REACTION: R08274
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Entry
R08274 Reaction
Definition
N-Desmethyltamoxifen + NADPH + H+ + Oxygen <=> alpha-Hydroxy-N-desmethyltamoxifen + H2O + NADP+
Equation
C16546
+
C00005
+
C00080
+
C00007
<=>
C16549
+
C00001
+
C00006
Comment
CYP3A4
Reaction class
RC00001
C00005_C00006
RC02232
C16546_C16549
Enzyme
1.14.14.-
Pathway
rn00982
Drug metabolism - cytochrome P450
Orthology
K17689
cytochrome P450 family 3 subfamily A4 [EC:
1.14.13.32
1.14.14.55
1.14.14.56
1.14.14.57
1.14.14.73
1.14.14.-]
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