KEGG   PATHWAY: roa03430
roa03430                    Pathway                                

Mismatch repair - Rhodococcus opacus PD630
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
roa03430  Mismatch repair

Other DBs
GO: 0006298
Rhodococcus opacus PD630 [GN:roa]
Pd630_LPD03043  ATP-dependent DNA helicase pcrA [KO:K03657] [EC:]
Pd630_LPD03048  putative DNA helicase II [KO:K03657] [EC:]
Pd630_LPD02168  ATP-dependent DNA helicase pcrA [KO:K03657] [EC:]
Pd630_LPD02495  Exodeoxyribonuclease 7 large subunit [KO:K03601] [EC:]
Pd630_LPD02494  Exodeoxyribonuclease 7 small subunit [KO:K03602] [EC:]
Pd630_LPD05515  Single-stranded DNA-binding protein [KO:K03111]
Pd630_LPD07778  Single-stranded DNA-binding protein [KO:K03111]
Pd630_LPD05163  DNA polymerase III subunit alpha [KO:K02337] [EC:]
Pd630_LPD00002  DNA polymerase III subunit beta [KO:K02338] [EC:]
Pd630_LPD00599  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:]
Pd630_LPD00600  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:]
Pd630_LPD05387  hypothetical protein [KO:K02340] [EC:]
Pd630_LPD00801  DNA polymerase III subunit gamma/tau [KO:K02341] [EC:]
Pd630_LPD05998  Tellurium resistance protein TerD [KO:K02342] [EC:]
Pd630_LPD05222  Uncharacterized protein [KO:K02342] [EC:]
Pd630_LPD01623  DNA polymerase III polC-type [KO:K02342] [EC:]
Pd630_LPD11031  DNA polymerase III polC-type [KO:K02342] [EC:]
Pd630_LPD01029  putative ATP-dependent helicase dinG [KO:K02342] [EC:]
Pd630_LPD03134  DNA ligase [KO:K01972] [EC:]
Pd630_LPD05785  putative DNA ligase [KO:K10747] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair] Japanese
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

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