Entry |
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Name |
Peptidoglycan biosynthesis - Shewanella baltica OS185
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Description |
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
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Class |
Metabolism; Glycan biosynthesis and metabolism
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Pathway map |

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Organism |
Shewanella baltica OS185 [GN: sbm]
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Gene |
Shew185_0401 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227] |
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Compound |
C00043 | UDP-N-acetyl-alpha-D-glucosamine |
C00448 | trans,trans-Farnesyl diphosphate |
C00692 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate |
C01212 | UDP-N-acetylmuramoyl-L-alanine |
C04574 | di-trans,poly-cis-Undecaprenyl diphosphate |
C04631 | UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine |
C04702 | UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) |
C04851 | MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol |
C04877 | UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate |
C04882 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine |
C05892 | UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine |
C05893 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine |
C05894 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine |
C05895 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine |
C05896 | Crosslinked peptidoglycan |
C05897 | Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine |
C05898 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine |
C17541 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine |
C17542 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine |
C17549 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine |
C17550 | Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine |
C17556 | di-trans,poly-cis-Undecaprenyl phosphate |
C17558 | di-trans,poly-cis-Undecaprenol |
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Reference |
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Authors |
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D |
Title |
The biosynthesis of peptidoglycan lipid-linked intermediates. |
Journal |
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Reference |
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Authors |
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG |
Title |
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. |
Journal |
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Reference |
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Authors |
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D |
Title |
Cytoplasmic steps of peptidoglycan biosynthesis. |
Journal |
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Reference |
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Authors |
van Heijenoort J |
Title |
Recent advances in the formation of the bacterial peptidoglycan monomer unit. |
Journal |
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Reference |
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Authors |
van Heijenoort J |
Title |
Formation of the glycan chains in the synthesis of bacterial peptidoglycan. |
Journal |
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Related pathway |
sbm00520 | Amino sugar and nucleotide sugar metabolism |
sbm00900 | Terpenoid backbone biosynthesis |
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KO pathway |
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LinkDB |
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