KEGG   REACTION: R10996
Entry
R10996                      Reaction                               
Definition
2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Equation
C00109 + C00068 <=> C21017 + C00011
Comment
Oxo-acid dehydrogenase complexes, subsequently R10997
Reaction class
RC00027  C00068_C21017
RC02743  C00109_C21017
Enzyme
1.2.4.4
Pathway
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R10996  2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
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