling pathway
    108537414 (GRB2)
   04062 Chemokine signaling pathway
    108537414 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108537414 (GRB2)
   04912 GnRH signaling pathway
    108537414 (GRB2)
   04915 Estrogen signaling pathway
    108537414 (GRB2)
   04917 Prolactin signaling pathway
    108537414 (GRB2)
   04926 Relaxin signaling pathway
    108537414 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    108537414 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    108537414 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108537414 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    108537414 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108537414 (GRB2)
   05206 MicroRNAs in cancer
    108537414 (GRB2)
   05205 Proteoglycans in cancer
    108537414 (GRB2)
   05203 Viral carcinogenesis
    108537414 (GRB2)
   05231 Choline metabolism in cancer
    108537414 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108537414 (GRB2)
   05225 Hepatocellular carcinoma
    108537414 (GRB2)
   05226 Gastric cancer
    108537414 (GRB2)
   05214 Glioma
    108537414 (GRB2)
   05221 Acute myeloid leukemia
    108537414 (GRB2)
   05220 Chronic myeloid leukemia
    108537414 (GRB2)
   05211 Renal cell carcinoma
    108537414 (GRB2)
   05215 Prostate cancer
    108537414 (GRB2)
   05213 Endometrial cancer
    108537414 (GRB2)
   05224 Breast cancer
    108537414 (GRB2)
   05223 Non-small cell lung cancer
    108537414 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    108537414 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    108537414 (GRB2)
   05160 Hepatitis C
    108537414 (GRB2)
   05163 Human cytomegalovirus infection
    108537414 (GRB2)
   05165 Human papillomavirus infection
    108537414 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108537414 (GRB2)
   01522 Endocrine resistance
    108537414 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rbb04131]
    108537414 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:rbb04990]
    108537414 (GRB2)
Membrane trafficking [BR:rbb04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    108537414 (GRB2)
Domain-containing proteins not elsewhere classified [BR:rbb04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   108537414 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 108537414
NCBI-ProteinID: XP_017740352
UniProt: A0A2K6KYS0
LinkDB
Position
Un
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagacggagccggcaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgtgacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattacgtcacccctgtgaaccggaacgtctaa

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