KEGG   Rhinopithecus roxellana (golden snub-nosed monkey): 104674419
Entry
104674419         CDS       T03989                                 

Gene name
PTPN11
Definition
(RefSeq) tyrosine-protein phosphatase non-receptor type 11 isoform X2
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
rro  Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro04014  Ras signaling pathway
rro04072  Phospholipase D signaling pathway
rro04360  Axon guidance
rro04625  C-type lectin receptor signaling pathway
rro04630  JAK-STAT signaling pathway
rro04650  Natural killer cell mediated cytotoxicity
rro04670  Leukocyte transendothelial migration
rro04722  Neurotrophin signaling pathway
rro04920  Adipocytokine signaling pathway
rro04931  Insulin resistance
rro05168  Herpes simplex virus 1 infection
rro05205  Proteoglycans in cancer
rro05211  Renal cell carcinoma
rro05220  Chronic myeloid leukemia
rro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    104674419 (PTPN11)
   04630 JAK-STAT signaling pathway
    104674419 (PTPN11)
   04072 Phospholipase D signaling pathway
    104674419 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    104674419 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    104674419 (PTPN11)
   04670 Leukocyte transendothelial migration
    104674419 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    104674419 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    104674419 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    104674419 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    104674419 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104674419 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    104674419 (PTPN11)
   05211 Renal cell carcinoma
    104674419 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    104674419 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    104674419 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rro01009]
    104674419 (PTPN11)
Enzymes [BR:rro01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     104674419 (PTPN11)
Protein phosphatases and associated proteins [BR:rro01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    104674419 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 104674419
NCBI-ProteinID: XP_010377025
UniProt: A0A2K6PEZ1
LinkDB
Position
10
AA seq 593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcggaaaacctactg
ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtatggaggggagaaatttgccactttggctgagttggttcagtat
tacatggaacatcacgggcaattaaaagagaagaatggagatgttattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacacctctctgggaaa
gaagcagagaaattgttaactgaaaaaggaaaacatggtagttttcttgtacgagagagc
cagagtcaccctggagattttgttctctctgtgcgcactggtgatgacaaaggggagagc
aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatatgac
gttggcggaggagaacggtttgattctttgacagatcttgtggaacattacaagaagaat
cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt
ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacagcaggagtgcaaa
cttctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa
aacatcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcct
gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgcctgcagaacacagtgaacgac
ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat
ggcgtcatgcgtgttaggaacgtcaaagaaagtgccgctcatgactatacgctaagagaa
cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt
cggacctggccggaccacggagtgcccagcgaccccgggggcgtgctggacttcctggag
gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt
gctggaattggccggacagggacattcattgtgattgatattcttattgacatcatcaga
gagaaaggtgttgactgcgacattgacgttcccaaaaccatccagatggtgcggtctcag
aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat
tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcac
gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccccctc
ccgccttgtactccaacaccaccctgtgcagaaatgagagaagacagtgctagagtctat
gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga

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