Rattus norvegicus (rat): 25496 Help Entry 25496             CDS       T01003                                  Gene name Notch1, NOTCH, TAN1 Definition (RefSeq) notch 1   KO K02599   Notch 1 Organism rno  Rattus norvegicus (rat) Pathway rno01522   Endocrine resistance rno04330   Notch signaling pathway rno04658   Th1 and Th2 cell differentiation rno04919   Thyroid hormone signaling pathway rno05020   Prion disease rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05206   MicroRNAs in cancer rno05224   Breast cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     25496 (Notch1)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     25496 (Notch1)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     25496 (Notch1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     25496 (Notch1)    05206 MicroRNAs in cancer     25496 (Notch1)   09162 Cancer: specific types    05224 Breast cancer     25496 (Notch1)   09164 Neurodegenerative disease    05020 Prion disease     25496 (Notch1)   09172 Infectious disease: viral    05165 Human papillomavirus infection     25496 (Notch1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     25496 (Notch1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_CA EGF_2 Ank_2 Notch NOD Ank DUF3454 NODP Ank_5 Ank_4 Ank_3 EGF_3 cEGF Motif Other DBs NCBI-GeneID:  25496 NCBI-ProteinID:  NP_001099191 RGD:  3187 Ensembl:  ENSRNOG00000019322 UniProt:  Q07008 LinkDB All DBs Structure PDB:  4XL1 5UK5 4XLW Thumbnails Position 3p13 AA seq 2531 aa AA seqDB search MPRLLAPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDP SPCLSTPCKNAGTCYVVDHGGIVDYACSCPLGFSGPLCLTPLANACLANPCRNGGTCDLL TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICGCPPGFHGPTCRQDVN ECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTT HECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ LMPNACQNGGTCHNSHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCE CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGA NPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMP GYEGVYCEINTDECASSPCLHNGRCVDKINEFLCQCPKGFSGHLCQYDVDECASTPCKNG AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGLCKDGVATFTCLCQPGYTGHHC ETNINECHSQPCRHGGTCQDRDNYYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKID GYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNEC NSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCR EGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKN SGVCKESEDYESFSCVCPTGWQGQTCEIDINECVKSPCRHGASCQNTNGSYRCLCQAGYT GRNCESDIDDCRPNPCHNGGSCTDGVNAAFCDCLPGFQGAFCEEDINECASNPCQNGANC TDCVDSYTCTCPTGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQY DVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGKCWQTNTQ YHCECRSGWTGFNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEEDKHYCHCQAGYTGS YCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCID LTNTYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFV GERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCRNGG VCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTG PECQFPASSPCVGSNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFTGGAGRDI PPPQIEEACELPECQEDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYF SDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLD CAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYY GREEELRKHPIKRSAVGWATTSLLPGTNGGRQRRELDPMDIHGSIVYLEIDNRQCVQSSS QCFQSATDVAAFLGALASLGSLNIPYKIEAVKSETVEPPLPSQLHLMYVAAAAFVLLFFV GCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQ NEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRVSAMAPTPPQGEVDAD CMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGET ALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDA RMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKN GANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIV RLLDEYNLVRSPQLHGTALGGTPTLSPTLCSPNGYLGNLKSATQGKKARKPSTKGLACSS KEAKDLKARRKKSQDGKGCLLDSSSMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSMP LSHLPGMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSHLPVASSASTVLSTNG TGAMNFTVGAPASLNGQCEWLPRLQNGMVPSQYNPLRPGVTPGTLSTQAAGLQHGMMGPI HSSLSTNTLSPIIYQGLPNTRLATQPHLVQTQQVQPQNLQIQPQNLQPPSQPHLSVSSAA NGHLGRSFLSGEPSQADVQPLGPSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPP SQHSYSSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTSMP SQITHIPEAFK NT seq 7596 nt NT seq  +upstreamnt  +downstreamnt atgccgcggctcctggcgcccttgctctgcctaacgctgctgcccgcgctcgccgcaaga ggcttgagatgctcccagccaagtgggacctgcctgaatggagggaggtgcgaagtggcc aacggcactgaagcctgtgtctgcagcggagcgttcgtgggccagcgatgccaggacccc agcccttgcctcagcacaccatgtaagaatgctggaacgtgctatgttgtggaccatggc ggcatcgtggactatgcctgcagttgccccctgggtttctctgggcccctctgcctgaca cctctggccaatgcctgcctggccaacccctgccgcaacggggggacctgtgacctgctc actctcacagaatacaagtgccggtgcccgccagggtggtcaggaaagtcatgtcagcaa gccgacccctgtgcctccaacccctgtgccaatggtggccagtgcctgccctttgagtct tcatacatctgtggctgcccgcccggcttccatggccccacctgcagacaagatgttaac gagtgcagccagaaccctgggttgtgccgtcatggcggcacgtgccacaatgagattggc tcctatcgctgtgcctgccgtgccacccacactggtccccactgcgagctgccctacgtg ccctgcagcccctcaccctgccagaacggaggcacctgccgccctacgggggacaccacc cacgagtgtgcctgcctgccaggctttgctggacagaactgtgaagaaaatgtggatgac tgcccaggaaacaactgcaagaacgggggtgcctgtgtggacggtgtgaatacctacaat tgccgctgcccaccggagtggacaggtcagtactgcacagaggatgtggacgagtgtcag ctcatgcccaacgcctgccagaatggcggaacctgccacaactcccacggtggctacaac tgcgtgtgtgtcaatggctggactggtgaggactgcagtgagaacattgatgactgtgcc agtgccgcctgttttcagggtgccacctgccatgaccgtgtggcttccttctactgcgag tgtccacatgggcgcacaggcctgctgtgccacctgaacgatgcgtgtatcagcaacccc tgcaacgagggctccaactgcgacaccaaccctgtcaacggcaaggccatctgcacttgc ccctcggggtacacggggccagcctgcagccaggacgtggatgagtgcgctctaggtgcc aacccgtgtgagcacgcgggcaagtgcctcaacacactgggctctttcgagtgtcagtgt ctacagggctacactgggccccgctgtgagattgatgtcaacgagtgcatctccaaccca tgtcagaatgatgccacgtgcctggaccagattggggagtttcagtgtatatgtatgcca ggttatgagggtgtatactgtgagatcaacacggacgagtgtgccagcagcccctgtcta cacaatggccgctgcgtggacaagatcaacgagttcctgtgtcagtgtcccaaaggcttc agcgggcacctgtgccagtatgacgtggatgagtgcgccagcacaccatgcaagaacggc gccaagtgcctggatgggcccaacacctacacctgcgtgtgcacagaaggttacacgggg acccactgcgaggtggacattgacgagtgtgaccctgacccctgtcactatggtttgtgc aaggatggtgtggccacctttacctgcctctgccagccaggctacacaggccatcactgt gagaccaacattaatgagtgtcacagccagccgtgccgccatggcggcacctgccaggac cgtgacaactactacctctgcttatgcctcaaggggaccacaggacccaactgtgagatc aatctggatgactgtgcgagcaacccctgtgactctggcacgtgtctggacaagatcgat ggctacgagtgtgcgtgcgagccaggctacacagggagcatgtgtaatgtcaacattgac gaatgtgcgggcagcccctgccacaacgggggcacctgtgaggatggcatcgccggcttc acttgccgctgccccgagggctaccacgaccctacgtgcctgtctgaggtcaacgagtgc aacagtaacccctgcatccatggagcttgccgggatggcctcaatggatacaaatgtgac tgtgcccctgggtggagtgggacaaactgtgacatcaacaacaatgagtgtgagtccaac ccttgtgtcaacggtggcacctgcaaagacatgaccagtggctacgtatgcacctgccga gaaggcttcagtggccctaactgccagaccaacattaacgaatgtgcttccaacccctgc ctgaaccagggcacctgcattgatgatgtcgctgggtacaaatgcaactgccctctgccc tatacaggagccacatgtgaggtggtgttggccccatgtgccaccagcccctgcaaaaac agtggggtatgcaaggagtctgaggactatgagagcttttcctgtgtctgtcccacaggc tggcaaggtcaaacctgcgagatcgacatcaatgagtgtgtgaaaagcccgtgtcgccat ggtgcctcttgccagaacaccaatggcagctaccgctgcctctgccaggctggctacacg ggtcgcaactgcgagagtgacatcgatgactgccgacccaacccatgtcacaacgggggt tcctgcactgacggggtcaacgcggccttctgcgactgcctgcccggcttccagggtgcc ttctgtgaggaggacatcaacgaatgcgccagcaatccatgccaaaatggcgccaactgc actgactgcgtggacagctacacgtgcacctgccccacgggcttcaatggcatccattgc gagaacaacacacctgactgtaccgagagctcctgtttcaatggtggcacctgtgtggat ggtatcaactccttcacctgtctgtgcccacctggcttcacgggcagctactgccagtat gacgtcaatgagtgtgactcacggccctgtctgcatggtggcacctgccaagacagctat ggtacctataagtgtacctgcccacagggctacactggtctcaactgccagaaccttgtg cgctggtgtgactcagctccctgcaagaatggcggcaagtgctggcagaccaacacacag taccactgcgagtgccgcagcggctggactggcttcaactgcgacgtgctcagtgtgtcc tgcgaggtggctgcacagaagcgaggcatcgatgtcactctcctatgccagcacggaggg ctctgtgtggatgaggaagacaagcattactgccactgccaggcaggatacacgggcagc tactgtgaggacgaggtggacgagtgctcacctaatccctgccagaacggagccacctgc actgactatctcggtggcttttcctgcaagtgtgtggctgggtaccatggctctaactgc tctgaggagatcaacgagtgcctatcccaaccctgccagaatgggggtacctgcattgat ctgaccaacacctacaagtgctcctgccccaggggcacacagggtgtacactgtgagatc aacgtcgatgactgccatcctcccctagaccctgcttcccgaagccccaaatgcttcaat aatggcacctgcgtggaccaggtgggtggctatacctgcacctgcccgccaggcttcgtc ggggagcggtgcgagggcgatgtcaatgagtgtctctccaacccctgtgacccacgtggc acccagaactgcgtgcagcgtgttaatgacttccactgcgagtgccgggctggccacact ggacgccgctgtgagtcggtcattaatggctgcaggggcaaaccatgcaggaatggaggt gtctgtgctgtggcctccaacaccgcccgtggattcatctgtaggtgccctgcgggcttc gagggtgccacttgtgaaaatgacgcccgcacttgtggcagtttgcgctgcctcaacggt ggtacgtgcatctcaggcccacgcagtcccacctgcctatgcctgggctccttcactggc cctgaatgccagttcccagccagcagcccctgtgtgggtagcaacccctgctacaatcag ggcacctgtgagcccacatccgagagccctttctaccgctgtctatgccctgccaaattc aacgggctgctgtgccacatcctggactacagcttcacaggtggcgccgggcgcgacatt cccccgccacagattgaggaggcctgcgaactgcctgagtgccaggaggatgcaggcaat aaggtctgcaaccttcagtgtaataatcacgcgtgtggctgggacggcggcgactgctcc ctcaacttcaatgacccttggaagaactgcactcagtccctgcagtgctggaagtatttt agtgacggccactgtgacagccagtgcaactcagctggctgcctttttgatggcttcgac tgccagctcaccgagggacagtgcaaccccctgtatgaccagtactgcaaggaccacttc agtgatggccactgcgaccagggctgcaacagtgccgagtgtgagtgggatggactggac tgtgcagagcatgtccccgagcgactggcagccggcacactggtgctggtggtgctgctt ccgcccgatcagctacgcaacaactccttccacttcctgcgggagctcagccacgtgctg cacaccaacgtggtcttcaagcgtgacgcgcagggccagcagatgatcttcccctactat ggccgcgaggaagagctacgcaagcacccgatcaagcgttctgcagtgggctgggccaca acgtcactgcttcctggcaccaatggtgggcgccagcgcagggagctggaccccatggac atccatggctccatcgtctacctggagatcgacaaccggcagtgtgtacagtcatcctcg caatgcttccagagcgccaccgatgtggctgccttcctaggtgctcttgcctccctcggc agcctcaatatcccctacaagatcgaagccgtaaagagtgagacggtggagcctccgctg ccctcacagctgcacctcatgtacgtggcggcagctgccttcgtgctcctgttctttgtg ggctgtggggtgctgctgtcccgcaagcgcaggcggcagcatggccagctctggttccct gagggtttcaaagtgtcagaggccagcaagaagaagcggagagaacccctcggcgaggac tcagtcggcctcaagcccctgaagaacgcctcagatggtgccctgatggacgacaatcag aacgagtggggggacgaagacctggagaccaagaagttccggtttgaggaaccagtggtt ctccctgacctggatgatcagactgaccaccggcagtggacccagcagcacctggatgcc gctgacctacgtgtgtctgccatggccccaacgccgcctcagggggaggtagatgctgac tgcatggacgtcaatgttcgaggaccagatggcttcactcccctaatgattgcctcctgc agcggagggggcctggagacaggcaacagtgaggaagaagaagatgcacctgctgtcatc tccgacttcatctatcagggtgccagcttgcacaaccagacggaccgcacaggggagact gccctgcacctggctgcccgatactctcgttcagatgctgccaagcgcttgctggaggcc agcgcagatgccaacatccaagacaacatggggcgtaccccattacatgccgctgtttct gcagacgctcagggtgtcttccagatcctgctccggaacagagccacagatctggatgcc cgaatgcatgatggcacaacccctctgatcctggcggcacgcctggccgtggaaggcatg ctagaggacctcatcaactctcacgctgatgtcaatgctgtggatgacctaggcaagtca gctctgcactgggcagccgctgtgaacaatgtggacgctgctgttgtgctcctgaagaac ggagccaacaaagacatgcagaacaacaaggaggagactcccctgttcctggccgcccgt gagggcagctatgagactgccaaagtgttgctggaccactttgccaaccgggacatcacg gatcacatggaccgattgccacgggacattgcacaggagcgcatgcaccacgatatcgtg cggcttttggatgaatacaacctggtgcgcagcccacagctgcatggcactgccttgggt ggcacacccactctgtctcccacactctgctcgcccaacggctacctgggcaacctcaag tctgccacacagggcaagaaggcccgaaagcccagcaccaaagggctggcttgcagtagc aaggaagctaaggacctcaaggcccggaggaagaagtcccaggatggcaagggctgcctg ttggacagctcaagcatgctgtcacccgtggactccctcgagtcaccccatggctacttg tcagatgtggcctcaccacccctccttccctccccgttccagcagtctccatccatgcct ctcagccacctgccaggtatgcctgacacccacctgggcatcagccacttgaatgtggca gccaagcccgagatggcagctctggccggaggcagccggttggcctttgagccaccccca ccacgcctctcccacctgcctgtagcctccagtgccagcacagtgctgagtaccaatggc acaggggctatgaatttcaccgtgggtgcaccggcaagcttgaatggccagtgtgagtgg cttccccggctccagaatggcatggtgcccagccagtacaacccgctaaggccaggtgtg actccgggcacactaagcacacaggcagctggcctccagcatggcatgatgggcccgata cacagcagcctctccaccaataccttgtccccgattatctaccagggcctgcccaacaca aggctggccacacagccccacctggtgcagacccagcaggtgcagccacagaacttacaa atccagcctcagaacctgcagccaccatcgcagccacacctcagtgtgagctcagcagcc aatgggcacctgggtcggagcttcctgagcggggagcccagccaggcagacgtacagccg ctgggccccagcagtctgcctgtgcacaccattctgccccaggaaagccaggctctgccg acatcactgccatcctccatggtcccacccatgaccactacccagttcctgacccctcct tctcagcacagctactcatcctcacctgtggacaacacccccagccaccagctgcaggtg ccagagcaccccttcctcaccccatcccctgagtcccctgaccagtggtccagctcctcc ccgcattccaacatctctgattggtccgagggcatctctagcccgcccacgagcatgccg tcccagatcacccacattccagaggcatttaagtaa

Rattus norvegicus (rat): 29492 Help Entry 29492             CDS       T01003                                  Gene name Notch2 Definition (RefSeq) notch 2   KO K20994   Notch 2 Organism rno  Rattus norvegicus (rat) Pathway rno01522   Endocrine resistance rno04330   Notch signaling pathway rno04658   Th1 and Th2 cell differentiation rno04919   Thyroid hormone signaling pathway rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05206   MicroRNAs in cancer rno05224   Breast cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     29492 (Notch2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     29492 (Notch2)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     29492 (Notch2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     29492 (Notch2)    05206 MicroRNAs in cancer     29492 (Notch2)   09162 Cancer: specific types    05224 Breast cancer     29492 (Notch2)   09172 Infectious disease: viral    05165 Human papillomavirus infection     29492 (Notch2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     29492 (Notch2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_CA DUF3454 EGF_2 Notch Ank_2 NOD Ank Ank_5 NODP Ank_3 Ank_4 cEGF Motif Other DBs NCBI-GeneID:  29492 NCBI-ProteinID:  NP_077334 RGD:  3188 Ensembl:  ENSRNOG00000018835 UniProt:  G3V8G9 LinkDB All DBs Position 2q34 AA seq 2471 aa AA seqDB search MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTYHNGTGYCRCPEGFLGE YCQHRDPCEKNRCQNGGTCVTQAMLGKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGT CHMLSWDTYECTCQVGFTGKQCQWTDVCLSHPCENGSTCSSVANQFSCRCPAGITGQKCD ADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTG DFTSECHCLPGFEGSNCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD ECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCLCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC LCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGACV DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQ VNECLSSPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCNNLVNGYR CTCKKGFKGYNCQVNIDECASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQTVLAPCSPN PCENAAVCKEAPNFESFTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECP PGFSGMDCEEDINDCLANPCQNGGSCVDKVNTFSCLCLPGFVGDKCQTDMNECLSEPCKN GGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGP FCLHDINECSSNPCLNSGTCVDGLGTYRCTCPLGYTGKNCQTLVNLCSPSPCKNKGTCAQ EKARPRCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLG YTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG TCIDLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGER CEGDINECLSNPCSSEGSLDCIQLKNNYQCVCRSAFTGRHCETFLDVCPQKPCLNGGTCA VASNVPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPHCFCLNRKDCESGCAS NPCQHGGTCYPQRQPPYYSCRCSPPFWGSHCESYTAPTSTPPATCLSQYCADKARDGICD EACNSHACQWDGGDCSLTMEDPWANCTSSLRCWEYINNQCDELCNTAECLFDNFECQRNS KTCKYDKYCADHFKDNHCDKGCNNEECGWDGLDCAADQPENLAEGILVIVVLLPPEQLLQ DSRSFLRALGTLLHTNLRIKQDSQGALMVYPYYGEKSAAMKKQKVARRSLPDEQEQEIIG SKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESEDPRNTPLLY LLAVAVVIILFLILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLKNL SVQVSEANLIGSTTSEHWGDDEGPQPKKAKAEDDEALLSEDDPVDRRPWTQQHLEAADIR RTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIIT DLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAA DAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSA LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITD HMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVLCGPNRSFLSLKHTPMG KKARRPNTKSTMPTSLPNLAKEAKDVKGSRRKKCLNEKVQLSESSVTLSPVDSLESPHTY VSDATSSPMITSPGILQASPTPLLAAAPAAPVHAQHALSFSNLHEMQPLAPGASTVLPSV SQLLSHHHIVPPGSGSAGSLGRLHSVPVPSDWMNRVEMSETQYSEMFGMVLAPAEGTHPG MAAPQSRAPEGKPIPTQREPLPPIVTFQLIPKGSLAQAAGAPQTQSGCPPAVAGPLPSMY QIPEMARLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAER TPNHGGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMS EPPHSNMQVYA NT seq 7416 nt NT seq  +upstreamnt  +downstreamnt atgcccgctctgcgtcccgccgcgctgcgggcgctgctgtggctctggctgtgcggcgcg ggccccgcgcacgctttgcagtgtcgaggtggtcaagagccctgtgtaaatgaggggacc tgtgttacctaccacaacggcacaggctactgccgatgtccagagggcttcttgggagaa tattgtcaacatcgagacccttgtgagaagaaccgctgtcagaatggtggtacttgtgtg acgcaggccatgttgggaaaagccacctgtcgatgtgctccagggttcacaggggaggac tgccaatactcgacctctcacccctgttttgtttcccgcccctgtcagaatggaggtacc tgccacatgctcagctgggacacctatgagtgcacctgtcaagttggcttcacaggaaag cagtgtcagtggacagatgtctgtctgtctcatccctgtgaaaatggaagcacctgtagc tctgtggccaaccagttctcctgcagatgtcctgcaggcatcacaggccagaagtgtgac gccgacatcaatgaatgtgacattccaggacgctgccaacatggaggcacctgcctcaac cttcctgggtcctaccgatgccaatgccctcagggcttcacaggccagcactgtgacagc ccgtacgtgccctgtgcaccctcaccctgcgtcaatggaggcacctgccgtcagactgga gacttcacttctgaatgccattgcctgccaggctttgaagggagcaactgcgagcggaat atcgacgactgccctaaccacaagtgtcagaatggaggggtgtgtgtggatggcgtcaat acttacaactgccgctgcccccctcagtggactgggcagttctgcacagaagacgtggat gagtgtctgctgcagcccaatgcttgtcagaatggaggcacttgcaccaaccgcaacgga ggctacggctgcgtgtgcgtgaacggctggagtggggatgactgcagcgagaacatcgat gactgtgccttcgcttcctgcacgccaggctccacctgtattgaccgtgtggcctccttc tcctgcctttgtccagagggaaaggcagggctcctgtgtcatctggatgatgcctgtatc agcaacccttgtcacaagggggcgctgtgtgataccaaccccctgaatgggcagtacatt tgcacctgcccacagggctacaagggcgctgactgcacagaagacgtggatgagtgtgct atggccaacagtaacccttgtgagcatgcaggaaagtgtgtgaatacagatggcgccttc cactgcgagtgtctgaagggctacgcagggcctcgctgtgagatggacatcaacgagtgt cactcagacccctgtcagaacgacgccacctgcctggataagattggaggcttcacctgt ctctgcatgccgggtttcaaaggtgtgcattgtgaactggaggtgaatgaatgccagagc aacccgtgtgtaaacaatgggcagtgtgtggacaaagtcaatcgcttccagtgtctgtgt ccccctggtttcacaggaccagtgtgccagatcgacattgacgactgctccagtactccc tgcctgaatggggccaagtgcatcgatcacccgaatggctatgaatgccagtgtgccaca ggattcactggcacactgtgtgatgagaacatcgacaactgtgacccggatccttgccac catggccagtgccaggatgggattgactcctacacctgcatctgcaaccccgggtacatg ggagccatctgtagtgaccagattgatgaatgctacagcagcccctgcctgaatgatgga cgctgcatcgacctggtgaacggctaccagtgcaactgccaaccgggtacctcaggcctt aattgtgaaattaattttgatgactgtgccagcaacccttgtctgcacggagcctgtgtg gacggcatcaaccgttacagttgtgtgtgctctccgggattcacagggcagaggtgcaac atagacattgatgagtgtgcctccaacccctgtcgcaagggtgcgacgtgcatcaatgac gtgaatggtttccggtgtatgtgccctgagggaccacaccatcccagctgctactcacag gtgaacgagtgtttgagcagtccctgcatccatggaaactgtactggaggtctcagtggc tataagtgcctctgcgatgcaggctgggttggtatcaactgcgaagtggacaaaaatgag tgtctttctaacccgtgccagaatggagggacatgtaataacctggtgaatggctacagg tgtacatgcaagaaggggttcaaaggctataactgccaggtgaacatagatgagtgtgcc tcgaacccgtgtctgaaccaagggacctgcctcgatgacgtcagtggctacacctgccac tgcatgctgccttacacaggcaagaattgtcaaacggtgttggcgccctgctcccctaac ccgtgtgagaacgctgcagtttgtaaagaggcacccaactttgagagcttcacctgcctg tgtgcccctggctggcaaggtcagcgctgtacagttgacgttgatgagtgtgtctccaag ccgtgtatgaacaatggcatctgccataatactcagggcagctacatgtgcgagtgccct cccggcttcagtggtatggactgtgaggaggacatcaatgactgccttgccaacccctgc cagaacggaggctcctgtgtggacaaagtgaacaccttctcctgcctgtgccttcctggc ttcgtaggggacaagtgccaaacagacatgaatgaatgtctgagcgagccctgtaagaat ggggggacctgctctgactacgtcaacagctacacctgcacgtgccctgcgggcttccat ggagtccactgtgaaaacaacatcgatgagtgcactgagagctcctgtttcaatggcggc acgtgtgttgatgggatcaactctttctcttgcttatgccctgtgggtttcactggtccc ttctgcctccatgatatcaatgagtgcagctctaacccgtgcctgaattcgggaacgtgt gttgatggcctgggtacctaccgatgcacctgtcccttgggctacactgggaaaaactgt cagaccctggtgaacctctgcagcccctctccatgtaaaaacaaaggaacttgtgctcag gaaaaggcaaggccacgctgcctgtgtccgcctggatgggatggcgcatactgtgatgtg ctcaatgtgtcctgtaaggcggcagccttgcagaaaggagtacctgttgaacacttgtgc cagcactcgggtatctgtatcaatgctggcaacacgcatcactgccagtgccccctgggc tacacggggagctactgcgaggaacagcttgacgagtgtgcgtccaatccatgccagcat ggtgccacctgcagtgacttcatcggaggatacagatgtgagtgtgttccagggtatcag ggtgtcaactgtgagtatgaagtggacgagtgccagaaccagccctgtcagaacggaggc acctgcatcgacctcgtgaaccatttcaagtgctcgtgcccaccaggcacccggggcctg ctttgtgaagagaacattgatgactgtgctgggggcccccactgccttaatggtggccag tgtgtggaccggattggaggctacagttgtcgctgtttgcctggctttgctggggagcgg tgtgagggggacatcaatgaatgcctgtccaatccttgcagctcagagggcagcctggac tgcattcagctcaaaaataactaccagtgtgtctgccgcagcgccttcacaggccgacac tgcgaaaccttcctagatgtgtgtccccagaagccttgcctgaatggagggacttgtgct gtggctagcaacgtgcctgatggcttcatttgtcgttgtcccccagggttctccggggca agatgccagagcagctgtggacaagtgaagtgcagaagaggggagcagtgtgtgcacacc gcctcgggaccccactgcttctgcctgaaccgcaaggactgcgagtcaggttgcgctagt aacccctgccagcacggaggcacctgctaccctcagcgccagcctccttactactcttgc cgctgctccccaccgttctggggcagccactgcgagagctacacagcccccaccagcacc cctcctgctacctgtctgagtcagtactgtgccgacaaggctcgggacggcatctgtgat gaggcctgcaacagtcatgcctgccagtgggatggaggtgactgttccctcactatggag gacccctgggccaactgcacctcctcacttcgctgctgggagtacatcaacaaccagtgt gatgagctgtgcaacactgcagagtgcctgtttgacaactttgaatgccagaggaatagc aaaacctgcaagtatgacaaatactgtgcagaccacttcaaagacaatcactgcgataag ggatgcaacaacgaggagtgtggctgggacgggctggactgcgctgcggaccagcctgag aacctggcggagggcatcctggtcatcgtggtgctcctaccccctgagcagctgcttcag gattctcgaagcttcttgagggccctgggcaccctgctccacaccaacttacgcattaaa caagactctcagggcgccctcatggtgtacccctactatggggagaagtcagctgccatg aagaagcagaaggtggcacgcaggtctcttcctgatgagcaggaacaggagataataggc tctaaggtatttctggaaatcgacaaccgacagtgtgttcaagactcagaccagtgcttc aagaacacagatgctgcagctgctctcctggcttctcatgccatccaagggaccttgtcc taccctctggtgtctgttgtcagtgaatcggaggatccaaggaacactccgctcctctat ctgcttgcggttgctgtggtcattatcctgttcctcatcctgctgggggtcatcatggca aagcggaagcgcaagcacggcttcctctggctgcctgaaggcttcacgcttcgccgagac tccagcaatcacaagcgccgtgaacctgtggggcaggatgccgtggggctgaagaatctc tcagtgcaagtgtcagaggcaaacctgatcggctccacgacaagcgagcattggggtgat gatgaaggaccccagccaaagaaagccaaggctgaggacgacgaggctttgctgtcggaa gacgaccctgtcgaccggcgcccctggacacagcagcaccttgaagctgcagacatccgc cggactccatccctggcgctcacccctcctcaggcagagcaggaggtggacgtgctggac gtgaatgtccgaggcccagatgggtgcaccccactgatgctggcttctctccgaggaggc agctcagacctgagtgatgaagatgaagatgctgaggactcttctgccaacatcatcaca gacttggtctaccaaggtgccagcctccaggcacagacggaccgcactggtgagatggcc ctgcaccttgcagcccgctattcgagagctgatgctgccaaacgcctcctggatgctggt gcagatgccaacgcccaggacaacatgggccgctgtcctcttcatgctgcagttgcagcg gatgcccaaggtgtcttccagattctgatccgcaaccgagtaacggatctagacgccagg atgaatgatggcactacccccctgatcctggctgcccgcctggctgtggaaggaatggtg gcagagctgatcaactgccaagcagatgtgaacgcagtggatgaccatggaaaatctgcc ctccactgggcagccgccgtcaataatgtggaggcaactcttttgctgttgaagaatggg gccaaccgggatatgcaggacaacaaggaagagacacctttgtttcttgctgcccgagag ggaagttatgaagcagccaaaatcctgttagaccactttgccaaccgggacatcacggac cacatggaccgccttccccgggatgtggctcgggaccgcatgcaccatgacatagttcgc ctcctggacgagtacaacgtgactcccagccctccggggactgtcttgacttctgctctc tcacctgtcctctgtgggcccaacaggtctttcctcagtctgaagcacaccccaatgggt aagaaggccagacggcccaacaccaagagcaccatgcccacaagcctgcctaaccttgcc aaggaggccaaggacgtcaaggggagcaggaggaagaagtgtctcaacgagaaggtccag ctctccgagagctcagtgactttatcccctgtcgactcgctcgagtctcctcacacatat gtttctgatgccacgtcttcccccatgatcacgtcccctgggatcttacaggcctcaccc acgcctcttctggctgctgccccagctgccccagtgcatgctcagcatgcactgtctttc tctaaccttcacgaaatgcagcctttggctcctggagccagcaccgtgctcccctcagtt agccagttgttgtcccaccaccacatcgtccccccagggagtggcagtgcaggaagcttg ggcaggttacattcagtccctgtcccctcagactggatgaaccgcgtggagatgagtgag acccagtacagtgaaatgtttggcatggtcctggctcctgcagagggaacccaccctggc atggcagctcctcagagcagagctccggaagggaagcccatccccacacagcgtgagccc ttgcctcccattgtaactttccagctcatcccgaaaggcagccttgctcaagcagctggg gctccccagacacagtccggctgccccccagctgtggcaggccccttgccctctatgtac cagatcccagagatggcccgtttgcccagtgtggctttcccacctaccatgatgccccag caggaggggcaggtagctcagaccattgtcccaacctatcaccctttcccagcctctgtg ggcaagtaccccacacccccttcccaacacagttatgcctcctcaaatgctgccgagcgc acccccaatcatggtggtcacctccagggcgagcacccgtacctgacaccatccccagag tctcctgaccaatggtcgagctcttcaccgcactctgcgtctgactggtcagatgtgacc accagcccaactcctggagggggtggaggcggtcagcggggacctggaacacacatgtcc gagccaccacacagcaacatgcaggtttatgcatga

Rattus norvegicus (rat): 406162 Help Entry 406162            CDS       T01003                                  Gene name Notch4 Definition (RefSeq) notch 4   KO K20996   Notch 4 Organism rno  Rattus norvegicus (rat) Pathway rno01522   Endocrine resistance rno04330   Notch signaling pathway rno04919   Thyroid hormone signaling pathway rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05206   MicroRNAs in cancer rno05224   Breast cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     406162 (Notch4)  09150 Organismal Systems   09152 Endocrine system    04919 Thyroid hormone signaling pathway     406162 (Notch4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     406162 (Notch4)    05206 MicroRNAs in cancer     406162 (Notch4)   09162 Cancer: specific types    05224 Breast cancer     406162 (Notch4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     406162 (Notch4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     406162 (Notch4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_CA Ank_2 Ank Ank_5 Notch Ank_3 Ank_4 EGF_3 EGF_2 NODP NOD cEGF Motif Other DBs NCBI-GeneID:  406162 NCBI-ProteinID:  NP_001002827 RGD:  1303282 Ensembl:  ENSRNOG00000000442 Vega:  OTTRNOG00000001714 UniProt:  Q6MG89 LinkDB All DBs Position 20p12 AA seq 1961 aa AA seqDB search MQRQWLLLLLLPLSFPVILTRELLCGGSPEPCANGGTCLRLSQGQGTCQCAPGFLGETCQ FPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDRCQSPLEELCP PSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCP TGFEGHICERDVNECFLEPGPCPRGTSCHNTLGSFQCLCPVGQEGPQCKLRKGACLPGTC LNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDDCVRNQCQNGATCQDGLGTYTCLCP KTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAGGFHCVCVSGWGGEGCDENLDDCAAAT CALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHVNAQCSTNPLTGSTLCICQPG YSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQP CHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQLNGFLCLCLPGF TGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEADECRSDPCPVGAS CLDLPGAFLCLCRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAED DCPCHHGHCQRSLCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTG LTCSEEITACHSGPCLNGGSCSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCM SKPGTFFCHCATGFQGLHCEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQT LIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNG GLCIDTGSSYFCRCPPGFEGKLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQN CSKVHDACQSGPCHNHGTCTPRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCH SLANAFYCQCLPGHTGQRCEVEMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTC SRKAPACGNHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCMHNG SCTETPGLGNPGFQCTCPPDSPGPRCQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCS LGVPDPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPPTCTPAYDQYCRDHFH NGHCEKGCNNAQCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVLSLTLR VGLWVRKDSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQTPGKETESLGAGFVVV MGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTGSPATR LPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPHRRRPPL GEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEKTASASRCQLWPLRSGCEGLPQAVMLT PPQECESELPDSDTCGPDGVTPLMSAVFCGGVQSTTVQRLGLGNPEPWEPLLDRGACPQA HTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLA SRQTAVDARTDDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNAR AARCLLQTGADKDAQDSREQTPLFLAAREGAVEVAQLLLEIGAARGLRDQAGLAPADVAR QRSHWDLLTLLEGAGPITQEARSHARNTPGGGAAPRCRTLSAGARPRGGGACLQARTWSV DLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGARVSQDDWPRDWVALEACGSA CSAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGRNQN NT seq 5886 nt NT seq  +upstreamnt  +downstreamnt atgcagcgccagtggctgctgcttctgctcttgccgctcagcttcccagtcatcctgacc agagagcttctgtgtggaggatccccagagccctgtgccaacggaggcacctgcctgagg ctatctcagggacaagggacctgccagtgtgcccctggatttctgggtgagacttgccag ttccctgacccctgctgggacacccaactctgcgagaacggtggcagctgtcaagccttg ctccccacagccccaagctcccacagccccacttctccactgaccccccacttctcctgc acctgcccctctggcttcactggtgatcgatgccaaagccctctggaagagctctgtccg ccttctttctgttccaacgggggtcactgctctgtccaggtctcgggccgcccacagtgt tcctgcgagcccgggtggacaggtgagcagtgccagctccgagacttctgctcagccaac ccctgtgccaacggaggtgtgtgcttggccacatacccccagatccagtgtcgttgtcca accggcttcgagggtcacatctgtgaacgcgacgtcaatgaatgcttcctggagcccgga ccctgccctcggggcacctcctgtcacaacaccttgggctccttccagtgcctctgccct gtggggcaggaaggtccccagtgcaagctcaggaagggagcctgccttcctggaacctgt ctcaatggaggcacctgccagctggtgccagagggagacactacctttcatctctgcctc tgtcccccaggtttcacagggctgaactgtgagatgaatccagatgactgtgtcaggaac cagtgtcagaacggggccacctgccaggatgggctgggcacctacacctgcctctgcccc aagacgtggaagggctgggactgctccgaagacatagatgaatgtgaagcccagggtccg cctcgatgcagaaacggtggcacctgccagaactcggctggtggctttcactgtgtgtgt gtgagtggctggggaggcgagggctgtgacgagaacctggatgactgtgcggccgccacc tgtgccctgggatccacctgcatcgaccgtgtgggctccttctcctgcctctgcccacct ggacgcacaggcctcctgtgccacctggaagacatgtgtttgaggcagccgtgccatgtg aatgcccagtgcagcaccaaccccctgacggggtctaccctctgcatatgccagccgggc tactcgggacccacctgccaccaagatctggatgagtgtcaaatggcccagcaaggaccc agtccctgtgaacacggcggctcctgcatcaacacccctggctccttcaactgcctctgc ctgcctggctacacgggctcccgctgcgaggctgaccacaatgagtgcctgtcgcagccc tgtcacccgggcagcacctgcctggacctgcttgccaccttccagtgcctctgcccacca ggcctggaagggaggctctgtgaagtggagatcaatgagtgtgcctctaacccctgcctc aaccaagctgcctgtcacgaccagctcaacggcttcctgtgcctctgccttcctggattc actggtgccagatgcgagaaagacatggacgagtgcagcagcgccccctgtgccaatggg gggcactgccaagaccagcctggagccttccactgcgagtgtctcccaggctttgaaggg ccacgctgtgagactgaagcggatgaatgtcggagtgacccctgccccgtgggagccagc tgccttgatcttcccggggcgttcctctgcctctgccggcctggtttcacaggtcaactt tgtgaggttcccttgtgtagccccatcctgtgccaacctggacagcaatgccaagaccag gaacacagagccccctgcctctgccctgacggaagtcctggctgtgttcctgctgaggac gactgcccctgccaccatggccattgccagagatccttgtgtgtgtgtaacgagggctgg actggaccagagtgtgagacagagctgggcggctgcctctccacaccctgtgcccatggg gggacctgccacccacagccctctggctacaactgtagctgccttgcaggctacacgggg ctgacctgtagtgaggagataacagcttgtcactcagggccctgtctcaatggtggctcc tgcagcatccatcctgagggctactcttgcacctgccctccaagtcacacaggtccccac tgccagactgccgtggaccactgtgcgtctgcctcgtgtctcaacgggggtacctgcatg agcaaacctggcactttcttctgccactgtgccactggcttccaggggctgcactgtgag aagaagattcaccccagctgtgcagacaacccctgcaggaacaaggcaacctgccaagac acacctcgaggggcccgctgcctctgcagccctggctacacaggaagcagctgccagact ctgatagacttgtgtgcccggaagccctgtccacacactgcccgatgcctccagagtggg ccctccttccactgcctgtgccaccagggatggacagggtctctctgtgacctcccactg tcctgccaggcggccgcgatgagccaaggtgtagagatctccaacctgtgccagaatggg ggcctctgtattgacacgggctcctcctatttctgtcgctgccctcctggattcgagggc aagttatgccaggatactgtgaacccctgcacgtccaagccttgccttcacggggctacc tgtgtgccccagcccaacggctatgtctgccagtgtgccccaggctatgaaggacagaac tgctcaaaagtacacgacgcttgccagtccgggccgtgccacaaccatggaacctgtacc cccaggcctggaggcttccactgtgcctgccctccaggttttgtggggctgcgctgtgag ggggatgtggacgagtgtctcgaccggccctgccacccctcgggcactgcgtcctgccat tctttagccaacgccttctattgccagtgtctgcctgggcacacaggccagcggtgtgaa gtggagatggacctctgccagagccagccctgctccaatggagggtcctgtgaggtcaca acaggaccgccccctggcttcacctgccgctgccccgagggttttgaaggccccacctgc agccgcaaagcccctgcctgcggcaaccatcattgccacaacggaggcctatgtctgccc tcccctaagccaggctccccacccctctgtgcctgcctcagtggcttcgggggccctgac tgtctgacacctccagctccaccagggtgcggtcctccctccccctgcatgcacaatggt agctgcactgagacccccgggttgggcaatcctggctttcaatgcacctgccctcctgac tctccggggccccggtgtcaaaggccaggggcgaatggatgtgagggccgaggtggcgat ggagcctgtgatgctggctgcagtggcccaggaggggactgggatggaggggactgttcc ctgggggtcccagacccctggaagggctgtcccccgcattcccagtgctggcttctcttc cgggatgggcggtgccacccacagtgcgactctgaggagtgtctgtttgatggctatgac tgtgagatccctccaacttgcaccccagcctacgaccagtactgccgagatcacttccac aacgggcactgtgagaaaggctgcaacaacgctcagtgtggctgggatgggggtgactgc aggccagaaggggatgactcagaggggggcccctccctggccctgctggtggtgctgagt cccccagccttggatcagcagctgcttgccctggctcgagtactgtccctgactctgagg gtcggtctctgggtgaggaaggacagtgaaggcaggaacatggtgttcccctatcctggg acccgggccaaagaggagctgagtggaactagagattcctcttcgtgggaaagacaagcc cctcacactcagaccccgggcaaagagacagagtcccttggtgcagggtttgtggtagtg atgggagtggatttgtcccgctgtggtccagagcatcctgcgtcccgctgtccccgggac tctgggctcctgctgcgtttccttgcagcaatggccgcagtgggagctctggagcccctg ctgcctggacccttgctggctgctcaccctcaagcagggaccgggtcccccgccacccgg cttccctggcccattctgtgttcgccagtggtcggggtgctcctcctggcccttggggct cttctcgtcctccagctcatccggcgccggcggcgggaacacggggccctgtggctgccc cctggtttcattcgaaggccacagacacagcaggcaccccaccggcggaggcccccactg ggcgaggacaacattggtctcaaggcgctgaagccagaggcagaagtggatgaggacgga gtggtcatgtgctcgggccctgaagagggcgaggcagaaaaaacagcctcagcctccagg tgccagctctggccactgcgcagcggctgtgaagggctcccacaggcagtcatgctgacc cctcctcaggagtgtgaatcagaacttccagattcggacacctgtggacctgatggggtg acacccctgatgtctgccgtcttctgtgggggagtgcagtccaccactgtacagagactg ggactaggaaatcccgaaccctgggaaccactgctggatagaggggcctgcccccaggct cacactgtgggcactggagagacgcccctgcacctagctgcccgattctctcggccaact gctgcccgacgcctcctggaggctggagccaaccccaaccagccagaccgggctgggcgt accccacttcacactgcagtagctgctgatgctcgggaggtttgccagctcctattggcc agcagacagaccgctgtagacgcgcgcacagacgacgggactacacctttgatgctggct gccaggttggccgtggaggacctggttgaagaattgatcgcagcccgagcagatgtagga gccagagataaaaggggaaaaactgcactgcactgggccgctgcagtgaacaacgcccga gctgcccgctgtctcctccagactggagcggataaagatgcccaggacagtagggagcag acgccgctgttcctggctgcgcgcgaaggcgccgtggaggtggcacagctgctgctggag atcggggcagcgcgggggctgcgggaccaggccgggctggccccagcagatgtggcccgc cagcgtagtcattgggacctgctgacgctgctggagggggcaggaccgatcacgcaggag gcccgttcgcacgcacgcaacacgccggggggcggggccgcgccgcgctgccggacgctg tctgccggagcgcgcccgcgcgggggcggagcttgtctgcaagctcgcacttggtcggtg gacttgggagcgcgccgaggggcggtatacgcgcgctgccggagccgatcaggaggctct ggaggcccctccatgcgcggccgcaggctttccgcggactcccgtggacgacgcggggct agagtatcacaggatgactggcctcgggactgggtggccctggaagcctgcggctctgcc tgcagtgcgccgatcccgcctcccagccttaccccgtccccagaacgcggatcccctcaa gtttcctggggtcttccagtccaccaagaggtccccttaaactcgggtggaaggaatcag aactag

Rattus norvegicus (rat): 56761 Help Entry 56761             CDS       T01003                                  Gene name Notch3 Definition (RefSeq) notch 3   KO K20995   Notch 3 Organism rno  Rattus norvegicus (rat) Pathway rno01522   Endocrine resistance rno04330   Notch signaling pathway rno04371   Apelin signaling pathway rno04658   Th1 and Th2 cell differentiation rno04919   Thyroid hormone signaling pathway rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05206   MicroRNAs in cancer rno05224   Breast cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     56761 (Notch3)    04371 Apelin signaling pathway     56761 (Notch3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     56761 (Notch3)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     56761 (Notch3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     56761 (Notch3)    05206 MicroRNAs in cancer     56761 (Notch3)   09162 Cancer: specific types    05224 Breast cancer     56761 (Notch3)   09172 Infectious disease: viral    05165 Human papillomavirus infection     56761 (Notch3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     56761 (Notch3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_CA Notch Ank Ank_2 Ank_5 NODP EGF_2 NOD DUF3454 Ank_3 Ank_4 cEGF EGF_3 Motif Other DBs NCBI-GeneID:  56761 NCBI-ProteinID:  NP_064472 RGD:  620761 Ensembl:  ENSRNOG00000004346 UniProt:  Q9R172 LinkDB All DBs Position 7q11 AA seq 2319 aa AA seqDB search MGPGARGRRRRRRLMALPPPPPPMRALPLLLLLLAGLGAAAPPCLDGSPCANGGRCTHQQ PSREAACLCLPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGVARFSCRCLRGFRGPDCS LPDPCFSSPCAHGAPCSVGSDGRYACACPPGYQGRNCRSDIDECRAGASCRHGGTCINTP GSFHCLCPLGYTGLLCENPIVPCAPSPCRNGGTCRQSSDVTYDCACLPGFEGQNCEVNVD DCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNLLGGH SCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSN PCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQ CGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTFCEVDIDECQSSPC VNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE GTLCERNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYGGKCL DLVDKYLCRCPPGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEI NECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPANHPCAHKPCSHGVCHDAPGGFQC VCDPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFHCTCAPGFQGHQCEVLSPCTPS LCEHGGHCESDPDQLTVCSCPPGWQGPRCQQDVDECAGASPCGPHGTCTNLPGSFRCICH GGYTGPFCDQDIDDCDPNPCLNGGSCQDGVGSFSCSCLSGFAGPRCARDVDECLSSPCGP GTCTDHVASFTCTCPPGYGGFHCETDLLDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGTH CQYKVDPCFSRPCLHGGICNPTHSGFECTCREGFTGNQCQNPVDWCSQAPCQNGGRCVQT GAYCICPPEWSGPLCDIPSLPCTEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVCPEGRMG SHCEQEVDPCTAQPCQHGGTCRGYMGGYVCECPTGYSGDSCEDDVDECASQPCQNGGSCI DLVAHYLCSCPPGTLGVLCEINEDDCGPGPSLDSGLRCLHNGTCVDLVGGFRCNCPPGYT GLHCEADINECRPGTCHAAHTRDCLQDPGGHFRCICLPGFTGPRCQTALFPCESQPCQHG GQCRPSLGRGGGLTFTCHCVQPFWGLRCERVARSCRELQCPVGIPCQQTARGPRCACPPG LSGPSCRVSRASPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETPSAA PEVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCSLNVDDPWRQCEALQCWRLFN NSRCDPACSSPACLYDNFDCYSGGRDRTCNPVYKKYCADHFADGRCDQGCNTEECGWDGL DCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPY HRPSPGSESRVRRELGPEVIGSVVMLEIDNRLCLKSAENDHCFPDAQSAADYLGALSAVE RLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPE GFALHKDIAAGHKGRREPVGQDALGMKNMTKGESLMGEVATDWNDSECPEAKRLKVEEPG MGAEEPVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASF CGGALEPMPAEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRL LDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAV EGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFL AAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPSGPHG LGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGPQGTRGRGKKLTLACPGPLADSSVT LSPVDSLDSPRPFGGPPASPGGFPLEGPYATTATTVSLAQLGASRAGPLGRQPPGGCVLS LGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGSQLLNPATPVSPHERPPPYLAAPGHGE EYPAAGTHSSPTKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSDSTPSPATATSA TAAGALPAQPHPISVPSLPQSQTQLGPQPEVTPKRQVMA NT seq 6960 nt NT seq  +upstreamnt  +downstreamnt atggggccgggggcccggggccgccgccgccgtcgtcgcctgatggccctgccaccgcca ccaccgcccatgcgggcgctgcccctgctgctgctgctgctagcggggctgggggctgca gcacccccttgtctggatggaagcccatgtgcaaatggaggtcgttgcacccaccagcag ccctcccgggaggctgcttgcctgtgcctgccaggctgggtgggtgagcggtgccagctg gaagacccttgccactctggcccctgtgccggccgaggcgtttgccagagttcagtggtg gcgggcgtcgcccggttctcctgtcgttgtctccgtggcttccgaggcccagactgctcc ctgccagacccctgcttcagcagcccctgtgctcacggtgccccctgctcagttgggtcg gatggccgatatgcctgtgcctgcccacctggctaccagggtcgcaactgccgaagcgac atagatgagtgccgagctggtgcgtcttgccgtcacggtggtacctgcatcaatacaccc ggatccttccactgcctgtgtccacttggctatacagggctgctgtgtgaaaaccccata gtgccctgcgccccttccccatgccgtaatggtggcacctgtaggcagagtagtgatgtc acatatgactgtgcttgtcttcctggcttcgagggccagaactgtgaagtcaatgtggat gactgtcctggacatcggtgtctcaatgggggaacgtgtgtggatggtgtcaatacttat aactgccagtgccctcctgagtggacaggccagttctgcacagaagatgtggatgagtgc cagttgcagcccaacgcttgccacaatgggggcacctgcttcaacctactgggcggccac agctgcgtatgcgtcaacggctggacgggcgagagctgcagtcagaatattgatgactgt gctacagccgtttgcttccatggggccacttgccatgaccgtgtggcctctttctattgt gcctgccctatggggaagaccggcctcttgtgtcatctggatgatgcatgtgtcagcaac ccctgccatgaagatgctatctgtgacacaaaccctgtgagtggtcgggccatctgcacc tgtccacccggcttcaccggaggggcgtgtgaccaggatgtggatgagtgctctattggt gctaacccctgtgaacatttgggtcggtgtgtgaacacacagggctcattcttgtgccag tgtggccgtggctatactggacctcgctgtgagactgatgtcaatgagtgtctgtctggg ccctgccgcaaccaggccacgtgtcttgaccgaattggccagttcacttgcatctgcatg gcaggcttcacaggaaccttctgtgaggtggacattgatgaatgtcagagcagcccatgt gtcaatggtggtgtctgcaaggatagagtcaatggcttcagctgcacctgcccatcagga ttcagtgggtccacgtgtcagctggatgtggatgaatgtgcaagcactccttgccggaac ggtgccaagtgtgtggaccagcctgacggctatgagtgtcgctgtgcagagggctttgag ggcaccctgtgtgagcgaaacgtggacgactgctctccggatccctgtcaccacgggcgc tgtgtcgacggcattgctagcttctcatgcgcttgtgcgccaggctacacgggcatacgc tgcgagagccaggtggatgagtgccgcagccagccctgccgatacgggggcaaatgtcta gacttggtggacaagtacctctgccgctgtcctcccggaaccacaggtgtgaactgcgaa gtcaacatcgatgattgcgccagcaacccctgtacctttggagtttgccgtgatggcatc aaccgctatgattgtgtctgtcagcctggattcacagggcccctctgcaacgtggagatc aatgagtgtgcatccagcccatgtggagagggtggctcctgtgtggacggggaaaatggc ttccactgcctctgcccacctggctccctgcctccactctgcctacctgcgaaccacccc tgtgcccacaagccctgtagtcatggagtctgccacgatgcaccaggcgggtttcaatgt gtgtgcgatcccggttggagtggccctcgttgcagccagagcctggctccagatgcctgt gagtcccagccctgccaggctggtggcacctgcaccagtgatggaataggcttccactgt acctgtgcccctggattccagggtcatcaatgtgaggtgctgtccccctgcactccaagt ctctgtgagcacggaggccactgtgagtctgaccctgaccagctgactgtctgttcctgt cctccaggctggcaaggccctcgatgccagcaggatgtggatgaatgtgctggtgcctca ccttgtggcccccatggtacctgcaccaacctgccagggagcttcaggtgcatctgccat ggaggatacactggccctttctgtgatcaggacattgacgactgtgaccccaacccgtgc ctcaatggtggctcctgccaggatggtgtgggctccttttcctgttcttgcctcagtggc tttgctggtcctcgctgtgctcgggatgtggatgaatgtctgagcagtccctgtggccct ggcacctgcactgatcatgtagcctctttcacctgtacctgtccacctggctatggaggc ttccactgtgagactgacttgctggactgcagccccagttcctgtttcaatggagggacc tgtgtggatggcgtgaactccttcagctgtctgtgtcgtcctggctacacaggcacacat tgccaatataaggttgacccctgcttctcccggccctgtctacatgggggcatctgcaac cccacccactcaggatttgaatgcacctgccgggagggcttcactgggaatcagtgtcag aacccagtggactggtgcagccaggcaccctgtcagaatgggggtcgctgtgtccagact ggggcttactgcatctgtccgcctgaatggagtggccccctgtgcgacataccaagccta ccctgcacggaggctgcagcccacatgggggtgcggttggagcagctgtgtcaggcgggt ggccagtgcatagacaaggaccactcccactactgtgtgtgtccggagggccgtatgggt agtcactgcgaacaggaggtggatccctgcacagcccagccttgccagcatgggggcacc tgccgtggttacatgggcggctatgtgtgtgagtgtccaaccggctactctggtgacagt tgtgaggatgatgtggatgagtgcgcttcccagccctgccagaatggaggctcctgtatt gatcttgtggctcactatctctgctcctgtccccctggcacactgggagttctctgtgag atcaatgaggatgactgtggcccaggcccatccttggactcaggcctccggtgcctacac aacggcacctgtgtggacctggtgggtggcttccgctgtaactgtcccccagggtacaca ggtctgcactgtgaggcggacatcaatgagtgccgacccggcacctgtcatgcagcacat acccgggactgcctacaagatccaggtgggcacttccgctgcatctgtctccctggcttc acagggcctcgatgtcagactgctctgttcccctgtgagtcccaaccgtgtcagcatgga ggccagtgccgtcccagcctaggccgtggaggtgggctgaccttcacctgtcactgtgtc cagccattctggggtctgcgttgcgagcgggtggcacgctcctgccgggagctgcagtgc ccagtgggtatcccatgccagcagacagcccgtgggccgcgctgtgcttgtcctcccggg ctgtctgggccctcctgccgggtttctagggcgtcaccctctggagctactaacaccagc tgcgctgctactccttgtctgcatgggggctcctgcctacctgtacagagtgtccctttc ttccgctgtgtatgcgctccgggctggggtggcccgcgttgcgagaccccttccgcagcc cctgaggtccctgaggagccacggtgcccgcgagccgcctgtcaggccaagcgaggggac cagaactgcgaccgtgagtgcaacagcccaggctgtggctgggacggcggtgactgctcg ctgaatgtggacgacccctggaggcagtgtgaggcactgcagtgctggcgtctcttcaac aacagccggtgcgatccagcctgcagctctcctgcctgcctctatgacaactttgactgc tactctggtggccgcgaccgcacctgcaacccggtttataagaagtactgcgccgaccac tttgcagatggccgttgtgaccagggctgtaacaccgaggagtgtggctgggatgggctg gactgtgccagtgaggtcccggcccttttggcccggggggttctggtcctcacagttctt ctgcctcctgaagagttgcttcgctctagtgctgacttcctgcagcgactcagcgctatt ctgcgcacctcgctgcgcttccgcctggatgcacgtggccaagccatggtctttccctac caccggccaagtcctggctccgaatcccgggttcgtcgtgagcttggcccagaggtgatc ggctctgtagtgatgctggagattgacaaccggctctgtctgaagtcagcggagaacgac cactgcttccctgacgcccagagtgctgccgactacctgggagccttgtcggcagtggag cggcttgatttcccatacccactacgggatgtgcgaggagagcccttggagcctccagag cagagcgtgccactgctgccgctgctggtggcaggggctgtctttctgctggtcatcttc gtcctgggtgtcatggttgccaggcgcaagcgagagcacagcaccctctggtttcctgag ggttttgcattacacaaggacatagctgctggccacaagggccggagggagcccgtggga caagacgcactgggcatgaagaacatgaccaagggtgagagtctgatgggggaggtggcc acagactggaatgactcagaatgcccagaggccaagagactgaaggtagaggagccaggc atgggggccgaggagcccgtggactgtcgccagtggacccaacaccacctggttgctgcc gatatccgtgtggcaccagccatggcactgactccacctcagggagatgcagatgccgat ggcatggatgtcaacgtacgagggcctgatggcttcaccccacttatgctggcctcgttc tgtgggggagccctggagccgatgccagctgaggaggatgaggccgatgacacgtcagcc agcattatatcagatctgatctgccaaggagcccagctcggggcacgaactgaccgaact ggcgagaccgccctgcatttggccgcccgatatgctcgagccgatgcggccaagcggcta ctggatgctggggcagacaccaacgcccaggatcattccggccgcacccctctgcacacc gcagtgacagctgatgcccagggtgtcttccagattctcatcaggaaccgctccactgac ctggatgcccgaatggcagatggctctactgcattgatcctggcagcccgcctggcggtg gagggaatggtggaagagctcatcgccagccacgcagatgtcaatgcagtggatgagctc gggaaatcggccttacactgggctgcagccgtgaacaatgtggaggctaccttggctctg ctgaaaaatggagccaacaaggacatgcaggacagcaaggaggagactccactgttcttg gccgcccgtgagggcagctatgaggctgccaagctgctgctggatcattttgccaaccgg gagatcacagatcacttggacaggctgccccgggatgtggcccaggagcggctgcaccag gacattgtgcggttgctggaccagcccagtggcccccgaagtccctctggtccccatggc ttggggccattgctctgcccaccaggagccttccttcctggcctcaaagcggtgcagtct gggaccaagaagagcaggaggccacctggcaagactgggctggggccccagggaactcgg ggtcggggcaagaagctgacactggcctgtccaggccctctggcagacagctctgtcaca ctgtcaccagtagactcgctggactcaccacggcctttcggtgggccccctgcttcccct ggaggcttccccttggagggtccctatgccaccacagccaccacggtgtccttggcacag ctgggtgcaagtcgggcgggtcctctggggcgccagcctcctgggggctgtgtgctcagc cttggtttgctcaaccctgtggctgttccccttgactgggcccggctgcctccacctgcc cctccagggccctcattcctgctgcccctggctccgggatcccagctgctcaacccggca accccagtttctccccatgagcggcccccaccctacctggctgctccaggacatggagag gaataccctgcagcagggacccacagcagccccacaaaggcccgcttcctgcgggttccc agcgagcatccttatttgaccccatctcctgagtccccagagcactgggccagcccgtcc cctccctccctctcagactggtccgactcaacgcctagtccagcaactgctaccagtgcc acagccgctggagccctgcctgctcaaccacaccccatatctgttccctccctccctcag tcccagactcagctggggccccagccagaagtaacccccaagaggcaggtgatggcctaa

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