KEGG   Rattus norvegicus (rat): 89830
Entry
89830             CDS       T01003                                 

Gene name
Ptch1, Ptch, Ptch2
Definition
(RefSeq) patched 1
  KO
K06225  patched 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04024  cAMP signaling pathway
rno04340  Hedgehog signaling pathway
rno04360  Axon guidance
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05217  Basal cell carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    89830 (Ptch1)
   04024 cAMP signaling pathway
    89830 (Ptch1)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    89830 (Ptch1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    89830 (Ptch1)
   05205 Proteoglycans in cancer
    89830 (Ptch1)
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    89830 (Ptch1)
SSDB
Motif
Pfam: Patched Sterol-sensing MENTAL
Other DBs
NCBI-GeneID: 89830
NCBI-ProteinID: NP_446018
RGD: 621425
Ensembl: ENSRNOG00000019354
UniProt: Q6UY90
LinkDB
Position
17p14
AA seq 1434 aa
MASAGNAAGALGRQAGGGRRRRTGGPHRAAPDRDYLHRPSYCDAAFALEQISKGKATGRK
APLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGG
RVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYN
RQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPL
RWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNST
KPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYE
HFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSF
SDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGIS
FNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSIS
NVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF
TSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHV
YYTTAEPRSEISVQPVTITQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSS
FAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQ
FKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQG
LQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGII
NPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQF
PFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISV
VLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGV
EFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFA
VLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHT
NNGSDSSDSEYSSQTTVSGISEELRHYEAQQGTGGPAHQVIVEATENPVFARSTVVHPDS
RHQPPLNSRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPS
NRDRSGPHGARSHNPRNPTSTAMGSSVPSYCQPITTVTASASVTVAVHPPPGPGRNPRGG
PCPGYESYPETDHGVFEDPHVPFHVRCERRDSKVEVIELQDVECEERPWGSSSN
NT seq 4305 nt   +upstreamnt  +downstreamnt
atggcctcggctggtaacgccgccggggccctgggcaggcaggccggcggcgggaggcgc
agacggaccgggggaccgcaccgcgccgcaccggaccgggactatctgcaccggcccagc
tactgcgacgccgccttcgctctggagcagatttccaaggggaaggctactggccggaaa
gcgccgctgtggctgagagcgaagtttcaaagactcttatttaaactgggttgttacatt
caaaagaactgcggcaagtttttggttgtgggtctcctcatatttggggccttcgctgtg
ggattaaaggcagctaatctcgagaccaacgtggaggagctgtgggtggaagttggtgga
cgagtgagtcgagaattaaattatacccgccagaagataggagaagaggctatgtttaat
cctcaactcatgattcagactccaaaagaagaaggcgctaatgtcctgaccacagaggcc
ctactacaacacctggactcagcactccaggccagccgtgtgcacgtctacatgtataac
aggcaatggaagttggaacatttatgctacaaatcaggggaacttatcacagagacaggc
tacatggatcagataatagaatacctttacccttgcttaatcattacacctttggactgc
ttctgggaaggggcaaagctacagtccgggacagcgtacctcctaggtaagcctccttta
cggtggacaaactttgaccccttggaattcctagaagagttaaagaaaataaactaccaa
gtggacagttgggaggaaatgctgaataaagccgaagttggccatgggtacatggaccgg
ccttgcctcaatccagccgacccagattgccctgccacagcccccaacaaaaattcaacc
aaacctcttgatgtggcccttgttttgaacggtggatgtcaaggtttatccaggaagtat
atgcattggcaggaggagttgattgtgggtggcaccgtcaagaacgccactggaaagctt
gtcagcgctcatgccctgcaaaccatgttccagttaatgactcccaagcaaatgtatgaa
cacttcaggggctacgactatgtctctcacatcaactggaatgaggatagggctgccgcc
atcctggaggcatggcagaggacttacgtggaggtggttcatcaaagtgttgccccaaac
tccactcaaaaggtgctttccttcaccaccacgaccctggacgacatcctaaaatccttc
tctgatgtcagtgtcatccgagtggccagtggctacctactgatgcttgcctacgcctgt
ttaaccatgctgcgctgggactgctccaagtcccagggtgccgtggggttggctggtgtc
ctgttggttgcactgtcagtggctgcaggattgggcctctgctccttgattggcatttcc
tttaatgctgcaacaactcaggttttgccatttcttgcccttggtgttggtgtggacgac
gtctttctcctggcccatgcattcagtgaaacgggacagaataagaggattccatttgag
gacaggactggggagtgcctcaagcgcacgggagccagcgtggccctcacctccatcagc
aatgtcactgccttcttcatggctgcattaatccctattcctgcactgcgagcgttctcc
ctccaggctgctgtggtggtggtattcaattttgccatggttctactcattttccctgca
attctcagcatggatttatacagacgtgaggacagaagattggatattttctgctgtttc
acaagcccctgtgtcagccgggtgattcaagttgaaccgcaggcctacacagagcctcat
agtaacacccggtacagccccccacccccgtacagcagccacagcttcgcccatgaaacc
cacatcaccatgcagtccaccgttcagctccgcacagaatatgaccctcacacacacgtc
tactacaccaccgccgagccgcgctctgagatctctgtacagcctgtcaccatcacccag
gacaccctcagctgtcagagccctgagagcaccagttccacccgggacctgctttctcaa
ttctctgactccagcctccactgccttgagcccccctgcaccaagtggacactttcttcg
tttgcagagaagcactacgctcctttcctcttgagacccaaagccaaggttgtggtaatc
cttcttttcctgggcttgctgggcgtcagcctttatgggaccacccgagtgagagacggg
ctggacctcacggacattgtcccccgggaaaccagagaatatgacttcatagctgcccag
ttcaagtacttctctttctacaacatgtatatagtcacccagaaagcagactacccaaat
atccaacacctgctttacgaccttcataagagtttcagcagtgtgaagtatgtcatgctg
gaggagaacaagcaacttccccaaatgtggctgcattactttagagactggctccaagga
cttcaggatgcatttgacagtgactgggaaaccgggaggatcatgccaaacaattataaa
aatggatctgatgatggggtcctcgcttacaaactcctggtgcagactggcagccgagac
aagcccatcgacattagtcagttgactaaacagcgtctggtggacgcagatggcatcatt
aatccgagcgctttctacatctacctgaccgcttgggtcagcaatgaccctgtagcttac
gctgcctcccaggccaacatccggcctcacagaccagagtgggtgcacgacaaagctgac
tacatgccagagaccaggctgagaatcccagcagcagagcccatagagtacgctcagttc
cctttctacctcaacggcctacgggacacctcagactttgtggaagccatagaaaaagtg
agagtcatctgtaacaactacacgagtctggggctgtccagctaccccaatggctacccc
ttcctgttctgggagcagtacatcagcctgcgtcactggctgctgctagccatcagcgtg
gtgctggcctgcacatttctagtgtgcgcagtcttcctcctgaacccctggacggccggg
atcattgtcatggtcctggctttgatgaccgttgagctcttcggcatgatgggcctcatt
gggatcaagctgagtgctgtgccggtggtcatcctgattgcgtctgttggcattggagta
gaattcaccgtccacgtggctttggcctttctgacagccattggggacaagaaccacagg
gctatgctcgccctggagcacatgttcgctcctgttctggacggtgctgtgtccactctg
ctgggtgtactgatgcttgcgggatccgaatttgacttcattgtcagatacttctttgcc
gtcctggccatcctcaccgtcttgggagttctcaacggactggttctgctgcctgtactc
ttatccttcttcggaccatgtcctgaggtgtctccagccaacggcctaaaccggctgccc
actccttcgcctgagccgcccccaagcgtcgtccggtttgccgtgcctcctggtcacacg
aacaatgggtctgattcctccgactccgagtacagctctcagaccacggtgtctggcatc
agtgaggagctcaggcactatgaagcacagcagggcaccggaggtcctgcccaccaagtg
attgtggaagccacagaaaaccccgtctttgcccggtccactgtggtgcatcctgactcc
agacatcagcctcccttgaactctcggcaacagccccacctggactctggctccctgtcc
cctggacggcaaggccagcagcctcgaagggatccccccagagaaggcttgcggccaccc
ccctacagaccgcgcagagacgcttttgaaatttctactgaagggcattctggccctagc
aatagggaccgctcgggcccccatggggcccgttctcacaaccctcggaacccaacgtcc
actgccatgggcagctctgtgcccagctactgccagcctatcaccactgtgacggcttcc
gcttctgtaactgtcgctgtgcaccccccacctggacctgggcgcaacccccgaggggga
ccctgtccaggctacgagagctaccccgagactgatcacggggtgttcgaggatccccat
gtgccttttcatgtcaggtgtgagaggagggactcgaaggtggaggttatagaactacag
gacgtggagtgtgaggagaggccgtgggggagcagctccaactag

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