KEGG   REACTION: R05531
Entry
R05531                      Reaction                               

Name
dTDP-D-desosamine:3-O-mycarosylerythronolide-B 5-O-beta-D-desosaminyltransferase
Definition
dTDP-D-desosamine + 3-O-alpha-Mycarosylerythronolide B <=> Erythromycin D + dTDP
Equation
Comment
desosaminyltransferase, EryCIII+EryCII, MegCIII+MegCII
Reaction class
RC00005  C00363_C11911
RC00049  C06630_C06633
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Orthology
K14368  3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278]
K15997  3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein
Reference
1  [PMID:9353926]
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
Other DBs
RHEA: 32094
LinkDB

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