KEGG   REACTION: R03194
Entry
R03194                      Reaction                               

Name
S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase
Definition
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Equation
2 C00019 + C01051 <=> 2 C00021 + C02463
Comment
multifunctional enzyme: siroheme synthase: uroporphyrinogen III methyltransferase (R03194+R03947+R02864)
subsequently R03947
two-step reaction (R07237+R07238)
Reaction class
RC00003  C00019_C00021
RC00871  C01051_C02463
Enzyme
Pathway
rn00860  Porphyrin and chlorophyll metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
M00925  Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Orthology
K00589  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02303  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02496  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K13542  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
K13543  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Other DBs
RHEA: 32462
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