KEGG   REACTION: R03102
Entry
R03102                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase
Definition
L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + H+
Equation
C04076 + C00003 + C00001 <=> C00956 + C00004 + C00080
Comment
NADP+ (see R03103)
two-step reaction (see R02317+R11231)
Reaction class
RC00001  C00003_C00004
RC00080  C00956_C04076
Enzyme
1.2.1.31
Pathway
rn00310  Lysine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R03102  L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + H+
Orthology
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Other DBs
RHEA: 12311
LinkDB

KEGG   REACTION: R02317
Entry
R02317                      Reaction                               
Name
(S)-2-amino-6-oxohexanoate hydro-lyase (spontaneous)
Definition
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
Equation
C00450 + C00001 <=> C04076
Comment
spontaneous
the second step of two-step reaction (see R10054, R00446+R02317)
the first step of two-step reaction (see R03102, R02317+R11231 / R03103, R02317+R11232)
Reaction class
RC00694  C00450_C04076
Enzyme
1.2.1.31        1.4.1.18
Pathway
rn00310  Lysine degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00960  Lysine degradation, bacteria, L-lysine => D-lysine => succinate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R02317  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.18
     R02317  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
Orthology
K19064  lysine 6-dehydrogenase [EC:1.4.1.18]
Other DBs
RHEA: 25124
LinkDB

KEGG   REACTION: R11231
Entry
R11231                      Reaction                               
Definition
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
Equation
C00450 + C00003 + 2 C00001 <=> C00956 + C00004 + C00080
Comment
second step of two-step reaction (see R03102, R02317+R11231)
Reaction class
RC00216  C00450_C00956
Enzyme
1.2.1.31
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R11231  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NAD+ + 2 H2O <=> L-2-Aminoadipate + NADH + H+
Other DBs
RHEA: 49479
LinkDB

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