KEGG   REACTION: R08215
Entry
R08215                      Reaction                               
Name
(-)-threo-iso(homo)3-citrate:NAD+ oxidoreductase (decarboxylating)
Definition
(-)-threo-Iso(homo)3-citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH + H+
Equation
C16600 + C00003 <=> C16589 + C00011 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00114  C16589_C16600
Enzyme
1.1.1.-
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01240  Biosynthesis of cofactors
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R08215  (-)-threo-Iso(homo)3-citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH + H+
Orthology
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
Reference
1  [PMID:10940051]
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
Other DBs
RHEA: 68411
LinkDB

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