KEGG   REACTION: R01700
Entry
R01700                      Reaction                               
Name
2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
Definition
2-Oxoglutarate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
Equation
C00026 + C15972 <=> C16254 + C00011
Comment
2-oxoglutarate dehydrogenase complex: 2-oxoglutarate dehydrogenase
a part of multi-step reaction (see R08549, R01700+R02570+R07618)
subsequently R02570
TPP-dependent enzyme (see R00621+R03316)
Reaction class
RC00627  C15972_C16254
RC02833  C00026_C16254
Enzyme
1.2.4.2
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2
     R01700  2-Oxoglutarate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
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