Rattus norvegicus (rat): 25738
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Entry
25738 CDS
T01003
Symbol
Plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00562
Inositol phosphate metabolism
rno01100
Metabolic pathways
rno01521
EGFR tyrosine kinase inhibitor resistance
rno04012
ErbB signaling pathway
rno04014
Ras signaling pathway
rno04015
Rap1 signaling pathway
rno04020
Calcium signaling pathway
rno04062
Chemokine signaling pathway
rno04064
NF-kappa B signaling pathway
rno04066
HIF-1 signaling pathway
rno04070
Phosphatidylinositol signaling system
rno04072
Phospholipase D signaling pathway
rno04360
Axon guidance
rno04370
VEGF signaling pathway
rno04613
Neutrophil extracellular trap formation
rno04650
Natural killer cell mediated cytotoxicity
rno04658
Th1 and Th2 cell differentiation
rno04659
Th17 cell differentiation
rno04660
T cell receptor signaling pathway
rno04664
Fc epsilon RI signaling pathway
rno04666
Fc gamma R-mediated phagocytosis
rno04670
Leukocyte transendothelial migration
rno04722
Neurotrophin signaling pathway
rno04750
Inflammatory mediator regulation of TRP channels
rno04919
Thyroid hormone signaling pathway
rno04933
AGE-RAGE signaling pathway in diabetic complications
rno04935
Growth hormone synthesis, secretion and action
rno05012
Parkinson disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05135
Yersinia infection
rno05167
Kaposi sarcoma-associated herpesvirus infection
rno05170
Human immunodeficiency virus 1 infection
rno05171
Coronavirus disease - COVID-19
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05206
MicroRNAs in cancer
rno05214
Glioma
rno05223
Non-small cell lung cancer
rno05225
Hepatocellular carcinoma
rno05231
Choline metabolism in cancer
rno05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05417
Lipid and atherosclerosis
Module
rno_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
25738 (Plcg1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
25738 (Plcg1)
04014 Ras signaling pathway
25738 (Plcg1)
04015 Rap1 signaling pathway
25738 (Plcg1)
04370 VEGF signaling pathway
25738 (Plcg1)
04064 NF-kappa B signaling pathway
25738 (Plcg1)
04066 HIF-1 signaling pathway
25738 (Plcg1)
04020 Calcium signaling pathway
25738 (Plcg1)
04070 Phosphatidylinositol signaling system
25738 (Plcg1)
04072 Phospholipase D signaling pathway
25738 (Plcg1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
25738 (Plcg1)
04650 Natural killer cell mediated cytotoxicity
25738 (Plcg1)
04660 T cell receptor signaling pathway
25738 (Plcg1)
04658 Th1 and Th2 cell differentiation
25738 (Plcg1)
04659 Th17 cell differentiation
25738 (Plcg1)
04664 Fc epsilon RI signaling pathway
25738 (Plcg1)
04666 Fc gamma R-mediated phagocytosis
25738 (Plcg1)
04670 Leukocyte transendothelial migration
25738 (Plcg1)
04062 Chemokine signaling pathway
25738 (Plcg1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
25738 (Plcg1)
04919 Thyroid hormone signaling pathway
25738 (Plcg1)
09156 Nervous system
04722 Neurotrophin signaling pathway
25738 (Plcg1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
25738 (Plcg1)
09158 Development and regeneration
04360 Axon guidance
25738 (Plcg1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
25738 (Plcg1)
05206 MicroRNAs in cancer
25738 (Plcg1)
05205 Proteoglycans in cancer
25738 (Plcg1)
05231 Choline metabolism in cancer
25738 (Plcg1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
25738 (Plcg1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
25738 (Plcg1)
05214 Glioma
25738 (Plcg1)
05223 Non-small cell lung cancer
25738 (Plcg1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
25738 (Plcg1)
05171 Coronavirus disease - COVID-19
25738 (Plcg1)
05167 Kaposi sarcoma-associated herpesvirus infection
25738 (Plcg1)
09171 Infectious disease: bacterial
05135 Yersinia infection
25738 (Plcg1)
09164 Neurodegenerative disease
05012 Parkinson disease
25738 (Plcg1)
05022 Pathways of neurodegeneration - multiple diseases
25738 (Plcg1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
25738 (Plcg1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
25738 (Plcg1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
25738 (Plcg1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
rno04131
]
25738 (Plcg1)
Enzymes [BR:
rno01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
25738 (Plcg1)
Membrane trafficking [BR:
rno04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
25738 (Plcg1)
Endocytosis
Macropinocytosis
Phospholipase C
25738 (Plcg1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
PH
C2
SH3_1
SH3_9
SH3_2
PH_12
GDPD
EF-hand_6
EF-hand_7
Motif
Other DBs
NCBI-GeneID:
25738
NCBI-ProteinID:
NP_037319
RGD:
3347
Ensembl:
ENSRNOG00000051490
UniProt:
P10686
Structure
PDB
LinkDB
All DBs
Position
3:169805299..169836040
Genome browser
AA seq
1290 aa
AA seq
DB search
MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRT
GERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq
3873 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgtcgggaccccctgcgccaacggctgcgggcccagcgcgccctccgaagcg
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccagaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggtgcggacaaaatcgaggggtccatcgatatccgagaaatcaaggag
atccgcccagggaagacttcccgggactttgaccgctaccaagaagaccctgccttccgg
ccagatcagtcacactgttttgtcatcctctatggaatggaattccgcctgaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctc
atggaagatacgctgcaggccgccacacccctgcaaattgagagatggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaggacctgaagaacatg
ctgtcacaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
cttgaacagcgcagcggggacatcacctatgggcagtttgctcagctttaccgcagcctc
atgtacagcgcccagaagacgatggaccttccgttcttggaaaccaacactttgaggact
ggagagcggccagagctttgccaggtgtccctttctgagttccagcagttccttcttgag
taccagggggagctgtgggctgtcgaccggcttcaggtgcaggaatttatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctggatgccgtgtgcccagaa
accatgaacaacccactgtctcactattggatctcttcctcgcataatacgtatctgact
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgaggatgggc
tgtcgctgcatcgagttggactgctgggatgggccagatgggatgccagtcatttaccat
gggcacaccctcaccaccaagattaagttctcagatgtcctgcacaccatcaaggagcac
gcgttcgtagcctcagagtaccctgtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaggaaggtgctcggtgacacgctcctcaccaag
cccgtggacattgccgctgatgggctcccttctcccaaccagctcaagaggaagatcctg
attaagcataagaagctggctgagggcagtgcctatgaggaggtgcctacctctgtgatg
tactccgagaatgatatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtacccccactactttgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggaaatgaggatgaagaggagccgaaggaggccagtggc
agcacagagctgcactcgagcgagaagtggttccacgggaagctcggggctgggcgcgac
gggcggcacattgctgagcgcctgctcaccgagtactgcatagagactggggctcccgat
ggctccttcctagtgcgagaaagtgagaccttcgtgggggactacacgctgtctttctgg
cggaatgggaaagtccagcactgccgtatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtgcccctgcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagacg
aatgcccatgagagcaaagagtggtaccacgcaagcctgactagagctcaggctgaacac
atgctgatgcgagtaccccgtgatggggccttcctggtgcggaagcgcaacgagcccaac
tcctatgccatctctttccgggctgagggaaagatcaagcactgccgagtacagcaggaa
ggccagactgtgatgctggggaactctgagtttgacagcctggtcgacctcatcagctac
tatgagaagcatcccctgtaccgcaaaatgaaactgcgctaccccatcaacgaggaggcg
ctggagaagattgggacagctgaacccgattatggggcactgtatgagggccgcaaccct
ggtttctatgtggaggccaaccctatgccaactttcaagtgtgcagtaaaagctctcttc
gactacaaggcccagagagaggatgagctgacttttaccaagagcgccatcatccagaat
gtggaaaagcaagatggtggctggtggcgtggggactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaatccagcaatcctagagccggagagggag
catctggatgagaacagcccactgggggacttgctgcgaggggtcttagatgtgccagcc
tgccagatcgccattcgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccgtcagtggctcagtggtccctagacgttgccgctgactcacaggaggagttgcag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggcttactgagggg
aagatgatggagaggaggaagaagatcgccttggagctctccgagctcgtggtctactgc
cggcctgttccctttgacgaagagaagattggcacagaacgcgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctctcgcatctaccctaagggtcagaggctggactcc
tccaattatgaccctctgcccatgtggatctgtggcagccagcttgtagctctcaatttt
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggtggacactgt
ggctatgtgctgcagccaagcaccatgagagatgaagcctttgacccctttgataagagc
agtctccgaggtctggagccctgtgtcatttgcattgaggtgctgggggccaggcatctg
ccgaagaatggccggggtattgtgtgtcctttcgtggagattgaagtggctggggcagag
tacgacagcaccaagcagaagacagagtttgtagtggacaatggactgaaccctgtgtgg
cctgcaaagcccttccacttccagatcagtaacccagagtttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacattttccctgctaaggagaatggtgacctc
agccctttcagtggtacatccctaagggaacgggcctcagatgcctccagccagctgttc
catgtccgggcccgggaagggtcctttgaagccagataccagcagccatttgaagacttc
cgcatctcgcaggagcatctcgcagaccattttgacagtcgggaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag
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integrated database retrieval system
