KEGG   PATHWAY: sasa04115
Entry
sasa04115                   Pathway                                

Name
p53 signaling pathway - Salmo salar (Atlantic salmon)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
sasa04115  p53 signaling pathway
sasa04115

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106612994  atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
106580118  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
106585648  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
106591441  atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
106563964  chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
100196817  gorab; golgin, RAB6 interacting [KO:K19748]
106609861  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597239  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597562  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597420  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106593772  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597741  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597260  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597762  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597621  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106594600  mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
106597585  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106583136  mdm4; MDM4, p53 regulator [KO:K10127]
106602901  tp53; tumor protein p53 [KO:K04451]
106608673  P53; cellular tumor antigen p53-like [KO:K04451]
106577554  cellular tumor antigen p53-like [KO:K04451]
106565657  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
106583085  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
106561617  G1/S-specific cyclin-D1-like [KO:K04503]
106562055  G1/S-specific cyclin-D1-like [KO:K04503]
106587137  G1/S-specific cyclin-D1 [KO:K04503]
100306852  ccnd1; cyclin D1 [KO:K04503]
106601568  G1/S-specific cyclin-D2-like [KO:K10151]
106606904  G1/S-specific cyclin-D2-like [KO:K10151]
106561356  G1/S-specific cyclin-D2-like [KO:K10151]
106573197  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
106576262  G1/S-specific cyclin-D2-like [KO:K10151]
100195486  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
106583090  G1/S-specific cyclin-D2-like [KO:K10152]
106565448  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
106583286  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
106600958  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
100286677  cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106588946  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
106605376  ccne2; cyclin E2 [KO:K06626]
106562012  G1/S-specific cyclin-E1-like [KO:K06626]
100195405  ccne2; cyclin E2 [KO:K06626]
106565437  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
100196712  cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
106567336  protein reprimo A-like [KO:K10128]
106581827  protein reprimo A-like [KO:K10128]
106566708  CCNB1; G2/mitotic-specific cyclin-B1-like [KO:K05868]
106562137  G2/mitotic-specific cyclin-B1-like [KO:K05868]
106563318  ccnb1; cyclin B1 [KO:K05868]
106587173  G2/mitotic-specific cyclin-B1-like [KO:K05868]
106587338  ccnb2; cyclin B2 [KO:K21770]
106607826  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100196122  cdc2; Cell division control protein 2 homolog [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106567216  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106566617  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106598934  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106560326  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106613608  GA45B; growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106568974  GA45A; growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106573930  GA45B; growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106563369  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106563370  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
100196442  ga45g; Growth arrest and DNA-damage-inducible protein GADD45 gamma [KO:K04402]
106585195  GA45G; growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106584172  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106584598  gtse1; G2 and S-phase expressed 1 [KO:K10129]
106577010  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
100380364  tnr6; Tumor necrosis factor receptor superfamily member 6 [KO:K04390]
106584778  p53-induced death domain-containing protein 1-like [KO:K10130]
106584781  p53-induced death domain-containing protein 1-like [KO:K10130]
106567553  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
106563139  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
106580524  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
106584955  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
106569473  caspase-8-like [KO:K04398] [EC:3.4.22.61]
106586254  caspase-8-like [KO:K04398] [EC:3.4.22.61]
106561376  uncharacterized LOC106561376 [KO:K04726]
106600761  apoptosis regulator BAX-like [KO:K02159]
106601126  apoptosis regulator BAX-like [KO:K02159]
106607327  apoptosis regulator BAX-like [KO:K02159]
106607328  apoptosis regulator BAX-like [KO:K02159]
106561972  BAX; apoptosis regulator BAX-like [KO:K02159]
106587134  BAX; apoptosis regulator BAX-like [KO:K02159]
106583949  apoptosis regulator BAX-like [KO:K02159]
106610856  apoptosis regulatory protein Siva-like [KO:K22744]
100196178  siva1; SIVA1 apoptosis inducing factor [KO:K22744]
106572112  bcl-2-like protein 1 [KO:K04570]
106565774  BCLX; bcl-2-like protein 1 [KO:K04570]
106582883  bcl-2-like protein 1 [KO:K04570]
100196057  bclx; Apoptosis regulator Bcl-X [KO:K04570]
106599248  apoptosis regulator Bcl-2-like [KO:K02161]
106569189  apoptosis regulator Bcl-2-like [KO:K02161]
106579593  apoptosis regulator Bcl-2-like [KO:K02161]
106590353  apoptosis regulator Bcl-2-like [KO:K02161]
106611351  tp53i3; tumor protein p53 inducible protein 3 [KO:K10133] [EC:1.-.-.-]
106603545  etoposide-induced protein 2.4 homolog [KO:K10134]
106567936  etoposide-induced protein 2.4 homolog [KO:K10134]
106583799  protein shisa-5-like [KO:K10135]
100196698  perp; PERP, TP53 apoptosis effector [KO:K10136]
106589683  perp; PERP, TP53 apoptosis effector [KO:K10136]
106613932  zmat3; zinc finger matrin-type 3 [KO:K10137]
106584304  zinc finger matrin-type protein 3-like [KO:K10137]
106573709  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
106560862  siah1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
106575069  cytochrome c [KO:K08738]
106582467  CYC; cytochrome c [KO:K08738]
106588840  cytochrome c iso-1/iso-2-like [KO:K08738]
106586251  CYC; cytochrome c [KO:K08738]
106609566  apoptotic protease-activating factor 1-like [KO:K02084]
106576445  apoptotic protease-activating factor 1-like [KO:K02084]
106572551  casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
106567147  caspase-9-like [KO:K04399] [EC:3.4.22.62]
106602722  CASP3; caspase-3-like [KO:K02187] [EC:3.4.22.56]
106612018  caspase-3-like [KO:K02187] [EC:3.4.22.56]
100194892  casp3; Caspase-3 [KO:K02187] [EC:3.4.22.56]
106576717  aifm2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
101448060  igfbp-3a1; insulin-like growth factor binding protein 3 paralog A1 [KO:K10138]
101448063  igfbp-3a2; insulin-like growth factor binding protein 3 paralog A2 [KO:K10138]
101448066  igfbp-3b1; insulin-like growth factor binding protein 3 paralog B1 [KO:K10138]
101448067  igfbp-3b2; insulin-like growth factor binding protein 3 paralog B2 [KO:K10138]
106609475  insulin-like growth factor I [KO:K05459]
100136517  insulin-like growth factor I [KO:K05459]
106608947  plasminogen activator inhibitor 1-like [KO:K03982]
106577897  plasminogen activator inhibitor 1-like [KO:K03982]
106579424  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
106605503  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
106573025  CD82 antigen-like [KO:K06509]
106572911  CD82 antigen-like [KO:K06509]
106587947  CD82 antigen-like [KO:K06509]
106587984  CD82 antigen-like [KO:K06509]
100195746  cd37; Leukocyte antigen CD37 [KO:K06509]
100195962  cd82; CD82 antigen [KO:K06509]
106587655  thrombospondin-1-like [KO:K16857]
106608163  thrombospondin-1-like [KO:K16857]
106610834  thrombospondin-1-like [KO:K16857]
106571097  thrombospondin-1-like [KO:K16857]
106584815  ddb2; damage specific DNA binding protein 2 [KO:K10140]
106570792  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
100194994  rir2; Ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106607664  rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
106603373  sestrin-3-like [KO:K10141]
106604703  sestrin-3-like [KO:K10141]
106607965  sesn1; sestrin 1 [KO:K10141]
106611768  sestrin-3-like [KO:K10141]
106571802  sestrin-1-like [KO:K10141]
106567842  sestrin-3-like [KO:K10141]
106607213  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106600774  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106578954  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106577009  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106589390  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106564303  tuberin-like [KO:K07207]
106575265  steap3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
106574427  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
106586584  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
106599409  rfwd2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
106569074  E3 ubiquitin-protein ligase RFWD2-like [KO:K10143] [EC:2.3.2.27]
106580050  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106585722  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106585368  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106604232  CCNG1; cyclin-G1-like [KO:K10145]
106612230  CCNG1; cyclin-G1-like [KO:K10145]
106572117  cyclin-G2-like [KO:K10146]
106568527  cyclin-G2-like [KO:K10146]
106580043  cyclin-G2-like [KO:K10146]
100194937  ccng2; cyclin G2 [KO:K10146]
106585380  cyclin-G2-like [KO:K10146]
106603268  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
106581525  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
106613321  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
sasa04110  Cell cycle
sasa04210  Apoptosis
sasa04218  Cellular senescence
KO pathway
ko04115   
LinkDB

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