KEGG   REACTION: R08549
Entry
R08549                      Reaction                               

Name
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating);
2-Oxoglutarate dehydrogenase complex
Definition
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
Equation
Comment
multienzyme system: ec 1.2.4.2, ec 2.3.1.61 and ec 1.8.1.4
multi-step reaction (see R01700+R02570+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00091
RC02833  C00026_C00091
Enzyme
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Other DBs
RHEA: 27789
LinkDB

KEGG   REACTION: R01700
Entry
R01700                      Reaction                               

Name
2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
Definition
2-Oxoglutarate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: oxoglutarate dehydrogenase
a part of multi-step reaction (see R08549, R01700+R02570+R07618)
subsequently R02570
TPP-dependent enzyme (see R00621+R03316)
Reaction class
RC00627  C15972_C16254
RC02833  C00026_C16254
Enzyme
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
LinkDB

KEGG   REACTION: R02570
Entry
R02570                      Reaction                               

Name
succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase
Definition
Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
Equation
Comment
2-oxoglutarate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase
a part of multi-step reaction (see R08549, R01700+R02570+R07618)
following after R01700
Reaction class
RC00004  C00010_C00091  C15973_C16254
RC02727  C00091_C16254
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Orthology
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Other DBs
RHEA: 15216
LinkDB

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               

Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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